메뉴 건너뛰기




Volumn 53, Issue 4, 2004, Pages 1141-1149

Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes

(23)  Silander, Kaisa a,e   Mohlke, Karen L a   Scott, Laura J b   Peck, Erin C a   Hollstein, Pablo a   Skol, Andrew D b   Jackson, Anne U b   Delonkas, Panagiotis c   Hunt, Sarah c   Stavrides, George c   Chines, Peter S a   Erdos, Michael R a   Narisu, Narisu a   Conneely, Karen N b   Li, Chun b,g   Fingerlin, Tasha E b   Dhanjal, Sharanjeet K d   Valle, Timo T e   Bergman, Richard N d   Tuomilehto, Jaakko e,f   more..


Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 4ALPHA;

EID: 12144291217     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.4.1141     Document Type: Article
Times cited : (246)

References (50)
  • 3
    • 0030766446 scopus 로고    scopus 로고
    • A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene
    • Zouali H, Hani EH, Philippi A, Vionnet N, Beckmann JS, Demenais F, Froguel P: A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. Hum Mol Genet 6:1401-1408, 1997
    • (1997) Hum Mol Genet , vol.6 , pp. 1401-1408
    • Zouali, H.1    Hani, E.H.2    Philippi, A.3    Vionnet, N.4    Beckmann, J.S.5    Demenais, F.6    Froguel, P.7
  • 8
    • 0035960122 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
    • Fajans SS, Bell GI, Polonsky KS: Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 345:971-980, 2001
    • (2001) N Engl J Med , vol.345 , pp. 971-980
    • Fajans, S.S.1    Bell, G.I.2    Polonsky, K.S.3
  • 9
    • 0032518210 scopus 로고    scopus 로고
    • An alternative splice variant of the tissue specific transcription factor HNF 4alpha predominates in undifferentiated murine cell types
    • Nakhei H, Lingott A, Lemm I, Ryffel GU: An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types. Nucleic Acid Res 26:497-504, 1998
    • (1998) Nucleic Acid Res , vol.26 , pp. 497-504
    • Nakhei, H.1    Lingott, A.2    Lemm, I.3    Ryffel, G.U.4
  • 11
    • 0038748298 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms
    • Eeckhoute J, Moerman E, Bouckenooghe T, Lukoviak B, Pattou F, Formstecher P, Kerr-Conte J, Vandewalle B, Laine B: Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms. Endocrinology 144:1686-1694, 2003
    • (2003) Endocrinology , vol.144 , pp. 1686-1694
    • Eeckhoute, J.1    Moerman, E.2    Bouckenooghe, T.3    Lukoviak, B.4    Pattou, F.5    Formstecher, P.6    Kerr-Conte, J.7    Vandewalle, B.8    Laine, B.9
  • 12
    • 0035807902 scopus 로고    scopus 로고
    • A transcription factor regulatory circuit in differentiated pancreatic cells
    • Boj SF, Parrizas M, Maestro MA, Ferrer J: A transcription factor regulatory circuit in differentiated pancreatic cells. Proc Natl Acad Sci U S A 98:14481-14486, 2001
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14481-14486
    • Boj, S.F.1    Parrizas, M.2    Maestro, M.A.3    Ferrer, J.4
  • 13
    • 0034892164 scopus 로고    scopus 로고
    • Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: Functional and pathological consequences
    • Ryffel GU: Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences. J Mol Endocrinol 27:11-29, 2001
    • (2001) J Mol Endocrinol , vol.27 , pp. 11-29
    • Ryffel, G.U.1
  • 14
    • 0030695445 scopus 로고    scopus 로고
    • The maturity-onset diabetes of the young (MODY1) transcription factor HNF 4alpha regulates expression of genes required for glucose transport and metabolism
    • Stoffel M, Duncan SA: The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism. Proc Natl Acad Sci U S A 94:13209-13214, 1997
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 13209-13214
    • Stoffel, M.1    Duncan, S.A.2
  • 15
    • 0034680936 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta-cell genes implicated in glucose metabolism and nutrient-induced insulin secretion
    • Wang H, Maechler P, Antinozzi PA, Hagenfeldt KA, Wollheim CB: Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta-cell genes implicated in glucose metabolism and nutrient-induced insulin secretion. J Biol Chem 275:35953-35959, 2000
    • (2000) J Biol Chem , vol.275 , pp. 35953-35959
    • Wang, H.1    Maechler, P.2    Antinozzi, P.A.3    Hagenfeldt, K.A.4    Wollheim, C.B.5
  • 16
    • 0037135622 scopus 로고    scopus 로고
    • Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha
    • Bartoov-Shifman R, Hertz R, Wang H, Wollheim CB, Bar-Tana J, Walker MD: Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha. J Biol Chem 277:25914-25919, 2002
    • (2002) J Biol Chem , vol.277 , pp. 25914-25919
    • Bartoov-Shifman, R.1    Hertz, R.2    Wang, H.3    Wollheim, C.B.4    Bar-Tana, J.5    Walker, M.D.6
  • 17
    • 0242349197 scopus 로고    scopus 로고
    • Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): Requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
    • Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM: Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A 100:4012-4017, 2003
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4012-4017
    • Rhee, J.1    Inoue, Y.2    Yoon, J.C.3    Puigserver, P.4    Fan, M.5    Gonzalez, F.J.6    Spiegelman, B.M.7
