Trks: Signal transduction and intracellular pathways

Microscopy Research and Technique

Volumn 45, Issue 4-5, 1999, Pages 210-216

  Klesse, Laura J ^a   Parada, Luis F ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Nerve growth factor; Neurons; PC12 cells; PI 3 kinase; Ras

Indexed keywords

AMINO ACIDS; ENZYME ACTIVITY; ENZYME INHIBITION; SIGNAL TRANSDUCTION; SIGNALING;

CELLULAR RESPONSE; INTRACELLULAR PATHWAYS; INTRACELLULAR SIGNALING; NERVE GROWTH FACTOR; NEUROTROPHINS; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASE; RAS; SIGNAL TRANSDUCTION PATHWAYS; SIGNALING CASCADES;

CHEMICAL ACTIVATION;

BRAIN DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; RAS PROTEIN; TYROSINE KINASE RECEPTOR;

ARTICLE; CELL STRAIN; CELL SURVIVAL; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; VERTEBRATE;

EID: 0033563189     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0029(19990515/01)45:4/5<210::AID-JEMT4>3.0.CO;2-F     Document Type: Article

References (73)

1. Barbacid M 1995. Structural and functional properties of the TRK family of neurotrophin receptors. Ann NY Acad Sci 766:442-458.
2. Bar-Sagi D, Feramisco JR. 1985. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42:841-848.
3. Barker PA, Shooter EM. 1994. Disruption of NGF binding to the low affinity neurotrophin p75LNTR reduces NGF binding to TrkA on PC12 cells. Neuron 13:203-215.
4. Borasio GD, John J, Wittinghofer A, Barde YA, Sendtner M, Heumann R. 1989. ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron 2:1087-1096.
5. Borasio GD, Markus A, Wittinghofer A, Barde Y A, Heumann R. 1993. Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons. J Cell Biol 121:665-672.
6. Borasio GD, Markus A, Heumann R, Ghezzi C, Sampietro A, Wittinghofer A, Silani V. 1996. Ras p21 protein promotes survival and differentiation of human embryonic neural crest-derived cells. Neuroscience 73:1121-1127.
7. Brannan CI, Perkins AS, Vogel KS, Ratner N, Nordlund ML, Reid SW, Buchberg AM, Jenkins NA, Parada LF, Copeland NG. 1994. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues [published erratum appears in Genes Dev 1994 8:2792]. Genes Dev 8:1019-1029.
8. Burgering BM, Coffer PJ. 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction [see comments]. Nature 376:599-602.
9. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318-1321.
10. Carter BD, Zirrgiebel U, Barde Y-A. 1995. Differential regulation of p21ras activation in neurons by nerve growth factor and brain-derived neurotrophic factor. J Biol Chem 270:21751-21757.
11. Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV. 1996. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 383:716-719.
12. Conover JC, Yancopoulos GD. 1997. Neurotrophin regulation of the developing nervous system: analyses of knockout mice. [Review] [87 refs]. Rev Neurosci 8:13-27.
13. Cowley S, Paterson H, Kemp P, Marshall CJ. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
14. Creedon DJ, Johnson EM, Lawrence JC. 1996. Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival. J Biol Chem 271: 20713-20718.
15. Crowder RJ, Freeman RS. 1998. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci 18:2933-2943.
16. Datta K, Bellacosa A, Chan TO, Tsichlis PN. 1996. Akt is a direct target of the phosphatidylinositol 3-kinase. activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells. J Biol Chem 271:30835-30839.
17. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
18. Deckwerth TL, Elliott JL, Knudson CM, Johnson EM, Snider WD, Korsmeyer SJ. 1996. BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17:401-411.
19. del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689.
20. Dikic I, Batzer AG, Blaikie P, Obermeier A, Ullrich A, Schlessinger J, Margolis B. 1995. Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain. J Biol Chem 270:15125-15129.
21. Dobrowsky RT, Jenkins GM, Hannun YA. 1995. Neurotrophins induce sphingomyelin hydrolysis: modulation by co-expression of p75 with Trk receptors. J Biol Chem 1995:22135-22142.
22. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt [see comments]. Science 275:661-665.
23. Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736.
24. Franke TF, Kaplan DR, Cantley LC, Toker A. 1997. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate [see comments]. Science 275:665-668.
25. Garcia I, Martinou I, Tsujimoto Y, Martinou J-C. 1997. Prevention of programmed cell death of sympathetic neurons by the bcl-2 Proto-Oncogene. Science 258:302-304.
26. Greene LA. 1978. Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. J Cell Biol 78:747-755.
27. Greene LA, Tischler AS. 1976. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424-2428.
28. Hagag N, Halegoua S, Viola M. 1986. Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21. Nature 319:680-682.
29. Hantzopoulos PA, Suri C, Glass MP, Goldfarb MP, Yancopolous GD. 1994. The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Neuron 13:187-201.
30. Hemmings BA. 1997. Akt signaling: linking membrane events to life and death decisions [comment]. [Review] [25 refs]. Science 275:628-630.
31. Hempstead BL, Martin-Zanca D, Kaplan DR, Parada LF, Chao MV. 1991. High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor [see comments]. Nature 350:678-683.
32. Jing S, Tapley P, Barbacid M. 1992. Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron 9:1067-1079.
33. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. 1991a. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor [see comments]. Science 252:554-558.
34. Kaplan DR, Martin-Zanca D, Parada LF. 1991b. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350:158-160.
35. Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, Tsichlis PN, Hay N. 1997. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev 11:701-713.
