-
1
-
-
33847206771
-
Alzheimer's disease: Progress in the development of antiamyloid disease-modifying therapies
-
Christensen DD. Alzheimer's disease: progress in the development of antiamyloid disease-modifying therapies. CNS Spectr. 12(2), 113-116, 119-123 (2007).
-
(2007)
CNS Spectr
, vol.12
, Issue.2
-
-
Christensen, D.D.1
-
2
-
-
34248160135
-
Clinical and economic outcomes - friend or foe?
-
Wimo A. Clinical and economic outcomes - friend or foe? Int. Psychogeriatr. 19(3), 497-507 (2007).
-
(2007)
Int. Psychogeriatr
, vol.19
, Issue.3
, pp. 497-507
-
-
Wimo, A.1
-
3
-
-
4544335597
-
Mild cognitive impairment as a diagnostic entity
-
Petersen RC. Mild cognitive impairment as a diagnostic entity. J. Intern. Med. 256(3), 183-194 (2004).
-
(2004)
J. Intern. Med
, vol.256
, Issue.3
, pp. 183-194
-
-
Petersen, R.C.1
-
4
-
-
4544350756
-
Mild cognitive impairment - beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment
-
Winblad B, Palmer K, Kivipelto M et al. Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J. Intern. Med. 256(3), 240-246 (2004).
-
(2004)
J. Intern. Med
, vol.256
, Issue.3
, pp. 240-246
-
-
Winblad, B.1
Palmer, K.2
Kivipelto, M.3
-
5
-
-
14644416500
-
Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
-
Bennett DA, Schneider JA, Bienias JL, Evans DA, Wilson RS. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology 64(5), 834-841 (2005).
-
(2005)
Neurology
, vol.64
, Issue.5
, pp. 834-841
-
-
Bennett, D.A.1
Schneider, J.A.2
Bienias, J.L.3
Evans, D.A.4
Wilson, R.S.5
-
6
-
-
33645102446
-
-
Ginsberg SD, Che S, Counts SE, Mufson EJ. Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. J. Neurochem. 96(5), 1401-1408 (2006). • The observed decrease in the expression of three-repeat tau compared to four-repeat tau in cholinergic basal forebrain (CBF) and hippocampal CA1 neurons in mild cognitive impairment (MCI) and Alzheimer's disease (AD), but not in normal aging, may have functional implications for neurofibrillary tangle formation.
-
Ginsberg SD, Che S, Counts SE, Mufson EJ. Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. J. Neurochem. 96(5), 1401-1408 (2006). • The observed decrease in the expression of three-repeat tau compared to four-repeat tau in cholinergic basal forebrain (CBF) and hippocampal CA1 neurons in mild cognitive impairment (MCI) and Alzheimer's disease (AD), but not in normal aging, may have functional implications for neurofibrillary tangle formation.
-
-
-
-
7
-
-
33645301867
-
Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease
-
Selective decreases in trkA, trkB and trkC but not p75NTR gene expression in CBF neurons may represent a shift from prosurvival to proapoptotic NGF signaling during the prodromal stages of AD, ••
-
Ginsberg SD, Che S, Wuu J, Counts SE, Mufson EJ. Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease. J. Neurochem. 97(2), 475-487 (2006). •• Selective decreases in trkA, trkB and trkC but not p75NTR gene expression in CBF neurons may represent a shift from prosurvival to proapoptotic NGF signaling during the prodromal stages of AD.
-
(2006)
J. Neurochem
, vol.97
, Issue.2
, pp. 475-487
-
-
Ginsberg, S.D.1
Che, S.2
Wuu, J.3
Counts, S.E.4
Mufson, E.J.5
-
8
-
-
30344469658
-
Neuropathologic substrate of mild cognitive impairment
-
Markesbery WR, Schmitt FA, Kryscio RJ et al. Neuropathologic substrate of mild cognitive impairment. Arch. Neurol. 63(1), 38-46 (2006).
-
(2006)
Arch. Neurol
, vol.63
, Issue.1
, pp. 38-46
-
-
Markesbery, W.R.1
Schmitt, F.A.2
Kryscio, R.J.3
-
9
-
-
0035099984
-
Mild cognitive impairment represents early-stage Alzheimer disease
-
First report to forward the hypothesis that MCI is preclinical AD and not a separate cognitive syndrome, ••
-
Morris JC, Storandt M, Miller JP et al. Mild cognitive impairment represents early-stage Alzheimer disease. Arch. Neurol. 58(3), 397-405 (2001). •• First report to forward the hypothesis that MCI is preclinical AD and not a separate cognitive syndrome.
-
(2001)
Arch. Neurol
, vol.58
, Issue.3
, pp. 397-405
-
-
Morris, J.C.1
Storandt, M.2
Miller, J.P.3
-
10
-
-
0242363668
-
Looking backward to move forward: Early detection of neurodegenerative disorders
-
DeKosky ST, Marek K. Looking backward to move forward: early detection of neurodegenerative disorders. Science 302(5646), 830-834 (2003).
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 830-834
-
-
DeKosky, S.T.1
Marek, K.2
-
11
-
-
0036810329
-
Alzheimer's disease and the basal forebrain cholinergic system: Relations to β-amyloid peptides, cognition, and treatment strategies
-
Auld DS, Kornecook TJ, Bastianetto S, Quirion R. Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies. Prog. Neurobiol. 68(3), 209-245 (2002).
-
(2002)
Prog. Neurobiol
, vol.68
, Issue.3
, pp. 209-245
-
-
Auld, D.S.1
Kornecook, T.J.2
Bastianetto, S.3
Quirion, R.4
-
12
-
-
55849106399
-
Basocortical cholinotrophic dysfunction during the early stages of Alzheimer's disease
-
Iqbal K, Winblad B Eds, Alzheimer's Association, Chicago, IL, USA
-
Mufson EJ, Counts SE. Basocortical cholinotrophic dysfunction during the early stages of Alzheimer's disease. In: Alzheimer's Disease and Related Disorders: Clinical and Basic Research Advances. Iqbal K, Winblad B (Eds). Alzheimer's Association, Chicago, IL, USA 204-210 (2004).
-
(2004)
Alzheimer's Disease and Related Disorders: Clinical and Basic Research Advances
, pp. 204-210
-
-
Mufson, E.J.1
Counts, S.E.2
-
13
-
-
0347914568
-
Human cholinergic basal forebrain: Chemoanatomy and neurologic dysfunction
-
Mufson EJ, Ginsberg SD, Ikonomovic MD, DeKosky ST. Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction. J. Chem. Neuroanat. 26(4), 233-242 (2003).
-
(2003)
J. Chem. Neuroanat
, vol.26
, Issue.4
, pp. 233-242
-
-
Mufson, E.J.1
Ginsberg, S.D.2
Ikonomovic, M.D.3
DeKosky, S.T.4
-
14
-
-
34548672350
-
Cholinotrophic molecular substrates of mild cognitive impairment in the elderly
-
Mufson EJ, Counts SE, Fahnestock M, Ginsberg SD. Cholinotrophic molecular substrates of mild cognitive impairment in the elderly. Curr. Alzheimer Res. 4(4), 340-350 (2007).
-
(2007)
Curr. Alzheimer Res
, vol.4
, Issue.4
, pp. 340-350
-
-
Mufson, E.J.1
Counts, S.E.2
Fahnestock, M.3
Ginsberg, S.D.4
-
15
-
-
45849142539
-
Galanin - 25 years with a multitalented neuropeptide: Galanin in Alzheimer's disease: neuroinhibitory or neuroprotective?
-
Counts SE, Perez SE, Mufson EJ. Galanin - 25 years with a multitalented neuropeptide: galanin in Alzheimer's disease: neuroinhibitory or neuroprotective? Cell. Mol. Life Sci. 65(12), 1842-1853 (2008).
-
(2008)
Cell. Mol. Life Sci
, vol.65
, Issue.12
, pp. 1842-1853
-
-
Counts, S.E.1
Perez, S.E.2
Mufson, E.J.3
-
16
-
-
0026440987
-
Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group
-
DeKosky ST, Harbaugh RE, Schmitt FA et al. Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group. Ann. Neurol. 32(5), 625-632 (1992).
-
(1992)
Ann. Neurol
, vol.32
, Issue.5
, pp. 625-632
-
-
DeKosky, S.T.1
Harbaugh, R.E.2
Schmitt, F.A.3
-
17
-
-
0034125843
-
On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis
-
Excellent review that highlights the importance of cholinergic function in cognition and the impact of cholinergic hypofunction on AD pathogenesis, •
-
Bartus RT. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp. Neurol. 163(2), 495-529 (2000). • Excellent review that highlights the importance of cholinergic function in cognition and the impact of cholinergic hypofunction on AD pathogenesis.
-
(2000)
Exp. Neurol
, vol.163
, Issue.2
, pp. 495-529
-
-
Bartus, R.T.1
-
18
-
-
85136406975
-
-
Davis KL, Mohs RC, Marin D et al. Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA 281(15), 1401-1406 (1999). • First study to demonstrate that decreases in neocortical choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activity are relatively late-stage AD phenomena.
-
Davis KL, Mohs RC, Marin D et al. Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA 281(15), 1401-1406 (1999). • First study to demonstrate that decreases in neocortical choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activity are relatively late-stage AD phenomena.
-
-
-
-
19
-
-
0036156958
-
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
-
Provides evidence for cholinergic plasticity during the preclinical stages of AD, •
-
DeKosky ST, Ikonomovic MD, Styren SD et al. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann. Neurol. 51(2), 145-155 (2002). • Provides evidence for cholinergic plasticity during the preclinical stages of AD.
-
(2002)
Ann. Neurol
, vol.51
, Issue.2
, pp. 145-155
-
-
DeKosky, S.T.1
Ikonomovic, M.D.2
Styren, S.D.3
-
20
-
-
16844377812
-
The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease
-
Counts SE, Mufson EJ. The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease. J. Neuropathol. Exp. Neurol. 64(4), 263-272 (2005).
-
(2005)
J. Neuropathol. Exp. Neurol
, vol.64
, Issue.4
, pp. 263-272
-
-
Counts, S.E.1
Mufson, E.J.2
-
21
-
-
0029979798
-
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
-
Gomez-Isla T, Price JL, McKeel DW Jr. et al. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 16(14), 4491-4500 (1996).
-
(1996)
J. Neurosci
, vol.16
, Issue.14
, pp. 4491-4500
-
-
Gomez-Isla, T.1
Price, J.L.2
McKeel Jr., D.W.3
-
22
-
-
0021145680
-
Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
-
Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 225(4667), 1168-1170 (1984).
-
(1984)
Science
, vol.225
, Issue.4667
, pp. 1168-1170
-
-
Hyman, B.T.1
Van Hoesen, G.W.2
Damasio, A.R.3
Barnes, C.L.4
-
23
-
-
0035131830
-
Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment
-
Kordower JH, Chu Y, Stebbins GT et al. Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann. Neurol. 49(2), 202-213 (2001).
