Structure-based design of α-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 18, 2007, Pages 6253-6261

  Siegel, Matthew ^a   Xia, Jiang ^b   Khosla, Chaitan ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Aldehyde; Celiac sprue; Class II major histocompatibility complex; Gliadin; Gluten; HLA DQ2; Immune disease; Inhibition; Peptide; Transglutaminase

Indexed keywords

ALPHA AMINO ALDEHYDE DERIVATIVE; ENZYME INHIBITOR; GLUTAMINASE; GLUTEN PEPTIDE DERIVATIVE; HLA DQ2 ANTIGEN; PEPTIDE DERIVATIVE; TRANSGLUTAMINASE 2; TRANSGLUTAMINASE 2 INHIBITOR; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ARTICLE; CELIAC DISEASE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL;

ALDEHYDES; AMIDES; ANTIGEN PRESENTATION; BINDING SITES; CELL PROLIFERATION; DRUG DESIGN; ENZYME INHIBITORS; GAMMA RAYS; GLUTEN; GTP-BINDING PROTEINS; HLA-DQ ANTIGENS; HUMANS; LIGANDS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; T-LYMPHOCYTES; TRANSGLUTAMINASES;

EID: 34447647295     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.020     Document Type: Article

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