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Volumn 176, Issue 4, 2006, Pages 2512-2521

Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: Role of the innate immune response in celiac disease

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; GLIADIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 12; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN P40; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 32044441878     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.4.2512     Document Type: Article
Times cited : (187)

References (60)
  • 1
    • 0031748509 scopus 로고    scopus 로고
    • Diagnosis of celiac sprue
    • Trier, J. S. 1998. Diagnosis of celiac sprue. Gastroenterology 115: 211-216.
    • (1998) Gastroenterology , vol.115 , pp. 211-216
    • Trier, J.S.1
  • 2
    • 0034235978 scopus 로고    scopus 로고
    • Current concepts of celiac disease pathogenesis
    • Schuppan, D. 2000. Current concepts of celiac disease pathogenesis. Gastroenterology 119: 234-242.
    • (2000) Gastroenterology , vol.119 , pp. 234-242
    • Schuppan, D.1
  • 3
    • 0027292775 scopus 로고
    • HLA susceptibility genes in celiac disease: Genetic mapping and role in pathogenesis
    • Sollid, L. M., and E. Thorsby. 1993. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 105: 910-922.
    • (1993) Gastroenterology , vol.105 , pp. 910-922
    • Sollid, L.M.1    Thorsby, E.2
  • 4
    • 0018909566 scopus 로고
    • Structural abnormalities of jejunal epithelial cell membranes in celiac sprue
    • Madara, J. L., and J. S. Trier. 1980. Structural abnormalities of jejunal epithelial cell membranes in celiac sprue. Lab. Invent. 43: 254-261.
    • (1980) Lab. Invent. , vol.43 , pp. 254-261
    • Madara, J.L.1    Trier, J.S.2
  • 5
    • 0031944553 scopus 로고    scopus 로고
    • Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue
    • Schulzke, J. D., C. J. Bentzel, I. Schulzke, E. O. Riecken, and M. Fromm. 1998. Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr. Res. 43: 435441.
    • (1998) Pediatr. Res. , vol.43 , pp. 435441
    • Schulzke, J.D.1    Bentzel, C.J.2    Schulzke, I.3    Riecken, E.O.4    Fromm, M.5
  • 6
    • 0034508690 scopus 로고    scopus 로고
    • Human zonulin, a potential modulator of intestinal tight junctions
    • Wang, W., S. Uzzau, S. E. Goldblum, and A. Fasano. 2000. Human zonulin, a potential modulator of intestinal tight junctions. J. Cell Sci. 113: 4435-4440.
    • (2000) J. Cell Sci. , vol.113 , pp. 4435-4440
    • Wang, W.1    Uzzau, S.2    Goldblum, S.E.3    Fasano, A.4
  • 7
    • 0034728821 scopus 로고    scopus 로고
    • Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease
    • Fasano, A., T. Not, W. Wang, S. Uzzau, I. Berti, A. Tommasini, and S. E. Goldblum. 2000. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 358: 1518-1519.
    • (2000) Lancet , vol.358 , pp. 1518-1519
    • Fasano, A.1    Not, T.2    Wang, W.3    Uzzau, S.4    Berti, I.5    Tommasini, A.6    Goldblum, S.E.7
  • 8
    • 0032806274 scopus 로고    scopus 로고
    • Duration of exposure to gluten and risk for autoimmune disorders in celiac patients
    • Ventura, A., G. Magazzu, and L. Greco. 1999. Duration of exposure to gluten and risk for autoimmune disorders in celiac patients. Gastroenterology 117: 197-303.
    • (1999) Gastroenterology , vol.117 , pp. 197-303
    • Ventura, A.1    Magazzu, G.2    Greco, L.3
  • 9
    • 0035374570 scopus 로고    scopus 로고
    • Zonula occludens toxin structure-function analysis: Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain
    • Di Pierro, M., R. Lu, S. Uzzau, W. Wang, K. Margaretten, C. Pazzani, F. Maimone, and A. Fasano. 2001. Zonula occludens toxin structure-function analysis: identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain. J. Biol. Chem. 276: 19160-19165.