-
(2001)
Ann. Neurol
, vol.49
, Issue.2
, pp. 202-213
-
-
Kordower, J.H.1
Chu, Y.2
Stebbins, G.T.3
-
24
-
-
0023095310
-
Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease
-
Demonstrates that cholinergic fiber sprouting occurs in the dentate gyrus in AD, possibly in response to deafferentation of glutamatergic perforant pathway fibers emanating from the entorhinal cortex, •
-
Hyman BT, Kromer LJ, Van Hoesen GW. Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease. Ann. Neurol. 21(3), 259-267 (1987). • Demonstrates that cholinergic fiber sprouting occurs in the dentate gyrus in AD, possibly in response to deafferentation of glutamatergic perforant pathway fibers emanating from the entorhinal cortex.
-
(1987)
Ann. Neurol
, vol.21
, Issue.3
, pp. 259-267
-
-
Hyman, B.T.1
Kromer, L.J.2
Van Hoesen, G.W.3
-
25
-
-
0015760852
-
Synaptic rearrangement in the dentate gyrus: Histochemical evidence of adjustments after lesions in immature and adult rats
-
Cotman CW, Matthews DA, Taylor D, Lynch G. Synaptic rearrangement in the dentate gyrus: histochemical evidence of adjustments after lesions in immature and adult rats. Proc. Natl Acad. Sci. USA 70(12), 3473-3477 (1973).
-
(1973)
Proc. Natl Acad. Sci. USA
, vol.70
, Issue.12
, pp. 3473-3477
-
-
Cotman, C.W.1
Matthews, D.A.2
Taylor, D.3
Lynch, G.4
-
26
-
-
0034843790
-
Molecules involved in reactive sprouting in the hippocampus
-
Savaskan NE, Nitsch R. Molecules involved in reactive sprouting in the hippocampus. Rev. Neurosci. 12(3), 195-215 (2001).
-
(2001)
Rev. Neurosci
, vol.12
, Issue.3
, pp. 195-215
-
-
Savaskan, N.E.1
Nitsch, R.2
-
27
-
-
0024449354
-
Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain
-
NTR as a specific marker for cholinergic neurons, ••
-
NTR as a specific marker for cholinergic neurons.
-
(1989)
Exp. Neurol
, vol.105
, Issue.3
, pp. 221-232
-
-
Mufson, E.J.1
Bothwell, M.2
Kordower, J.H.3
-
28
-
-
0028873975
-
Neurochemical correlates of dementia severity in Alzheimer's disease: Relative importance of the cholinergic deficits
-
Bierer LM, Haroutunian V, Gabriel S et al. Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J. Neurochem. 64(2), 749-760 (1995).
-
(1995)
J. Neurochem
, vol.64
, Issue.2
, pp. 749-760
-
-
Bierer, L.M.1
Haroutunian, V.2
Gabriel, S.3
-
29
-
-
0037224741
-
Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease
-
Rinne JO, Kaasinen V, Jarvenpaa T et al. Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 74(1), 113-115 (2003).
-
(2003)
J. Neurol. Neurosurg. Psychiatry
, vol.74
, Issue.1
, pp. 113-115
-
-
Rinne, J.O.1
Kaasinen, V.2
Jarvenpaa, T.3
-
30
-
-
0033867948
-
Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: A positron emission tomography study
-
Shinotoh H, Namba H, Fukushi K et al. Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: a positron emission tomography study. Ann. Neurol. 48(2), 194-200 (2000).
-
(2000)
Ann. Neurol
, vol.48
, Issue.2
, pp. 194-200
-
-
Shinotoh, H.1
Namba, H.2
Fukushi, K.3
-
31
-
-
3142547230
-
Cholinergic enhancement of frontal lobe activity in mild cognitive impairment
-
Saykin AJ, Wishart HA, Rabin LA et al. Cholinergic enhancement of frontal lobe activity in mild cognitive impairment. Brain 127(Pt 7), 1574-1583 (2004).
-
(2004)
Brain
, vol.127
, Issue.PART 7
, pp. 1574-1583
-
-
Saykin, A.J.1
Wishart, H.A.2
Rabin, L.A.3
-
32
-
-
0027337833
-
Neurological cholinesterases in the normal brain and in Alzheimer's disease: Relationship to plaques, tangles, and patterns of selective vulnerability
-
Wright CI, Geula C, Mesulam MM. Neurological cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability. Ann. Neurol. 34(3), 373-384 (1993).
-
(1993)
Ann. Neurol
, vol.34
, Issue.3
, pp. 373-384
-
-
Wright, C.I.1
Geula, C.2
Mesulam, M.M.3
-
33
-
-
20244371673
-
Rate of progression of cognitive decline in Alzheimer's disease: Effect of butyrylcholinesterase K gene variation
-
Holmes C, Ballard C, Lehmann D et al. Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation. J. Neurol. Neurosurg. Psychiatry 76(5), 640-643 (2005).
-
(2005)
J. Neurol. Neurosurg. Psychiatry
, vol.76
, Issue.5
, pp. 640-643
-
-
Holmes, C.1
Ballard, C.2
Lehmann, D.3
-
34
-
-
0037375876
-
Cholinesterases: New roles in brain function and in Alzheimer's disease
-
Giacobini E. Cholinesterases: new roles in brain function and in Alzheimer's disease. Neurochem. Res. 28(3-4), 515-522 (2003).
-
(2003)
Neurochem. Res
, vol.28
, Issue.3-4
, pp. 515-522
-
-
Giacobini, E.1
-
35
-
-
0018129338
-
Changes in brain cholinesterases in senile dementia of Alzheimer type
-
Perry EK, Perry RH, Blessed G, Tomlinson BE. Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathol. Appl. Neurobiol. 4(4), 273-277 (1978).
-
(1978)
Neuropathol. Appl. Neurobiol
, vol.4
, Issue.4
, pp. 273-277
-
-
Perry, E.K.1
Perry, R.H.2
Blessed, G.3
Tomlinson, B.E.4
-
36
-
-
0036202343
-
Advances in the pharmacotherapy of Alzheimer's disease
-
Gauthier S. Advances in the pharmacotherapy of Alzheimer's disease. CMAJ 166(5), 616-623 (2002).
-
(2002)
CMAJ
, vol.166
, Issue.5
, pp. 616-623
-
-
Gauthier, S.1
-
37
-
-
0011162190
-
Selective loss of central cholinergic neurons in Alzheimer's disease
-
Davies P, Maloney AJ. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2(8000), 1403 (1976).
-
(1976)
Lancet
, vol.2
, Issue.8000
, pp. 1403
-
-
Davies, P.1
Maloney, A.J.2
-
38
-
-
0021802167
-
Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type: Possible role in cell loss
-
Saper CB, German DC, White CL III. Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type: possible role in cell loss. Neurology 35(8), 1089-1095 (1985).
-
(1985)
Neurology
, vol.35
, Issue.8
, pp. 1089-1095
-
-
Saper, C.B.1
German, D.C.2
White III, C.L.3
-
39
-
-
0019410162
-
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
-
Whitehouse PJ, Price DL, Clark AW, Coyle JT, DeLong MR. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann. Neurol. 10(2), 122-126 (1981).
-
(1981)
Ann. Neurol
, vol.10
, Issue.2
, pp. 122-126
-
-
Whitehouse, P.J.1
Price, D.L.2
Clark, A.W.3
Coyle, J.T.4
DeLong, M.R.5
-
40
-
-
0033530073
-
Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease
-
Gilmor ML, Erickson JD, Varoqui H et al. Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease. J. Comp. Neurol. 411(4), 693-704 (1999).
-
(1999)
J. Comp. Neurol
, vol.411
, Issue.4
, pp. 693-704
-
-
Gilmor, M.L.1
Erickson, J.D.2
Varoqui, H.3
-
41
-
-
0025288472
-
Choline acetyltransferase activity and [3H] vesamicol binding in the temporal cortex of patients with Alzheimer's disease, Parkinson's disease, and rats with basal forebrain lesions
-
Ruberg M, Mayo W, Brice A et al. Choline acetyltransferase activity and [3H] vesamicol binding in the temporal cortex of patients with Alzheimer's disease, Parkinson's disease, and rats with basal forebrain lesions. Neuroscience 35(2), 327-333 (1990).
-
(1990)
Neuroscience
, vol.35
, Issue.2
, pp. 327-333
-
-
Ruberg, M.1
Mayo, W.2
Brice, A.3
-
42
-
-
0031745813
-
The cholinergic gene locus
-
Eiden LE. The cholinergic gene locus. J. Neurochem. 70(6), 2227-2240 (1998).
-
(1998)
J. Neurochem
, vol.70
, Issue.6
, pp. 2227-2240
-
-
Eiden, L.E.1
-
43
-
-
0031772148
-
Coordinate expression of the vesicular acetylcholine transporter and choline acetyltransferase following septohippocampal pathway lesions
-
Gilmor ML, Counts SE, Wiley RG, Levey AI. Coordinate expression of the vesicular acetylcholine transporter and choline acetyltransferase following septohippocampal pathway lesions. J. Neurochem. 71(6), 2411-2420 (1998).
-
(1998)
J. Neurochem
, vol.71
, Issue.6
, pp. 2411-2420
-
-
Gilmor, M.L.1
Counts, S.E.2
Wiley, R.G.3
Levey, A.I.4
-
44
-
-
0032543714
-
Ultrastructural analysis of the progression of neurodegeneration in the septum following fimbria-fornix transection
-
Ginsberg SD, Martin LJ. Ultrastructural analysis of the progression of neurodegeneration in the septum following fimbria-fornix transection. Neuroscience 86, 1259-1272 (1998).
-
(1998)
Neuroscience
, vol.86
, pp. 1259-1272
-
-
Ginsberg, S.D.1
Martin, L.J.2
-
45
-
-
0034941330
-
Nerve growth factor signaling, neuroprotection, and neural repair
-
Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu. Rev. Neurosci. 24, 1217-1281 (2001).
-
(2001)
Annu. Rev. Neurosci
, vol.24
, pp. 1217-1281
-
-
Sofroniew, M.V.1
Howe, C.L.2
Mobley, W.C.3
-
46
-
-
0023176143
-
Neuronal size and density in the nucleus basalis of Meynert in Alzheimer's disease
-
Rinne JO, Paljarvi L, Rinne UK. Neuronal size and density in the nucleus basalis of Meynert in Alzheimer's disease. J. Neurol. Sci. 79(1-2), 67-76 (1987).
-
(1987)
J. Neurol. Sci
, vol.79
, Issue.1-2
, pp. 67-76
-
-
Rinne, J.O.1
Paljarvi, L.2
Rinne, U.K.3
-
47
-
-
0021059767
-
Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase
-
Pearson RC, Sofroniew MV, Cuello AC et al. Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase. Brain Res. 289(1-2), 375-379 (1983).
