메뉴 건너뛰기




Volumn 27, Issue 10, 2002, Pages 1035-1048

Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease

Author keywords

Alzheimer's disease; Cathepsin D; CDNA microarray; Cholinergic basal forebrain; RNA amplification; Synaptophysin

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CATHEPSIN D; NEUROTROPHIN RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE; SYNAPTOPHYSIN; SYNAPTOTAGMIN;

EID: 0036808469     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020952704398     Document Type: Article
Times cited : (124)

References (96)
  • 1
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus, R. T., Dean, R. L., 3rd, Beer, B., and Lippa, A. S. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-414.
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 3
    • 0031904324 scopus 로고    scopus 로고
    • Abnormalities of neural circuitry in Alzheimer's disease: Hippocampus and cortical cholinergic innervation
    • discussion S65-S67
    • Geula, C. 1998. Abnormalities of neural circuitry in Alzheimer's disease: hippocampus and cortical cholinergic innervation. Neurology 51:S18-S29; discussion S65-S67.
    • (1998) Neurology , vol.51 , pp. S18-S29
    • Geula, C.1
  • 4
    • 0020397384 scopus 로고
    • Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities
    • Wilcock, G. K., Esiri, M. M., Bowen, D. M., and Smith, C. C. 1982. Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities. J. Neurol. Sci. 57:407-417.
    • (1982) J. Neurol. Sci. , vol.57 , pp. 407-417
    • Wilcock, G.K.1    Esiri, M.M.2    Bowen, D.M.3    Smith, C.C.4
  • 5
    • 0020676699 scopus 로고
    • Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey
    • Mesulam, M. M., Mufson, E. J., Levey, A. I., and Wainer, B. H. 1983. Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey. J. Comp. Neurol. 214:170-197.
    • (1983) J. Comp. Neurol. , vol.214 , pp. 170-197
    • Mesulam, M.M.1    Mufson, E.J.2    Levey, A.I.3    Wainer, B.H.4
  • 6
    • 0032904563 scopus 로고    scopus 로고
    • Cognitive functions of the basal forebrain
    • Baxter, M. G. and Chiba, A. A. 1999. Cognitive functions of the basal forebrain. Curr. Opin. Neurobiol. 9:178-183.
    • (1999) Curr. Opin. Neurobiol. , vol.9 , pp. 178-183
    • Baxter, M.G.1    Chiba, A.A.2
  • 7
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies, P. and Maloney, A. J. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2:1403.
    • (1976) Lancet , vol.2 , pp. 1403
    • Davies, P.1    Maloney, A.J.2
  • 8
    • 0024449354 scopus 로고
    • Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain
    • Mufson, E. J., Bothwell, M., and Kordower, J. H. 1989. Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain. Exp. Neurol. 105:221-232.
    • (1989) Exp. Neurol. , vol.105 , pp. 221-232
    • Mufson, E.J.1    Bothwell, M.2    Kordower, J.H.3
  • 9
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse, P. J., Price, D. L., Struble, R. G., Clark, A. W., Coyle, J. T., and Delon, M. R. 1982. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 215:1237-1239.
    • (1982) Science , vol.215 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3    Clark, A.W.4    Coyle, J.T.5    Delon, M.R.6
  • 10
    • 0035959515 scopus 로고    scopus 로고
    • Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease
    • Chu, Y., Cochran, E. J., Bennett, D. A., Mufson, E. J., and Kordower, J. H. 2001. Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease. J. Comp. Neurol. 437:296-307.
    • (2001) J. Comp. Neurol. , vol.437 , pp. 296-307
    • Chu, Y.1    Cochran, E.J.2    Bennett, D.A.3    Mufson, E.J.4    Kordower, J.H.5
  • 11
    • 0033809884 scopus 로고    scopus 로고
    • Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease
    • Mufson, E. J., Ma, S. Y., Cochran, E. J., Bennett, D. A., Beckett, L. A., Jaffar, S., Saragovi, H. U., and Kordower, J. H. 2000. Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease. J. Comp. Neurol. 427:19-30.
    • (2000) J. Comp. Neurol. , vol.427 , pp. 19-30
    • Mufson, E.J.1    Ma, S.Y.2    Cochran, E.J.3    Bennett, D.A.4    Beckett, L.A.5    Jaffar, S.6    Saragovi, H.U.7    Kordower, J.H.8
  • 13
    • 0024333157 scopus 로고
    • Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients
    • Kordower, J. H., Gash, D. M., Bothwell, M., Hersh, L., and Mufson, E. J. 1989. Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients. Neurobiol. Aging 10:67-74.
