Review article: Future research on coeliac disease - A position report from the European multistakeholder platform on coeliac disease (CDEUSSA)

Alimentary Pharmacology and Therapeutics

Volumn 27, Issue 11, 2008, Pages 1030-1043

  Troncone, R ^a   Ivarsson, A ^b   Szajewska, H ^c   Mearin, M L ^d,e  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UMEÅ UNIVERSITY   (Sweden)

^c MEDICAL UNIVERSITY OF WARSAW   (Poland)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELIAC DISEASE; EARLY DIAGNOSIS; EUROPEAN UNION; GENOTYPE ENVIRONMENT INTERACTION; HEALTH CARE ORGANIZATION; HUMAN; MEDICAL RESEARCH; PRIMARY PREVENTION; PRIORITY JOURNAL; PUBLIC HEALTH SERVICE; QUALITY OF LIFE; RESEARCH PRIORITY; REVIEW;

BIOMEDICAL RESEARCH; CELIAC DISEASE; DIAGNOSIS, DIFFERENTIAL; EUROPE; GLUTEN; HUMANS;

EID: 42949110060     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2008.03668.x     Document Type: Review

References (80)

1. Monsuur AJ, Wijmenga C. Understanding the molecular basis of celiac disease: what genetic studies reveal. Ann Med 2006 38 : 578 91.
2. Auricchio S, Mazzacca G, Tosi R, et al. Coeliac disease as a familial condition: identification of asymptomatic coeliac patients within family groups. Gastroenterol Int 1988 1 : 25 31.
3. Greco L, Romino R, Coto I, et al. The first large population-based twin study of coeliac disease. Gut 2002 50 : 624 8.
4. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002 2 : 647 55.
5. Farrell RJ, Kelly CP. Celiac sprue. New Engl J Med 2002 346 : 180 8.
6. Fasano A. Clinical presentation of celiac disease in the pediatric population. Gastroenterology 2005 128 : S68 73.
7. Collin P, Huhtala H, Virta L, et al. Diagnosis of celiac disease in clinical practice: physician's alertness to the condition essential. J Clin Gastroenterol 2007 41 : 152 6.
8. Catassi C, Kryszak D, Louis-Jacques O, et al. Detection of celiac disease in primary care: A multicenter case-finding study in North America. Am J Gastroenterol 2007 102 : 1 7.
9. Korponay-Szabo IR, Haltunen T, Szalai Z, et al. In vivo targeting of intestinal and extraintestinal transglutaminase 2 coeliac autoantibodies. Gut 2004 53 : 641 8.
10. Barone MV, Caputo I, Ribecco MT, et al. Humoral immune response to tissue transglutaminase is related to epithelial cell proliferation in celiac disease. Gastroenterology 2007 132 : 1245 53.
11. Marsh MN. Gluten, major histocompatibility complex and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten sensitivity. Gastroenterology 1992 102 : 330 54.
12. Paparo F, Petrone E, Tosco A, et al. Clinical, HLA, and small bowel immunohistochemical features of children with positive serum antiendomysium antibodies and architecturally normal small intestinal mucosa. Am J Gastroenterol 2005 100 : 2294 8.
13. Sollid LM, Jabri B. Is celiac disease an autoimmune disorder? Curr Opin Immunol 2005 17 : 595 600.
14. Van Heel DA, Franke L, Hunt KA, et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 2007 39 : 827 9.
15. Monsuur AJ, De Bakker PI, Alizadeh BZ, et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat Genet 2005 37 : 1341 4.
16. Norris JM, Barriga K, Hoffenberg EJ, et al. Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA 2005 293 : 2343 51.
17. Hoffenberg EJ, MacKenzie T, Barriga KJ, et al. A prospective study of the incidence of childhood celiac disease. J Pediatr 2003 143 : 308 14.
18. Simell S, Kupila A, Hoppu S, et al. Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility. Scand J Gastroenterol 2005 40 : 1182 91.
19. Walker-Smith JA, Guandalini S, Schmitz J, et al. Revised citeria for diagnosis of coeliac disease. Arch Dis Child 1990 65 : 909 11.
20. Bardella MT, Velio P, Cesana BM, Prampolini M, et al. Coeliac disease: a histological follow-up study. Histopatology 2007 50 : 465 71.
21. Matysiak-Budnik T, Malamut G, Patey-Mariaud de Serre N, et al. Long-term follow-up of 61 celiac patients diagnosed in childhood: evolution toward latency is possible on a normal diet. Gut 2007 56 : 1339 40.
22. Hopman EGD, von Blomberg BME, Batstra MR, et al. Gluten tolerance in adult patients with celiac disease 20 years after diagnosis?. Eur J Gastroenterol Hepatol 2008 20 : 423 9.
23. Mariani P, Viti MG, Montuori M, et al. The gluten-free diet: a nutritional risk for adolescents with celiac disease. J Pediatr Gastroenterol Nutr 1998 27 : 519 23.
24. Hopman EG, le Cessie S, von Blomberg BME, et al. Nutritional management of the gluten-free diet in young people with celiac disease in the Netherlands. J Pediatr Gastroenterol Nutr 2006 43 : 102 8.