  • 20
    • 0034189694 scopus 로고    scopus 로고
    • Approaches to allele frequency determination
    • Kwok PY: Approaches to allele frequency determination. Pharmacogenomics 1:231-235, 2000
    • (2000) Pharmacogenomics , vol.1 , pp. 231-235
    • Kwok, P.Y.1
  • 23
    • 1842422877 scopus 로고    scopus 로고
    • A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4α gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population
    • Love-Gregory LD, Wasson J, Ma J, Jin CH, Glaser B, Suarez BK, Permutt MA: A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4α gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population. Diabetes 53:1134-1140, 2004
    • (2004) Diabetes , vol.53 , pp. 1134-1140
    • Love-Gregory, L.D.1    Wasson, J.2    Ma, J.3    Jin, C.H.4    Glaser, B.5    Suarez, B.K.6    Permutt, M.A.7
  • 26
    • 0030920610 scopus 로고    scopus 로고
    • Sequence mapping by electronic PCR
    • Schuler GD: Sequence mapping by electronic PCR. Genome Res 7:541-550, 1997
    • (1997) Genome Res , vol.7 , pp. 541-550
    • Schuler, G.D.1
  • 31
    • 0022673130 scopus 로고
    • Longitudinal data analysis for discrete and continuous outcomes
    • Zeger SL, Liang KY: Longitudinal data analysis for discrete and continuous outcomes. Biometrics 42:121-130, 1986
    • (1986) Biometrics , vol.42 , pp. 121-130
    • Zeger, S.L.1    Liang, K.Y.2
  • 32
    • 0030728925 scopus 로고    scopus 로고
    • Allele-sharing models: LOD scores and accurate linkage tests
    • Kong A, Cox NJ: Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61:1179-1188, 1997
    • (1997) Am J Hum Genet , vol.61 , pp. 1179-1188
    • Kong, A.1    Cox, N.J.2
  • 33
    • 1542374068 scopus 로고    scopus 로고
    • Assessing whether an allele can account in part for a linkage signal: The genotype-IBD sharing test (GIST)
    • Li C, Scott LJ, Boehnke M: Assessing whether an allele can account in part for a linkage signal: the genotype-IBD sharing test (GIST). Am J Hum Genet 74:418-431, 2004
    • (2004) Am J Hum Genet , vol.74 , pp. 418-431
    • Li, C.1    Scott, L.J.2    Boehnke, M.3
  • 34
    • 0034017850 scopus 로고    scopus 로고
    • GOLD: Graphical overview of linkage disequilibrium
    • Abecasis GR, Cookson WOC: GOLD: graphical overview of linkage disequilibrium. Bioinformatics 16:182-183, 2000
    • (2000) Bioinformatics , vol.16 , pp. 182-183
    • Abecasis, G.R.1    Cookson, W.O.C.2
  • 35
    • 10744222156 scopus 로고    scopus 로고
    • Identification and characterization of multi-species conserved sequences
    • Margulies EH, Blanchette M, Haussler D, Green ED, NISC Comparative Sequencing Program: Identification and characterization of multi-species conserved sequences. Genome Research 13:2507-2518, 2003
    • (2003) Genome Research , vol.13 , pp. 2507-2518
    • Margulies, E.H.1    Blanchette, M.2    Haussler, D.3    Green, E.D.4
  • 36
    • 0036208832 scopus 로고    scopus 로고
    • Patterns of linkage disequilibrium in the human genome
    • Ardlie KG, Kruglyak L, Seielstad M: Patterns of linkage disequilibrium in the human genome. Nat Rev Genet 3:299-309, 2002
    • (2002) Nat Rev Genet , vol.3 , pp. 299-309
    • Ardlie, K.G.1    Kruglyak, L.2    Seielstad, M.3
  • 41
    • 0031802866 scopus 로고    scopus 로고
    • Exclusion of the hepatocyte nuclear factor 4α as a candidate gene for late-onset NIDDM linked with chromosome 20q
    • Malecki MT, Antonellis A, Casey P, Ji L, Wantman M, Warram JH, Krolewski AS: Exclusion of the hepatocyte nuclear factor 4α as a candidate gene for late-onset NIDDM linked with chromosome 20q. Diabetes 47:970-972, 1998
    • (1998) Diabetes , vol.47 , pp. 970-972
    • Malecki, M.T.1    Antonellis, A.2    Casey, P.3    Ji, L.4    Wantman, M.5    Warram, J.H.6    Krolewski, A.S.7
  • 45
    • 0344019489 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1α G319S: A private mutation in Oji-Cree associated with type 2 diabetes
    • Hegele RA, Cao H, Harris SB, Hanley AJ, Zinman B: Hepatocyte nuclear factor-1α G319S: a private mutation in Oji-Cree associated with type 2 diabetes (Letter). Diabetes Care 22:524, 1999
    • (1999) Diabetes Care , vol.22 , pp. 524
    • Hegele, R.A.1    Cao, H.2    Harris, S.B.3    Hanley, A.J.4    Zinman, B.5
  • 46
    • 0038206737 scopus 로고    scopus 로고
    • Growing evidence for diabetes susceptibility genes from genome scan data
    • McCarthy MI: Growing evidence for diabetes susceptibility genes from genome scan data. Curr Diab Rep 3:159-167, 2003
    • (2003) Curr Diab Rep , vol.3 , pp. 159-167
    • McCarthy, M.I.1
  • 48
    • 0035676129 scopus 로고    scopus 로고
    • Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to type II diabetes mellitus
    • Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O: Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to type II diabetes mellitus. Diabetologia 44:2220-2226, 2001
    • (2001) Diabetologia , vol.44 , pp. 2220-2226
    • Ek, J.1    Andersen, G.2    Urhammer, S.A.3    Gaede, P.H.4    Drivsholm, T.5    Borch-Johnsen, K.6    Hansen, T.7    Pedersen, O.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.