    • (1989) Neurobiol. Aging , vol.10 , pp. 67-74
    • Kordower, J.H.1    Gash, D.M.2    Bothwell, M.3    Hersh, L.4    Mufson, E.J.5
  • 14
    • 0031194454 scopus 로고    scopus 로고
    • Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease
    • Mufson, E. J., Lavine, N., Jaffar, S., Kordower, J. H., Quirion, R., and Saragovi H. U. 1997. Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease. Exp. Neurol. 146:91-103.
    • (1997) Exp. Neurol. , vol.146 , pp. 91-103
    • Mufson, E.J.1    Lavine, N.2    Jaffar, S.3    Kordower, J.H.4    Quirion, R.5    Saragovi, H.U.6
  • 16
    • 0026440987 scopus 로고
    • Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations
    • Intraventricular Bethanecol Study Group
    • DeKosky, S. T., Harbaugh, R. E., Schmitt, F. A., Bakay, R. A., Chui, H. C., Knopman, D. S., Reeder, T. M., Shetter, A. G., Senter, H. J., and Markesbery, W. R. 1992. Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group. Ann. Neurol. 32:625-632.
    • (1992) Ann. Neurol. , vol.32 , pp. 625-632
    • DeKosky, S.T.1    Harbaugh, R.E.2    Schmitt, F.A.3    Bakay, R.A.4    Chui, H.C.5    Knopman, D.S.6    Reeder, T.M.7    Shetter, A.G.8    Senter, H.J.9    Markesbery, W.R.10
  • 18
    • 0033530073 scopus 로고    scopus 로고
    • Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease
    • Gilmor, M. L., Erickson, J. D., Varoqui, H., Hersh, L. B., Bennett, D. A., Cochran, E. J., Mufson, E. J., and Levey, A. I. 1999. Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease. J. Comp. Neurol. 411:693-704.
    • (1999) J. Comp. Neurol. , vol.411 , pp. 693-704
    • Gilmor, M.L.1    Erickson, J.D.2    Varoqui, H.3    Hersh, L.B.4    Bennett, D.A.5    Cochran, E.J.6    Mufson, E.J.7    Levey, A.I.8
  • 19
    • 0031657896 scopus 로고    scopus 로고
    • Neurofibrillary degeneration and cell loss in the nucleus basalis in comparison to cortical Alzheimer pathology
    • Cullen, K. M. and Halliday, G. M. 1998. Neurofibrillary degeneration and cell loss in the nucleus basalis in comparison to cortical Alzheimer pathology. Neurobiol. Aging 19:297-306.
    • (1998) Neurobiol. Aging , vol.19 , pp. 297-306
    • Cullen, K.M.1    Halliday, G.M.2
  • 20
    • 0025770134 scopus 로고
    • The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
    • Price, J. L., Davis, P. B., Morris, J. C., and White, D. L. 1991. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol. Aging 12:295-312.
    • (1991) Neurobiol. Aging , vol.12 , pp. 295-312
    • Price, J.L.1    Davis, P.B.2    Morris, J.C.3    White, D.L.4
  • 21
    • 0033922730 scopus 로고    scopus 로고
    • Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert
    • Sassin, I., Schultz, C., Thal, D. R., Rub, U., Arai, K., Braak, E., and Braak, H. 2000. Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert. Acta Neuropathol. (Berl.) 100:259-269.
    • (2000) Acta Neuropathol. (Berl.) , vol.100 , pp. 259-269
    • Sassin, I.1    Schultz, C.2    Thal, D.R.3    Rub, U.4    Arai, K.5    Braak, E.6    Braak, H.7
  • 22
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • Alonso, A. C., Grundke-Iqbal, I., and Iqbal, K. 1996. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat. Med. 2:783-787.
    • (1996) Nat. Med. , vol.2 , pp. 783-787
    • Alonso, A.C.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 23
    • 0017649032 scopus 로고
    • Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin
    • Cleveland, D. W., Hwo, S. Y., and Kirschner, M. W. 1977. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J. Mol. Biol. 116:207-225.
    • (1977) J. Mol. Biol. , vol.116 , pp. 207-225
    • Cleveland, D.W.1    Hwo, S.Y.2    Kirschner, M.W.3
  • 24
    • 0028989895 scopus 로고
    • Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease
    • Callahan, L. M. and Coleman, P. D. 1995. Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease. Neurobiol. Aging 16:311-314.
    • (1995) Neurobiol. Aging , vol.16 , pp. 311-314
    • Callahan, L.M.1    Coleman, P.D.2
  • 25
    • 0033933738 scopus 로고    scopus 로고
    • Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons
    • Ginsberg, S. D., Hemby, S. E., Lee, V. M., Eberwine, J. H., and Trojanowski, J. Q. 2000. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann. Neurol. 48:77-87.