    • (2001) J. Biol. Chem. , vol.276 , pp. 19160-19165
    • Di Pierro, M.1    Lu, R.2    Uzzau, S.3    Wang, W.4    Margaretten, K.5    Pazzani, C.6    Maimone, F.7    Fasano, A.8
  • 10
    • 85039356829 scopus 로고    scopus 로고
    • Zonulin is structurally and functionally related to the mucosal mast cell-derived mast cell protease II
    • Abstr
    • Adams, D., E. Fang, S. N. Vogel, and A. Fasano. 2004. Zonulin is structurally and functionally related to the mucosal mast cell-derived mast cell protease II. Gastroenterology 126: A520 (Abstr.).
    • (2004) Gastroenterology , vol.126
    • Adams, D.1    Fang, E.2    Vogel, S.N.3    Fasano, A.4
  • 11
    • 32044469570 scopus 로고    scopus 로고
    • The Vibrio cholerae-generated zonula occludens toxin (Zot) N-terminal cleavage site contains a protease-activated receptor activating peptide (PAR-AP) that retains biological activity on intestinal tight junctions
    • Abstr
    • Thakar, M. S. Vogel, J. Kao, and A. Fasano. The Vibrio cholerae-generated zonula occludens toxin (Zot) N-terminal cleavage site contains a protease-activated receptor activating peptide (PAR-AP) that retains biological activity on intestinal tight junctions. 2005. Gastreonterology 128: A541 (Abstr.).
    • (2005) Gastreonterology , vol.128
    • Thakar, M.1    Vogel, S.2    Kao, J.3    Fasano, A.4
  • 12
    • 0033959607 scopus 로고    scopus 로고
    • Affinity purification and partial characterization of the zonulin/zonula occludens toxin (Zot) receptor from human brain
    • Lu, R., W. Wang, S. Uzzau, R. Vigorito, H. R. Zielke, and A. Fasano. 2000. Affinity purification and partial characterization of the zonulin/zonula occludens toxin (Zot) receptor from human brain. J. Neurochem. 74: 320-326.
    • (2000) J. Neurochem. , vol.74 , pp. 320-326
    • Lu, R.1    Wang, W.2    Uzzau, S.3    Vigorito, R.4    Zielke, H.R.5    Fasano, A.6
  • 13
    • 85039361423 scopus 로고    scopus 로고
    • Involvement of the proteinase-activated receptor 2 (PAR-2) in the Zot/zonulin-mediated regulation of intestinal tight junctions
    • Abstr
    • Clemente, M. G., S. N. Vogel, M. Hollenberg, S. De Virgilis, and A. Fasano. Involvement of the proteinase-activated receptor 2 (PAR-2) in the Zot/zonulin-mediated regulation of intestinal tight junctions. 2004. Gastroenterology 126: A519 (Abstr.).
    • (2004) Gastroenterology , vol.126
    • Clemente, M.G.1    Vogel, S.N.2    Hollenberg, M.3    De Virgilis, S.4    Fasano, A.5
  • 15
    • 0028126085 scopus 로고
    • Organization and function of the cytoskeleton in polarized epithelial cell as component of the protein sorting machinery
    • Mays, R. W., K. A. Beck, and W. J. Nelson. 1994. Organization and function of the cytoskeleton in polarized epithelial cell as component of the protein sorting machinery. Curr. Opin. Cell Biol. 6: 16-24.
    • (1994) Curr. Opin. Cell Biol. , vol.6 , pp. 16-24
    • Mays, R.W.1    Beck, K.A.2    Nelson, W.J.3
  • 16
    • 0033521140 scopus 로고    scopus 로고
    • Protein interactions at the tight junction: Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3
    • Wittchen, E. S., J. Haskins, and B. R. Stevenson. 1999. Protein interactions at the tight junction: actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J. Biol. Chem. 274: 35179-35185.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35179-35185
    • Wittchen, E.S.1    Haskins, J.2    Stevenson, B.R.3
  • 19
    • 24044493977 scopus 로고    scopus 로고
    • Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins
    • Sander, G. R., A. G. Cummins, T. Henshall, and B. C. Powell. 2005. Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins. FEBS Lett. 579: 4851-4855.