36. Klesse LJ, Parada LF. 1998. p21 Ras and phosphatidylinositol-3 kinase are required for survival of wildtype and NF1 mutant sensory neurons. J Neurosci 18:10420-10428.
37. Klesse LJ, Meyers KA, Marshall CJ, Parada LF. 1999. Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. Oncogene (in press).
38. Klinz FJ, Wolff P, Heumann R. 1996. Nerve growth factor-stimulated mitogen-activated protein kinase activity is not necessary for neurite outgrowth of chick dorsal root ganglion sensory and sympathetic neurons. J Neurosci Res 46:720-726.
39. Klippel A, Reinhard C, Kavanaugh WM, Apell G, Escobedo MA, Williams LT. 1996. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol Cell Biol 16:4117-4127.
40. Klippel A, Kavanaugh WM, Pot D, Williams LT. 1997. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol Cell Biol 17:338-344.
41. Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J. 1997. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 89:693-702.
42. Kremer NE, D'Arcangelo G, Thomas SM, DeMarco M, Brugge JS, Halegoua S. 1991. Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions. J Cell Biol 115:809-819.
43. Kulik G, Klippel A, Weber MJ. 1997. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17:1595-1606.
44. Marte BM, Downward J. 1997. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. [Review] [41 refs]. Trends Biochem Sci 22:355-358.
45. Nakamura T, Sanokawa R, Sasaki Y, Ayusawa D, Oishi M, Mori N. 1996. N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. Oncogene 13:1111-1121.
46. Nobes CD, Tolkovsky AM. 1995. Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF LIF CNTF and cAMP. Eur J Neurosci 7:344-350.
47. Nobes CD, Reppas JB, Markus A, Tolkovsky AM. 1996. Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons. Neuroscience 70:1067-1079.
48. Obermeier A, Lammers R, Wiesmuller KH, Jung G, Schlessinger J, Ullrich A. 1993. Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex, J Biol Chem 268:22963-22966.
49. Obermeier A, Bradshaw RA, Seedorf K, Choidas A, Schlessinger J, Ullrich A. 1994. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma. EMBO J 13:1585-1590.
50. Ong SH, Goh KC, Lim YP, Low BC, Klint P, Claesson-Welsh L, Cao X, Tan YH, Guy G. R. 1996. Sucl-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2. Biochem Biophys Res Commun 225:1021-1026.
51. Rabin SJ, Cleghon V, Kaplan DR. 1993. SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol Cell Biol 13:2203-2213.
52. Raffioni S, Bradshaw RA. 1992. Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells. Proc Natl Acad Sci USA 89:9121-9125.
53. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J. 1994. Phosphatidylinositol-3-OH kinase as a direct target of Ras [see comments]. Nature 370:527-532.
54. Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J. 1996. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. Embo J 15:2442-2451.
55. Rukenstein A, Rydel RE, Greene LA. 1991. Multiple agents rescue PC12 cells from serum-free cell death by translation-and transcription-independent mechanisms. J Neurosci 11:2552-2563.
56. Segal RA, Greenberg ME. 1996. Intracellular signaling pathways activated by neurotrophic factors. [Review] [208 refs]. Annu Rev Neurosci 19:463-489.
57. Snider WD, Silos-Santiago I. 1996. Dorsal root ganglion neurons require functional neurotrophin receptors for survival during development. [Review] [56 refs]. Philos Trans R Soc Lond B Biol Sci 351:395-403.
58. Soltoff SP, Rabin SL, Cantley LC, Kaplan DR. 1992. Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. J Biol Chem 267:17472-17477.
59. Squinto SP, Stitt TN, Aldrich TH, Davis S, Bianco SM, Radziejewski C, Glass DJ, Masiakowski P, Furth ME, Valenzuela DM, DiStefano PS, Yancopolous GD. 1991. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell 65:885-893.
60. Stephens RM, Loeb DM, Copeland TD, Pawson T, Greene LA, Kaplan DR. 1994. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron 12:691-705.
61. Szeberenyi J, Cai H, Cooper GM. 1990. Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol Cell Biol 10:5324-5332.
62. Szeberenyi J, Erhardt P, Cai H, Cooper GM. 1992. Role of Ras in signal transduction from the nerve growth factor receptor: relationship to protein kinase C, calcium and cyclic AMP. Oncogene 7:2105-2113.
63. Tischler AS, Greene LA. 1975. Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells. Nature 258:341-342.
64. Tsoulfas P, Stephens RM, Kaplan DR, Parada LF. 1996. TrkC isoforms with inserts in the Kinase Domain show impaired signaling responses. J Biol Chem 271:5691-5697.
65. Vetter ML, Martin-Zanca D, Parada LF, Bishop JM, Kaplan DR. 1991. Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipaseC-γ1 by a kinase activity associated with the product of the trk protooncogene. Proc Natl Acad Sci USA 88:5650-5654.
66. Virdee K, Tolkovsky AM. 1996. Inhibition of p42 and p44 mitogen-activated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neurones. J Neurochem 67:1801-1805.
67. Vogel KS, Brannan CI, Jenkins NA, Copeland NG, Parada LF. 1995. Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons. Cell 82:733-742.
68. Wang JK, Xu H, Li HC, Goldfarb M 1996. Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras. Oncogene 13:721-729.
69. Wood KW, Qi H, D'Arcangelo G, Armstrong RC, Roberts TM, Halegoua S. 1993. The cytoplasmic raf oncogene induces a neuronal phenotype in PC 12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proc Natl Acad Sci USA 90:5016-5020.
70. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331.
71. Yao R, Cooper GM. 1995. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006.
72. York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, Stork PJS. 1998. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392:622-626.
73. Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. 1996. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) [see comments]. Cell 87:619-628.