    • (2000) Ann. Neurol. , vol.48 , pp. 77-87
    • Ginsberg, S.D.1    Hemby, S.E.2    Lee, V.M.3    Eberwine, J.H.4    Trojanowski, J.Q.5
  • 26
    • 0037128935 scopus 로고    scopus 로고
    • Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    • Stamer, K., Vogel, R., Thies, E., Mandelkow, E., and Mandelkow, E. M. 2002. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J. Cell. Biol. 156:1051-1063.
    • (2002) J. Cell. Biol. , vol.156 , pp. 1051-1063
    • Stamer, K.1    Vogel, R.2    Thies, E.3    Mandelkow, E.4    Mandelkow, E.M.5
  • 27
    • 0028235419 scopus 로고
    • Synaptic and neuritic alterations during the progression of Alzheimer's disease
    • Masliah, E., Mallory, M., Hansen. L., DeTeresa, R., Alford, M., and Terry R. 1994. Synaptic and neuritic alterations during the progression of Alzheimer's disease. Neurosci. Lett. 174:67-72.
    • (1994) Neurosci. Lett. , vol.174 , pp. 67-72
    • Masliah, E.1    Mallory, M.2    Hansen, L.3    DeTeresa, R.4    Alford, M.5    Terry, R.6
  • 28
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • Selkoe, D. J. 1999. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399:A23-A31.
    • (1999) Nature , vol.399 , pp. A23-A31
    • Selkoe, D.J.1
  • 30
    • 0031957978 scopus 로고    scopus 로고
    • Analysis of message expression in single neurons of Alzheimer's disease brain
    • Callahan, L. M., Chow, N., Cheetham, J. E., Cox, C., and Coleman, P. D. 1998. Analysis of message expression in single neurons of Alzheimer's disease brain. Neurobiol. Aging 19:S99-S105.
    • (1998) Neurobiol. Aging , vol.19 , pp. S99-S105
    • Callahan, L.M.1    Chow, N.2    Cheetham, J.E.3    Cox, C.4    Coleman, P.D.5
  • 37
    • 0035131830 scopus 로고    scopus 로고
    • Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment
    • Kordower, J. H., Chu, Y., Stebbins, G. T., DeKosky, S. T., Cochran, E. J., Bennett, D., and Mufson, E. J. 2001. Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann Neurol. 49:202-213.
    • (2001) Ann Neurol. , vol.49 , pp. 202-213
    • Kordower, J.H.1    Chu, Y.2    Stebbins, G.T.3    DeKosky, S.T.4    Cochran, E.J.5    Bennett, D.6    Mufson, E.J.7
  • 39
    • 0031454720 scopus 로고    scopus 로고
    • Metric properties of nurses' ratings of parkinsonian signs with a modified Unified Parkinson's Disease Rating Scale
    • Bennett, D. A., Shannon, K. M., Beckett, L. A., Goetz, C. G., and Wilson, R. S. 1997. Metric properties of nurses' ratings of parkinsonian signs with a modified Unified Parkinson's Disease Rating Scale. Neurology 49:1580-1587.
    • (1997) Neurology , vol.49 , pp. 1580-1587
    • Bennett, D.A.1    Shannon, K.M.2    Beckett, L.A.3    Goetz, C.G.4    Wilson, R.S.5
  • 41
    • 0024321863 scopus 로고
    • Interrater reliability of the NIH stroke scale
    • Goldstein, L. B., Bertels, C., and Davis, J. N. 1989. Interrater reliability of the NIH stroke scale. Arch. Neurol. 46:660-662.
    • (1989) Arch. Neurol. , vol.46 , pp. 660-662
    • Goldstein, L.B.1    Bertels, C.2    Davis, J.N.3
  • 42
    • 0031019981 scopus 로고    scopus 로고
    • Reliability of the National Institutes of Health Stroke Scale. Extension to non-neurologists in the context of a clinical trial
    • Goldstein, L. B. and Samsa, G. P. 1997. Reliability of the National Institutes of Health Stroke Scale. Extension to non-neurologists in the context of a clinical trial. Stroke 28:307-310.
    • (1997) Stroke , vol.28 , pp. 307-310
    • Goldstein, L.B.1    Samsa, G.P.2
  • 43
    • 0016823810 scopus 로고
    • "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician
    • Folstein, M. F., Folstein, S. E., and McHugh, P. R. 1975. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12:189-198.
    • (1975) J. Psychiatr. Res. , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 44
    • 0024453856 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease
    • Morris, J. C., Heyman, A., Mobs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., and Clark, C. 1989. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 39:1159-1165.
