The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth

Oncogene

Volumn 18, Issue 32, 1999, Pages 4586-4597

  Ashcroft, Margaret ^a   Stephens, Robert M ^a   Hallberg, Bengt ^b,c   Downward, Julian ^b   Kaplan, David R ^a,d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UMEÅ UNIVERSITY   (Sweden)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Differentiation; NGF; PC12; Phosphatidylinositol 3 kinase; Survival; Trk

Indexed keywords

INOSITOL 1,3,4 TRISPHOSPHATE; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL KINASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CELL SURVIVAL; ENZYME ACTIVATION; HUMANS; ISOENZYMES; NERVE GROWTH FACTORS; NEURITES; NEURONS; PC12 CELLS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; TYROSINE;

EID: 0033549893     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202814     Document Type: Article

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