Increased enterocyte apoptosis and Fas-Fas ligand system in celiac disease

American Journal of Clinical Pathology

Volumn 115, Issue 4, 2001, Pages 494-503

  Ciccocioppo, Rachele ^b   Di Sabatino, Antonio ^b   Parroni, Raffaella ^b   Muzi, Paola ^b   D'Alò, Simona ^b   Ventura, Terenzio ^b   Pistoia, Maria Antonietta ^b   Cifone, Maria Grazia ^b   Corazza, Gino Roberto ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b NONE

Author keywords

Apoptosis; Celiac disease; Ceramide; Fas FasL system; Lamina propria mononuclear cells; Mucosal morphometry

Indexed keywords

ANTIBODY; DEOXYRIBONUCLEOTIDE; DIGOXIGENIN; DNA NUCLEOTIDYLEXOTRANSFERASE; FAS ANTIGEN; FAS LIGAND;

ADULT; APOPTOSIS; ARTICLE; CELIAC DISEASE; CELL STRUCTURE; CONTROLLED STUDY; DUODENUM BIOPSY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; INTESTINE MUCOSA; INTESTINE VILLUS ATROPHY; LAMINA PROPRIA; LYMPHOCYTIC INFILTRATION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE INJURY;

ADULT; AGED; ANTIGENS, CD45; ANTIGENS, CD95; APOPTOSIS; AUTORADIOGRAPHY; BIOPSY; CELIAC DISEASE; CELLS, CULTURED; CERAMIDES; COCULTURE TECHNIQUES; DUODENOSCOPY; DUODENUM; ENTEROCYTES; FAS LIGAND PROTEIN; FEMALE; HUMANS; IN SITU NICK-END LABELING; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MONOCYTES;

EID: 0035057254     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/UV54-BHP3-A66B-0QUD     Document Type: Article

References (44)