    • (2005) FEBS Lett. , vol.579 , pp. 4851-4855
    • Sander, G.R.1    Cummins, A.G.2    Henshall, T.3    Powell, B.C.4
  • 20
    • 0014122519 scopus 로고
    • Chemical, physical, biological properties of a lipopolysaccharide from Escherichia coli K-235
    • McIntire, F. C., H. W. Sievert, G. H. Barlow, R. A. Finley, and A. Y. Lee. 1967. Chemical, physical, biological properties of a lipopolysaccharide from Escherichia coli K-235. Biochemistry 6: 2363-2372.
    • (1967) Biochemistry , vol.6 , pp. 2363-2372
    • McIntire, F.C.1    Sievert, H.W.2    Barlow, G.H.3    Finley, R.A.4    Lee, A.Y.5
  • 21
    • 0018292881 scopus 로고
    • Toxicity of wheat flour proteins and protein-derived peptides for in vitro developing intestine from rat fetus
    • De Ritis, G., P. Occorsio, S. Auricchio, F. Gramenzi, G. Morisi, and V. Silano. 1979. Toxicity of wheat flour proteins and protein-derived peptides for in vitro developing intestine from rat fetus. Pediatr. Res. 13: 1255-1261.
    • (1979) Pediatr. Res. , vol.13 , pp. 1255-1261
    • De Ritis, G.1    Occorsio, P.2    Auricchio, S.3    Gramenzi, F.4    Morisi, G.5    Silano, V.6
  • 24
    • 0031137733 scopus 로고    scopus 로고
    • CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol
    • Perera, P. Y., S. N. Vogel, G. R. Detore, A. Haziot, and S. M. Goyert. 1997. CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol. J. Immunol 158: 4422-4429.
    • (1997) J. Immunol. , vol.158 , pp. 4422-4429
    • Perera, P.Y.1    Vogel, S.N.2    Detore, G.R.3    Haziot, A.4    Goyert, S.M.5
  • 25
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai, T., O. Adachi, T. Ogawa, K. Takeda, and S. Akira. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11: 115-122.
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 27
    • 0026557524 scopus 로고
    • IFN-γ mediates increased glucocorticoid receptor expression in murine macrophages
    • Salkowski, C. A., and S. N. Vogel. 1992. IFN-γ mediates increased glucocorticoid receptor expression in murine macrophages. J. Immunol. 148: 2770-2777.
    • (1992) J. Immunol. , vol.148 , pp. 2770-2777
    • Salkowski, C.A.1    Vogel, S.N.2
  • 28
    • 0036829115 scopus 로고    scopus 로고
    • Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure
    • El Asmar, R., P. Panigrahi, P. Bamford, I. Berti, T. Not, G. V. Coppa, C. Catassi, and A. Fasano. 2002. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology 123: 1607-1615.
    • (2002) Gastroenterology , vol.123 , pp. 1607-1615
    • El Asmar, R.1    Panigrahi, P.2    Bamford, P.3    Berti, I.4    Not, T.5    Coppa, G.V.6    Catassi, C.7    Fasano, A.8
  • 29
    • 0028324655 scopus 로고
    • Taxol provides a second signal for murine macrophage tumoricidal activity
    • Manthey, C. L., P. Y. Perera, C. A. Salkowski, and S. N. Vogel. 1994. Taxol provides a second signal for murine macrophage tumoricidal activity. J. Immunol. 152: 825-831.
