ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes

Diabetes

Volumn 54, Issue 4, 2005, Pages 1207-1213

  Abate, Nicola ^a   Chandalia, Manisha ^a   Satija, Pankaj ^a   Adams Huet, Beverley ^a   Grundy, Scott M ^a   Sandeep, Sreedharan ^b   Radha, Venkatesan ^b   Deepa, Raj ^b   Mohan, Viswanathan ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MADRAS DIABETES RESEARCH FOUNDATION   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; DNA; GLUCOSE; GLUTAMINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LYSINE; TRIACYLGLYCEROL;

ADULT; AGE; ALLELE; ARTICLE; ASIAN; BLOOD PRESSURE; BODY MASS; CAUCASIAN; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; DNA POLYMORPHISM; ENPP1 GENE; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FEMALE; GENETIC MARKER; GENETIC SUSCEPTIBILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INDIA; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ONSET AGE; PHENOTYPE; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; QUESTIONNAIRE; SEX DIFFERENCE; SOUTHEAST ASIA; TRIACYLGLYCEROL BLOOD LEVEL; UNITED STATES;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; DIABETES MELLITUS, TYPE 2; ENVIRONMENT; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INDIA; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; PHOSPHORIC DIESTER HYDROLASES; POLYMORPHISM, GENETIC; PYROPHOSPHATASES; RISK FACTORS; TEXAS;

EID: 15944371462     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.4.1207     Document Type: Article

References (31)

1. Abate N, Chandalia M: The impact of ethnicity on type 2 diabetes. J Diabetes Complications 17:39-58, 2003
2. Chandalia M, Abate N, Garg A, Stray Gundersen J, Grundy SM: Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men. J Clin Endocrinol Metab 84:2329-2335, 1999
3. Ramachandran A, Jali MV, Mohan V, Snehalatha C, Viswanathan M: High prevalence of diabetes in an urban population in south India. BMJ 297: 587-590, 1988
4. Ramachandran A, Snehalatha C, Dharmaraj D, Viswanathan M: Prevalence of glucose intolerance in Asian Indians: urban-rural difference and significance of upper body adiposity. Diabetes Care 15:1348-1355, 1992
5. McKeigue PM, Marmot MG, Syndercombe Court YD, Cottier DE, Rahman S, Riemersma RA: Diabetes, hyperinsulinaemia, and coronary risk factors in Bangladeshis in east London. Br Heart J 60:390-396, 1988
6. McKeigue PM, Pierpoint T, Ferrie JE, Marmot MG: Relationship of glucose intolerance and hyperinsulinaemia to body fat pattern in South Asians and Europeans. Diabetologia 35:785-791, 1992
7. Mather HM, Keen H: The Southall Diabetes Survey: prevalence of known diabetes in Asians and Europeans. BMJ 291:1081-1084, 1985
8. Abate N, Carulli L, Cabo-Chan A Jr, Chandalia M, Snell PG, Grundy SM: Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance. J Clin Endocrinol Metab 88:5927-5934, 2003
9. Pizzuti A, Frittitta L, Argiolas A, Baratta R, Goldfine ID, Bozzali M, Ercolino T, Scarlato G, Iacoviello L, Vigneri R, Tassi V, Trischitta V: A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes 48:1881-1884, 1999
10. Frittitta L, Baratta R, Spampinato D, Di Paola R, Pizzuti A, Vigneri R, Trischitta V: The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance. J Clin Endocrinol Metab 86:5888-5891, 2001
11. Gu HF, Almgren P, Lindholm E, Frittitta L, Pizzuti A, Trischitta V, Groop LC: Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis. Diabetes 49:1601-1603, 2000
12. Kubaszek A, Pihlajamaki J, Karhapaa P, Vauhkonen I, Laakso M: The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia. Diabetes Care 26:464-467, 2003
13. González-Sánchez JL, Martínez-Larrad MT, Fernández-Pérez C, Kubaszek A, Laakso M, Serrano-Ríos M: K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population. Obes Res 11:603-605, 2003
14. Rasmussen SK, Urhammer SA, Pizzuti A, Echwald SM, Ekstrom CT, Hansen L, Hansen T, Borch-Johnsen K, Frittitta L, Trischitta V, Pedersen O: The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians. Diabetes 49:1608-1611, 2000
15. Kubaszek A, Markkanen A, Eriksson JG, Forsen T, Osmond C, Barker DJ, Laakso M: The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth. J Clin Endocrinol Metab 89:2044-2047, 2004
16. Hamaguchi K, Terao H, Kusuda Y, Yamashita T, Hazoury Bahles JA, Cruz LLM, Brugal VLI, Jongchong WB, Yoshimatsu H, Sakata T: The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes. J Clin Endocrinol Metab 89:1359-1364, 2004
17. Laukkanen O, Pihlajamaki J, Lindstrom J, Eriksson J, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M: Finnish Diabetes Prevention Study Group. Common polymorphisms in the genes regulating the early insulin signaling pathway: effects on weight change and the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetologia 47:871-877, 2004
18. Deepa M, Pradeepa R, Rema M, Mohan A, Deepa R, Shanthirani S, Mohan V: The Chennai Urban Rural Epidemiology Study (CURES): study design and methodology (urban component) (CURES-1). J Assoc Physicians India 51:863-870, 2003
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419, 1985
20. Yeni-Komshian H, Carantoni M, Abbasi F, Reaven GM: Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy nondiabetic volunteers. Diabetes Care 23:171-175, 2000
21. Wacholder S, Rothmah N, Caporaso N: Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. J Natl Cancer Inst 92:1151-1158, 2000
22. Maddux BA, Goldfine ID: Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes 49:13-19, 2000
23. Frittitta L, Youngren JF, Sbraccia P, D'Adamo M, Buongiorno A, Vigneri R, Goldfine ID, Trischitta V: Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity. Diabetologia 40:282-289, 1997
24. Frittitta L, Youngren J, Vigneri R, Maddux BA, Trischitta V, Goldfine ID: PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity. Diabetologia 39:1190-1195, 1996
25. Youngren JF, Maddux BA, Sasson S, Sbraccia P, Tapscott EB, Swanson MS, Dohm GL, Goldfihe ID: Skeletal muscle content of membrane glycoprotein PC-1 in obesity: relationship to muscle glucose transport. Diabetes 45:1324-1328, 1996
26. Maddux BA, Sbraccia P, Kumakura S, Sasson S, Youngren J, Fisher A, Spencer S, Grupe A, Henzel W, Stewart TA, Reaven GM, Goldfine ID: Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus. Nature 373:448-451, 1995
27. Redden DT, Allison DB: Nonreplication in genetic association studies of obesity and diabetes research. J Nutr 133:3323-3326, 2003
28. Lalouel JM, Rohrwasser A: Power and replication in case-control studies. Am J Hypertens 15:201-205, 2002
29. Hirschhorn JN, Altshuler D: Once and again-issues surrounding replication in genetic association studies. J Clin Endocrinol Metab 87:4438-4441, 2002
30. Morrison JA, Gruppo R, Glueck CJ, Stroop D, Fontaine RN, Wang P, Smith KL: Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene is strongly associated with race but not with insulin resistance in black and white children. Metabolism 53:465-468, 2004
31. Pritchard JK, Rosenberg NA: Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 65:220-228