-
(1983)
Brain Res
, vol.289
, Issue.1-2
, pp. 375-379
-
-
Pearson, R.C.1
Sofroniew, M.V.2
Cuello, A.C.3
-
48
-
-
0002347440
-
Nerve growth factor in Alzheimer's disease
-
Peter AA, Morrison JH Eds, Kluwer Academic/Plenum Press, NY, USA
-
Mufson EJ, Kordower JH. Nerve growth factor in Alzheimer's disease. In: Cerebral Cortex. Peter AA, Morrison JH (Eds). Kluwer Academic/Plenum Press, NY, USA 681-731 (1999).
-
(1999)
Cerebral Cortex
, pp. 681-731
-
-
Mufson, E.J.1
Kordower, J.H.2
-
49
-
-
0023888321
-
Processing of the native nerve growth factor precursor to form biologically active nerve growth factor
-
Edwards RH, Selby MJ, Garcia PD, Rutter WJ. Processing of the native nerve growth factor precursor to form biologically active nerve growth factor. J. Biol. Chem. 263(14), 6810-6815 (1988).
-
(1988)
J. Biol. Chem
, vol.263
, Issue.14
, pp. 6810-6815
-
-
Edwards, R.H.1
Selby, M.J.2
Garcia, P.D.3
Rutter, W.J.4
-
50
-
-
1542349149
-
Neurobiology: A move to sort life from death
-
Kaplan DR, Miller FD. Neurobiology: a move to sort life from death. Nature 427(6977), 798-799 (2004).
-
(2004)
Nature
, vol.427
, Issue.6977
, pp. 798-799
-
-
Kaplan, D.R.1
Miller, F.D.2
-
51
-
-
0036344505
-
Neurotrophin signaling through the p75 neurotrophin receptor
-
Roux PP, Barker PA. Neurotrophin signaling through the p75 neurotrophin receptor. Prog. Neurobiol. 67(3), 203-233 (2002).
-
(2002)
Prog. Neurobiol
, vol.67
, Issue.3
, pp. 203-233
-
-
Roux, P.P.1
Barker, P.A.2
-
52
-
-
0000326996
-
Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival
-
NTR by NGF leads to apoptotic signaling which can be prevented by co-expression with TrkA, •
-
NTR by NGF leads to apoptotic signaling which can be prevented by co-expression with TrkA.
-
(1998)
J. Neurosci
, vol.18
, Issue.9
, pp. 3273-3281
-
-
Yoon, S.O.1
Casaccia-Bonnefil, P.2
Carter, B.3
Chao, M.V.4
-
53
-
-
0034014639
-
Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones
-
Frade JM. Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones. J. Cell Sci. 113 (Pt 7), 1139-1148 (2000).
-
(2000)
J. Cell Sci
, vol.113
, Issue.PART 7
, pp. 1139-1148
-
-
Frade, J.M.1
-
54
-
-
0032559622
-
The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
-
Bamji SX, Majdan M, Pozniak CD et al. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J. Cell Biol. 140(4), 911-923 (1998).
-
(1998)
J. Cell Biol
, vol.140
, Issue.4
, pp. 911-923
-
-
Bamji, S.X.1
Majdan, M.2
Pozniak, C.D.3
-
55
-
-
0035976524
-
Regulation of cell survival by secreted proneurotrophins
-
Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science 294(5548), 1945-1948 (2001).
-
(2001)
Science
, vol.294
, Issue.5548
, pp. 1945-1948
-
-
Lee, R.1
Kermani, P.2
Teng, K.K.3
Hempstead, B.L.4
-
56
-
-
0034279150
-
Neurotrophins induce death of hippocampal neurons via the p75 receptor
-
Friedman WJ. Neurotrophins induce death of hippocampal neurons via the p75 receptor. J. Neurosci. 20(17), 6340-6346 (2000).
-
(2000)
J. Neurosci
, vol.20
, Issue.17
, pp. 6340-6346
-
-
Friedman, W.J.1
-
57
-
-
10744219632
-
-
NTR.
-
NTR.
-
-
-
-
58
-
-
0037093730
-
Dual role for p75(NTR) signaling in survival and cell death: Can intracellular mediators provide an explanation?
-
Mamidipudi V, Wooten MW. Dual role for p75(NTR) signaling in survival and cell death: can intracellular mediators provide an explanation? J. Neurosci. Res. 68(4), 373-384 (2002).
-
(2002)
J. Neurosci. Res
, vol.68
, Issue.4
, pp. 373-384
-
-
Mamidipudi, V.1
Wooten, M.W.2
-
59
-
-
1642540257
-
Neurotrophins and their receptors: Signaling trios in complex biological systems
-
Teng KK, Hempstead BL. Neurotrophins and their receptors: signaling trios in complex biological systems. Cell. Mol. Life Sci. 61(1), 35-48 (2004).
-
(2004)
Cell. Mol. Life Sci
, vol.61
, Issue.1
, pp. 35-48
-
-
Teng, K.K.1
Hempstead, B.L.2
-
60
-
-
0034848604
-
The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease
-
Fahnestock M, Michalski B, Xu B, Coughlin MD. The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol. Cell. Neurosci. 18(2), 210-220 (2001).
-
(2001)
Mol. Cell. Neurosci
, vol.18
, Issue.2
, pp. 210-220
-
-
Fahnestock, M.1
Michalski, B.2
Xu, B.3
Coughlin, M.D.4
-
61
-
-
2942536284
-
-
NTR and sortilin.
-
NTR and sortilin.
-
-
-
-
62
-
-
2042465006
-
The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
-
Highlights an ongoing debate on the conditions underlying prosurvival and proapoptotic proNGF siganling, •
-
Fahnestock M, Yu G, Michalski B et al. The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor. J. Neurochem. 89(3), 581-592 (2004). • Highlights an ongoing debate on the conditions underlying prosurvival and proapoptotic proNGF siganling.
-
(2004)
J. Neurochem
, vol.89
, Issue.3
, pp. 581-592
-
-
Fahnestock, M.1
Yu, G.2
Michalski, B.3
-
63
-
-
0034851615
-
The pro-sequence facilitates folding of human nerve growth factor from Escherichia coli inclusion bodies
-
Rattenholl A, Lilie H, Grossmann A et al. The pro-sequence facilitates folding of human nerve growth factor from Escherichia coli inclusion bodies. Eur. J. Biochem. 268(11), 3296-3303 (2001).
-
(2001)
Eur. J. Biochem
, vol.268
, Issue.11
, pp. 3296-3303
-
-
Rattenholl, A.1
Lilie, H.2
Grossmann, A.3
-
64
-
-
4644268336
-
-
Counts SE, Nadeem M, Wuu J et al. Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease. Ann. Neurol. 56(4), 520-531 (2004). • Neocortical TrkA protein levels are reduced in early-stage AD suggesting a loss of CBF neurotrophic support and possible increased proapoptotic proNGF/p75NTR interactions.
-
Counts SE, Nadeem M, Wuu J et al. Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease. Ann. Neurol. 56(4), 520-531 (2004). • Neocortical TrkA protein levels are reduced in early-stage AD suggesting a loss of CBF neurotrophic support and possible increased proapoptotic proNGF/p75NTR interactions.
-
-
-
-
65
-
-
24944522343
-
Measurement of thirteen biological markers in csf of patients with Alzheimer's disease and other dementias
-
Blasko I, Lederer W, Oberbauer H et al. Measurement of thirteen biological markers in csf of patients with Alzheimer's disease and other dementias. Dement Geriatr. Cogn. Disord. 21(1), 9-15 (2005).
-
(2005)
Dement Geriatr. Cogn. Disord
, vol.21
, Issue.1
, pp. 9-15
-
-
Blasko, I.1
Lederer, W.2
Oberbauer, H.3
-
66
-
-
26844507790
-
A TrkA-to-p75NTR molecular switch activates amyloid β-peptide generation during aging
-
Costantini C, Weindruch R, Della Valle G, Puglielli L. A TrkA-to-p75NTR molecular switch activates amyloid β-peptide generation during aging. Biochem. J. 391(Pt 1), 59-67 (2005).
-
(2005)
Biochem. J
, vol.391
, Issue.PART 1
, pp. 59-67
-
-
Costantini, C.1
Weindruch, R.2
Della Valle, G.3
Puglielli, L.4
-
67
-
-
39849110118
-
Insights into the interaction of sortilin with proneurotrophins: A computational approach
-
Paiardini A, Caputo V. Insights into the interaction of sortilin with proneurotrophins: a computational approach. Neuropeptides 42(2), 205-214 (2008).
-
(2008)
Neuropeptides
, vol.42
, Issue.2
, pp. 205-214
-
-
Paiardini, A.1
Caputo, V.2
-
68
-
-
34248169119
-
-
Nyborg AC, Ladd TB, Zwizinski CW, Lah JJ, Golde TE. Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Mol. Neurodegener. 1, 3 (2006).
-
Nyborg AC, Ladd TB, Zwizinski CW, Lah JJ, Golde TE. Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Mol. Neurodegener. 1, 3 (2006).
-
-
-
-
69
-
-
35548930820
-
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
-
Jansen P, Giehl K, Nyengaard JR et al. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat. Neurosci. 10(11), 1449-1457 (2007).
-
(2007)
Nat. Neurosci
, vol.10
, Issue.11
, pp. 1449-1457
-
-
Jansen, P.1
Giehl, K.2
Nyengaard, J.R.3
-
70
-
-
16644378634
-
Multi-tasking by the p75 neurotrophin receptor: Sortilin things out?
-
59, 867-871
-
Bronfman FC, Fainzilber M. Multi-tasking by the p75 neurotrophin receptor: sortilin things out? EMBO Rep. 5(9), 867-871 (2004).
-
(2004)
EMBO Rep
-
-
Bronfman, F.C.1
Fainzilber, M.2
-
71
-
-
20044370999
-
ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
-
Teng HK, Teng KK, Lee R et al. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J. Neurosci. 25(22), 5455-5463 (2005).
-
(2005)
J. Neurosci
, vol.25
, Issue.22
, pp. 5455-5463
-
-
Teng, H.K.1
Teng, K.K.2
Lee, R.3
-
72
-
-
4644297646
-
Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA
-
A peptide agonist of TrkA restores cognitive function and cholinergic markers in aged, cognitively impaired rats, •
-
Bruno MA, Clarke PB, Seltzer A et al. Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA. J. Neurosci. 24(37), 8009-8018 (2004). • A peptide agonist of TrkA restores cognitive function and cholinergic markers in aged, cognitively impaired rats.
-
(2004)
J. Neurosci
, vol.24
, Issue.37
, pp. 8009-8018
-
-
Bruno, M.A.1
Clarke, P.B.2
Seltzer, A.3
-
73
-
-
37049012118
-
Small molecule neurotrophin receptor ligands: Novel strategies for targeting Alzheimer's disease mechanisms
-
Excellent review of current therapeutic strategies for stimulating neurotrophin receptors for the treatment of AD, •
-
Longo FM, Yang T, Knowles JK et al. Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms. Curr. Alzheimer Res. 4(5), 503-506 (2007). • Excellent review of current therapeutic strategies for stimulating neurotrophin receptors for the treatment of AD.
