A genome scan for loci linked to quantitative insulin traits in persons without diabetes: The Framingham Offspring Study

Diabetologia

Volumn 46, Issue 4, 2003, Pages 579-587

  Panhuysen, C I M ^a   Cupples, L A ^a   Wilson, P W F ^b,c   Herbert, A G ^c   Myers, R H ^c   Meigs, J B ^d  

^a BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^b FRAMINGHAM HEART STUDY   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Chromosome mapping; Chromosomes; Diabetes mellitus; Human; Insulin; Insulin resistance; Non insulin dependent; Pair 11; Pair 17; Pair 9

Indexed keywords

ARTICLE; CHROMOSOME 11; CHROMOSOME 19; CHROMOSOME 9; COMPUTER SIMULATION; DIABETES MELLITUS; FEMALE; GENE LOCUS; GENETIC SUSCEPTIBILITY; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; QUANTITATIVE TRAIT;

EID: 0037955823     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1066-z     Document Type: Article

References (43)

1. American Diabetes Association (1997) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus [comment]. Diabetes Care. 20: 1183-1197
2. Saad MF, Knowler WC, Pettitt DJ, Nelson RG, Charles MA, Bennett PH (1991) A two-step model for development of non-insulin dependent diabetes mellitus. Am J Med 90:229-235
3. Pratley RE, Weyer C (2001) The role of impaired early insulin secretion in the pathogenesis of Type 2 diabetes mellitus. Diabetologia 44:929-945
4. Pratley RE, Thompson DB, Prochazka M et al. (1998) An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J Clin Invest 101:1757-1764
5. Mitchell BD, Cole SA, Hsueh WC et al. (2000) Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans. Diabetes 49:513-516
6. Watanabe RM, Ghosh S, Langefeld CD et al. (2000) The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. II. An autosomal genome scan for diabetes-related quantitative-trait loci. Am J Hum Genet 67:1186-1200
7. Kannel WB, Feinleib M, Mcnamara JR, Garrison RJ, Castelli WP (1979) An investigation of coronary heart disease in families: the Framingham Offspring Study. Am J Epidemiol 110:281-290
8. World Health Organization (1980) WHO Expert Committee on Diabetes mellitus: Second Report World Health Organization, Geneva
9. Kannel WB, Sorlie P (1979) Some health benefits of physical activity: the Framingham Study. Arch Intern Med 139:857-861
10. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
11. Howard G, Bergman R, Wagenknecht LE et al. (1998) Ability of alternative indices of insulin sensitivity to predict cardiovascular risk: comparison with the "minimal model". Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Ann Epidemiol 8:358-369
12. Bonora E, Targher G, Alberiche M et al. (2000) Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care: 23:57-63
13. Haffner SMMH, Gaskill SP, Stern MP (1995) Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes 44:1386-1391
14. Haffner SM, Kennedy E, Gonzalez C, Stern MP, Miettinen H (1996) A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care 19:1138-1141
15. Haffner SM, Miettinen H, Gaskill SP, Stern MP (1996) Decreased insulin action and insulin secretion predict the development of impaired glucose tolerance. Diabetologia 39:1201-1207
16. Weber JL, May PE (1989) Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet 44:388-396
17. Yuan B, Vaske D, Weber JL, Beck J, Sheffield VC (1997) Improved set of short-tandem-repeat polymorphisms for screening the human genome. Am J Hum Genet 60:459-460
18. Fulker DW, Cherny SS, Cardon LR (1995) Multipoint interval mapping of quantitative trait loci, using sib pairs. Am J Hum Genet 56:1224-1233
19. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
20. Knowler WC, Pettitt DJ, Savage PJ, Bennett PH (1981) Diabetes incidence in Pima Indians: contributions of obesity and parental diabetes. Am J Epidemiol 113:144-156
21. Looker H C, Knowler W C, Hanson R L (2001) Changes in BMI and weight before and after the development of type 2 diabetes. Diabetes Care 24:1917-1922
22. Colditz GA, Willett WC, Stampfer MJ et al. (1990) Weight as a risk factor for clinical diabetes in women. Am J Epidemiol 132:501-513
23. Wannamethee SG, Shaper AG (1999) Weight change and duration of overweight and obesity in the incidence of type 2 diabetes. Diabetes Care 22:1266-1272
24. Brancati FL, Wang NY, Mead LA, Liang KY, Klag MJ (1999) Body weight patterns from 20 to 49 years of age and subsequent risk for diabetes mellitus: the Johns Hopkins Precursors Study. Arch Intern Med 159:957-963
25. Campbell PJ, Carlson MG (1993) Impact of obesity on insulin action in NIDDM. Diabetes 42:405-410
26. Elbein SC, Wegner K, Kahn SE (2000) Reduced beta-cell compensation to the insulin resistance associated with obesity in members of caucasian familial type 2 diabetic kindreds. Diabetes Care 23:221-227
27. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91
28. Boden G (1997) Role of fatty acids in the pathogenesis of insulin resistance and NIDDM [Review]. Diabetes 46:3-10
29. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327-334
30. Steppan CM, Bailey ST, Bhat S et al. (2001) The hormone resistin links obesity to diabetes. Nature 409:307-312
31. Hotta K, Funahashi T, Bodkin NL et al. (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126-1133
32. Stunkard AJ, Harris JR, Pedersen NL, Mcclearn GE (1990) The body-mass index of twins who have been reared apart. N Engl J Med 322:1483-1487
33. Chagnon YC, Perusse L, Weisnagel SJ, Rankinen T, Bouchard C (2000) The human obesity gene map: the 1999 update. Obes Res 8:89-117
34. Hanson RL, Ehm MG, Pettitt DJ et al. (1998) An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. Am J Hum Genet 63:1130-1138
35. Mitchell BD, Kammerer CM, Mahaney MC et al. (1996) Genetic analysis of the IRS. Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures. Arterioscler Thromb Vasc Biol 16:281-288
36. Hong Y, Despres JP, Rice T et al. (2000) Evidence of pleiotropic loci for fasting insulin, total fat mass, and abdominal visceral fat in a sedentary population: the HERITAGE family study. Obes Res 8:151-159
37. Kissebah AH, Sonnenberg GE, Myklebust J et al. (2000) Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci USA 97:14478-14483
38. Norman RA, Thompson DB, Foroud T et al. (1997) Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group. Am J Hum Genet 60:166-173
39. Eckenrode S, Marron MP, Nicholls R et al. (2000) Fine-mapping of the type 1 diabetes locus(IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses. Hum Genet 106:14-18
40. Yip RG, Wolfe MM (2000) GIP biology and fat metabolism. Life Sci 66:91-103
41. Ghosh S, Watanabe RM, Valle TT et al. (2000) The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet 67:1174-1185
42. Aguilar-Bryan L, Nichols CG, Wechsler SW et al. (1995) Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 268:423-426
43. Luo TH, Zhao Y, Li G et al. (2001) A genome-wide search for type II diabetes susceptibility genes in Chinese Hans. Diabetologia 44:501-506