Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study

Scandinavian Journal of Gastroenterology

Volumn 40, Issue 5, 2005, Pages 564-572

  Kaukinen, Katri ^a,b   Peräaho, Markku ^a,b   Collin, Pekka ^a,b   Partanen, Jukka ^c   Woolley, Nina ^c   Kaartinen, Tanja ^c   Nuutinen, Tuula ^a   Halttunen, Tuula ^a,b   Mäki, Markku ^a,b   Korponay Szabo, Ilma ^a,b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c FINNISH RED CROSS BLOOD SERVICE   (Finland)

Author keywords

Coeliac disease; IgA deposit; Intraepitehlial lymphocytes; Latency; Transglutaminase antibodies

Indexed keywords

HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; IMMUNOGLOBULIN A; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY PRODUCING CELL; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; GENETIC DISORDER; GLUTEN FREE DIET; HUMAN; IMMUNOGLOBULIN DEPOSITION; INTESTINE VILLUS ATROPHY; LYMPHOCYTE; MALE; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SMALL INTESTINE MUCOSA;

ADULT; CELIAC DISEASE; FEMALE; GLUTEN; GTP-BINDING PROTEINS; HLA-DQ ANTIGENS; HUMANS; IMMUNOGLOBULIN A; INTESTINAL MUCOSA; INTESTINE, SMALL; LYMPHOCYTES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TRANSGLUTAMINASES;

EID: 21044456731     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520510023422     Document Type: Article

References (40)

