The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway

Journal of Biological Chemistry

Volumn 276, Issue 25, 2001, Pages 23097-23104

  Roux, Philippe P ^b   Bhakar, Asha L ^b   Kennedy, Timothy E ^b   Barker, Philip A ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL ACTIVATION; ENZYMES;

APOPTOSIS; PHOSPHORYLATION;

BIOCHEMISTRY;

CERAMIDE; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P75; PROTEIN P85; PROTEIN SHC; PROTEIN TYROSINE PHOSPHATASE; SPHINGOMYELIN PHOSPHODIESTERASE; STAUROSPORINE; AKT1 PROTEIN, RAT; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; STRESS ACTIVATED PROTEIN KINASE; TYROSINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; ADENOVIRUS; ANIMAL; CELL STRAIN; CELL STRAIN COS1; GENETIC RECOMBINATION; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL SURVIVAL; COS CELLS; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, NERVE GROWTH FACTOR; RECEPTORS, NERVE GROWTH FACTOR; RECOMBINATION, GENETIC; TYROSINE;

EID: 0035933783     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011520200     Document Type: Article

References (67)

1. Lewin, G. R., and Barde, Y. A. (1996) Annu. Rev. Neurosci. 19, 289-317
2. Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., and Greenberg, M. E. (1997) Science 275, 661-665
3. Kaplan, D. R., and Miller, F. D. (2000) Curr. Opin. Neurobiol. 10, 381-391
4. Bellacosa, A., Chan, T. O., Ahmed, N. N., Datta, K., Malstrom, S., Stokoe, D., McCormick, F., Feng, J., and Tsichlis, P. (1998) Oncogene 17, 313-325
5. Toker, A., and Newton, A. C. (2000) J. Biol. Chem. 275, 8271-8274
6. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. (1999) Cell 96, 857-868
7. Kennedy, S. G., Kandel, E. S., Cross, T. K., and Hay, N. (1999) Mol. Cell. Biol. 19, 5800-5810
8. Fujita, E., Jinbo, A., Matuzaki, H., Konishi, H., Kikkawa, U., and Momoi, T. (1999) Biochem. Biophys. Res. Commun. 264, 550-555
9. Tang, Y., Zhou, H., Chen, A., Pittman, R. N., and Field, J. (2000) J. Biol. Chem. 275, 9106-9109
10. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997) Cell 91, 231-241
11. Ozes, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., and Donner, D. B. (1999) Nature 401, 82-85
12. Romashkova, J. A., and Makarov, S. S. (1999) Nature 401, 86-90
13. Barker, P. (1998) Cell Death Differ. 5, 346-356
14. Barrett, G. L. (2000) Prog. Neurobiol. 61, 205-229
15. Barker, P. A., and Shooter, E. M. (1994) Neuron 13, 203-215
16. Verdi, J. M., Birren, S. J., Ibanez, C. F., Persson, H., Kaplan, D. R., Benedetti, M., Chao, M. V., and Anderson, D. J. (1994) Neuron 12, 733-745
17. Ryden, M., Hempstead, B., and Ibanez, C. F. (1997) J. Biol. Chem. 272, 16322-16328
18. Brennan, C., Rivas-Plata, K., and Landis, S. C. (1999) Nat. Neurosci. 2, 699-705
19. Bibel, M., Hoppe, E., and Barde, Y. A. (1999) EMBO J. 18, 616-622
20. Dobrowsky, R. T., Werner, M. H., Castellino, A. M., Chao, M. V., and Hannun, Y. A. (1994) Science 265, 1596-1598
21. Dobrowsky, R. T., Jenkins, G. M., and Hannun, Y. A. (1995) J. Biol. Chem. 270, 22135-22142
22. Brann, A. B., Scott, R., Neuberger, Y., Abulafia, D., Boldin, S., Fainzilber, M., and Futerman, A. H. (1999) J. Neurosci. 19, 8199-8206
23. Carter, B. D., Kaltschmidt, C., Kaltschmidt, B., Offenhauser, N., Bohm, M. R., Baeuerle, P. A., and Barde, Y. A. (1996) Science 272, 542-545
24. Bhakar, A. L., Roux, P. P., Lachance, C., Kryl, D., Zeindler, C., and Barker, P. A. (1999) J. Biol. Chem. 274, 21443-21449
25. Khursigara, G., Orlinick, J. R., and Chao, M. V. (1999) J. Biol. Chem. 274, 2597-2600
26. Aloyz, R. S., Bamji, S. X., Pozniak, C. D., Toma, J. G., Atwal, J., Kaplan, D. R., and Miller, F. D. (1998) J. Cell Biol. 143, 1691-1703
27. Bamji, S. X., Majdan, M., Pozniak, C. D., Belliveau, D. J., Aloyz, R., Kohn, J., Causing, C. G., and Miller, F. D. (1998) J. Cell Biol. 140, 911-923
28. Yoon, S. O., Casaccia-Bonnefil, P., Carter, B., and Chao, M. V. (1998) J. Neurosci. 18, 3273-3281
29. Casaccia-Bonnefil, P., Carter, B. D., Dobrowsky, R. T., and Chao, M. V. (1996) Nature 383, 716-719
30. Frade, J. M., Rodriguez-Tebar, A., and Barde, Y. A. (1996) Nature 383, 166-168