    • (1989) Neurology , vol.39 , pp. 1159-1165
    • Morris, J.C.1    Heyman, A.2    Mobs, R.C.3    Hughes, J.P.4    Van Belle, G.5    Fillenbaum, G.6    Mellits, E.D.7    Clark, C.8
  • 45
    • 0030758156 scopus 로고    scopus 로고
    • Around the WORLD backward: An algorithm for scoring the MMSE WORLD item
    • Beckett, L. A., Wilson, R. S., Bennett, D. A., and Morris, M. C. 1997. Around the WORLD backward: An algorithm for scoring the MMSE WORLD item. Neurology 48:1733-1734.
    • (1997) Neurology , vol.48 , pp. 1733-1734
    • Beckett, L.A.1    Wilson, R.S.2    Bennett, D.A.3    Morris, M.C.4
  • 46
    • 0026633625 scopus 로고
    • Diagnosis of dementia in a heterogeneous population. A comparison of paradigm-based diagnosis and physician's diagnosis
    • Pittman, J., Andrews, H., Tatemichi, T., Link, B., Struening, E., Stern, Y., and Mayeux, R. 1992. Diagnosis of dementia in a heterogeneous population. A comparison of paradigm-based diagnosis and physician's diagnosis. Arch. Neurol. 49:461-467.
    • (1992) Arch. Neurol. , vol.49 , pp. 461-467
    • Pittman, J.1    Andrews, H.2    Tatemichi, T.3    Link, B.4    Struening, E.5    Stern, Y.6    Mayeux, R.7
  • 47
    • 0030066467 scopus 로고    scopus 로고
    • Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study
    • Snowdon, D. A., Kemper, S. J., Mortimer, J. A., Greiner, L. H., Wekstein, D. R., and Markesbery, W. R. 1996. Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study. JAMA 275: 528-532.
    • (1996) JAMA , vol.275 , pp. 528-532
    • Snowdon, D.A.1    Kemper, S.J.2    Mortimer, J.A.3    Greiner, L.H.4    Wekstein, D.R.5    Markesbery, W.R.6
  • 48
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., and Stadlan, E. M. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 49
    • 0031255112 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease
    • Hyman, B. T. and Trojanowski, J. Q. 1997. Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J. Neuropathol. Exp. Neurol. 56:1095-1097.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 1095-1097
    • Hyman, B.T.1    Trojanowski, J.Q.2
  • 50
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., van Belle, G., and Berg, L. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41:479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Van Belle, G.9    Berg, L.10
  • 51
    • 0031045396 scopus 로고    scopus 로고
    • Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques
    • Ginsberg, S. D., Crino, P. B., Lee, V. M., Eberwine, J. H., and Trojanowski, J. Q. 1997. Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques. Ann. Neurol. 41:200-209.
    • (1997) Ann. Neurol. , vol.41 , pp. 200-209
    • Ginsberg, S.D.1    Crino, P.B.2    Lee, V.M.3    Eberwine, J.H.4    Trojanowski, J.Q.5
  • 53
    • 0002498012 scopus 로고    scopus 로고
    • The use of fixed human postmortem brain tissue to study mRNA expression in neurodegenerative diseases: Applications of microdissection and mRNA amplification
    • Geschwind, D. H. and Gregg, J. (eds.), MIT Press, Boston
    • Van Deerlin, V. M. D., Ginsberg, S. D., Lee, V. M.-Y., and Trojanowski, J. Q. 2002. The use of fixed human postmortem brain tissue to study mRNA expression in neurodegenerative diseases: Applications of microdissection and mRNA amplification. Pages 201-235, in Geschwind, D. H. and Gregg, J. (eds.), Microarrays for the Neurosciences: An Essential Guide, MIT Press, Boston.
    • (2002) Microarrays for the Neurosciences: An Essential Guide , pp. 201-235
    • Van Deerlin, V.M.D.1    Ginsberg, S.D.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4
  • 54
    • 0023791061 scopus 로고
    • Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): Distribution, morphology, and colocalization with cholinergic enzymes
    • Kordower, J. H., Bartus, R. T., Bothwell, M., Schatteman, G., and Gash, D. M. 1988. Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): Distribution, morphology, and colocalization with cholinergic enzymes. J. Comp. Neurol. 277:465-486.
    • (1988) J. Comp. Neurol. , vol.277 , pp. 465-486
    • Kordower, J.H.1    Bartus, R.T.2    Bothwell, M.3    Schatteman, G.4    Gash, D.M.5
  • 55
    • 0024374634 scopus 로고
    • Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: Colocalization with cholinergic neurons
    • Mufson, E. J., Bothwell, M., Hersh, L. B., and Kordower, J. H. 1989. Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: Colocalization with cholinergic neurons. J. Comp. Neurol. 285:196-217.
