New susceptibility locus for NIDDM is localized to human chromosome 20q

Diabetes

Volumn 46, Issue 5, 1997, Pages 876-881

  Ji, Linong ^a,b   Malecki, Maciek ^a,b   Warram, James H ^a,c   Yang, Yadong ^a,b   Rich, Stephen S ^d   Krolewski, Andrzej S ^a,b,c  

^a JOSLIN DIABETES CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; CHROMOSOME 20Q; FEMALE; GENE LOCATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL; RISK ASSESSMENT; SIBLING;

EID: 0030907295     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.5.876     Document Type: Article

References (32)

1. Rich SS: Mapping genes in diabetes: genetic epidemiological perspective. Diabetes 39:1315-1319, 1990
2. Elbein SC, Hoffman MD, Bragg KL: The genetics of NIDDM: an update. Diabetes Care 17:1523-1533, 1994
3. Kahn CR, Vincent D, Doria A: Genetics of non-insulin-dependent (type II) diabetes mellitus. Annu Rev Med 47:509-531, 1996
4. Froguel P, Vaxillaire M, Sun F, Velho G, Zouali H, Butel MO, Lesage S, Vionnet N, Clement K, Fougerousse F, Tanizawa Y, Weissenbach J, Beckmann JS, Lathrop GM, Passa P, Permutt MA, Cohen D: Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature 356:162-164, 1992
5. Bell GI, Xiang KS, Newman MV, Wu SH, Wright LG, Fajans SS, Spielman RS, Cox NJ: Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc Natl Acad Sci USA 88:1484-1488, 1991
6. Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI: Mutations in the hepatocyte nuclear factor-4a gene in the maturity-onset diabetes of the young (MODY1). Nature 384:458-460, 1996
7. Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P: A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nature Genet 9:418-423, 1995
8. Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Turner RC, Velho G, Chevre JC, Froguel P, Bell GI: Mutations in the hepatocyte nuclear factor-1a gene in maturity-onset diabetes of the young (MODY3). Nature 384:455-458, 1996
9. Baroni MG, Alcolado JC, Needham EW, Pozzilli P, Stocks J, Galton DJ: Sib-pair analysis of adenosine deaminase locus in NIDDM. Diabetes 41:1640-1643, 1992
10. Dow E, Gelding SV, Skinner E, Hewitt JE, Gray IP, Mather H, Williamson R, Johnston DG: Genetic analysis of glucokinase and the chromosome 20 diabetes susceptibility locus in families with type 2 diabetes. Diabetic Med 11:856-861, 1994
11. Chuang LM, Chiu KC, Wu HP, Jou TS, Tai TY, Lin BJ: Exclusion of adenosine deaminase gene locus on chromosome 20q12-13.1 in familial NIDDM in Taiwanese patients. Diabetologia 38:1490-1491, 1995
12. Lesage S, Hani EH, Philippi A, Vaxillaire M, Hager J, Passa P, Demenais F, Froguel P, Vionnet N: Linkage analyses of the MODY3 locus on chromosome 12q with late-onset NIDDM. Diabetes 44:1243-1217, 1995
13. Elbein SC, Chiu KC, Hoffman MD, Mayorga RA, Bragg KL, Leppert MF: Linkage analysis of 19 candidate regions for insulin resistance in familial NIDDM. Diabetes 44:1259-1265, 1995
14. Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DL, Concannon P, Stirling B, Morrison VA, Wapelhorst B, Spielman RS, Gogolin-Ewens KJ, Shephard JM, Williams SR, Risch N, Hinds D, Iwasaki N, Ogata M, Omori Y, Petzold C, Rietzsch H, Schroder HE, Schulze J, Cox NJ, Menzel S, Boriraj VV, Chen X, Lim LR, Lindner T, Mereu LE, Wang YQ, Xiang K, Yamagata K, Yang Y, Bell GI: A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nature Genet 13:161-166, 1996
15. Mahtani MM, Widen E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forsblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, Reeve-Daly MP, Weaver A, Brettin T, Duyk G, Lander ES, Groop LC: Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nature Genet 14:90-94, 1996