31. Frade, J. M., and Barde, Y. A. (1999) Development 126, 683-690
32. Gu, C., Casaccia-Bonnefil, P., Srinivasan, A., and Chao, M. V. (1999) J. Neurosci. 19, 3043-3049
33. Frade, J. M. (2000) J. Cell Sci. 113, 1139-1148
34. Ye, X., Mehlen, P., Rabizadeh, S., Van Arsdale, T., Zhang, H., Shin, H., Wang, J. J., Leo, E., Zapata, J., Hauser, C. A., Reed, J. C., and Bredesen, D. E. (1999) J. Biol. Chem. 274, 30202-30208
35. Bilderback, T. R., Grigsby, R. J., and Dobrowsky, R. T. (1997) J. Biol. Chem. 272, 10922-10927
36. Chittka, A., and Chao, M. V. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 10705-10710
37. Casademunt, E., Carter, B. D., Benzel, I., Frade, J. M., Dechant, G., and Barde, Y. A. (1999) EMBO J. 18, 6050-6061
38. Irie, S., Hachiya, T., Rabizadeh, S., Maruyama, W., Mukai, J., Li, Y., Reed, J. C., Bredesen, D. E., and Sato, T. A. (1999) FEBS Lett. 460, 191-198
39. Mukai, J., Hachiya, T., Shoji-Hoshino, S., Kimura, M. T., Nadano, D., Suvanto, P., Hanaoka, T., Li, Y., Irie, S., Greene, L. A., and Sato, T. A. (2000) J. Biol. Chem. 275, 17566-17570
40. Yamashita, T., Tucker, K. L., and Barde, Y. A. (1999) Neuron 24, 585-593
41. Salehi, A. H., Roux, P. P., Kubu, C. J., Zeindler, C., Bhakar, A., Tannis, L. L., Verdi, J. M., and Barker, P. A. (2000) Neuron 27, 279-288
42. Zundel, W., and Giaccia, A. (1998) Genes Dev. 12, 1941-1946
43. Zhou, H., Summers, S. A., Birnbaum, M. J., and Pittman, R. N. (1998) J. Biol. Chem. 273, 16568-16575
44. Schubert, K. M., Scheid, M. P., and Duronio, V. (2000) J. Biol. Chem. 275, 13330-13335
45. Radeke, M. J., Misko, T. P., Hsu, C., Herzenberg, L. A., and Shooter, E. M. (1987) Nature 325, 593-597
46. Majdan, M., Lachance, C., Gloster, A., Aloyz, R., Zeindler, C., Bamji, S., Bhakar, A., Belliveau, D., Fawcett, J., Miller, F. D., and Barker, P. A. (1997) J. Neurosci. 17, 6988-6998
47. Robbins, S. M., Quintrell, N. A., and Bishop, J. M. (1995) Mol. Cell. Biol. 15, 3507-3515
48. Roux, P. P., Colicos, M. A., Barker, P. A., and Kennedy, T. E. (1999) J. Neurosci. 19, 6887-6896
49. Laemmli, U. K. (1970) Nature 227, 680-685
50. Boldin, M., Mett, I., Varfolomeev, E., Chumakov, I., Shemeravni, Y., Camonis, J., and Wallach, D. (1995) J. Biol. Chem. 270, 387-391
51. Cochran, B. H. (1993) Natl. Inst. Drug Abuse Res. Monogr. 125, 3-24
52. Mahadeo, D., Kaplan, L., Chao, M. V., and Hempstead, B. L. (1994) J. Biol. Chem. 269, 6884-6891
53. Liu, L., Damen, J. E., Ware, M., Hughes, M., and Krystal, G. (1997) Leukemia (Baltimore) 11, 181-184
54. Grob, P. M., Ross, A. H., Koprowski, H., and Bothwell, M. (1985) J. Biol. Chem. 260, 8044-8049
55. Frade, J. M., and Barde, Y. A. (1998) Neuron 20, 35-41
56. Blochl, A., and Sirrenberg, C. (1996) J. Biol. Chem. 271, 21100-21107
57. MacPhee, I. J., and Barker, P. A. (1997) J. Biol. Chem. 272, 23547-23551
58. Westwick, J. K., Bielawska, A. E., Dbaibo, G., Hannun, Y. A., and Brenner, D. A. (1995) J. Biol. Chem. 270, 22689-22692
59. Verheij, M., van Blitterswijk, W. J., and Bartelink, H. (1998) Acta Oncol. 37, 575-581
60. Sato, T., Irie, S., Kitada, S., and Reed, J. C. (1995) Science 268, 411-415
61. Li, Y., Kanki, H., Hachiya, T., Ohyama, T., Irie, S., Tang, G., Mukai, J., and Sato, T. (2000) Int. J. Cancer 87, 473-479
62. Yanagisawa, J., Takahashi, M., Kanki, H., Yano-Yanagisawa, H., Tazunoki, T., Sawa, E., Nishitoba, T., Kamishohara, M., Kobayashi, E., Kataoka, S., and Sato, T. (1997) J. Biol. Chem. 272, 8539-8545
63. Wong, B. R., Besser, D., Kim, N., Arron, J. R., Vologodskaia, M., Hanafusa, H., and Choi, Y. (1999) Mol. Cell 4, 1041-1049
64. Rabizadeh, S., Ye, X., Wang, J. J., and Bredesen, D. E. (1999) Cell Death Differ. 6, 1222-1227
65. Rabizadeh, S., Oh, J., Zhong, L. T., Yang, J., Bitler, C. M., Butcher, L. L., and Bredesen, D. E. (1993) Science 261, 345-348
66. Chan, F. K., Chun, H. J., Zheng, L., Siegel, R. M., Bui, K. L., and Lenardo, M. J. (2000) Science 288, 2351-2354
67. Siegel, R. M., Frederiksen, J. K., Zacharias, D. A., Chan, F. K., Johnson, M., Lynch, D., Tsien, R. Y., and Lenardo, M. J. (2000) Science 288, 2354-2357