    • (1989) J. Comp. Neurol. , vol.285 , pp. 196-217
    • Mufson, E.J.1    Bothwell, M.2    Hersh, L.B.3    Kordower, J.H.4
  • 56
    • 0023839066 scopus 로고
    • Expression of NGF receptor in the developing and adult primate central nervous system
    • Schatteman, G. C., Gibbs, L., Lanahan, A. A., Claude, P., and Bothwell, M. 1988. Expression of NGF receptor in the developing and adult primate central nervous system. J. Neurosci. 8: 860-873.
    • (1988) J. Neurosci. , vol.8 , pp. 860-873
    • Schatteman, G.C.1    Gibbs, L.2    Lanahan, A.A.3    Claude, P.4    Bothwell, M.5
  • 57
    • 0020423085 scopus 로고
    • A comparison of fixatives and immunohistochemical technics for use with monoclonal antibodies to cell surface antigens
    • Hancock, W. W., Becker, G. J., and Atkins, R. C. 1982. A comparison of fixatives and immunohistochemical technics for use with monoclonal antibodies to cell surface antigens. Am. J. Clin. Pathol. 78:825-831.
    • (1982) Am. J. Clin. Pathol. , vol.78 , pp. 825-831
    • Hancock, W.W.1    Becker, G.J.2    Atkins, R.C.3
  • 58
    • 0028585824 scopus 로고
    • APOE is a major susceptibility gene for Alzheimer's disease
    • Roses, A. D. and Saunders, A. M. 1994. APOE is a major susceptibility gene for Alzheimer's disease. Curr. Opin. Biotechnol. 5:663-667.
    • (1994) Curr. Opin. Biotechnol. , vol.5 , pp. 663-667
    • Roses, A.D.1    Saunders, A.M.2
  • 59
    • 85011844627 scopus 로고    scopus 로고
    • Amplification of transcripts using terminal continuation
    • Submitted
    • Che, S. and Ginsberg, S. D. 2002. Amplification of transcripts using terminal continuation. Nat. Biotechnol. Submitted.
    • (2002) Nat. Biotechnol.
    • Che, S.1    Ginsberg, S.D.2
  • 60
    • 0036808012 scopus 로고    scopus 로고
    • RNA amplification in brain tissues
    • Ginsberg, S. D. and Che, S. 2002. RNA amplification in brain tissues. Neurochem. Res. 27:981-992.
    • (2002) Neurochem. Res. , vol.27 , pp. 981-992
    • Ginsberg, S.D.1    Che, S.2
  • 63
    • 0003278818 scopus 로고    scopus 로고
    • Neuron specific age related decreases in dopamine receptor subtype mRNAs
    • in press
    • Hemby, S. E. Trojanowski, J. Q., and Ginsberg, S. D. 2002. Neuron specific age related decreases in dopamine receptor subtype mRNAs. J. Comp. Neurol., in press.
    • (2002) J. Comp. Neurol.
    • Hemby, S.E.1    Trojanowski, J.Q.2    Ginsberg, S.D.3
  • 64
    • 0028090302 scopus 로고
    • The Trk family of neurotrophin receptors
    • Barbacid, M. 1994. The Trk family of neurotrophin receptors. J Neurobiol 25:1386-1403.
    • (1994) J Neurobiol. , vol.25 , pp. 1386-1403
    • Barbacid, M.1
  • 65
    • 0031148892 scopus 로고    scopus 로고
    • Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease
    • Boissiere, F., Faucheux, B., Ruberg, M., Agid, Y., and Hirsch, E. C. 1997. Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease. Exp. Neurol. 145:245-252.
    • (1997) Exp. Neurol. , vol.145 , pp. 245-252
    • Boissiere, F.1    Faucheux, B.2    Ruberg, M.3    Agid, Y.4    Hirsch, E.C.5
  • 66
    • 0030939457 scopus 로고    scopus 로고
    • Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease
    • Mufson, E. J., Li, J. M., Sobreviela, T., and Kordower, J. H. 1996. Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease. Neuroreport 8:25-29.
    • (1996) Neuroreport , vol.8 , pp. 25-29
    • Mufson, E.J.1    Li, J.M.2    Sobreviela, T.3    Kordower, J.H.4
  • 67
    • 0025096474 scopus 로고
    • Cholinergic neurons of the nucleus basalis express elevated levels of nerve growth factor receptor mRNA in senile dementia of the Alzheimer's type
    • Ernfors, P., Lindefors, N., Chan-Palay, V., and Persson, H. 1990. Cholinergic neurons of the nucleus basalis express elevated levels of nerve growth factor receptor mRNA in senile dementia of the Alzheimer's type. Dementia 1:138-145.
