A TrkA-to-p75NTR molecular switch activates amyloid β-peptide generation during aging

Biochemical Journal

Volumn 391, Issue 1, 2005, Pages 59-67

  Costantini, Claudio ^a   Weindruch, Richard ^a   Della Valle, Giuliano ^b   Puglielli, Luigi ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Aging; Alzheimer's disease; Amyloid precursor protein; Ceramide; Neurotrophin; p75 NTR (p75 neurotrophin receptor)

Indexed keywords

AGING OF MATERIALS; BRAIN;

CALORIC RESTRICTION; NERVE GROWTH FACTOR (NGF); SENILE PLAQUES;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CERAMIDE; MANUMYCIN; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR; PROTEIN P75; PROTEIN TYROSINE KINASE A; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; AMIDE; NERVE GROWTH FACTOR RECEPTOR; POLYENE;

AGING; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DRUG INHIBITION; GENE SWITCHING; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; RECEPTOR UPREGULATION; SECOND MESSENGER; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BRAIN CORTEX; C57BL MOUSE; GENE DELETION; GENETICS; METABOLISM; TUMOR CELL LINE;

ANIMALIA;

AGING; AMYLOID BETA-PROTEIN; ANIMALS; CALORIC RESTRICTION; CELL LINE, TUMOR; CERAMIDES; CEREBRAL CORTEX; GENE DELETION; HUMANS; MALE; MICE; MICE, INBRED C57BL; POLYENES; POLYUNSATURATED ALKAMIDES; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKA;

EID: 26844507790     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050700     Document Type: Article

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