1. Walker-Smith JA, Guandalini S, Schmitz J, Shmerling DH, Visakorpi JK. Revised criteria for diagnosis of coeliac disease. Arch Dis Child 1990;65:909-11.
2. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ("celiac sprue"). Gastroenterology 1992;102:330-54.
3. Ferguson A, Murray D. Quantitation of intraepithelial lymphocytes in human jejunum. Gut 1971;12:988-94.
4. Kakar S, Nehra V, Murray JA, Dayharsh GA, Burgar LJ. Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture. Am J Gastroenterol 2003;98:2027-33.
5. Spencer J, Isaacson PG, Diss TC, MacDonald TT. Expression of disulfide-linked and non-disulfide-linked forms of the T cell receptor gamma/delta heterodimer in human intestinal intraepithelial lymphocytes. Eur J Immunol 1989;19:1335-8.
6. Mäki M, Holm K, Collin P, Savilahti E. Increase in gamma/delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease. Gut 1991;32:1412-4.
7. Kaukinen K, Collin P, Holm K, Karvonen A-L, Pikkarainen P, Mäki M. Small bowel mucosal inflammation in reticulin or gliadin antibody-positive patients without villous atrophy. Scand J Gastroenterol 1998;33:944-9.
8. Iltanen S, Holm K, Partanen J, Laippala P, Mäki M. Increased density of jejunal gamma/delta+T cells in patients having normal mucosa: marker of operative autoimmune mechanisms. Autoimmunity 1999;29:179-87.
9. Pesce G, Pesce F, Fiorino N, Barabino A, Villaggio B, Canonica GW, et al. Intraepithelial gamma/delta-positive T lymphocytes and intestinal villous atrophy. Int Arch Allergy Immunol 1996;110:233-7.
10. Collin P, Helin H, Mäki M, Hällström O, Karvonen A-L. Follow-up of patients positive in reticulin and gliadin antibody tests with normal small bowel biopsy findings. Scand J Gastroenterol 1993;28:595-8.
11. Troncone R. Latent coeliac disease in Italy. Acta Paediatr 1995;84:1252-7.
12. Feighery C, Weir DG, Whelan A, Willoughby R, Youngprapakorn S, Lynch S, et al. Diagnosis of gluten-sensitive enteropathy: is exclusive reliance on histology appropriate? Eur J Gastroenterol Hepatol 1998;10:919-25.
13. Arranz E, Ferguson A. Intestinal antibody pattern of celiac disease: occurrence in patients with normal jejunal biopsy histology. Gastroenterology 1993;104:1263-72.
14. Wahnschafffe U, Ullrich R, Riecken EO, Schulzke JD. Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome. Gastroenterology 2001;121:1329-38.
15. Corazza GR, Andreani ML, Biagi F, Bonvicini F, Bernardi M, Gasbarrini G. Clinical, pathological, and antibody pattern of latent celiac disease: report of three adult cases. Am J Gastroenterol 1996;91:2203-7.
16. Niveloni S, Pedreira S, Sugai E, Vazquez H, Smecuol E, Fiorini A, et al. The natural history of gluten sensitivity: report of two new celiac disease patients resulting from long-term follow-up of nonatrophic, first-degree relatives. Am J Gastroenterol 2000;95:463-8.
17. Cooper BT, Holmes GKT, Ferguson R, Thompson RA, Allan RN, Cooke WT. Gluten-sensitive diarrhea without evidence of celiac disease. Gastroenterology 1980;79:801-6.
18. Kaukinen K, Mäki M, Partanen J, Sievänen H, Collin P. Celiac disease without villous atrophy. Revision of criteria called for. Dig Dis Sci 2001;46:879-87.
19. Marzari R, Sblattero D, Florian F, Tongiorgi E, Not T, Tommasini A, et al. Molecular dissection of tissue transglutaminase autoantibody response in celiac disease. J Immunol 2001;166:4170-6.
20. Korponay-Szabo IR, Halttunen T, Szalai Z, Laurila K, Kiraly R, Kovacs JB, et al. In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies. Gut 2004;53:641-8.
21. Armitage P, Berry G, editors. Statistical methods in medical research. Oxford: Blackwell Scientific Publications; 1987.
22. Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med 2002;346:180-8.
23. Svedlund J, Sjödin I, Dotevall G. GSRS: a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci 1988; 33:129-34.
24. Kuitunen P, Kosnai I, Savilahti E. Morphometric study of the jejunal mucosa in various childhood enteropathies with special reference to intraepithelial lymphocytes. J Pediatr Gastroenterol Nutr 1982;1:525-31.
25. Savilahti E, Reunala T, Mäki M. Increase of lymphocytes bearing the gamma/delta T cell receptor in the jejunum of patients with dermatitis herpetiformis. Gut 1992;33:206-11.
26. Arranz E, Bode J, Kingstone K, Ferguson A. Intestinal antibody pattern of coeliac disease: association with gamma/delta T cell receptor expression by intraepithelial lymphocytes, and other indices of potential coeliac disease. Gut 1994;35:476-82.
27. Sulkanen S, Halttunen T, Laurila K, Kolho K-L, Korponay-Szabo I, Sarnesto A, et al. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology 1998;115:1322-8.
28. Mäki M, Mustalahti K, Kokkonen J, Kulmala P, Haapalahti M, Karttunen T, et al. Prevalence of celiac disease among children in Finland. N Engl J Med 2003;348:2517-24.
29. Chan KN, Phillips AD, Walker-Smith JA, Koskimies S, Spencer J. Density of gamma/delta T cells in small bowel mucosa related to HLA-DQ status without coeliac disease. Lancet 1993;342:492-3.
30. Kaukinen K, Turjanmaa K, Mäki M, Partanen J, Venäläinen R, Reunala T, et al. Intolerance to cereals is not specific for coeliac disease. Scand J Gastroenterol 2000;35:942-6.
31. Mäki M, Holm K, Lipsanen V, Hällström O, Viander M, Collin P, et al. Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease. Lancet 1991;338:1350-3.
32. Iltanen S, Holm K, Ashorn M, Ruuska T, Laippala P, Mäki M. Changing jejunal gamma/delta T cell receptor (TCR)-bearing intraepithelial lymphocyte density in coeliac disease. Clin Exp Immunol 1999;117:51-5.
33. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003;163:286-92.
34. Rostami K, Kerckhaert J, Tiemessen R, von Blomberg ME, Meijer J, Mulder CJJ. Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac disease: disappointing in clinical practice. Am J Gastroenterol 1999;94:888-94.
35. Picarelli A, Maiuri L, Frate A, Greco M, Auricchio S, Londei M. Production of antiendomysial antibodies after in-vitro gliadin challenge of small intestine biopsy samples from patients with coeliac disease. Lancet 1996;348:1065-7.
36. Mawhinney H, Love AHG. Anti-reticulin antibody in jejunal juice in coeliac disease. Clin Exp Immunol 1975;21:394-8.
37. Sblattero D, Florian F, Azzoni E, Ziberna F, Tommasini A, Not T, et al. One-step cloning of anti tissue transglutaminase scFv from subjects with celiac disease. J Autoimmunity 2004;22:65-72.
38. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002;2:647-55.
39. Karell K, Louka AS, Moodie SJ, Ascher H, Clot F, Greco L, et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European genetics cluster on celiac disease. Hum Immunol 2003;64:469-77.
40. Picarelli A, Maiuri L, Mazzilli MC, Coletta S, Ferrante P, Di-Giovambattista F, et al. Gluten-sensitive disease with mild enteropathy. Gastroenterology 1996;111:608-16.