16. Stern MP, Duggirala R, Mitchell BD, Reinhart LJ, Shivakumar S, Shippman PA, Uresandi OC, Benavides E, Blangero J, O'Connell P: Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans. Genome Res 6:724-734, 1996
17. Cook JT, Shields DC, Page RC, Levy JC, Hattersley AT, Shaw JA, Neil HA, Wainscoat JS, Turner RC: Segregation analysis of NIDDM in Caucasian families. Diabetologia 37:1231-1240, 1994
18. Harris MI, Hadden WC, Knowler WC, Bennet PH: International criteria for the diagnosis of diabetes and impaired glucose tolerance. Diabetes Care 8:562-567, 1985
19. Maniatis T, Fritsch EF, Sambrook J: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1982
20. Bowden DW, Akots G, Rothschild CB, Falls KF, Sheehy MJ, Hayward C, Mackie A, Baird J, Brock D, Antonarakis SE: Linkage analysis of maturity-onset diabetes of the young (MODY): genetic heterogeneity and nonpenetrance. Am J Hum Genet 50:607-618, 1992
21. Bowden DW, Gravius TC, Akots G, Fajans SS: Identification of genetic markers flanking the locus for maturity-onset diabetes of the young on human chromosome 20. Diabetes 41:88-92, 1992
22. Rothschild CB, Akots G, Hayworth R, Pettenati MJ, Rao PN, Wood P, Stolz FM, Hansmann I, Serino K, Keith TP, Fajans SS, Bowden DW: A genetic map of chromosome 20q12-q13.1: multiple highly polymorphic microsatellite and RFLP markers linked to the maturity-onset diabetes of the young (MODY) locus. Am J Hum Genet 52:110-123, 1993
23. Stoffel M, Le Beau MM, Espinosa R: A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene. Proc Natl Acad Sci USA 93:3937-3941, 1996
24. Weber JL, May PE: Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet 44:388-396, 1989
25. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES: Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363, 1996
26. Hodge SE: The information contained in multiple sibling pairs. Genet Epidemiol 1:109-122, 1984
27. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516, 1993
28. Bowden D, Howard T, Sale M, Qadri A, Spray B, Rich S, Freedman B: Linkage of genetic markers in the MODY1 region of chromosome 20 to NIDDM in families enriched for nephropathy (Abstract). Diabetes 45 (Suppl. 2):79A, 1996
29. Zouali H, Stoffel M, Vionnet N, Philippi A, Passa P, Demenais F, Froguel P: Linkage of non-insulin-dependent diabetes mellitus to the gene in the phosphoenolpyruvate carboxykinase region on chromosome 20 (Abstract). Diabetes 44 (Suppl. 1):185A, 1995
30. Huston TJ, Stein LD, Gerety SS, Ma J, Castle AB, Silva J, Slonim DK, Baptista R, Kruglyak L, Xu SH, Hu X, Colbert AME, Rosenberg C, Reeve-Daly MP, Rozen S, Hui L, Wu X, Vestergaard C, Wilson KM, Bae JS, Maitra S, Ganiatsas S, Evans CA, DeAngelis MM, Ingalls KA, Nahf RW, Horton LT Jr, Anderson MO, Collymore AJ, Ye W, Kouyoumjian V, Zemsteva IS, Tam J, Devine R, Courtney DF, Renaud MT, Nguyen H, O'Connor TJ, Fizames C, Faure S, Gyapay G, Dib C, Morissette J, Orlin JB, Birren BW, Goodman N, Weissenbach J, Hawkins TL, Foote S, Page DC, Lander ES: An STS-based map of the human genome. Science 270:1945-1954, 1995
31. Herman WH, Fajans SS, Ortiz FJ, Smith MJ, Sturis J, Bell GI, Polonsky KS, Halter JB: Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree. Diabetes 43:40-46, 1994
32. Byrne MM, Sturis J, Fajans SS, Ortiz FJ, Stoltz A, Stoffel M, Smith MJ, Bell GI, Halter JB, Polonsky KS: Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. Diabetes 44:699-704, 1995