Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis

Journal of Neuroscience

Volumn 22, Issue 1, 2002, Pages 156-166

  Harrington, Anthony W ^a   Kim, Ju Young ^a   Yoon, Sung Ok ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; C jun N terminal kinase; NGF; P75; Rac GTPase; Signal transduction

Indexed keywords

GUANOSINE TRIPHOSPHATASE; NEUROTROPHIN RECEPTOR; PROTEIN P75; RAC PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME ACTIVITY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SUPERIOR CERVICAL GANGLION;

EID: 0036140118     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-01-00156.2002     Document Type: Article

References (62)

1. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
2. The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death
3. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
4. p75 is important for axon growth, Schwann cell migration during development
5. The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo
6. Time-course changes of nerve growth factor, corticotropin-releasing hormone, and nitric oxide synthase isoforms and their possible role in the development of inflammatory response in experimental allergic encephalomyelitis
7. Neurotrophins live or let die: Does p75NTR decide?
8. Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75
9. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
10. The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death
11. NG2-positive oligodendrocyte progenitor cells in adult human brain, multiple sclerosis lesions
12. Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor
13. Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons
14. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
15. Signalling through the neurotrophin receptor p75NTR
16. JNK1: A protein kinase stimulated by UV light and Ha-ras that binds and phosphorylates the c-Jun activation domain
17. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor
18. Up-regulated p75NTR neurotrophin receptor on glial cells in MS plaques
19. Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons
20. Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein
21. Nerve growth factor activation of nuclear factor kappaB through its p75 receptor is an anti-apoptotic signal in RN22 Schwannoma cells
22. Oligodendrocyte apoptosis mediated by caspase activation
23. Induction of nerve growth factor receptor (p75NGFr) mRNA within hypoglossal motoneurons following axonal injury
24. A simplified system for generating recombinant adenoviruses
25. Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanisms
26. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation
27. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
28. Perpheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia in vivo
29. Association of the p75 neurotrophin receptor with TRAF6
30. Axotomy induces nerve growth factor receptor immunoreactivity in spinal motor neurons
31. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
32. p75 neurotrophin receptor expression on adult human oligodendrocytes: Signaling without cell death in response to NGF
33. 1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
34. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
35. Physiology of the neurotrophins
36. Morphological, biochemical, and functional characterization of bulk isolated glial progenitor cells
37. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway
38. CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults
39. Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway
40. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue
41. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
42. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and CdC42Hs
43. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase
44. Low affinity NGF receptor expression in the central nervous system during experimental allergic encephalomyelitis
45. Co-induction of p75NTR, p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat
46. Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75
47. PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity
48. p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure
49. NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor, facilitates nerve growth factor-dependent apoptosis
50. Induction of nerve growth factor receptor in Schwann cells after axotomy
51. p75(NGFR) and cholinergic neurons in the developing forebrain: A re-examination
52. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
53. RhoA inhibits the nerve growth factor-induced Rac1 activation through a Rho-associated kinase-dependent pathway
54. Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth
55. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
56. Specific activation of a c-Jun NH2-terminal kinase isoform and induction of neurite outgrowth in PC-12 cells by staurosporine
57. Differential responses to nerve growth factor and epidermal growth factor in neurite outgrowth of PC12 cells are determined by Rac1 activation systems
58. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
59. Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation
60. Adenovirus-mediated gene delivery into neuronal precursors of the adult mouse brain
61. A dominant role of the juxtamembrane region of the TrkA nerve growth factor receptor during neuronal cell differentiation
62. Competitive signaling between TrkA and p75 determines cell survival