    • (1994) J. Immunol. , vol.152 , pp. 825-831
    • Manthey, C.L.1    Perera, P.Y.2    Salkowski, C.A.3    Vogel, S.N.4
  • 30
    • 0028924980 scopus 로고
    • Differential expression of interferon regulatory factor 1 (1RF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages
    • Barber, S. A., M. J. Fultz, C. A. Salkowski, and S. N. Vogel. 1995. Differential expression of interferon regulatory factor 1 (1RF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages. Infect. Immun. 63: 601-608.
    • (1995) Infect. Immun. , vol.63 , pp. 601-608
    • Barber, S.A.1    Fultz, M.J.2    Salkowski, C.A.3    Vogel, S.N.4
  • 31
    • 0027260963 scopus 로고
    • Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schitosoma mansoni
    • Wynn, T. A., I. Eltoum, A. W. Cheever, F. A. Lewis, W. C. Cause, and A. Sher. 1993. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schitosoma mansoni. J. Immunol. 151: 1430-1440.
    • (1993) J. Immunol. , vol.151 , pp. 1430-1440
    • Wynn, T.A.1    Eltoum, I.2    Cheever, A.W.3    Lewis, F.A.4    Cause, W.C.5    Sher, A.6
  • 32
    • 0027208743 scopus 로고
    • Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation
    • Gazzinelli, R. T., I. Eltoum, T. A. Wynn, and A. Sher. 1993. Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. J. Immunol. 151: 3672-3681.
    • (1993) J. Immunol. , vol.151 , pp. 3672-3681
    • Gazzinelli, R.T.1    Eltoum, I.2    Wynn, T.A.3    Sher, A.4
  • 33
    • 0025061069 scopus 로고
    • Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni
    • Sher, A., R. I. Coffman, S. Heiny, P. Scott, and A. W. Chever. 1990. Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proc. Natl. Acad. Sci. USA 87: 61-65.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 61-65
    • Sher, A.1    Coffman, R.I.2    Heiny, S.3    Scott, P.4    Chever, A.W.5
  • 34
    • 0030032290 scopus 로고    scopus 로고
    • Induction and regulation of IL-15 expression in murine macrophages
    • Doherty, T. M., R. A. Seder, and A. Sher. 1996. Induction and regulation of IL-15 expression in murine macrophages. J. Immunol. 156: 735-741.
    • (1996) J. Immunol. , vol.156 , pp. 735-741
    • Doherty, T.M.1    Seder, R.A.2    Sher, A.3
  • 36
    • 0031848913 scopus 로고    scopus 로고
    • Pulmonary and hepatic gene expression following cecal ligation and puncture: Monophosphoryl lipid a prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration
    • Salkowski, C. A., G. Detore, A. Franks, M. C. Falk, and S. N. Vogel. 1998. Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration. Infect. Immun. 66: 3569-3578.
    • (1998) Infect. Immun. , vol.66 , pp. 3569-3578
    • Salkowski, C.A.1    Detore, G.2    Franks, A.3    Falk, M.C.4    Vogel, S.N.5
  • 37
    • 0034043956 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine, and Toll-like receptor 2 and 4 gene expression
    • Medvedev, A. E., K. M. Kopydlowski, and S. N. Vogel. 2000. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine, and Toll-like receptor 2 and 4 gene expression. J. Immunol. 64: 5564.
    • (2000) J. Immunol. , vol.64 , pp. 5564
    • Medvedev, A.E.1    Kopydlowski, K.M.2    Vogel, S.N.3
  • 39
    • 0035881949 scopus 로고    scopus 로고
    • Induction of tolerance to lipopolysaccharide and mycobacterial components of Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4
    • Medvedev, A. E., P. Henneke, A. Schromm, E. Lien, R. Ingalls, M. J. Fenton, D. T. Golenbock, and S. N. Vogel. 2001. Induction of tolerance to lipopolysaccharide and mycobacterial components of Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4. J. Immunol. 167: 2257-2267.
