The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 21, 2003, Pages 12390-12395

  Vader, Willemijn ^a   Stepniak, Dariusz ^a   Kooy, Yvonne ^a   Mearin, Luisa ^a   Thompson, Allan ^a   Van Rood, Jon J ^a   Spaenij, Liesbeth ^a   Koning, Frits ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTEN; HLA DQ ANTIGEN; HLA DQ2 2 ANTIGEN; HLA DQ2 5 ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CELIAC DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; GENETIC PREDISPOSITION; GENETIC RISK; HETEROZYGOSITY; HOMOZYGOSITY; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIGEN-PRESENTING CELLS; BASE SEQUENCE; CELIAC DISEASE; DIMERIZATION; DNA; GENE DOSAGE; GLUTEN; HETEROZYGOTE; HLA-DQ ANTIGENS; HOMOZYGOTE; HUMANS; PROTEIN BINDING; RISK FACTORS; T-LYMPHOCYTES;

EID: 0142091358     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2135229100     Document Type: Article

References (29)

1. van de Wal, Y., Kooy, Y. M. C., Drijfhout, J. W., Amons, R. & Koning, F. (1996) Immunogenetics 44, 246-253.
2. Vartdal, F., Johansen, B. H., Friede, T., Thorpe, C. J., Stevanovic, S., Eriksen, J. E., Sletten, K., Thorsby, E., Rammensee, H. G. & Sollid, L. M. (1996) Eur. J. Immunol. 26, 2764-2772.
3. Molberg, O., McAdam, S. N., Korner, R., Quarsten, H., Kristiansen, C., Madsen, L., Fugger, L., Scott, H., Noren, O., Roepstorff, P., et al. (1998) Nat. Med. 4, 713-717.
4. van de Wal, Y., Kooy, Y., van Veelen, P., Pena, S., Mearin, L., Papadopoulos, G. & Koning, F. (1998) J. Immunol. 161, 1585-1588.
5. Vader, L. W., De Ru, A., van der Wal, Y., Kooy, Y. M., Benckhuijsen, W., Mearin, M. L., Drijfhout, J. W., van Veelen, P. & Koning, F. (2002) J. Exp. Med. 195, 643-649.
6. van de Wal, Y., Kooy, Y. M., Drijfhout, J. W., Amons, R., Papadopoulos, G. K. & Koning, F. (1997) Immunogenetics 46, 484-492.
7. Quarsten, H., Molberg, O., Fugger, L., McAdam, S. N. & Sollid, L. M. (1999) Eur. J. Immunol. 29, 2506-2514.
8. Sollid, L. M., Markussen, G., Ek, J., Gjerde, H., Vartdal, F. & Thorsby, E. (1989) J. Exp. Med. 169, 345-350.
9. Louka, A. S., Nilsson, S., Olsson, M., Talseth, B., Lie, B. A., Ek, J., Gudjonsdottir, A. H., Ascher, H. & Sollid, L. M. (2002) Tissue Antigens 60, 147-154.
10. Mearin, M. L., Biemond, I., Pena, A. S., Polanco, I., Vazquez, C., Schreuder, G. T., de Vries, R. R. & van Rood, J. J. (1983) Gut 24, 532-537.
11. Ploski, R., Ek, J., Thorsby, E. & Sollid, L. M. (1993) Tissue Antigens 41, 173-177.
12. Spits, H., Borst, J., Giphart, M., Coligan, J., Terhorst, C. & De Vries, J. E. (1984) Eur. J. Immunol. 14, 299-304.
13. Heemskerk, M. H., Blom, B., Nolan, G., Stegmann, A. P., Bakker, A. Q., Weijer, K., Res, P. C. & Spits, H. (1997) J. Exp. Med. 186, 1597-1602.
14. Ruggieri, L., Aiuti, A., Salomoni, M., Zappone, E., Ferrari, G. & Bordignon, C. (1997) Hum. Gene Ther. 8, 1611-1623.
15. Kinsella, T. M. & Nolan, G. P. (1996) Hum. Gene Ther. 7, 1405-1413.
16. Heemskerk, M. H., de Paus, R. A., Lurvink, E. G., Koning, F., Mulder, A., Willemze, R., van Rood, J. J. & Falkenburg, J. H. (2001) Proc. Natl. Acad. Sci. USA 98, 6806-6811.
17. Marsh, S. G. & Bodmer, J. G. (1989) Immunol. Today 10, 305-312.
18. Anderson, R. P., Degano, P., Godkin, A. J., Jewell, D. P. & Hill, A. V. (2000) Nat. Med. 6, 337-342.
19. Arentz-Hansen, H., Korner, R., Molberg, O., Quarsten, H., Vader, W., Kooy, Y. M., Lundin, K. E., Koning, F., Roepstorff, P., Sollid, L. M., et al. (2000) J. Exp. Med. 191, 603-612.
20. Arentz-Hansen, H., McAdam, S. N., Molberg, O., Fleckenstein, B., Lundin, K. E., Jorgensen, T. J., Jung, G., Roepstorff, P. & Sollid, L. M. (2002) Gastroenterology 123, 803-809.
21. Sjostrom, H., Lundin, K. E., Molberg, O., Korner, R., McAdam, S. N., Anthonsen, D., Quarsten, H., Noren, O., Roepstorff, P., Thorsby, E., et al. (1998) Scand. J. Immunol. 48, 111-115.
22. Vader, W., Kooy, Y., van Veelen, P., De Ru, A., Harris, D., Benckhuijsen, W., Pena, S., Mearin, L., Drijfhout, J. W. & Koning, F. (2002) Gastroenterology 122, 1729-1737.
23. van de Wal, Y., Kooy, Y. M., van Veelen, P. A., Pena, S. A., Mearin, L. M., Molberg, O., Lundin, K. E., Sollid, L. M., Mutis, T., Benckhuijsen, W. E., et al. (1998) Proc. Natl. Acad. Sci. USA 95, 10050-10054.
24. van de Wal, Y., Kooy, Y. M., van Veelen, P., Vader, W., August, S. A., Drijfhout, J. W., Pena, S. A. & Koning, F. (1999) Eur. J. Immunol. 29, 3133-3139.
25. Charron, D. J., Lotteau, V. & Turmel, P. (1984) Nature 312, 157-159.
26. Ivarsson, A., Persson, L. A., Nystrom, L., Ascher, H., Cavell, B., Danielsson, L., Dannaeus, A., Lindberg, T., Lindquist, B., Stenhammar, L., et al. (2000) Acta Paediatr. 89, 165-171.
27. van Overbeek, F. M., Uil-Dieterman, I. G., Mol, I. W., Kohler-Brands, L., Heymans, H. S. & Mulder, C. J. (1997) Eur. J. Gastroenterol. Hepatol. 9, 1097-1099.
28. Ting, J. P. & Trowsdale, J. (2002) Cell 109, Suppl., S21-S33.
29. Thorsby, E. (1997) Hum. Immunol. 53, 1-11.