-
(2007)
Curr. Alzheimer Res
, vol.4
, Issue.5
, pp. 503-506
-
-
Longo, F.M.1
Yang, T.2
Knowles, J.K.3
-
74
-
-
33646241085
-
Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade
-
Bruno MA, Cuello AC. Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. Proc. Natl. Acad. Sci. USA 103(17), 6735-6740 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, Issue.17
, pp. 6735-6740
-
-
Bruno, M.A.1
Cuello, A.C.2
-
75
-
-
55849147787
-
Increased MMP-9 cortical level and activity in subjects with mild cognitive impairment
-
Presented at:, San Diego, CA, USA, 3-7 November
-
Bruno MA, Counts SE, Mufson EJ, Cuello AC. Increased MMP-9 cortical level and activity in subjects with mild cognitive impairment. Presented at: Society for Neuroscience Annual Meeting. San Diego, CA, USA, 3-7 November 2007.
-
(2007)
Society for Neuroscience Annual Meeting
-
-
Bruno, M.A.1
Counts, S.E.2
Mufson, E.J.3
Cuello, A.C.4
-
76
-
-
12244291232
-
Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases
-
Lorenzl S, Albers DS, LeWitt PA et al. Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases. J. Neurol. Sci. 207(1-2), 71-76 (2003).
-
(2003)
J. Neurol. Sci
, vol.207
, Issue.1-2
, pp. 71-76
-
-
Lorenzl, S.1
Albers, D.S.2
LeWitt, P.A.3
-
77
-
-
37149052133
-
Profiles of matrix metalloproteinases and their inhibitors in plasma of patients with dementia
-
Lorenzl S, Buerger K, Hampel H, Beal MF. Profiles of matrix metalloproteinases and their inhibitors in plasma of patients with dementia. Int. Psychogeriatr. 20(1), 67-76 (2008).
-
(2008)
Int. Psychogeriatr
, vol.20
, Issue.1
, pp. 67-76
-
-
Lorenzl, S.1
Buerger, K.2
Hampel, H.3
Beal, M.F.4
-
78
-
-
0032836427
-
Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications
-
Zucker S, Hymowitz M, Conner C et al. Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications. Ann. NY Acad. Sci. 878, 212-227 (1999).
-
(1999)
Ann. NY Acad. Sci
, vol.878
, pp. 212-227
-
-
Zucker, S.1
Hymowitz, M.2
Conner, C.3
-
79
-
-
0029556562
-
Structural and functional properties of the TRK family of neurotrophin receptors
-
Barbacid M. Structural and functional properties of the TRK family of neurotrophin receptors. Ann. NY Acad. Sci. 766, 442-458 (1995).
-
(1995)
Ann. NY Acad. Sci
, vol.766
, pp. 442-458
-
-
Barbacid, M.1
-
80
-
-
0032535448
-
A function-structure model for NGF-activated TRK
-
Cunningham ME, Greene LA. A function-structure model for NGF-activated TRK. EMBO J. 17(24), 7282-7293 (1998).
-
(1998)
EMBO J
, vol.17
, Issue.24
, pp. 7282-7293
-
-
Cunningham, M.E.1
Greene, L.A.2
-
81
-
-
0031409894
-
Growth factor receptors: Structure, mechanism, and drug discovery
-
McInnes C, Sykes BD. Growth factor receptors: structure, mechanism, and drug discovery. Biopolymers 43(5), 339-366 (1997).
-
(1997)
Biopolymers
, vol.43
, Issue.5
, pp. 339-366
-
-
McInnes, C.1
Sykes, B.D.2
-
82
-
-
0032698075
-
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
-
Bonni A, Brunet A, West AE et al. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286(5443), 1358-1362 (1999).
-
(1999)
Science
, vol.286
, Issue.5443
, pp. 1358-1362
-
-
Bonni, A.1
Brunet, A.2
West, A.E.3
-
83
-
-
0004594704
-
Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways
-
Descamps S, Toillon RA, Adriaenssens E et al. Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways. J. Biol. Chem. 276(21), 17864-17870 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, Issue.21
, pp. 17864-17870
-
-
Descamps, S.1
Toillon, R.A.2
Adriaenssens, E.3
-
84
-
-
0034044227
-
-
Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 10(3), 381-391 (2000). • One of many excellent reviews by the authors discussing the multiple intracellular signaling pathways stimulated by NGF and other neurotrophins.
-
Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 10(3), 381-391 (2000). • One of many excellent reviews by the authors discussing the multiple intracellular signaling pathways stimulated by NGF and other neurotrophins.
-
-
-
-
85
-
-
0032861127
-
Extracellular-signal-regulated kinase signalling in neurons
-
Grewal SS, York RD, Stork PJ. Extracellular-signal-regulated kinase signalling in neurons. Curr. Opin. Neurobiol. 9(5), 544-553 (1999).
-
(1999)
Curr. Opin. Neurobiol
, vol.9
, Issue.5
, pp. 544-553
-
-
Grewal, S.S.1
York, R.D.2
Stork, P.J.3
-
86
-
-
0025875819
-
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
-
Gomez N, Cohen P. Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases. Nature 353(6340), 170-173 (1991).
-
(1991)
Nature
, vol.353
, Issue.6340
, pp. 170-173
-
-
Gomez, N.1
Cohen, P.2
-
87
-
-
0026754369
-
Activation of the MAP kinase pathway by the protein kinase raf
-
Howe LR, Leevers SJ, Gomez N et al. Activation of the MAP kinase pathway by the protein kinase raf. Cell 71(2), 335-342 (1992).
-
(1992)
Cell
, vol.71
, Issue.2
, pp. 335-342
-
-
Howe, L.R.1
Leevers, S.J.2
Gomez, N.3
-
88
-
-
0030479324
-
Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N?acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade
-
Kamata H, Tanaka C, Yagisawa H et al. Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N?acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade. J. Biol. Chem. 271(51), 33018-33025 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, Issue.51
, pp. 33018-33025
-
-
Kamata, H.1
Tanaka, C.2
Yagisawa, H.3
-
89
-
-
0035869733
-
Neurite growth promotion by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: Role of phosphoinositide 3-kinase and mitogen activated protein kinase
-
Kimpinski K, Mearow K. Neurite growth promotion by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: role of phosphoinositide 3-kinase and mitogen activated protein kinase. J. Neurosci. Res. 63(6), 486-499 (2001).
-
(2001)
J. Neurosci. Res
, vol.63
, Issue.6
, pp. 486-499
-
-
Kimpinski, K.1
Mearow, K.2
-
90
-
-
0032518291
-
Nerve growth factor promotes activation of the ?, ? and g isoforms of protein kinase B in PC12 pheochromocytoma cells
-
Andjelkovic M, Suidan HS, Meier R et al. Nerve growth factor promotes activation of the ?, ? and g isoforms of protein kinase B in PC12 pheochromocytoma cells. Eur. J. Biochem. 251(1-2), 195-200 (1998).
-
(1998)
Eur. J. Biochem
, vol.251
, Issue.1-2
, pp. 195-200
-
-
Andjelkovic, M.1
Suidan, H.S.2
Meier, R.3
-
91
-
-
0033549893
-
The selective and inducible activation of endogenous PI 3?kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth
-
Ashcroft M, Stephens RM, Hallberg B, Downward J, Kaplan DR. The selective and inducible activation of endogenous PI 3?kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth. Oncogene 18(32), 4586-4597 (1999).
-
(1999)
Oncogene
, vol.18
, Issue.32
, pp. 4586-4597
-
-
Ashcroft, M.1
Stephens, R.M.2
Hallberg, B.3
Downward, J.4
Kaplan, D.R.5
-
92
-
-
0032864021
-
Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival
-
Vaillant AR, Mazzoni I, Tudan C et al. Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival. J. Cell Biol. 146(5), 955-966 (1999).
-
(1999)
J. Cell Biol
, vol.146
, Issue.5
, pp. 955-966
-
-
Vaillant, A.R.1
Mazzoni, I.2
Tudan, C.3
-
93
-
-
0033563189
-
Trks: Signal transduction and intracellular pathways
-
Klesse LJ, Parada LF. Trks: signal transduction and intracellular pathways. Microsc. Res. Tech. 45(4-5), 210-216 (1999).
-
(1999)
Microsc. Res. Tech
, vol.45
, Issue.4-5
, pp. 210-216
-
-
Klesse, L.J.1
Parada, L.F.2
-
94
-
-
0028199799
-
Trk receptors use redundant signal transduction pathways involving SHC and PLC-g 1 to mediate NGF responses
-
Stephens RM, Loeb DM, Copeland TD et al. Trk receptors use redundant signal transduction pathways involving SHC and PLC-g 1 to mediate NGF responses. Neuron 12(3), 691-705 (1994).
-
(1994)
Neuron
, vol.12
, Issue.3
, pp. 691-705
-
-
Stephens, R.M.1
Loeb, D.M.2
Copeland, T.D.3
-
95
-
-
0025992877
-
Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-γ 1 by a kinase activity associated with the product of the trk protooncogene
-
Vetter ML, Martin-Zanca D, Parada LF, Bishop JM, Kaplan DR. Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-γ 1 by a kinase activity associated with the product of the trk protooncogene. Proc. Natl Acad. Sci. USA 88(13), 5650-5654 (1991).
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, Issue.13
, pp. 5650-5654
-
-
Vetter, M.L.1
Martin-Zanca, D.2
Parada, L.F.3
Bishop, J.M.4
Kaplan, D.R.5
-
96
-
-
0035369840
-
Trk receptors: Mediators of neurotrophin action
-
Patapoutian A, Reichardt LF. Trk receptors: mediators of neurotrophin action. Curr. Opin. Neurobiol. 11(3), 272-280 (2001).
-
(2001)
Curr. Opin. Neurobiol
, vol.11
, Issue.3
, pp. 272-280
-
-
Patapoutian, A.1
Reichardt, L.F.2
-
97
-
-
0642316039
-
Nerve growth factor: Structure, function and therapeutic implications for Alzheimer's disease
-
Comprehensive review that covers all aspects of NGF biology, •
-
Lad SP, Neet KE, Mufson EJ. Nerve growth factor: structure, function and therapeutic implications for Alzheimer's disease. Curr. Drug Target CNS Neurol. Disord. 2(5), 315-334 (2003). • Comprehensive review that covers all aspects of NGF biology.
-
(2003)
Curr. Drug Target CNS Neurol. Disord
, vol.2
, Issue.5
, pp. 315-334
-
-
Lad, S.P.1
Neet, K.E.2
Mufson, E.J.3
-
98
-
-
0033215974
-
Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons
-
Brann AB, Scott R, Neuberger Y et al. Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons. J. Neurosci. 19(19), 8199-8206 (1999).