    • (2001) J. Immunol. , vol.167 , pp. 2257-2267
    • Medvedev, A.E.1    Henneke, P.2    Schromm, A.3    Lien, E.4    Ingalls, R.5    Fenton, M.J.6    Golenbock, D.T.7    Vogel, S.N.8
  • 40
    • 0032530613 scopus 로고    scopus 로고
    • Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-α, signal transduction
    • DeLude, R., A. Yoshimura, R. R. Ingalls, and D. T. Golenbock. 1998. Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-α, signal transduction. J. Immunol. 161: 3001-3009.
    • (1998) J. Immunol. , vol.161 , pp. 3001-3009
    • Delude, R.1    Yoshimura, A.2    Ingalls, R.R.3    Golenbock, D.T.4
  • 42
    • 0033564325 scopus 로고    scopus 로고
    • Cutting edge: Cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin
    • Heine, H., C. J. Kirschning, E. Lien, B. G. Monks, M. Rothe, and D. T. Golenbock. 1999. Cutting edge: cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin. J. Immunol. 162: 6971-6975.
    • (1999) J. Immunol. , vol.162 , pp. 6971-6975
    • Heine, H.1    Kirschning, C.J.2    Lien, E.3    Monks, B.G.4    Rothe, M.5    Golenbock, D.T.6
  • 44
    • 3343010394 scopus 로고    scopus 로고
    • Gliadin stimulates human monocytes to production of IL-8 and TNF-α through a mechanism involving NF-κB
    • Jelinkova, L., L. Tuckova, J. Cinova, Z. Flegelova, and H. Tlaskalova-Hogenova H. 2004. Gliadin stimulates human monocytes to production of IL-8 and TNF-α through a mechanism involving NF-κB. FEBS Lett. 571: 81-85.
    • (2004) FEBS Lett. , vol.571 , pp. 81-85
    • Jelinkova, L.1    Tuckova, L.2    Cinova, J.3    Flegelova, Z.4    Tlaskalova-Hogenova, H.H.5
  • 45
    • 0033821851 scopus 로고    scopus 로고
    • Activation of macrophages by food antigens: Enhancing effect of gluten on nitric oxide and cytokine production
    • Tuckova, L., Z. Flegelova, H. Tlaskalova-Hogenova, and Z. Zidek. 2000. Activation of macrophages by food antigens: enhancing effect of gluten on nitric oxide and cytokine production. J. Leukocyte Biol. 67: 312-318.
    • (2000) J. Leukocyte Biol. , vol.67 , pp. 312-318
    • Tuckova, L.1    Flegelova, Z.2    Tlaskalova-Hogenova, H.3    Zidek, Z.4
  • 46
    • 3242742752 scopus 로고    scopus 로고
    • Wheat gluten causes dendritic cell maturation and chemokine secretion
    • Nikulina, M., C. Habich, S. B. Flohe, F. W. Scott, and H. Kolb. 2004. Wheat gluten causes dendritic cell maturation and chemokine secretion. J. Immunol. 173: 1925-1933.
    • (2004) J. Immunol. , vol.173 , pp. 1925-1933
    • Nikulina, M.1    Habich, C.2    Flohe, S.B.3    Scott, F.W.4    Kolb, H.5
  • 47
    • 85039347230 scopus 로고    scopus 로고
    • 2004. Method to use Zot to inhibit lymphocyte proliferation in an antigen-specific manner. Patent No. U.S. 6,733,562 B1
    • Fasano, A., M. Sztein, R. Lu, and M. Tanner. 2004. Method to use Zot to inhibit lymphocyte proliferation in an antigen-specific manner. Patent No. U.S. 6,733,562 B1.
    • Fasano, A.1    Sztein, M.2    Lu, R.3    Tanner, M.4
  • 48
    • 2142762520 scopus 로고    scopus 로고
    • TLRs: Differential adapter utilization by Toll-like receptors mediates TLR-specific patterns of gene expression
    • Vogel, S. N., K. A. Fitzgerald, and M. J. Fenton. 2003. TLRs: differential adapter utilization by Toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 3: 466-477.
