Binding of nerve growth factor to its p75 receptor in stressed cells induces selective IκB-β degradation and NF-κB nuclear translocation

Journal of Neurochemistry

Volumn 79, Issue 2, 2001, Pages 391-399

  Cosgaya, Jose Miguel ^a   Shooter, Eric M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

I B; Neurotrophin; Nuclear factor B; p75; PCNA; Stress

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIN; PROTEIN P75; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; STRESS;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD PHYSIOLOGY; CELL LINE; I-KAPPA B PROTEINS; MICE; NERVE GROWTH FACTOR; NF-KAPPA B; PROTEIN ISOFORMS; PROTEINS; RATS; RECEPTOR, NERVE GROWTH FACTOR; RECEPTORS, NERVE GROWTH FACTOR; STRESS; TNF RECEPTOR-ASSOCIATED FACTOR 6;

ANIMALIA;

EID: 0034770141     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00573.x     Document Type: Article

References (47)

1. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
2. Nerve growth factor and its low-affinity receptor promote Schwann cell migration
3. Purification of a new neurotrophic factor from mammalian brain
4. LNTR reduces NGF binding to TrkA on PC12 cells
5. The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development
6. Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness
7. The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-κB activity under physiological conditions, but direct p75NTR-mediated NF-κB activation requires cell stress
8. NTR
9. Lntr receptors
10. Activation of nuclear factor κB and bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IκBα
11. Selective activation of NF-κB by nerve growth factor through the neurotrophin receptor p75
12. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
13. Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism
14. p75 neurotrophin receptor signaling: Mechanisms for neurotrophic modulation of cell stress?
15. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor
16. NF-κB signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells
17. Induction of cell death by endogenous nerve growth factor through its p75 receptor
18. Nerve growth factor activation of nuclear factor κB through its p75 receptor is an anti-apoptotic signal in RN22 schwannoma cells
19. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
20. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary
21. Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: Melanoma p75 functions independently of Trka
22. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-κB activation at the level of TRAF6
23. Alternative splicing variants of IκB β establish differential NF-κB signal responsiveness in human cells
24. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family
25. Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
26. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains
27. Association of the p75 neurotrophin receptor with TRAF6
28. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
29. The trk proto-oncogene encodes a receptor for nerve growth factor
30. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
31. The trkB tyrosine protein kinase is a receptor for neurotrophin-4
32. Neurotrophins induce release of neurotrophins by the regulated secretory pathway
33. NTR
34. p75 neurotrophin receptor expression on adult human oligodendrocytes: Signaling without cell death in response to NGF
35. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
36. Physiology of the neurotrophins
37. Differential IκB kinase activation and IκBα degradation by interleukin-1β and tumor necrosis factor-α in human U937 monocytic cells. Evidence for additional regulatory steps in κB-dependent transcription
38. Achieving transcriptional specificity with NF-κB
39. Induction of apoptosis by the low-affinity NGF receptor
40. Gene transfer and molecular cloning of the rat nerve growth factor receptor
41. Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor
42. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction
43. Regulation of neural cell adhesion molecule expression on cultured mouse Schwann cells by nerve growth factor
44. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation
45. Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells
46. IκB proteins: Structure, function and regulation
47. Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival