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Volumn 93, Issue 12, 2008, Pages 4633-4642

The genetics of type 2 diabetes: A realistic appraisal in 2008

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMORPHISM; GENE LOCUS; GENETIC RISK; GENETIC VARIABILITY; GENOME; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETICS; RISK ASSESSMENT;

EID: 57349103144     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-1345     Document Type: Review
Times cited : (101)

References (110)
  • 1
    • 0035960122 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
    • Fajans SS, Bell GI, Polonsky KS 2001 Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 345:971-980
    • (2001) N Engl J Med , vol.345 , pp. 971-980
    • Fajans, S.S.1    Bell, G.I.2    Polonsky, K.S.3
  • 2
  • 5
    • 25844441709 scopus 로고    scopus 로고
    • Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F, Todd JA, Rich SS; Type 1 Diabetes Genetics Consortium 2005 Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes 54:2995-3001
    • Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F, Todd JA, Rich SS; Type 1 Diabetes Genetics Consortium 2005 Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes 54:2995-3001
  • 6
    • 0242524453 scopus 로고    scopus 로고
    • The inherited basis of diabetes mellitus: Implications for the genetic analysis of complex traits
    • Florez JC, Hirschhorn JN, Altshuler D 2003 The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet 4:257-291
    • (2003) Annu Rev Genomics Hum Genet , vol.4 , pp. 257-291
    • Florez, J.C.1    Hirschhorn, J.N.2    Altshuler, D.3
  • 7
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K 1996 The future of genetic studies of complex human diseases. Science 273:1516-1517
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 8
    • 2042437650 scopus 로고    scopus 로고
    • Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S
    • Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blocker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowki J, Thierry-Mieg D, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ 2001 Initial sequencing and analysis of the human genome. Nature 409:860-921
  • 9
    • 0035865322 scopus 로고    scopus 로고
    • Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D 2001 A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409:928-933
    • Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D 2001 A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409:928-933
  • 10
    • 0345164399 scopus 로고    scopus 로고
    • Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPARγ2 missense mutation
    • Yen CJ, Beamer BA, Negri C, Silver K, Brown KA, Yarnall DP, Burns DK, Roth J, Shuldiner AR 1997 Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: identification of a Pro12Ala PPARγ2 missense mutation. Biochem Biophys Res Commun 241:270-274
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 270-274
    • Yen, C.J.1    Beamer, B.A.2    Negri, C.3    Silver, K.4    Brown, K.A.5    Yarnall, D.P.6    Burns, D.K.7    Roth, J.8    Shuldiner, A.R.9
  • 11
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J 1998 A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20:284-287
    • (1998) Nat Genet , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3    Pihlajamaki, J.4    Mykkanen, L.5    Kuusisto, J.6    Laakso, M.7    Fujimoto, W.8    Auwerx, J.9
  • 13
    • 0031773333 scopus 로고    scopus 로고
    • Missense mutations in the pancreatic islet beta cell inwardly rectifying K+- channel gene (KIR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians
    • Hani EH, Boutin P, Durand E, Inoue H, Permutt MA, Velho G, Froguel P 1998 Missense mutations in the pancreatic islet beta cell inwardly rectifying K+- channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians. Diabetologia 41:1511-1515
    • (1998) Diabetologia , vol.41 , pp. 1511-1515
    • Hani, E.H.1    Boutin, P.2    Durand, E.3    Inoue, H.4    Permutt, M.A.5    Velho, G.6    Froguel, P.7
  • 18
    • 23644445645 scopus 로고    scopus 로고
    • A large-scale association analysis of common variation of the HNF1α gene with type 2 diabetes in the U.K. Caucasian population
    • Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM 2005 A large-scale association analysis of common variation of the HNF1α gene with type 2 diabetes in the U.K. Caucasian population. Diabetes 54:2487-2491
    • (2005) Diabetes , vol.54 , pp. 2487-2491
    • Weedon, M.N.1    Owen, K.R.2    Shields, B.3    Hitman, G.4    Walker, M.5    McCarthy, M.I.6    Hattersley, A.T.7    Frayling, T.M.8
  • 23
    • 34547510624 scopus 로고    scopus 로고
    • Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G, Manolescu A, Rafnar T, Gudbjartsson D, Agnarsson BA, Baker A, Sigurdsson A, Benediktsdottir KR, Jakobsdottir M, Blondal T, Stacey SN, Helgason A, Gunnarsdottir S, Olafsdottir A, Kristinsson KT, Birgisdottir B, Ghosh S, Thorlacius S, Magnusdottir D, Stefansdottir G, Kristjansson K, Bagger Y, Wilensky RL, Reilly MP, Morris AD, Kimber CH, Adeyemo A, Chen Y, Zhou J, So WY, Tong PC, Ng MC, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Tres A, Fuertes F, Ruiz-Echarri M, Asin L, Saez B, van Boven E, Klaver S, Swinkels DW, Aben KK, Graif T, Cashy J, Suarez BK, van Vierssen Trip O, Frigge ML, Ober C, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Palmer CN, Rotimi C, Chan JC, Pedersen O, Sigurdsson G, Benediktsson R, Jonsson E, Einarsson GV, Mayordomo JI, Catalona WJ, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K 2007 Two variants on chromosome 17 confer prostate canc
    • Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G, Manolescu A, Rafnar T, Gudbjartsson D, Agnarsson BA, Baker A, Sigurdsson A, Benediktsdottir KR, Jakobsdottir M, Blondal T, Stacey SN, Helgason A, Gunnarsdottir S, Olafsdottir A, Kristinsson KT, Birgisdottir B, Ghosh S, Thorlacius S, Magnusdottir D, Stefansdottir G, Kristjansson K, Bagger Y, Wilensky RL, Reilly MP, Morris AD, Kimber CH, Adeyemo A, Chen Y, Zhou J, So WY, Tong PC, Ng MC, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Tres A, Fuertes F, Ruiz-Echarri M, Asin L, Saez B, van Boven E, Klaver S, Swinkels DW, Aben KK, Graif T, Cashy J, Suarez BK, van Vierssen Trip O, Frigge ML, Ober C, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Palmer CN, Rotimi C, Chan JC, Pedersen O, Sigurdsson G, Benediktsson R, Jonsson E, Einarsson GV, Mayordomo JI, Catalona WJ, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K 2007 Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet 39:977-983
  • 24
    • 51249110837 scopus 로고    scopus 로고
    • A genetic link between type 2 diabetes and prostate cancer
    • Frayling TM, Colhoun H, Florez JC 2008 A genetic link between type 2 diabetes and prostate cancer. Diabetologia 51:1757-1760
    • (2008) Diabetologia , vol.51 , pp. 1757-1760
    • Frayling, T.M.1    Colhoun, H.2    Florez, J.C.3
  • 25
    • 79959524146 scopus 로고    scopus 로고
    • The International Hap Map Consortium 2005 A haplotype map of the human genome. Nature 437:1299-1320
    • The International Hap Map Consortium 2005 A haplotype map of the human genome. Nature 437:1299-1320
  • 26
    • 1842422877 scopus 로고    scopus 로고
    • A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4α gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population
    • Love-Gregory LD, Wasson J, Ma J, Jin CH, Glaser B, Suarez BK, Permutt MA 2004 A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4α gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population. Diabetes 53:1134-1140
    • (2004) Diabetes , vol.53 , pp. 1134-1140
    • Love-Gregory, L.D.1    Wasson, J.2    Ma, J.3    Jin, C.H.4    Glaser, B.5    Suarez, B.K.6    Permutt, M.A.7
  • 30
    • 85031381492 scopus 로고    scopus 로고
    • Modest T2D association of HNF4AP2 promoter SNPs observed in meta-analysis of more than 18,000T2D individuals and controls
    • Scott LJ, Mohlke KL, Collins FS, Boehnke M 2005 Modest T2D association of HNF4AP2 promoter SNPs observed in meta-analysis of more than 18,000T2D individuals and controls. ASHG Abstracts 1779. http://www.ashg.org/cgi-bin/ashg05s/ashg05?author=Scott&sort= pgmnums&sbutton-Detail&absno=1779&sid=888914
    • (2005) ASHG Abstracts 1779
    • Scott, L.J.1    Mohlke, K.L.2    Collins, F.S.3    Boehnke, M.4
  • 31
    • 44749085712 scopus 로고    scopus 로고
    • Newly identified loci highlight β-cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?
    • Florez JC 2008 Newly identified loci highlight β-cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia 51:1100-1110
    • (2008) Diabetologia , vol.51 , pp. 1100-1110
    • Florez, J.C.1
  • 34
    • 85031375850 scopus 로고    scopus 로고
    • McAteer J, Jablonski KA, Pollin TI, Dabelea D, Ehrmann D, Kahn SE, Franks PW, Shuldiner AR, Knowler WC, Florez JC, Altshuler D 2007 Discovery of rare variants in MODY genes and impact on progression to diabetes in the Diabetes Prevention Program (DPP). ADA Annual Scientific Sessions Abstracts 372-OR. http://professional.diabetes.org/Abstracts_Display.aspx?TYP=1&CID= 55551
    • McAteer J, Jablonski KA, Pollin TI, Dabelea D, Ehrmann D, Kahn SE, Franks PW, Shuldiner AR, Knowler WC, Florez JC, Altshuler D 2007 Discovery of rare variants in MODY genes and impact on progression to diabetes in the Diabetes Prevention Program (DPP). ADA Annual Scientific Sessions Abstracts 372-OR. http://professional.diabetes.org/Abstracts_Display.aspx?TYP=1&CID= 55551
  • 38
    • 39049100084 scopus 로고    scopus 로고
    • Florez JC, Jablonski KA, McAteer J, Sandhu MS, Wareham NJ, Barroso I, Franks PW, Altshuler D, Knowler WC; Diabetes Prevention Program Research Group 2008 Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Diabetologia 51:451-457
    • Florez JC, Jablonski KA, McAteer J, Sandhu MS, Wareham NJ, Barroso I, Franks PW, Altshuler D, Knowler WC; Diabetes Prevention Program Research Group 2008 Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Diabetologia 51:451-457
  • 41
    • 23044493861 scopus 로고    scopus 로고
    • Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
    • Meyre D, Bouatia-Naji N, Tounian A, Samson C, Froguel P 2005 Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 37:863-867
    • (2005) Nat Genet , vol.37 , pp. 863-867
    • Meyre, D.1    Bouatia-Naji, N.2    Tounian, A.3    Samson, C.4    Froguel, P.5
  • 43
    • 33845434199 scopus 로고    scopus 로고
    • No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians
    • Weedon MN, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM 2006 No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians. Diabetes 55:3175-3179
    • (2006) Diabetes , vol.55 , pp. 3175-3179
    • Weedon, M.N.1    Shields, B.2    Hitman, G.3    Walker, M.4    McCarthy, M.I.5    Hattersley, A.T.6    Frayling, T.M.7
  • 45
    • 42449116149 scopus 로고    scopus 로고
    • The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: Evidence from an updated meta-analysis in 42,042 subjects
    • McAteer JB, Prudente S, Bacci S, Lyon HN, Hirschhorn JN, Trischitta V, Florez JC 2008 The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects. Diabetes 57:1125-1130
    • (2008) Diabetes , vol.57 , pp. 1125-1130
    • McAteer, J.B.1    Prudente, S.2    Bacci, S.3    Lyon, H.N.4    Hirschhorn, J.N.5    Trischitta, V.6    Florez, J.C.7
  • 46
    • 48249098981 scopus 로고    scopus 로고
    • Haplotype structure of the ENPP1 gene and nominal association of the K121Q polymorphism with glycemic traits in the Framingham Heart Study
    • Stolerman ES, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC 2008 Haplotype structure of the ENPP1 gene and nominal association of the K121Q polymorphism with glycemic traits in the Framingham Heart Study. Diabetes 57:1971-1977
    • (2008) Diabetes , vol.57 , pp. 1971-1977
    • Stolerman, E.S.1    Manning, A.K.2    McAteer, J.B.3    Dupuis, J.4    Fox, C.S.5    Cupples, L.A.6    Meigs, J.B.7    Florez, J.C.8
  • 47
    • 33750595696 scopus 로고    scopus 로고
    • New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals
    • Bochenski J, Placha G, Wanic K, Malecki M, Sieradzki J, Warram J, Krolewski A 2006 New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals. Diabetes 55:2626-2630