    • (1990) Dementia , vol.1 , pp. 138-145
    • Ernfors, P.1    Lindefors, N.2    Chan-Palay, V.3    Persson, H.4
  • 69
    • 0026693260 scopus 로고
    • Effects of estrogen and fimbria/fornix transection on p75NGFR and ChAT expression in the medial septum and diagonal band of Broca
    • Gibbs, R. B. and Pfaff, D. W. 1992. Effects of estrogen and fimbria/fornix transection on p75NGFR and ChAT expression in the medial septum and diagonal band of Broca. Exp. Neurol. 116:23-39.
    • (1992) Exp. Neurol. , vol.116 , pp. 23-39
    • Gibbs, R.B.1    Pfaff, D.W.2
  • 70
    • 0027944164 scopus 로고
    • trk-immunoreactivity in the monkey central nervous system: Forebrain
    • Kordower, J. H., Chen, E. Y., Sladek, J. R., Jr., and Mufson, E. J. 1994. trk-immunoreactivity in the monkey central nervous system: forebrain. J. Comp. Neurol. 349:20-35.
    • (1994) J. Comp. Neurol. , vol.349 , pp. 20-35
    • Kordower, J.H.1    Chen, E.Y.2    Sladek, J.R.3    Mufson, E.J.4
  • 71
    • 0027938821 scopus 로고
    • TrkA-immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin
    • Sobreviela, T., Clary, D. O., Reichardt, L. F., Brandabur, M. M., Kordower, J. H., and Mufson. E. J. 1994. TrkA-immunoreactive profiles in the central nervous system: colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin. J. Comp. Neurol. 350:587-611.
    • (1994) J. Comp. Neurol. , vol.350 , pp. 587-611
    • Sobreviela, T.1    Clary, D.O.2    Reichardt, L.F.3    Brandabur, M.M.4    Kordower, J.H.5    Mufson, E.J.6
  • 72
    • 0343554739 scopus 로고    scopus 로고
    • Expression of catalytic trkB gene in the striatum and the basal forebrain of patients with Alzheimer's disease: An in situ hybridization study
    • Boissiere, F., Faucheux, B., Agid, Y., and Hirsch, E. C. 1997. Expression of catalytic trkB gene in the striatum and the basal forebrain of patients with Alzheimer's disease: An in situ hybridization study. Neurosci. Lett. 221:141-144.
    • (1997) Neurosci. Lett. , vol.221 , pp. 141-144
    • Boissiere, F.1    Faucheux, B.2    Agid, Y.3    Hirsch, E.C.4
  • 73
    • 0030601663 scopus 로고    scopus 로고
    • Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease
    • Salehi, A., Verhaagen, J., Dijkhuizen, P. A., and Swaab, D. F. 1996. Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience 75:373-387.
    • (1996) Neuroscience , vol.75 , pp. 373-387
    • Salehi, A.1    Verhaagen, J.2    Dijkhuizen, P.A.3    Swaab, D.F.4
  • 74
    • 0032904490 scopus 로고    scopus 로고
    • Distribution and retrograde transport of trophic factors in the central nervous system: Functional implications for the treatment of neurodegenerative diseases
    • Mufson, E. J., Kroin, J. S., Sendera, T. J., and Sobreviela, T. 1999. Distribution and retrograde transport of trophic factors in the central nervous system: Functional implications for the treatment of neurodegenerative diseases. Prog. Neurobiol. 57:451-484.
    • (1999) Prog. Neurobiol. , vol.57 , pp. 451-484
    • Mufson, E.J.1    Kroin, J.S.2    Sendera, T.J.3    Sobreviela, T.4
  • 75
    • 0026046426 scopus 로고
    • Brain-derived neurotrophic factor: Subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies
    • Wetmore, C., Cao, Y. H., Pettersson, R. F., and Olson, L. 1991. Brain-derived neurotrophic factor: Subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies. Proc. Natl. Acad. Sci. USA 88:9843-9847.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 9843-9847
    • Wetmore, C.1    Cao, Y.H.2    Pettersson, R.F.3    Olson, L.4
  • 76
    • 0033536017 scopus 로고    scopus 로고
    • Synergistic effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on cultured basal forebrain cholinergic neurons from postnatal 2-week-old rats
    • Hashimoto, Y., Abiru, Y., Nishio, C., and Hatanaka, H. 1999. Synergistic effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on cultured basal forebrain cholinergic neurons from postnatal 2-week-old rats. Brain Res. Dev. Brain Res. 115:25-32.
