Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease

Immunity

Volumn 21, Issue 3, 2004, Pages 357-366

  Meresse, Bertrand ^a   Chen, Zhangguo ^a   Ciszewski, Cezary ^a   Tretiakova, Maria ^a   Bhagat, Govind ^b   Krausz, Thomas N ^a   Raulet, David H ^c   Lanier, Lewis L ^d   Groh, Veronika ^e   Spies, Thomas ^e   Ebert, Ellen C ^f   Green, Peter H ^b   Jabri, Bana ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b Coll Phys Surgs at Columbia Univ ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Fred Hutchinson Cancer Research Center   (United States)

^f UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; NATURAL KILLER CELL RECEPTOR NKG2D; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; CELIAC DISEASE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; IN VIVO STUDY; LYMPHOCYTE TRANSFORMATION; LYMPHOKINE ACTIVATED KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGED; CELIAC DISEASE; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-15; INTESTINAL MUCOSA; KILLER CELLS; LYMPHOCYTE ACTIVATION; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 4444240035     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2004.06.020     Document Type: Article

References (40)

1. Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285:1999;727-729
2. Billadeau D.D., Upshaw J.L., Schoon R.A., Dick C.J., Leibson P.J. NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nat. Immunol. 4:2003;557-564
3. Braud V.M., Allan D.S., O'Callaghan C.A., Soderstrom K., D'Andrea A., Ogg G.S., Lazetic S., Young N.T., Bell J.I., Phillips J.H., et al. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature. 391:1998;795-799
4. Brooks C.G. Reversible induction of natural killer cell activity in cloned murine cytotoxic T lymphocytes. Nature. 305:1983;155-158
5. Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., Fanslow W., Kubin M., Chalupny N.J. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity. 14:2001;123-133
6. Diefenbach A., Tomasello E., Lucas M., Jamieson A.M., Hsia J.K., Vivier E., Raulet D.H. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 3:2002;1142-1149
7. Dubois S., Mariner J., Waldmann T.A., Tagaya Y. IL15Ralpha recycles and presents IL15 in trans to neighboring cells. Immunity. 17:2002;537-547
8. Fehniger T.A., Caligiuri M.A. Interleukin 15. biology and relevance to human disease Blood. 97:2001;14-32
9. + T cells. J. Exp. Med. 193:2001;219-231
10. Gamero A.M., Ussery D., Reintgen D.S., Puleo C.A., Djeu J.Y. Interleukin 15 induction of lymphokine-activated killer cell function against autologous tumor cells in melanoma patient lymphocytes by a CD18-dependent, perforin-related mechanism. Cancer Res. 55:1995;4988-4994
11. Gilfillan S., Ho E.L., Cella M., Yokoyama W.M., Colonna M. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3:2002;1150-1155
12. Green P.H., Jabri B. Coeliac disease. Lancet. 362:2003;383-391
13. Groh V., Bahram S., Bauer S., Herman A., Beauchamp M., Spies T. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. USA. 93:1996;12445-12450
14. Groh V., Rhinehart R., Randolph-Habecker J., Topp M.S., Ridell S.R., Spies T. Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2:2001;255-260
15. Groh V., Wu J., Yee C., Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature. 419:2002;734-738
16. Groh V., Bruhl A., El-Gabalawy H., Nelson J.L., Spies T. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA. 100:2003;9452-9457
17. Jabri B., de Serre N.P., Cellier C., Evans K., Gache C., Carvalho C., Mougenot J.F., Allez M., Jian R., Desreumaux P., et al. Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease. Gastroenterology. 118:2000;867-879
18. Jabri B., Selby J.M., Negulescu H., Lee L., Roberts A.I., Beavis A., Lopez-Botet M., Ebert E.C., Winchester R.J. TCR specificity dictates CD94/NKG2A expression by human CTL. Immunity. 17:2002;487-499
19. Jamieson A.M., Diefenbach A., McMahon C.W., Xiong N., Carlyle J.R., Raulet D.H. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity. 17:2002;19-29
20. Jiang K., Zhong B., Gilavry D.L., Corliss B.C., Hong-Geller E., Wei S., Djeu J.Y. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat. Immunol. 1:2000;419-425
21. Koning F. The molecular basis of celiac disease. J. Mol. Recognit. 16:2003;333-336
22. Lanier L.L. On guard-activating NK cell receptors. Nat. Immunol. 2:2001;23-27
23. Lanier L.L., Corliss B., Wu J., Phillips J.H. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity. 8:1998;693-701
24. Lee N., Llano M., Carretero M., Ishitani A., Navarro F., Lopez-Botet M., Geraghty D.E. HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc. Natl. Acad. Sci. USA. 95:1998;5199-5204
25. Maiuri L., Ciacci C., Ricciardelli I., Vacca L., Raia V., Auricchio S., Picard J., Osman M., Quaratino S., Londei M. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet. 362:2003;30-37
26. Mention J.J., Ben Ahmed M., Begue B., Barbe U., Verkarre V., Asnafi V., Colombel J.F., Cugnenc P.H., Ruemmele F.M., McIntyre E., et al. Interleukin 15. a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease Gastroenterology. 125:2003;730-745
27. Raulet D.H. Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3:2003;781-790
28. Roberts A.I., Lee L., Schwarz E., Groh V., Spies T., Ebert E.C., Jabri B. NKG2D receptors induced by IL15 costimulate CD28-negative effector CTL in the tissue microenvironment. J. Immunol. 167:2001;5527-5530
29. Sollid L.M. Molecular basis of celiac disease. Annu. Rev. Immunol. 18:2000;53-81
30. Speiser D.E., Pittet M.J., Valmori D., Dunbar R., Rimoldi D., Lienard D., MacDonald H.R., Cerottini J.C., Cerundolo V., Romero P. In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. J. Exp. Med. 190:1999;775-782
31. Steinle A., Li P., Morris L.M., Groh V., Lanier L.L., Strong R.K., Spies T. Interactions of human MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics. 53:2001;279-287
32. Taunk J., Roberts A.I., Ebert E.C. Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors. Gastroenterology. 102:1992;69-75
33. + T cells. Blood. 103:2003;3065-3072
34. Vivier E., Tomasello E., Paul P. Lymphocyte activation via NKG2D. towards a new paradigm in immune recognition? Curr. Opin. Immunol. 14:2002;306-311
35. Waldmann T.A., Tagaya Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu. Rev. Immunol. 17:1999;19-49
36. Wu J., Song Y., Bakker A.B., Bauer S., Spies T., Lanier L.L., Phillips J.H. An activating immunoreceptor complex formed by NKG2D and DAP10. Science. 285:1999;730-732
37. Wu J., Cherwinski H., Spies T., Phillips J.H., Lanier L.L. DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. J. Exp. Med. 192:2000;1059-1068
38. Yano S., Komine M., Fujimoto M., Okochi H., Tamaki K. Interleukin 15 induces the signals of epidermal proliferation through ERK and PI3-kinase in a human epidermal keratinocyte cell line, HaCaT. Biochem. Biophys. Res. Commun. 301:2003;841-847
39. Yokoyama W.M. Now you see it, now you don't. Nat. Immunol. 1:2000;95-97
40. Zompi S., Hamerman J.A., Ogasawara K., Schweighoffer E., Tybulewicz V.L., Di Santo J.P., Lanier L.L., Colucci F. NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat. Immunol. 4:2003;565-572