    • (2006) Diabetes , vol.55 , pp. 2626-2630
    • Bochenski, J.1    Placha, G.2    Wanic, K.3    Malecki, M.4    Sieradzki, J.5    Warram, J.6    Krolewski, A.7
  • 50
    • 0842285701 scopus 로고    scopus 로고
    • Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies
    • Song Y, Niu T, Manson JE, Kwiatkowski DJ, Liu S 2004 Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies. Am J Hum Genet 74:208-222
    • (2004) Am J Hum Genet , vol.74 , pp. 208-222
    • Song, Y.1    Niu, T.2    Manson, J.E.3    Kwiatkowski, D.J.4    Liu, S.5
  • 55
    • 0030766446 scopus 로고    scopus 로고
    • A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene
    • Zouali H, Hani EH, Philippi A, Vionnet N, Beckmann JS, Demenais F, Froguel P 1997 A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. Hum Mol Genet 6:1401-1408
    • (1997) Hum Mol Genet , vol.6 , pp. 1401-1408
    • Zouali, H.1    Hani, E.H.2    Philippi, A.3    Vionnet, N.4    Beckmann, J.S.5    Demenais, F.6    Froguel, P.7
  • 56
    • 13044277561 scopus 로고    scopus 로고
    • Ghosh S, Watanabe RM, Hauser ER, Valle T, Magnuson VL, Erdos MR, Langefeld CD, Balow Jr J, Ally DS, Kohtamaki K, Chines P, Birznieks G, Kaleta HS, Musick A, Te C, Tannenbaum J, Eldridge W, Shapiro S, Martin C, Witt A, So A, Chang J, Shurtleff B, Porter R, Kudelko K, Unni A, Segal L, Sharaf R, Blaschak-Harvan J, Eriksson J, Tenkula T, Vidgren G, Ehnholm C, Tuomilehto-Wolf E, Hagopian W, Buchanan TA, Tuomilehto J, Bergman RN, Collins FS, Boehnke M 1999 Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. Proc Natl Acad Sci USA 96:2198-2203
    • Ghosh S, Watanabe RM, Hauser ER, Valle T, Magnuson VL, Erdos MR, Langefeld CD, Balow Jr J, Ally DS, Kohtamaki K, Chines P, Birznieks G, Kaleta HS, Musick A, Te C, Tannenbaum J, Eldridge W, Shapiro S, Martin C, Witt A, So A, Chang J, Shurtleff B, Porter R, Kudelko K, Unni A, Segal L, Sharaf R, Blaschak-Harvan J, Eriksson J, Tenkula T, Vidgren G, Ehnholm C, Tuomilehto-Wolf E, Hagopian W, Buchanan TA, Tuomilehto J, Bergman RN, Collins FS, Boehnke M 1999 Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. Proc Natl Acad Sci USA 96:2198-2203
  • 57
    • 0033764737 scopus 로고    scopus 로고
    • Ghosh S, Watanabe RM, Valle TT, Hauser ER, Magnuson VL, Langefeld CD, Ally DS, Mohlke KL, Silander K, Kohtamaki K, Chines P, Balow Jr J, Birznieks G, Chang J, Eldridge W, Erdos MR, Karanjawala ZE, Knapp JI, Kudelko K, Martin C, Morales-Mena A, Musick A, Musick T, Pfahl C, Porter R, Rayman JB 2000 The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet 67:1174-1185
    • Ghosh S, Watanabe RM, Valle TT, Hauser ER, Magnuson VL, Langefeld CD, Ally DS, Mohlke KL, Silander K, Kohtamaki K, Chines P, Balow Jr J, Birznieks G, Chang J, Eldridge W, Erdos MR, Karanjawala ZE, Knapp JI, Kudelko K, Martin C, Morales-Mena A, Musick A, Musick T, Pfahl C, Porter R, Rayman JB 2000 The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet 67:1174-1185
  • 61
    • 0032910599 scopus 로고    scopus 로고
    • A genomewide search for type 2 diabetes susceptibility genes in Utah Caucasians
    • Elbein SC, Hoffman MD, Teng K, Leppert MF, Hasstedt SJ 1999 A genomewide search for type 2 diabetes susceptibility genes in Utah Caucasians. Diabetes 48:1175-1182
    • (1999) Diabetes , vol.48 , pp. 1175-1182
    • Elbein, S.C.1    Hoffman, M.D.2    Teng, K.3    Leppert, M.F.4    Hasstedt, S.J.5
  • 62
    • 0033652271 scopus 로고    scopus 로고
    • Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24
    • Vionnet N, Hani El H, Dupont S, Gallina S, Francke S, Dotte S, De Matos F, Durand E, Lepretre F, Lecoeur C, Gallina P, Zekiri L, Dina C, Froguel P 2000 Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet 67:1470-1480