    • (1999) Brain Res. Dev. Brain Res. , vol.115 , pp. 25-32
    • Hashimoto, Y.1    Abiru, Y.2    Nishio, C.3    Hatanaka, H.4
  • 77
    • 0029038125 scopus 로고
    • Cultured basal forebrain cholinergic neurons from postnatal rats show both overlapping and non-overlapping responses to the neurotrophins
    • Nonomura, T., Nishio, C., Lindsay, R. M., and Hatanaka, H. 1995. Cultured basal forebrain cholinergic neurons from postnatal rats show both overlapping and non-overlapping responses to the neurotrophins. Brain. Res. 683:129-139.
    • (1995) Brain. Res. , vol.683 , pp. 129-139
    • Nonomura, T.1    Nishio, C.2    Lindsay, R.M.3    Hatanaka, H.4
  • 78
    • 0033517723 scopus 로고    scopus 로고
    • Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease
    • Allen, S. J., Wilcock, G. K., and Dawbarn, D. 1999. Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease. Biochem. Biophys. Res. Commun. 264:648-651.
    • (1999) Biochem. Biophys. Res. Commun. , vol.264 , pp. 648-651
    • Allen, S.J.1    Wilcock, G.K.2    Dawbarn, D.3
  • 79
    • 0032805204 scopus 로고    scopus 로고
    • BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies Neuropathol
    • Ferrer, I., Marin, C., Rey, M. J., Ribalta, T., Goutan, E., Blanco, R., Tolosa, E., and Marti, E. 1999. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. J. Neuropathol. Exp. Neurol. 58:729- 739.
    • (1999) J. Exp. Neurol. , vol.58 , pp. 729-739
    • Ferrer, I.1    Marin, C.2    Rey, M.J.3    Ribalta, T.4    Goutan, E.5    Blanco, R.6    Tolosa, E.7    Marti, E.8
  • 80
    • 0034087784 scopus 로고    scopus 로고
    • Region-specific neurotrophin imbalances in Alzheimer disease: Decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas
    • Hock, C., Heese, K., Hulette, C., Rosenberg, C., and Otten, U. 2000. Region-specific neurotrophin imbalances in Alzheimer disease: Decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch. Neurol. 57:846-851.
    • (2000) Arch. Neurol. , vol.57 , pp. 846-851
    • Hock, C.1    Heese, K.2    Hulette, C.3    Rosenberg, C.4    Otten, U.5
  • 82
    • 0033768568 scopus 로고    scopus 로고
    • Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease
    • Savaskan, E., Muller-Spahn, F., Olivieri, G., Bruttel, S., Otten, U., Rosenberg, C., Hulette, C., and Hock, C. 2000. Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease. Eur. Neurol. 44: 172-180.
    • (2000) Eur. Neurol. , vol.44 , pp. 172-180
    • Savaskan, E.1    Muller-Spahn, F.2    Olivieri, G.3    Bruttel, S.4    Otten, U.5    Rosenberg, C.6    Hulette, C.7    Hock, C.8
  • 83
    • 0035830408 scopus 로고    scopus 로고
    • Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
    • Masliah, E., Mallory, M., Alford, M., DeTeresa, R., Hansen, L. A., McKeel, D. W., Jr., and Morris, J. C. 2001. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology 56:127-129.
    • (2001) Neurology , vol.56 , pp. 127-129
    • Masliah, E.1    Mallory, M.2    Alford, M.3    DeTeresa, R.4    Hansen, L.A.5    McKeel, D.W.6    Morris, J.C.7
  • 84
    • 0031778614 scopus 로고    scopus 로고
    • Neurochemical dissection of synaptic pathology in Alzheimer's disease
    • Davidsson, P. and Blennow, K. 1998. Neurochemical dissection of synaptic pathology in Alzheimer's disease. Int. Psychogeriatr. 10:11-23.
    • (1998) Int. Psychogeriatr. , vol.10 , pp. 11-23
    • Davidsson, P.1    Blennow, K.2
  • 85
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • DeKosky, S. T. and Scheff, S. W. 1990. Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity. Ann. Neurol. 27:457-464.
    • (1990) Ann. Neurol. , vol.27 , pp. 457-464
    • DeKosky, S.T.1    Scheff, S.W.2
  • 87
    • 0033029043 scopus 로고    scopus 로고
    • Genetics of synaptic vesicle function: Toward the complete functional anatomy of an organelle
    • Fernandez-Chacon, R. and Sudhof, T. C. 1999. Genetics of synaptic vesicle function: Toward the complete functional anatomy of an organelle. Annu. Rev. Physiol. 61:753-776.