-
(1999)
J. Neurosci
, vol.19
, Issue.19
, pp. 8199-8206
-
-
Brann, A.B.1
Scott, R.2
Neuberger, Y.3
-
99
-
-
0035879182
-
A novel p75NTR signaling pathway promotes survival, not death, of immunopurified neocortical subplate neurons
-
DeFreitas MF, McQuillen PS, Shatz CJ. A novel p75NTR signaling pathway promotes survival, not death, of immunopurified neocortical subplate neurons. J. Neurosci. 21(14), 5121-5129 (2001).
-
(2001)
J. Neurosci
, vol.21
, Issue.14
, pp. 5121-5129
-
-
DeFreitas, M.F.1
McQuillen, P.S.2
Shatz, C.J.3
-
100
-
-
0028108788
-
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor
-
Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265(5178), 1596-1599 (1994).
-
(1994)
Science
, vol.265
, Issue.5178
, pp. 1596-1599
-
-
Dobrowsky, R.T.1
Werner, M.H.2
Castellino, A.M.3
Chao, M.V.4
Hannun, Y.A.5
-
101
-
-
0033951624
-
The p75 neurotrophin receptor and neuronal apoptosis
-
Barrett GL. The p75 neurotrophin receptor and neuronal apoptosis. Prog. Neurobiol. 61(2), 205-229 (2000).
-
(2000)
Prog. Neurobiol
, vol.61
, Issue.2
, pp. 205-229
-
-
Barrett, G.L.1
-
102
-
-
0037155796
-
Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase
-
Brann AB, Tcherpakov M, Williams IM, Futerman AH, Fainzilber M. Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase. J. Biol. Chem. 277(12), 9812-9818 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, Issue.12
, pp. 9812-9818
-
-
Brann, A.B.1
Tcherpakov, M.2
Williams, I.M.3
Futerman, A.H.4
Fainzilber, M.5
-
103
-
-
0036140118
-
Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis
-
Harrington AW, Kim JY, Yoon SO. Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis. J. Neurosci. 22(1), 156-166 (2002).
-
(2002)
J. Neurosci
, vol.22
, Issue.1
, pp. 156-166
-
-
Harrington, A.W.1
Kim, J.Y.2
Yoon, S.O.3
-
104
-
-
0033597822
-
The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kB activity under physiological conditions, but direct p75NTR-mediated NF-kB activation requires cell stress
-
Bhakar AL, Roux PP, Lachance C et al. The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kB activity under physiological conditions, but direct p75NTR-mediated NF-kB activation requires cell stress. J. Biol. Chem. 274(30), 21443-21449 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, Issue.30
, pp. 21443-21449
-
-
Bhakar, A.L.1
Roux, P.P.2
Lachance, C.3
-
105
-
-
0034770141
-
Binding of nerve growth factor to its p75 receptor in stressed cells induces selective IkB-β degradation and NF-κB nuclear translocation
-
Cosgaya JM, Shooter EM. Binding of nerve growth factor to its p75 receptor in stressed cells induces selective IkB-β degradation and NF-κB nuclear translocation. J. Neurochem. 79(2), 391-399 (2001).
-
(2001)
J. Neurochem
, vol.79
, Issue.2
, pp. 391-399
-
-
Cosgaya, J.M.1
Shooter, E.M.2
-
106
-
-
0034667635
-
NF-κB signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells
-
Foehr ED, Lin X, O'Mahony A et al. NF-κB signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells. J. Neurosci. 20(20), 7556-7563 (2000).
-
(2000)
J. Neurosci
, vol.20
, Issue.20
, pp. 7556-7563
-
-
Foehr, E.D.1
Lin, X.2
O'Mahony, A.3
-
107
-
-
0034677893
-
Nerve growth factor activation of nuclear factor kB through its p75 receptor is an anti-apoptotic signal in RN22 schwannoma cells
-
Gentry JJ, Casaccia-Bonnefil P, Carter BD. Nerve growth factor activation of nuclear factor kB through its p75 receptor is an anti-apoptotic signal in RN22 schwannoma cells. J. Biol. Chem. 275(11), 7558-7565 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, Issue.11
, pp. 7558-7565
-
-
Gentry, J.J.1
Casaccia-Bonnefil, P.2
Carter, B.D.3
-
108
-
-
0032809906
-
p75-mediated NF-κB activation enhances the survival response of developing sensory neurons to nerve growth factor
-
Hamanoue M, Middleton G, Wyatt S et al. p75-mediated NF-κB activation enhances the survival response of developing sensory neurons to nerve growth factor. Mol. Cell. Neurosci. 14(1), 28-40 (1999).
-
(1999)
Mol. Cell. Neurosci
, vol.14
, Issue.1
, pp. 28-40
-
-
Hamanoue, M.1
Middleton, G.2
Wyatt, S.3
-
109
-
-
0035149557
-
Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor
-
Hughes AL, Messineo-Jones D, Lad SP, Neet KE. Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor. J. Neurosci. Res. 63(1), 10-19 (2001).
-
(2001)
J. Neurosci. Res
, vol.63
, Issue.1
, pp. 10-19
-
-
Hughes, A.L.1
Messineo-Jones, D.2
Lad, S.P.3
Neet, K.E.4
-
110
-
-
0035933783
-
The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway
-
Roux PP, Bhakar AL, Kennedy TE, Barker PA. The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem. 276(25), 23097-23104 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, Issue.25
, pp. 23097-23104
-
-
Roux, P.P.1
Bhakar, A.L.2
Kennedy, T.E.3
Barker, P.A.4
-
111
-
-
0033406696
-
Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR)
-
Susen K, Heumann R, Blochl A. Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR). FEBS Lett. 463(3), 231-234 (1999).
-
(1999)
FEBS Lett
, vol.463
, Issue.3
, pp. 231-234
-
-
Susen, K.1
Heumann, R.2
Blochl, A.3
-
112
-
-
55849131540
-
NGF family of neurotrophins and their receptors: Early involvement in the progression of Alzheimer's disease
-
Dawbarn D, Allen SJ Eds, Oxford University Press, Oxford, UK
-
Mufson EJ, Counts SE, Fahnestock M, Ginsberg SD. NGF family of neurotrophins and their receptors: early involvement in the progression of Alzheimer's disease. In: Neurobiology of Alzheimer's Disease. Dawbarn D, Allen SJ (Eds). Oxford University Press, Oxford, UK 283-321 (2007).
-
(2007)
Neurobiology of Alzheimer's Disease
, pp. 283-321
-
-
Mufson, E.J.1
Counts, S.E.2
Fahnestock, M.3
Ginsberg, S.D.4
-
113
-
-
21044458854
-
A Phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
-
Reveals encouraging outcomes from the initial NGF gene therapy trials, ••
-
Tuszynski MH, Thal L, Pay M et al. A Phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat. Med. 11(5), 551-555 (2005). •• Reveals encouraging outcomes from the initial NGF gene therapy trials.
-
(2005)
Nat. Med
, vol.11
, Issue.5
, pp. 551-555
-
-
Tuszynski, M.H.1
Thal, L.2
Pay, M.3
-
114
-
-
0027380155
-
Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection
-
Morse JK, Wiegand SJ, Anderson K et al. Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection. J. Neurosci. 13(10), 4146-4156 (1993).
-
(1993)
J. Neurosci
, vol.13
, Issue.10
, pp. 4146-4156
-
-
Morse, J.K.1
Wiegand, S.J.2
Anderson, K.3
-
115
-
-
42049112538
-
The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors
-
Skaper SD. The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors. CNS Neurol. Disord. Drug Targets 7(1), 46-62 (2008).
-
(2008)
CNS Neurol. Disord. Drug Targets
, vol.7
, Issue.1
, pp. 46-62
-
-
Skaper, S.D.1
-
116
-
-
36049003755
-
Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death
-
Jang SW, Okada M, Sayeed I et al. Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death. Proc. Natl Acad. Sci. USA 104(41), 16329-16334 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, Issue.41
, pp. 16329-16334
-
-
Jang, S.W.1
Okada, M.2
Sayeed, I.3
-
118
-
-
0000672241
-
m2 muscarinic acetylcholine receptor-immunoreactive neurons are not reduced within the nucleus basalis in Alzheimer's disease: Relationship with cholinergic and galaninergic perikarya
-
Mufson EJ, Jaffar S, Levey AI. m2 muscarinic acetylcholine receptor-immunoreactive neurons are not reduced within the nucleus basalis in Alzheimer's disease: relationship with cholinergic and galaninergic perikarya. J. Comp. Neurol. 392(3), 313-329 (1998).
-
(1998)
J. Comp. Neurol
, vol.392
, Issue.3
, pp. 313-329
-
-
Mufson, E.J.1
Jaffar, S.2
Levey, A.I.3
-
119
-
-
37149055806
-
α7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer's disease
-
Counts SE, He B, Che S et al. α7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer's disease. Arch. Neurol. 64(12), 1771-1776 (2007).
-
(2007)
Arch. Neurol
, vol.64
, Issue.12
, pp. 1771-1776
-
-
Counts, S.E.1
He, B.2
Che, S.3
-
120
-
-
20644443926
-
Increased α 7 nicotinic acetylcholine receptor protein levels in Alzheimer's disease patients
-
Chu LW, Ma ES, Lam KK, Chan MF, Lee DH. Increased α 7 nicotinic acetylcholine receptor protein levels in Alzheimer's disease patients. Dement. Geriatr. Cogn. Disord. 19(2-3), 106-112 (2005).
-
(2005)
Dement. Geriatr. Cogn. Disord
, vol.19
, Issue.2-3
, pp. 106-112
-
-
Chu, L.W.1
Ma, E.S.2
Lam, K.K.3
Chan, M.F.4
Lee, D.H.5
-
121
-
-
0345434817
-
Regional distribution of nicotinic receptor subunit mRNAs in human brain: Comparison between Alzheimer and normal brain
-
Hellstrom-Lindahl E, Mousavi M, Zhang X, Ravid R, Nordberg A. Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain. Brain Res. Mol. Brain Res. 66(1-2), 94-103 (1999).
-
(1999)
Brain Res. Mol. Brain Res
, vol.66
, Issue.1-2
, pp. 94-103
-
-
Hellstrom-Lindahl, E.1
Mousavi, M.2
Zhang, X.3
Ravid, R.4
Nordberg, A.5
-
122
-
-
0037440372
-
Alzheimer's disease is associated with a selective increase in α7 nicotinic acetylcholine receptor immunoreactivity in astrocytes
-
Teaktong T, Graham A, Court J et al. Alzheimer's disease is associated with a selective increase in α7 nicotinic acetylcholine receptor immunoreactivity in astrocytes. Glia 41(2), 207-211 (2003).