    • (2000) Am J Hum Genet , vol.67 , pp. 1470-1480
    • Vionnet, N.1    Hani, E.H.2    Dupont, S.3    Gallina, S.4    Francke, S.5    Dotte, S.6    De Matos, F.7    Durand, E.8    Lepretre, F.9    Lecoeur, C.10    Gallina, P.11    Zekiri, L.12    Dina, C.13    Froguel, P.14
  • 63
    • 0034893106 scopus 로고    scopus 로고
    • Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, Sampson M, O'Rahilly S, Frayling TM, Bell JI, Lathrop GM, Bennett A, Dhillon R, Fletcher C, Groves CJ, Jones E, Prestwich P, Simecek N, Rao PV, Wishart M, Foxon R, Howell S, Smedley D, Cardon LR, Menzel S, McCarthy MI 2001 A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet 69:553-569
    • Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, Sampson M, O'Rahilly S, Frayling TM, Bell JI, Lathrop GM, Bennett A, Dhillon R, Fletcher C, Groves CJ, Jones E, Prestwich P, Simecek N, Rao PV, Wishart M, Foxon R, Howell S, Smedley D, Cardon LR, Menzel S, McCarthy MI 2001 A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet 69:553-569
  • 64
    • 0036317628 scopus 로고    scopus 로고
    • A genome-wide scan for loci linked to plasma levels of glucose and HbA1c in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study
    • Meigs JB, Panhuysen CI, Myers RH, Wilson PW, Cupples LA 2002 A genome-wide scan for loci linked to plasma levels of glucose and HbA1c in a community-based sample of Caucasian pedigrees: the Framingham Offspring Study. Diabetes 51:833-840
    • (2002) Diabetes , vol.51 , pp. 833-840
    • Meigs, J.B.1    Panhuysen, C.I.2    Myers, R.H.3    Wilson, P.W.4    Cupples, L.A.5
  • 65
    • 0037312885 scopus 로고    scopus 로고
    • Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: Evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24
    • Hsueh WC, St. Jean PL, Mitchell BD, Pollin TI, Knowler WC, Ehm MG, Bell CJ, Sakul H, Wagner MJ, Burns DK, Shuldiner AR 2003 Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24. Diabetes 52:550-557
    • (2003) Diabetes , vol.52 , pp. 550-557
    • Hsueh, W.C.1    St. Jean, P.L.2    Mitchell, B.D.3    Pollin, T.I.4    Knowler, W.C.5    Ehm, M.G.6    Bell, C.J.7    Sakul, H.8    Wagner, M.J.9    Burns, D.K.10    Shuldiner, A.R.11
  • 66
    • 32544451924 scopus 로고    scopus 로고
    • Grant SFA, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323
    • Grant SFA, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323
  • 67
  • 71
    • 33746075560 scopus 로고    scopus 로고
    • Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PIW, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D; Diabetes Prevention Program Research Group 2006 TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241-250
    • Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PIW, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D; Diabetes Prevention Program Research Group 2006 TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241-250
  • 76
    • 34247855851 scopus 로고    scopus 로고
    • Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion
    • Wang J, Kuusisto J, Vanttinen M, Kuulasmaa T, Lindstrom J, Tuomilehto J, Uusitupa M, Laakso M 2007 Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia 50:1192-1200
    • (2007) Diabetologia , vol.50 , pp. 1192-1200
    • Wang, J.1    Kuusisto, J.2    Vanttinen, M.3    Kuulasmaa, T.4    Lindstrom, J.5    Tuomilehto, J.6    Uusitupa, M.7    Laakso, M.8
  • 78
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Consortium 2003 The International HapMap Project. Nature 426:789-796
    • The International HapMap Consortium 2003 The International HapMap Project. Nature 426:789-796
  • 79
    • 0035071957 scopus 로고    scopus 로고
    • A new statistical method for haplotype reconstruction from population data