    • (1999) Annu. Rev. Physiol. , vol.61 , pp. 753-776
    • Fernandez-Chacon, R.1    Sudhof, T.C.2
  • 89
    • 0028879044 scopus 로고
    • Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: Implication of phosphoprotein phosphatase involvement
    • Baum, L., Seger, R., Woodgett, J. R., Kawabata, S., Maruyama, K., Koyama, M., Silver, J., and Saitoh, T. 1995. Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: Implication of phosphoprotein phosphatase involvement. Brain Res. Mol. Brain Res. 34:1-17.
    • (1995) Brain Res. Mol. Brain Res. , vol.34 , pp. 1-17
    • Baum, L.1    Seger, R.2    Woodgett, J.R.3    Kawabata, S.4    Maruyama, K.5    Koyama, M.6    Silver, J.7    Saitoh, T.8
  • 90
    • 0030813929 scopus 로고    scopus 로고
    • Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons
    • Merrick, S. E., Trojanowski, J. Q., and Lee, V. M. 1997. Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons. J. Neurosci. 17:5726-5737.
    • (1997) J. Neurosci. , vol.17 , pp. 5726-5737
    • Merrick, S.E.1    Trojanowski, J.Q.2    Lee, V.M.3
  • 91
    • 0345512210 scopus 로고
    • Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
    • Pearson, R. C., Esiri, M. M., Hiorns, R. W., Wilcock, G. K., and Powell, T. P. 1985. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. Proc. Natl. Acad. Sci. USA 82:4531-4534.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 4531-4534
    • Pearson, R.C.1    Esiri, M.M.2    Hiorns, R.W.3    Wilcock, G.K.4    Powell, T.P.5
  • 92
    • 0019440757 scopus 로고
    • Regional pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading
    • Brun, A. and Englund, E. 1981. Regional pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading. Histopathology 5:549-564.
    • (1981) Histopathology , vol.5 , pp. 549-564
    • Brun, A.1    Englund, E.2
  • 93
    • 0028947294 scopus 로고
    • Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
    • Cataldo, A. M., Barnett, J. L., Berman, S. A., Li, J., Quarless, S., Bursztajn, S., Lippa, C., and Nixon, R. A. 1995. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron 14:671-680.
    • (1995) Neuron , vol.14 , pp. 671-680
    • Cataldo, A.M.1    Barnett, J.L.2    Berman, S.A.3    Li, J.4    Quarless, S.5    Bursztajn, S.6    Lippa, C.7    Nixon, R.A.8
  • 94
    • 0030045552 scopus 로고    scopus 로고
    • Properties of the endosomal-lysosomal system in the human central nervous system: Disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease
    • Cataldo, A. M., Hamilton, D. J., Barnett, J. L., Paskevich, P. A., and Nixon, R. A. 1996. Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J. Neurosci. 16:186-199.
    • (1996) J. Neurosci. , vol.16 , pp. 186-199
    • Cataldo, A.M.1    Hamilton, D.J.2    Barnett, J.L.3    Paskevich, P.A.4    Nixon, R.A.5
  • 95
    • 0030836345 scopus 로고    scopus 로고
    • Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathologic evidence for a mechanism of increased beta-amyloidogenesis
    • Cataldo, A. M., Barnett, J. L., Pieroni, C., and Nixon, R. A. 1997. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. J. Neurosci. 17:6142-6151.
    • (1997) J. Neurosci. , vol.17 , pp. 6142-6151
    • Cataldo, A.M.1    Barnett, J.L.2    Pieroni, C.3    Nixon, R.A.4
  • 96
    • 0037085458 scopus 로고    scopus 로고
    • Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: Role for altered lysosomal hydrolase distribution in beta-amyloidogenesis
    • Mathews, P. M., Guerra, C. B., Jiang, Y., Grbovic, O. M., Kao, B. H., Schmidt, S. D., Dinakar, R., Mercken, M., Hille-Rehfeld, A., Rohrer, J., Mehta, P., Cataldo, A. M., and Nixon, R. A. 2002. Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: Role for altered lysosomal hydrolase distribution in beta-amyloidogenesis. J. Biol. Chem, 277:5299-5307.
    • (2002) J. Biol. Chem. , vol.277 , pp. 5299-5307
    • Mathews, P.M.1    Guerra, C.B.2    Jiang, Y.3    Grbovic, O.M.4    Kao, B.H.5    Schmidt, S.D.6    Dinakar, R.7    Mercken, M.8    Hille-Rehfeld, A.9    Rohrer, J.10    Mehta, P.11    Cataldo, A.M.12    Nixon, R.A.13


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.