-
(2003)
Glia
, vol.41
, Issue.2
, pp. 207-211
-
-
Teaktong, T.1
Graham, A.2
Court, J.3
-
123
-
-
0037066072
-
Intracellular accumulation of β-amyloid(1-42) in neurons is facilitated by the α 7 nicotinic acetylcholine receptor in Alzheimer's disease
-
Nagele RG, D'Andrea MR, Anderson WJ, Wang HY. Intracellular accumulation of β-amyloid(1-42) in neurons is facilitated by the α 7 nicotinic acetylcholine receptor in Alzheimer's disease. Neuroscience 110(2), 199-211 (2002).
-
(2002)
Neuroscience
, vol.110
, Issue.2
, pp. 199-211
-
-
Nagele, R.G.1
D'Andrea, M.R.2
Anderson, W.J.3
Wang, H.Y.4
-
124
-
-
34249823327
-
The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor
-
Small DH, Maksel D, Kerr ML et al. The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor. J. Neurochem. 101(6), 1527-1538 (2007).
-
(2007)
J. Neurochem
, vol.101
, Issue.6
, pp. 1527-1538
-
-
Small, D.H.1
Maksel, D.2
Kerr, M.L.3
-
125
-
-
0034006944
-
β-amyloid(1-42) binds to ?7 nicotinic acetylcholine receptor with high affinity: Implications for Alzheimer's disease pathology
-
Wang HY, Lee DH, D'Andrea MR et al. β-amyloid(1-42) binds to ?7 nicotinic acetylcholine receptor with high affinity: implications for Alzheimer's disease pathology. J. Biol. Chem. 275(8), 5626-5632 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, Issue.8
, pp. 5626-5632
-
-
Wang, H.Y.1
Lee, D.H.2
D'Andrea, M.R.3
-
126
-
-
40449112324
-
Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease
-
Counts SE, He B, Che S, Ginsberg SD, Mufson EJ. Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease. Neurodegener. Dis. 5(3-4), 228-231 (2008).
-
(2008)
Neurodegener. Dis
, vol.5
, Issue.3-4
, pp. 228-231
-
-
Counts, S.E.1
He, B.2
Che, S.3
Ginsberg, S.D.4
Mufson, E.J.5
-
127
-
-
40449084828
-
M1 muscarinic agonists target major hallmarks of Alzheimer's disease - the pivotal role of brain M1 receptors
-
Fisher A. M1 muscarinic agonists target major hallmarks of Alzheimer's disease - the pivotal role of brain M1 receptors. Neurodegener. Dis. 5(3-4), 237-240 (2008).
-
(2008)
Neurodegener. Dis
, vol.5
, Issue.3-4
, pp. 237-240
-
-
Fisher, A.1
-
128
-
-
37049003111
-
M1 muscarinic agonists target major hallmarks of Alzheimer's disease - an update
-
Fisher A. M1 muscarinic agonists target major hallmarks of Alzheimer's disease - an update. Curr. Alzheimer Res. 4(5), 577-580 (2007).
-
(2007)
Curr. Alzheimer Res
, vol.4
, Issue.5
, pp. 577-580
-
-
Fisher, A.1
-
129
-
-
0036676048
-
AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease
-
Fisher A, Brandeis R, Bar-Ner RH et al. AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease. J. Mol. Neurosci. 19(1-2), 145-153 (2002).
-
(2002)
J. Mol. Neurosci
, vol.19
, Issue.1-2
, pp. 145-153
-
-
Fisher, A.1
Brandeis, R.2
Bar-Ner, R.H.3
-
130
-
-
33344458827
-
M1 receptors play a central role in modulating AD-like pathology in transgenic mice
-
The selective M1 muscarinic agonist AF267B rescues APP/PS1/tau triple transgenic AD-like mice from spatial cognitive deficits and reduces amyloid and neurofibrillary tangle pathology, •
-
Caccamo A, Oddo S, Billings LM et al. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron 49(5), 671-682 (2006). • The selective M1 muscarinic agonist AF267B rescues APP/PS1/tau triple transgenic AD-like mice from spatial cognitive deficits and reduces amyloid and neurofibrillary tangle pathology.
-
(2006)
Neuron
, vol.49
, Issue.5
, pp. 671-682
-
-
Caccamo, A.1
Oddo, S.2
Billings, L.M.3
-
131
-
-
33745416559
-
Single cell gene expression profiling in Alzheimer's disease
-
Ginsberg SD, Che S, Counts SE, Mufson EJ. Single cell gene expression profiling in Alzheimer's disease. NeuroRx 3(3), 302-318 (2006).
-
(2006)
NeuroRx
, vol.3
, Issue.3
, pp. 302-318
-
-
Ginsberg, S.D.1
Che, S.2
Counts, S.E.3
Mufson, E.J.4
-
132
-
-
33747760358
-
Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
-
Scheff SW, Price DA, Schmitt FA, Mufson EJ. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol. Aging 27(10), 1372-1384 (2005).
-
(2005)
Neurobiol. Aging
, vol.27
, Issue.10
, pp. 1372-1384
-
-
Scheff, S.W.1
Price, D.A.2
Schmitt, F.A.3
Mufson, E.J.4
-
133
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
-
Terry RD, Masliah E, Salmon DP et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30(4), 572-580 (1991).
-
(1991)
Ann. Neurol
, vol.30
, Issue.4
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
-
134
-
-
33749237719
-
Neuronal gene expression profiling: Uncovering the molecular biology of neurodegenerative disease
-
Mufson EJ, Counts SE, Che S, Ginsberg SD. Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease. Prog. Brain Res. 158, 197-222 (2006).
-
(2006)
Prog. Brain Res
, vol.158
, pp. 197-222
-
-
Mufson, E.J.1
Counts, S.E.2
Che, S.3
Ginsberg, S.D.4
-
135
-
-
0036808469
-
Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease
-
Mufson EJ, Counts SE, Ginsberg SD. Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease. Neurochem. Res. 27(10), 1035-1048 (2002).
-
(2002)
Neurochem. Res
, vol.27
, Issue.10
, pp. 1035-1048
-
-
Mufson, E.J.1
Counts, S.E.2
Ginsberg, S.D.3
-
136
-
-
0033933738
-
Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons
-
Ginsberg SD, Hemby SE, Lee VM, Eberwine JH, Trojanowski JQ. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann. Neurol. 48(1), 77-87 (2000).
-
(2000)
Ann. Neurol
, vol.48
, Issue.1
, pp. 77-87
-
-
Ginsberg, S.D.1
Hemby, S.E.2
Lee, V.M.3
Eberwine, J.H.4
Trojanowski, J.Q.5
-
137
-
-
27644478606
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur. J. Neurosci. 22(8), 1942-1950 (2005).
-
(2005)
Eur. J. Neurosci
, vol.22
, Issue.8
, pp. 1942-1950
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Gong, C.X.4
-
138
-
-
17644410079
-
Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase?1
-
Rahman A, Grundke-Iqbal I, Iqbal K. Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase?1. Neurochem. Res. 30(2), 277-287 (2005).
-
(2005)
Neurochem. Res
, vol.30
, Issue.2
, pp. 277-287
-
-
Rahman, A.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
139
-
-
33947503437
-
Cortical biochemistry in MCI and Alzheimer disease: Lack of correlation with clinical diagnosis
-
Forman MS, Mufson EJ, Leurgans S et al. Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis. Neurology 68(10), 757-763 (2007).
-
(2007)
Neurology
, vol.68
, Issue.10
, pp. 757-763
-
-
Forman, M.S.1
Mufson, E.J.2
Leurgans, S.3
-
140
-
-
2542511697
-
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum
-
Mesulam M, Shaw P, Mash D, Weintraub S. Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann. Neurol. 55(6), 815-828 (2004).
-
(2004)
Ann. Neurol
, vol.55
, Issue.6
, pp. 815-828
-
-
Mesulam, M.1
Shaw, P.2
Mash, D.3
Weintraub, S.4
-
141
-
-
0024745894
-
Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
-
Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3(4), 519-526 (1989).
-
(1989)
Neuron
, vol.3
, Issue.4
, pp. 519-526
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Rutherford, D.4
Crowther, R.A.5
-
142
-
-
0024387161
-
Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: Differential expression of tau protein mRNAs in human brain
-
Goedert M, Spillantini MG, Potier MC, Ulrich J, Crowther RA. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J. 8(2), 393-399 (1989).
-
(1989)
EMBO J
, vol.8
, Issue.2
, pp. 393-399
-
-
Goedert, M.1
Spillantini, M.G.2
Potier, M.C.3
Ulrich, J.4
Crowther, R.A.5
-
143
-
-
4944230199
-
Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease
-
Boutajangout A, Boom A, Leroy K, Brion JP. Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease. FEBS Lett. 576(1-2), 183-189 (2004).
-
(2004)
FEBS Lett
, vol.576
, Issue.1-2
, pp. 183-189
-
-
Boutajangout, A.1
Boom, A.2
Leroy, K.3
Brion, J.P.4
-
144
-
-
11144283513
-
Transcriptional and conformational changes of the tau molecule in Alzheimer's disease
-
Hyman BT, Augustinack JC, Ingelsson M. Transcriptional and conformational changes of the tau molecule in Alzheimer's disease. Biochim. Biophys. Acta 1739(2-3), 150-157 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1739
, Issue.2-3
, pp. 150-157
-
-
Hyman, B.T.1
Augustinack, J.C.2
Ingelsson, M.3
-
145
-
-
2942667812
-
Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions
-
Togo T, Akiyama H, Iseki E et al. Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions. Acta Neuropathol. 107(6), 504-508 (2004).
-
(2004)
Acta Neuropathol
, vol.107
, Issue.6
, pp. 504-508
-
-
Togo, T.1
Akiyama, H.2
Iseki, E.3
-
146
-
-
45849128307
-
-
Crawley JN. Galanin - 25 years with a multitalented neuropeptide: galanin impairs cognitive abilities in rodents: relevance to Alzheimer's disease. Cell. Mol. Life Sci. 65(12), 1836-1841 (2008).
-
Crawley JN. Galanin - 25 years with a multitalented neuropeptide: galanin impairs cognitive abilities in rodents: relevance to Alzheimer's disease. Cell. Mol. Life Sci. 65(12), 1836-1841 (2008).
-
-
-
-
147
-
-
45849091110
-
Galanin - 25 years with a multitalented neuropeptide: Galanin acts as a trophic factor to the central and peripheral nervous systems
-
Hobson SA, Bacon A, Elliot-Hunt CR et al. Galanin - 25 years with a multitalented neuropeptide: galanin acts as a trophic factor to the central and peripheral nervous systems. Cell. Mol. Life Sci. 65(12), 1806-1812 (2008).