    • Stephens M, Smith NJ, Donnelly P 2001 A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989
    • (2001) Am J Hum Genet , vol.68 , pp. 978-989
    • Stephens, M.1    Smith, N.J.2    Donnelly, P.3
  • 80
    • 12244264435 scopus 로고    scopus 로고
    • Genetic power calculator: Design of linkage and association genetic mapping studies of complex traits
    • Purcell S, Cherny SS, Sham PC 2003 Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149-150
    • (2003) Bioinformatics , vol.19 , pp. 149-150
    • Purcell, S.1    Cherny, S.S.2    Sham, P.C.3
  • 81
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett JC, Fry B, Maller J, Daly MJ 2005 Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 83
    • 16844366786 scopus 로고    scopus 로고
    • Genome-wide strategies for detecting multiple loci that influence complex diseases
    • Marchini J, Donnelly P, Cardon LR 2005 Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet 37:413-417
    • (2005) Nat Genet , vol.37 , pp. 413-417
    • Marchini, J.1    Donnelly, P.2    Cardon, L.R.3
  • 84
    • 12344261638 scopus 로고    scopus 로고
    • Parental phenotypes in family-based association analyses
    • Purcell S, Sham P, Daly MJ 2005 Parental phenotypes in family-based association analyses. Am J Hum Genet 76:249-259
    • (2005) Am J Hum Genet , vol.76 , pp. 249-259
    • Purcell, S.1    Sham, P.2    Daly, M.J.3
  • 86
    • 33846653970 scopus 로고    scopus 로고
    • WHAP: Haplotype-based association analysis
    • Purcell S, Daly MJ, Sham PC 2007 WHAP: haplotype-based association analysis. Bioinformatics 23:255-256
    • (2007) Bioinformatics , vol.23 , pp. 255-256
    • Purcell, S.1    Daly, M.J.2    Sham, P.C.3
  • 88
    • 34347344976 scopus 로고    scopus 로고
    • A new multipoint method for genome-wide association studies by imputation of genotypes
    • Marchini J, Howie B, Myers S, McVean G, Donnelly P 2007 A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet 39:906-913
    • (2007) Nat Genet , vol.39 , pp. 906-913
    • Marchini, J.1    Howie, B.2    Myers, S.3    McVean, G.4    Donnelly, P.5
  • 90
    • 4344665860 scopus 로고    scopus 로고
    • Identification and cloning of a β-cell-specific Zinc transporter, ZnT-8, localized into insulin secretory granules
    • Chimienti F, Devergnas S, Favier A, Seve M 2004 Identification and cloning of a β-cell-specific Zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53:2330-2337
    • (2004) Diabetes , vol.53 , pp. 2330-2337
    • Chimienti, F.1    Devergnas, S.2    Favier, A.3    Seve, M.4
  • 91
    • 1342263517 scopus 로고    scopus 로고
    • Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
    • Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS 2004 Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 131:797-806
    • (2004) Development , vol.131 , pp. 797-806
    • Bort, R.1    Martinez-Barbera, J.P.2    Beddington, R.S.3    Zaret, K.S.4
  • 92
    • 34249888775 scopus 로고    scopus 로고
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University and Novartis Institutes for BioMedical Research 2007 Genomewide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University and Novartis Institutes for BioMedical Research 2007 Genomewide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336
  • 93
    • 34249895023 scopus 로고    scopus 로고
    • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, The Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT 2007 Replication of genome-wide association signals in U.K. samples reveals risk loci for type 2 diabetes. Science 316:1336-1341
    • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, The Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT 2007 Replication of genome-wide association signals in U.K. samples reveals risk loci for type 2 diabetes. Science 316:1336-1341