1. Molberg Ø, Mcadam SN, Korner R, et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med. 1998;4:713-717.
2. Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997;3:797-801.
3. Moss SF, Attia L, Scholes JV, et al. Increased small intestinal apoptosis in coeliac disease. Gut. 1996;39:811-817.
4. Nagata S. Apoptosis by death factor. Cell. 1997;88:355-365.
5. De Maria R, Testi R. Fas-FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity. Immunol Today. 1998;19:121-125.
6. Nagata S, Golstein P. The Fas death factor. Science. 1995; 267:1449-1456.
7. Leithauser F, Dhein J, Mechtersheimer G, et al. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab Invest. 1993; 69:415-429.
8. Itoh N, Yonehara S, Ishii A, et al. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell. 1991;66:233-239.
9. Lynch DH, Ramsdell F, Alderson MR. Fas and FasL in the homeostatic regulation of immune responses. Immunol Today. 1995;16:569-574.
10. Moretta A. Molecular mechanisms in cell-mediated cytotoxicity. Cell. 1997;90:13-18.
11. French LE, Tschopp J. Thyroiditis and hepatitis: Fas on the road to disease. Nat Med. 1997;3:387-388.
12. Badley AD, Dockrell D, Simpson M, et al. Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor. J Exp Med. 1997;185:55-64.
13. Cifone MG, De Maria R, Roncaioli P, et al. Apoptotic signaling through CD95 (Fas/APO-1) activates an acidic sphingomyelinase. J Exp Med. 1994;180:1547-1552.
14. Cifone MG, Roncaioli P, De Maria R, et al. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J. 1995;14:5859-5864.
15. Gulbins ER, Bissonette R, Mahboubi A, et al. Fas-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity. 1995;2:341-351.
16. Ciccocioppo R, Di Sabatino A, Parroni R, et al. Cytolytic mechanisms of intraepithelial lymphocytes in coeliac disease. Clin Exp Immunol. 2000;120:235-240.
17. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493-501.
18. Holt PR, Pascal RR, Kotler DP. Effect of aging upon small intestinal structures in the Fischer rat. J Gerontol. 1984;39:642-647.
19. Dunnill MS, Whitehead R. A method for the quantitation of small intestinal biopsy specimens. J Clin Pathol. 1972;25:243-246.
20. Corazza GR, Frazzoni M, Dixon MF, et al. Quantitative assessment of the mucosal architecture of jejunal biopsy specimens: a comparison between linear measurement, stereology, and computer aided microscopy. J Clin Pathol. 1985;38:765-770.
21. Boirivant M, Pica R, De Maria R, et al. Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis. J Clin Invest. 1996;98:2616-2622.
22. Potten CS. The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metastasis Rev. 1992;11:179-195.
23. Hall PA, Coates PJ, Ansari B, et al. Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J Cell Sci. 1994;107:3569-3577.
24. Shibahara T, Sato N, Waguri S, et al. The fate of effete epithelial cells at the villus tips of the human small intestine. Arch Histol Cytol 1995;58:205-219.
25. Potten CS. Epithelial cell growth and differentiation, II: intestinal apoptosis. Am J Physiol. 1997;273:G253-G257.
26. Beaulieu JF. Differential expression of the VLA family of integrins along the crypt-villus axis in the human small intestine. J Cell Sci. 1992;102:427-436.
27. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol. 1994;124:619-626.
28. Moller P, Walczak H, Riedl S, et al. Paneth cells express high levels of CD95 ligand transcripts. Am J Pathol. 1996;149:9-13.
29. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science. 1995;267:1456-1462.
30. Sakai T, Kimura Y, Inagaki-Ohara K, et al. Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice. Gastroenterology. 1997;113:168-174.
31. Lin T, Brunner T, Tietz B, et al. Fas ligand-mediated killing by intestinal intraepithelial lymphocytes: participation in intestinal graft-versus-host disease. J Clin Invest. 1998; 101:570-577.
32. Krams SM, Hajashi M, Fox CM, et al. CD8+ cells are not necessary for allograft rejection or the induction of apoptosis in an experimental model of small intestinal transplantation. J Immunol. 1998;160:3673-3680.
33. Ikeda H, Suzuki Y, Suzuki M, et al. Apoptosis is a major mode of cell death caused by ischaemia and ischaemia-reperfusion injury to the rat intestinal epithelium. Gut. 1998;42:530-537.
34. Halstensen TS, Brandtzaeg P. Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ alpha/beta cells in the lamina propria but proliferation (Ki-67) of alpha/beta and gamma/delta cells in the epithelium. Eur J Immunol. 1993;23:505-510.
35. Kontakou M, Przemioslo RT, Sturgess RP, et al. Cytokine mRN A expression in the mucosa of treated coeliac patients after wheat peptide challenge. Gut. 1995;37:52-57.
36. Nilsen EM, Lundin KE, Krajci P, et al. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut. 1995;37:766-776.
37. Kägi D, Vignaux F, Ledermann B, et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science. 1994;265:528-530.
38. MacDonald TT, Spencer J. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med. 1988;167:1341-1349.
39. Chott A, Gerdes D, Spooner A, et al. Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function. Am J Pathol. 1997;151:435-442.
40. Nishio A, Katakai T, Oshima C, et al. A possible involvement of Fas-Fas ligand signaling in the pathogenesis of autoimmune gastritis. Gastroenterology. 1996;111:959-967.
41. Ueyama H, Kiyohara T, Sawada N, et al. High Fas ligand expression on lymphocytes in lesions of ulcerative colitis. Gut. 1998;43:48-55.
42. Micheau O, Solary E, Hammann A, et al. Fas ligand independent, FADD-mediated activation of the Fas death pathway by anticancer drugs. J Biol Chem. 1999;274:7987-7992.
43. Tew JG, Phipps RP, Mandel TE. The maintenance and regulation of the humoral immune response: persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells. Immunol Rev. 1980;53:175-179.
44. Obeid LM, Linardic CM, Karolak LA, et al. Programmed cell death induced by ceramide. Science. 1993;259:1769-1771.