25. Mendez E, Vela C, Immer U, Janssen FW. Report of a collaborative trial to investigate the performance of the R5 enzyme linked immunoassay to determine gliadin in gluten-free food. Eur J Gastroenterol Hepatol 2005 17 : 1053 63.
26. Catassi C, Fabiani E, Iacono G, et al. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr 2007 85 : 160 6.
27. Rostom A, Dubé C, Cranney A, et al. Evidence Report/Technology Assessment No. 104 Prepared by the University of Ottawa Evidence-based Practice Center, under Contract No. 290-02-0021.) AHRQ Publication No. 04-E029-2. Rockville, MD : Agency for Healthcare Research and Quality. July 2004
28. Hernando A, Mujico JR, Juanas D, et al. Confirmation of the cereal type in oat products highly contaminated with gluten. J Am Diet Assoc 2006 106 : 665 6.
29. Arentz-Hansen H, Fleckenstein B, Molberg O, et al. The molecular basis for oat intolerance in patients with celiac disease. PLoS Med 2004 1 : e1.
30. Silano M, Benedetto RD, Maialetti F, et al. Avenins from different cultivars of oats elicit response by celiac peripheral lymphocytes. Scand J Gastroenterol 2007 42 : 1302 5.
31. Spaenij-Dekking L, Kooy-Winkelaar Y, van Veelen P, et al. Natural variation in toxicity of wheat accessions for celiac disease patients. Potential for selection and breeding of non-toxic wheat varieties. Gastroenterology 2005 129 : 797 806.
32. Spaenij-Dekking L, Kooy-Winkelaar Y, Koning F. The Ethiopian cereal tef in celiac disease. N Engl J Med 2005 353 : 1748 9.
33. Shan L, Molberg Ø, Parrot I, et al. Structural basis for gluten intolerance in celiac sprue. Science 2002 297 : 2275 9.
34. Shan L, Marti T, Sollid LM, et al. Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue. Biochem J 2004 383 : 311 8.
35. Stepniak D, Spaenij-Dekking L, Mitea C, et al. Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. Am J Physiol Gastrointest Liver Physiol 2006 291 : G621 9.
36. Stepniak D, Koning F. Enzymatic gluten detoxification: the proof of the pudding is in the eating! Trends Biotechnol 2006 24 : 433 4.
37. Paterson BM, Lammers KM, Arrieta MC, et al. The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in celiac disease subjects: a proof of concept study. Aliment Pharmacol Ther 2007 26 : 757 66.
38. Sollid LM, Khosla C. Future therapeutic options for celiac disease. Nat Clin Pract Gastroenterol Hepatol 2005 2 : 140 7.
39. Salvati VM, Mazzarella G, Gianfrani C, et al. Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa. Gut 2005 54 : 46 53.
40. Rossi M, Maurano F, Luongo D. Immunomodulatory strategies for celiac disease. Int Rev Immunol 2005 24 : 479 99.
41. Gianfrani C, Levings MK, Sartirana C, et al. Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells. J Immunol 2006 177 : 4178 86.
42. Maiuri L, Ciacci C, Ricciardelli I, et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 2003 362 : 30 7.
43. Benahmed M, Meresse B, Arnulf B, et al. Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease. Gastroenterology 2007 132 : 994 1008.
44. Mention JJ, Ben Ahmed M, Begue B, et al. Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 2003 125 : 730 45.
45. Ivarsson A, Persson LÅ, Hernell O, eds. Primary prevention of coeliac disease by favourable infant feeding practices. In : Catassi C, Fasano A, Corazza GR, eds. Primary Prevention of Celiac Disease - The Utopia of the Next Millennium? Pisa : AIC Press, 2003 : 43 60.
46. Ivarsson A. The Swedish epidemic of coeliac disease explored using an epidemiological approach - some lessons to be learnt. In : Mulder C, Cellier C. Coeliac Disease, Best Pract Res Clin Gastroenterol, Amsterdam : Elsevier Ltd. 2005 : 425 40.
47. Akobeng AK, Ramanan AV, Buchan I, et al. Effects of breastfeeding on risk of CD: a systematic review and meta analysis of observational studies. Arch Dis Child 2006 91 : 39 43.
48. Ivarsson A, Hernell O, Stenlund H, et al. Breast-feeding protects against coeliac disease. Am J Clin Nutr 2002 75 : 914 21.
49. Ivarsson A, Persson LÅ, Nyström L, et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr 2000 89 : 165 71.
50. Vader W, Stepniak D, Kooy Y, et al. The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses. Proc Natl Acad Sci U S A 2003 14 : 100.
51. Prioult G, Fliss I, Pecquert S. Effect of probiotic bacteria on introduction and mantainance of oral tolerance to beta-lactoglobulin in gnotobiotic mice. Clin Diagn Lab Immunol 2003 10 : 787 92.