-
(2008)
Cell. Mol. Life Sci
, vol.65
, Issue.12
, pp. 1806-1812
-
-
Hobson, S.A.1
Bacon, A.2
Elliot-Hunt, C.R.3
-
148
-
-
0023728879
-
Galanin hyperinnervates surviving neurons of the human basal nucleus of Meynert in dementias of Alzheimer's and Parkinson's disease: A hypothesis for the role of galanin in accentuating cholinergic dysfunction in dementia
-
Chan-Palay V. Galanin hyperinnervates surviving neurons of the human basal nucleus of Meynert in dementias of Alzheimer's and Parkinson's disease: a hypothesis for the role of galanin in accentuating cholinergic dysfunction in dementia. J. Comp. Neurol. 273(4), 543-557 (1988).
-
(1988)
J. Comp. Neurol
, vol.273
, Issue.4
, pp. 543-557
-
-
Chan-Palay, V.1
-
149
-
-
2342580152
-
-
Counts SE, Perez SE, Ginsberg SD, De Lacalle S, Mufson EJ. Galanin in Alzheimer disease. Mol. Interv. 3(3), 137-156 (2003).
-
Counts SE, Perez SE, Ginsberg SD, De Lacalle S, Mufson EJ. Galanin in Alzheimer disease. Mol. Interv. 3(3), 137-156 (2003).
-
-
-
-
150
-
-
0027324260
-
Galaninergic innervation of the cholinergic vertical limb of the diagonal band (Ch2) and bed nucleus of the stria terminalis in aging, Alzheimer's disease and Down's syndrome
-
Mufson EJ, Cochran E, Benzing W, Kordower JH. Galaninergic innervation of the cholinergic vertical limb of the diagonal band (Ch2) and bed nucleus of the stria terminalis in aging, Alzheimer's disease and Down's syndrome. Dementia 4(5), 237-250 (1993).
-
(1993)
Dementia
, vol.4
, Issue.5
, pp. 237-250
-
-
Mufson, E.J.1
Cochran, E.2
Benzing, W.3
Kordower, J.H.4
-
151
-
-
33645104059
-
Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer's disease
-
Counts SE, Chen EY, Che S et al. Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 21(4), 205-214 (2006).
-
(2006)
Dement. Geriatr. Cogn. Disord
, vol.21
, Issue.4
, pp. 205-214
-
-
Counts, S.E.1
Chen, E.Y.2
Che, S.3
-
152
-
-
0036095993
-
Novel excitatory actions of galanin on rat cholinergic basal forebrain neurons: Implications for its role in Alzheimer's disease
-
Jhamandas JH, Harris KH, MacTavish D, Jassar BS. Novel excitatory actions of galanin on rat cholinergic basal forebrain neurons: implications for its role in Alzheimer's disease. J. Neurophysiol. 87(2), 696-704 (2002).
-
(2002)
J. Neurophysiol
, vol.87
, Issue.2
, pp. 696-704
-
-
Jhamandas, J.H.1
Harris, K.H.2
MacTavish, D.3
Jassar, B.S.4
-
153
-
-
30744448642
-
Galanin attenuates β-amyloid (Aβ) toxicity in rat cholinergic basal forebrain neurons
-
Ding X, MacTavish D, Kar S, Jhamandas JH. Galanin attenuates β-amyloid (Aβ) toxicity in rat cholinergic basal forebrain neurons. Neurobiol. Dis. 21(2), 413-420 (2006).
-
(2006)
Neurobiol. Dis
, vol.21
, Issue.2
, pp. 413-420
-
-
Ding, X.1
MacTavish, D.2
Kar, S.3
Jhamandas, J.H.4
-
154
-
-
20444363135
-
Galanin plasticity in the cholinergic basal forebrain in Alzheimer's disease and transgenic mice
-
Mufson EJ, Counts SE, Perez SE, Binder L. Galanin plasticity in the cholinergic basal forebrain in Alzheimer's disease and transgenic mice. Neuropeptides 39(3), 232-236 (2005).
-
(2005)
Neuropeptides
, vol.39
, Issue.3
, pp. 232-236
-
-
Mufson, E.J.1
Counts, S.E.2
Perez, S.E.3
Binder, L.4
-
155
-
-
0029569152
-
Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: Focusing on phosphatases
-
Trojanowski JQ, Lee VM. Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases. Faseb J. 9(15), 1570-1576 (1995).
-
(1995)
Faseb J
, vol.9
, Issue.15
, pp. 1570-1576
-
-
Trojanowski, J.Q.1
Lee, V.M.2
-
156
-
-
0035859885
-
Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptors
-
Liu HX, Brumovsky P, Schmidt R et al. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Proc. Natl. Acad. Sci. USA 98(17), 9960-9964 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, Issue.17
, pp. 9960-9964
-
-
Liu, H.X.1
Brumovsky, P.2
Schmidt, R.3
-
157
-
-
0037439628
-
The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons
-
Mahoney SA, Hosking R, Farrant S et al. The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons. J. Neurosci. 23(2), 416-421 (2003).
-
(2003)
J. Neurosci
, vol.23
, Issue.2
, pp. 416-421
-
-
Mahoney, S.A.1
Hosking, R.2
Farrant, S.3
-
158
-
-
0031039835
-
Nerve growth factor induces galanin gene expression in the rat basal forebrain: Implications for the treatment of cholinergic dysfunction
-
Planas B, Kolb PE, Raskind MA, Miller MA. Nerve growth factor induces galanin gene expression in the rat basal forebrain: implications for the treatment of cholinergic dysfunction. J. Comp. Neurol. 379(4), 563-570 (1997).
-
(1997)
J. Comp. Neurol
, vol.379
, Issue.4
, pp. 563-570
-
-
Planas, B.1
Kolb, P.E.2
Raskind, M.A.3
Miller, M.A.4
-
159
-
-
34248572114
-
Cholinesterase inhibitors reduce cortical A? in dementia with Lewy bodies
-
Ballard CG, Chalmers KA, Todd C et al. Cholinesterase inhibitors reduce cortical A? in dementia with Lewy bodies. Neurology 68(20), 1726-1729 (2007).
-
(2007)
Neurology
, vol.68
, Issue.20
, pp. 1726-1729
-
-
Ballard, C.G.1
Chalmers, K.A.2
Todd, C.3
-
160
-
-
0036185530
-
Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease
-
Lopez OL, Becker JT, Wisniewski S et al. Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 72(3), 310-314 (2002).
-
(2002)
J. Neurol. Neurosurg. Psychiatry
, vol.72
, Issue.3
, pp. 310-314
-
-
Lopez, O.L.1
Becker, J.T.2
Wisniewski, S.3
-
161
-
-
1842830710
-
Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease
-
Krishnan KR, Charles HC, Doraiswamy PM et al. Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease. Am. J. Psychiatry 160(11), 2003-2011 (2003).
-
(2003)
Am. J. Psychiatry
, vol.160
, Issue.11
, pp. 2003-2011
-
-
Krishnan, K.R.1
Charles, H.C.2
Doraiswamy, P.M.3
-
162
-
-
12844271665
-
A preclinical view of cholinesterase inhibitors in neuroprotection: Do they provide more than symptomatic benefits in Alzheimer's disease?
-
Francis PT, Nordberg A, Arnold SE. A preclinical view of cholinesterase inhibitors in neuroprotection: do they provide more than symptomatic benefits in Alzheimer's disease? Trends Pharmacol. Sci. 26(2), 104-111 (2005).
-
(2005)
Trends Pharmacol. Sci
, vol.26
, Issue.2
, pp. 104-111
-
-
Francis, P.T.1
Nordberg, A.2
Arnold, S.E.3
-
163
-
-
33748117752
-
Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease
-
Nordberg A. Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease. Alzheimer Dis. Assoc. Disord. 20(2 Suppl. 1), S12-S18 (2006).
-
(2006)
Alzheimer Dis. Assoc. Disord
, vol.20
, Issue.2 SUPPL. 1
-
-
Nordberg, A.1
-
164
-
-
0029863697
-
Acetylcholinesterase accelerates assembly of amyloid-β-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme
-
Inestrosa NC, Alvarez A, Perez CA et al. Acetylcholinesterase accelerates assembly of amyloid-β-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron 16(4), 881-891 (1996).
-
(1996)
Neuron
, vol.16
, Issue.4
, pp. 881-891
-
-
Inestrosa, N.C.1
Alvarez, A.2
Perez, C.A.3
-
165
-
-
0033998977
-
Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease: Final analysis of a US multicentre open-label study
-
Rogers SL, Doody RS, Pratt RD, Ieni JR. Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease: final analysis of a US multicentre open-label study. Eur. Neuropsychopharmacol. 10(3), 195-203 (2000).
-
(2000)
Eur. Neuropsychopharmacol
, vol.10
, Issue.3
, pp. 195-203
-
-
Rogers, S.L.1
Doody, R.S.2
Pratt, R.D.3
Ieni, J.R.4
-
166
-
-
0029078561
-
NGF-mediated synaptic sprouting in the cerebral cortex of lesioned primate brain
-
Burgos I, Cuello AC, Liberini P, Pioro E, Masliah E. NGF-mediated synaptic sprouting in the cerebral cortex of lesioned primate brain. Brain Res. 692(1-2), 154-160 (1995).
-
(1995)
Brain Res
, vol.692
, Issue.1-2
, pp. 154-160
-
-
Burgos, I.1
Cuello, A.C.2
Liberini, P.3
Pioro, E.4
Masliah, E.5
-
167
-
-
0030605874
-
Atrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugate
-
Charles V, Mufson EJ, Friden PM, Bartus RT, Kordower JH. Atrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugate. Brain Res. 728(2), 193-203 (1996).
-
(1996)
Brain Res
, vol.728
, Issue.2
, pp. 193-203
-
-
Charles, V.1
Mufson, E.J.2
Friden, P.M.3
Bartus, R.T.4
Kordower, J.H.5
-
168
-
-
0024213874
-
Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons
-
Hartikka J, Hefti F. Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons. J. Neurosci. Res. 21(2-4), 352-364 (1988).
-
(1988)
J. Neurosci. Res
, vol.21
, Issue.2-4
, pp. 352-364
-
-
Hartikka, J.1
Hefti, F.2
-
169
-
-
0023948713
-
Nerve growth factor promotes survival of cultured magnocellular cholinergic neurons from nucleus basalis of Meynert in postnatal rats
-
Hatanaka H, Nihonmatsu I, Tsukui H. Nerve growth factor promotes survival of cultured magnocellular cholinergic neurons from nucleus basalis of Meynert in postnatal rats. Neurosci. Lett. 90(1-2), 63-68 (1988).
-
(1988)
Neurosci. Lett
, vol.90
, Issue.1-2
, pp. 63-68
-
-
Hatanaka, H.1
Nihonmatsu, I.2
Tsukui, H.3
-
170
-
-
0022486717
-
-
Hefti F. Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J. Neurosci. 6(8), 2155-2162 (1986). • Seminal study revealing that exogenous NGF rescues septohippocampal cholinergic neuron loss following transection of the fimbria-fornix pathway.