    • (2003) Mol. Interv. , vol.3 , pp. 466-477
    • Vogel, S.N.1    Fitzgerald, K.A.2    Fenton, M.J.3
  • 51
    • 1642447710 scopus 로고    scopus 로고
    • Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease
    • Kim, C. Y., H. Quarsten, E. Berseng, C. Khosla, and L. M. Sollid. 2004. Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc. Natl. Acad. Sci. USA 101: 4175-4179.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4175-4179
    • Kim, C.Y.1    Quarsten, H.2    Berseng, E.3    Khosla, C.4    Sollid, L.M.5
  • 52
    • 84878086063 scopus 로고    scopus 로고
    • Pathological and therapeutical implications of macromolecules passage through the tight junction
    • M. Cereijido and J. Anderson, eds. CRC Press, Boca Raton, FL
    • Fasano, A. 2001. Pathological and therapeutical implications of macromolecules passage through the tight junction. In Tight Junctions. M. Cereijido and J. Anderson, eds. CRC Press, Boca Raton, FL. pp. 697-722.
    • (2001) Tight Junctions , pp. 697-722
    • Fasano, A.1
  • 54
    • 85039349723 scopus 로고    scopus 로고
    • The gut protein zonulin is increased in patients with type 1 diabetes and their first degree relatives
    • Abstr
    • Counts, D. R., M. G. Clemente, and A. Fasano. 2002. The gut protein zonulin is increased in patients with type 1 diabetes and their first degree relatives. Pediatr. Res. 51: 123A (Abstr.).
    • (2002) Pediatr. Res. , vol.51
    • Counts, D.R.1    Clemente, M.G.2    Fasano, A.3
  • 55
    • 14544277099 scopus 로고    scopus 로고
    • Role of the intestinal tight junction modulator zonulin in the pathogenesis of type-1 diabetes in BB diabetic prone rats
    • Watts, T., I. Berti, A. Sapone, T. Gerarduzzi, T. Not, R. Zielke, and A. Fasano. 2005. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type-1 diabetes in BB diabetic prone rats. Proc. Natl. Acad. Sci. USA 102: 2916-2921.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2916-2921
    • Watts, T.1    Berti, I.2    Sapone, A.3    Gerarduzzi, T.4    Not, T.5    Zielke, R.6    Fasano, A.7
  • 56
    • 4444240035 scopus 로고    scopus 로고
    • Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
    • Meresse, B., Z. Chen, C. Ciszewski, M. Tretiakova, G. Bhagat, T. N. Krausz, D. H. Raulet, L. L. Lanier, V. Groh, T. Spies, et al. 2004. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21: 357-366.
    • (2004) Immunity , vol.21 , pp. 357-366
    • Meresse, B.1    Chen, Z.2    Ciszewski, C.3    Tretiakova, M.4    Bhagat, G.5    Krausz, T.N.6    Raulet, D.H.7    Lanier, L.L.8    Groh, V.9    Spies, T.10
  • 58
    • 17044385039 scopus 로고    scopus 로고
    • TLR signaling in the gut in health and disease
    • Abreu, M. T., M. Fukata, and M. Arditi. 2005. TLR signaling in the gut in health and disease. J. Immunol. 174: 4453-4460.
    • (2005) J. Immunol. , vol.174 , pp. 4453-4460
    • Abreu, M.T.1    Fukata, M.2    Arditi, M.3
  • 60
    • 20244372724 scopus 로고    scopus 로고
    • Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis
    • Fukata, M., K. S. Michelsen, R. Eri, L. S. Thomas, B. Hu, K. Lukasek, C. C. Nast, J. Lechago, R. Xu, Y. Naiki, et al. 2005. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am. J. Physiol. 288: G1055-G1065.
    • (2005) Am. J. Physiol. , vol.288
    • Fukata, M.1    Michelsen, K.S.2    Eri, R.3    Thomas, L.S.4    Hu, B.5    Lukasek, K.6    Nast, C.C.7    Lechago, J.8    Xu, R.9    Naiki, Y.10


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