  • 94
    • 34249885875 scopus 로고    scopus 로고
    • Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345
    • Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345
  • 95
    • 34249828965 scopus 로고    scopus 로고
    • Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K 2007 A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39:770-775
    • Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K 2007 A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39:770-775
  • 96
    • 34248594090 scopus 로고    scopus 로고
    • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889-894
    • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889-894
  • 101
    • 36849023376 scopus 로고    scopus 로고
    • Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: Evidence for replication from diabetes-related quantitative traits and from independent populations
    • Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton J, Yin J, Chang CY, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, Shuldiner AR 2007 Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations. Diabetes 56:3053-3062
    • (2007) Diabetes , vol.56 , pp. 3053-3062
    • Rampersaud, E.1    Damcott, C.M.2    Fu, M.3    Shen, H.4    McArdle, P.5    Shi, X.6    Shelton, J.7    Yin, J.8    Chang, C.Y.9    Ott, S.H.10    Zhang, L.11    Zhao, Y.12    Mitchell, B.D.13    O'Connell, J.14    Shuldiner, A.R.15
  • 103
    • 42349106044 scopus 로고    scopus 로고
    • Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Bostrom KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jorgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjogren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ, Illig T, Hveem K, Hu FB, Laakso M, Stefans
    • Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Bostrom KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jorgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjogren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645
  • 104
    • 33745279392 scopus 로고    scopus 로고
    • Evaluating and improving power in whole-genome association studies using fixed marker sets
    • Pe'er I, de Bakker PIW, Maller J, Yelensky R, Altshuler D, Daly MJ 2006 Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat Genet 38:663-667
    • (2006) Nat Genet , vol.38 , pp. 663-667
    • Pe'er, I.1    de Bakker, P.I.W.2    Maller, J.3    Yelensky, R.4    Altshuler, D.5    Daly, M.J.6
  • 107
    • 56349096931 scopus 로고    scopus 로고
    • Lango H, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN 30 June 2008 Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 10.2337/db2308-0504
    • Lango H, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN 30 June 2008 Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 10.2337/db2308-0504
  • 108
    • 0037955823 scopus 로고    scopus 로고
    • A genome scan for loci linked to quantitative insulin traits in persons without diabetes: The Framingham Offspring Study
    • Panhuysen CIM, Cupples LA, Wilson PW, Herbert AG, Myers RH, Meigs JB 2003 A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study. Diabetologia 46:579-587
    • (2003) Diabetologia , vol.46 , pp. 579-587
    • Panhuysen, C.I.M.1    Cupples, L.A.2    Wilson, P.W.3    Herbert, A.G.4    Myers, R.H.5    Meigs, J.B.6
  • 109
    • 34548032087 scopus 로고    scopus 로고
    • Genome-wide association studies provide new insights into type 2 diabetes aetiology
    • Frayling TM 2007 Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 8:657-662
    • (2007) Nat Rev Genet , vol.8 , pp. 657-662
    • Frayling, T.M.1


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