-
Hefti F. Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J. Neurosci. 6(8), 2155-2162 (1986). • Seminal study revealing that exogenous NGF rescues septohippocampal cholinergic neuron loss following transection of the fimbria-fornix pathway.
-
-
-
-
171
-
-
0036044105
-
Nerve growth factor and cholinergic CNS neurons studied in organotypic brain slices. Implication in Alzheimer's disease?
-
Humpel C, Weis C. Nerve growth factor and cholinergic CNS neurons studied in organotypic brain slices. Implication in Alzheimer's disease? J. Neural Transm. Suppl. (62), 253-263 (2002).
-
(2002)
J. Neural Transm. Suppl
, vol.62
, pp. 253-263
-
-
Humpel, C.1
Weis, C.2
-
172
-
-
0001641539
-
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection
-
Williams LR, Varon S, Peterson GM et al. Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection. Proc. Natl. Acad. Sci. USA 83(23), 9231-9235 (1986).
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, Issue.23
, pp. 9231-9235
-
-
Williams, L.R.1
Varon, S.2
Peterson, G.M.3
-
173
-
-
0028237702
-
Oral administration of NGF synthesis stimulators recovers reduced brain NGF content in aged rats and cognitive dysfunction in basal-forebrain-lesioned rats
-
Nabeshima T, Nitta A, Fuji K, Kameyama T, Hasegawa T. Oral administration of NGF synthesis stimulators recovers reduced brain NGF content in aged rats and cognitive dysfunction in basal-forebrain-lesioned rats. Gerontology 40 (Suppl. 2), 46-56 (1994).
-
(1994)
Gerontology
, vol.40
, Issue.SUPPL. 2
, pp. 46-56
-
-
Nabeshima, T.1
Nitta, A.2
Fuji, K.3
Kameyama, T.4
Hasegawa, T.5
-
174
-
-
0035959515
-
Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease
-
Chu Y, Cochran EJ, Bennett DA, Mufson EJ, Kordower JH. Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease. J. Comp. Neurol. 437(3), 296-307 (2001).
-
(2001)
J. Comp. Neurol
, vol.437
, Issue.3
, pp. 296-307
-
-
Chu, Y.1
Cochran, E.J.2
Bennett, D.A.3
Mufson, E.J.4
Kordower, J.H.5
-
175
-
-
0033809884
-
Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease
-
Mufson EJ, Ma SY, Cochran EJ et al. Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease. J. Comp. Neurol. 427(1), 19-30 (2000).
-
(2000)
J. Comp. Neurol
, vol.427
, Issue.1
, pp. 19-30
-
-
Mufson, E.J.1
Ma, S.Y.2
Cochran, E.J.3
-
176
-
-
0037016848
-
Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease
-
Mufson EJ, Ma SY, Dills J et al. Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease. J. Comp. Neurol. 443(2), 136-153 (2002).
-
(2002)
J. Comp. Neurol
, vol.443
, Issue.2
, pp. 136-153
-
-
Mufson, E.J.1
Ma, S.Y.2
Dills, J.3
-
177
-
-
0029904388
-
Neurotrophins and Alzheimer's disease: Beyond the cholinergic neurons
-
Knusel B, Gao H. Neurotrophins and Alzheimer's disease: beyond the cholinergic neurons. Life Sci. 58(22), 2019-2027 (1996).
-
(1996)
Life Sci
, vol.58
, Issue.22
, pp. 2019-2027
-
-
Knusel, B.1
Gao, H.2
-
178
-
-
0035026831
-
Neurotrophic factor therapy - prospects and problems
-
Apfel SC. Neurotrophic factor therapy - prospects and problems. Clin. Chem. Lab. Med. 39(4), 351-355 (2001).
-
(2001)
Clin. Chem. Lab. Med
, vol.39
, Issue.4
, pp. 351-355
-
-
Apfel, S.C.1
-
179
-
-
0342803126
-
Nerve growth factor treatment in dementia
-
Jonhagen ME. Nerve growth factor treatment in dementia. Alzheimer Dis. Assoc. Disord. 14 (Suppl. 1), S31-S38 (2000).
-
(2000)
Alzheimer Dis. Assoc. Disord
, vol.14
, Issue.SUPPL. 1
-
-
Jonhagen, M.E.1
-
180
-
-
0034646215
-
A Phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291
-
McArthur JC, Yiannoutsos C, Simpson DM et al. A Phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291. Neurology 54(5), 1080-1088 (2000).
-
(2000)
Neurology
, vol.54
, Issue.5
, pp. 1080-1088
-
-
McArthur, J.C.1
Yiannoutsos, C.2
Simpson, D.M.3
-
181
-
-
0032961275
-
Recent developments in the drug treatment of Alzheimer's disease
-
Sramek JJ, Cutler NR. Recent developments in the drug treatment of Alzheimer's disease. Drugs Aging 14(5), 359-373 (1999).
-
(1999)
Drugs Aging
, vol.14
, Issue.5
, pp. 359-373
-
-
Sramek, J.J.1
Cutler, N.R.2
-
182
-
-
0036369587
-
Nerve growth factor for the treatment of diabetic neuropathy: What went wrong, what went right, and what does the future hold?
-
Apfel SC. Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold? Int. Rev. Neurobiol. 50, 393-413 (2002).
-
(2002)
Int. Rev. Neurobiol
, vol.50
, pp. 393-413
-
-
Apfel, S.C.1
-
183
-
-
0031037424
-
Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor
-
Winkler J, Ramirez GA, Kuhn HG et al. Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor. Ann. Neurol. 41(1), 82-93 (1997).
-
(1997)
Ann. Neurol
, vol.41
, Issue.1
, pp. 82-93
-
-
Winkler, J.1
Ramirez, G.A.2
Kuhn, H.G.3
-
184
-
-
0029548385
-
Ex vivo gene therapy for Alzheimer's disease and spinal cord injury
-
Blesch A, Tuszynski M. Ex vivo gene therapy for Alzheimer's disease and spinal cord injury. Clin. Neurosci. 3(5), 268-274 (1995).
-
(1995)
Clin. Neurosci
, vol.3
, Issue.5
, pp. 268-274
-
-
Blesch, A.1
Tuszynski, M.2
-
185
-
-
0025599916
-
Gene therapy in the CNS: Intracerebral grafting of genetically modified cells
-
Gage FH, Rosenberg MB, Tuszynski MH et al. Gene therapy in the CNS: intracerebral grafting of genetically modified cells. Prog. Brain Res. 86, 205-217 (1990).
-
(1990)
Prog. Brain Res
, vol.86
, pp. 205-217
-
-
Gage, F.H.1
Rosenberg, M.B.2
Tuszynski, M.H.3
-
186
-
-
0024821904
-
Survival, growth and function of damaged cholinergic neurons
-
Gage FH, Tuszynski MH, Chen KS, Armstrong D, Buzsaki G. Survival, growth and function of damaged cholinergic neurons. EXS 57, 259-274 (1989).
-
(1989)
EXS
, vol.57
, pp. 259-274
-
-
Gage, F.H.1
Tuszynski, M.H.2
Chen, K.S.3
Armstrong, D.4
Buzsaki, G.5
-
187
-
-
0020565380
-
NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?
-
Gnahn H, Hefti F, Heumann R, Schwab ME, Thoenen H. NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain? Brain Res. 285(1), 45-52 (1983).
-
(1983)
Brain Res
, vol.285
, Issue.1
, pp. 45-52
-
-
Gnahn, H.1
Hefti, F.2
Heumann, R.3
Schwab, M.E.4
Thoenen, H.5
-
188
-
-
0024394332
-
Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases
-
Hefti F, Hartikka J, Knusel B. Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases. Neurobiol. Aging 10(5), 515-533 (1989).
-
(1989)
Neurobiol. Aging
, vol.10
, Issue.5
, pp. 515-533
-
-
Hefti, F.1
Hartikka, J.2
Knusel, B.3
-
189
-
-
0024709111
-
NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat
-
Higgins GA, Koh S, Chen KS, Gage FH. NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat. Neuron 3(2), 247-256 (1989).
-
(1989)
Neuron
, vol.3
, Issue.2
, pp. 247-256
-
-
Higgins, G.A.1
Koh, S.2
Chen, K.S.3
Gage, F.H.4
-
190
-
-
0030002982
-
Gene therapy in the adult primate brain: Intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration
-
Tuszynski MH, Roberts J, Senut MC, U HS, Gage FH. Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther. 3(4), 305-314 (1996).
-
(1996)
Gene Ther
, vol.3
, Issue.4
, pp. 305-314
-
-
Tuszynski, M.H.1
Roberts, J.2
Senut, M.C.3
HS, U.4
Gage, F.H.5
-
191
-
-
0026008812
-
Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain
-
Tuszynski MH, Sang H, Yoshida K, Gage FH. Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain. Ann. Neurol. 30(5), 625-636 (1991).
-
(1991)
Ann. Neurol
, vol.30
, Issue.5
, pp. 625-636
-
-
Tuszynski, M.H.1
Sang, H.2
Yoshida, K.3
Gage, F.H.4
-
192
-
-
0025513602
-
Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration
-
Tuszynski MH, U HS, Amaral DG, Gage FH. Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. J. Neurosci. 10(11), 3604-3614 (1990).
-
(1990)
J. Neurosci
, vol.10
, Issue.11
, pp. 3604-3614
-
-
Tuszynski, M.U.H.1
Amaral, D.G.2
Gage, F.H.3
-
193
-
-
0030601663
-
Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease
-
Salehi A, Verhaagen J, Dijkhuizen PA, Swaab DF. Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience 75(2), 373-387 (1996).
-
(1996)
Neuroscience
, vol.75
, Issue.2
, pp. 373-387
-
-
Salehi, A.1
Verhaagen, J.2
Dijkhuizen, P.A.3
Swaab, D.F.4
-
194
-
-
47149108940
-
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
-
Doody RS, Gavrilova SI, Sano M et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study. Lancet 372(9634), 207-215 (2008).
-
(2008)
Lancet
, vol.372
, Issue.9634
, pp. 207-215
-
-
Doody, R.S.1
Gavrilova, S.I.2
Sano, M.3
-
195
-
-
0033806794
-
Delivery of neurotrophic factors to neuronal targets: Toward gene therapy in the CNS
-
Blesch A. Delivery of neurotrophic factors to neuronal targets: toward gene therapy in the CNS. Drug News Perspect. 13(5), 269-280 (2000).
-
(2000)
Drug News Perspect
, vol.13
, Issue.5
, pp. 269-280
-
-
Blesch, A.1
-
196
-
-
20944448555
-
Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial
-
Gilman S, Koller M, Black RS et al. Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64(9), 1553-1562 (2005).
-
(2005)
Neurology
, vol.64
, Issue.9
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.S.3
-
197
-
-
0038100154
-
Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease
-
Hock C, Konietzko U, Streffer JR et al. Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38(4), 547-554 (2003).
-
(2003)
Neuron
, vol.38
, Issue.4
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
|