52. Forsberg G, Fahlgren A, Horstedt P, et al. Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease. Am J Gastroenterol 2004 99 : 894 904.
53. Stene LC, Honeyman MC, Hoffenberg EJ, et al. Rotavirus infection frequency and risk of celiac disease in early childhood: a longitudinal study. Am J Gastroenterol 2006 101 : 2333 40.
54. Zanoni G, Navone R, Lunardi C, et al. In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. Plos Med 2006 3 : 1637 53.
55. Ivarsson A, Hernell O, Nyström L, et al. Children born in the summer have an increased risk for coeliac disease. J Epidemiol Community Health 2003 57 : 36 9.
56. Bourgey MM, Calcagno GG, Tinto NN, et al. HLA-related genetic risk for coeliac disease. Gut 2007 56 : 1054 9.
57. Lebenthal E, Branski D. Celiac disease: an emerging global problem. J Pediatr Gastroenterol Nutr 2002 35 : 472 4.
58. Mäki M, Mustalahti K, Kokkonen J, et al. Prevalence of Celiac disease among children in Finland. N Engl J Med 2003 348 : 2517 24.
59. Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003 163 : 286 92.
60. Green P, Stavropoulos S, Panagi S, et al. Characteristics of adult celiac disease in the USA: results of a national survey. Am J Gastroenterol 2001 96 : 126 31.
61. Mustalahti K, Lohiniemi S, Collin P, et al. Gluten-free diet and quality of life in patients with screen-detected celiac disease. Eff Clin Pract 2002 5 : 105 13.
62. Gill TM, Feinstein AR. A critical appraisal of the quality of life measurements. JAMA 1994 272 : 619 26.
63. Kolsteren MMP, Koopman HM, Schalekamp G, et al. Health-related quality of life in children with celiac disease. J Pediatr 2001 138 : 593 5.
64. Cranney A, Zarkadas M, Graham ID, et al. The Canadian celiac health survey - the Ottawa chapter pilot. BMC Gastroenterol 2003 3 : 8.
65. Usai P, Minerba L, Marini B, et al. Case control study on health-related quality of life in adult coeliac disease. Digest Liver Dis 2002 34 : 547 52.
66. Hallert C, Sandlund O, Broqvist M. Perceptions of health-related quality of life of men and women living with coeliac disease. Scand J Caring Sci 2003 17 : 301 7.
67. Hauser W, Gold J, Stallmach A, et al. Development and validation of the Celiac Disease Questionnaire (CDQ), a disease-specific health-related quality of life measure for adult patients with celiac disease. J Clin Gastroenterol 2007 4 : 157 66.
68. Brooks R, Rabin RE, de Charro F (eds). The Measurement and Valuation of Health Status using EQ-5D: A European Perspective. Dordrecht : Kluwer Academic Publishers, 2003.
69. Zarkadas M, Cranney A, Case S, et al. The impact of a gluten-free diet on adults with coeliac disease: results of a national survey. J Hum Nutr Diet 2006 19 : 41 9.
70. Hin H, Bird G, Fisher P, Mahy N, et al. Coeliac disease in primary care: case finding study. BMJ 1999 318 : 164 7.
71. Farrell RJ. What's the case for case-finding in primary care for coeliac disease? Dig Liver Dis 2006 38 : 468 70.
72. Collin P, Huhtala H, Virta L, et al. Diagnosis of celiac disease in clinical practice: physician's alertness to the condition essential. J Clin Gastroenterol 2007 41 : 152 6.
73. Beaglehole R, Bonita R, Kjellström T. Basic Epidemiology. Geneva : World Health Organization, 1993 1 175.
74. Mearin ML. Celiac disease among children and adolescents. Curr Probl Pediatr Adolesc Health Care 2007 37 : 86 105.
75. Drummond M, Sculper MJ, Torrance GW, O'Brien B, Stoddart GL. Methods for the Economic Evaluation of Health Care Programmes, 3rd edn. Oxford : Oxford University Press, 2006.
76. Schuppan D, Hahn EG. IgA anti-tissue transglutaminase: setting the stage for coeliac disease screening. Eur J Gastroenterol Hepatol 2001 13 : 635 7.
77. Mearin ML, Ivarsson A, Dickey W. Celiac disease: is it time for mass screening? In : Mulder C, Cellier C. Coeliac Disease, Best Pract Res Clin Gastroenterol, Amsterdam : Elsevier Ltd. 2005 : 441 52.
78. Collin P. Should adults be screened for celiac disease? what are the benefits and harms of screening? Gastroenterology 2005 128 : 104 8.
79. NIH Consensus Development Conference on Celiac Disease. National Institutes of Health Consensus Development Conference Statement, 28-30 June, 2004. Available at: http://consensus.nih.gov/2004/2004CeliacDisease118html.htm
80. Fabiani E, Taccari LM, Ratsch IM, et al. Compliance with gluten-free diet in adolescents with screening-detected celiac disease: a 5-year follow-up study. J Pediatr 2000 136 : 841 3.