Structural basis for ligand binding and specificity in adrenergic receptors: Implications for GPCR-targeted drug discovery

Biochemistry

Volumn 47, Issue 42, 2008, Pages 11013-11023

  Huber, Thomas ^a   Menon, Santosh ^a   Sakmar, Thomas P ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGON; BINDING ENERGY; BIOCHEMISTRY; CELL MEMBRANES; CHROMOPHORES; CONFORMATIONS; DATA STRUCTURES; DYNAMICS; LIGANDS; MOLECULAR DYNAMICS; QUANTUM CHEMISTRY; THREE DIMENSIONAL;

ACTIVE SITES; ADRENERGIC RECEPTORS; BINDING POCKETS; COMPLEMENTARY; CONFORMATIONAL CHANGES; CONFORMATIONAL DYNAMICS; COUPLED RECEPTORS; DRUG DISCOVERIES; EXTRACELLULAR; G PROTEINS; KEY FEATURES; LIGAND BINDINGS; LIGAND SPECIFICITIES; LOOP STRUCTURES; MEMBRANE BILAYERS; MOLECULAR DYNAMICS SIMULATIONS; RECEPTOR CONFORMATIONS; ROD CELLS; SHEET STRUCTURES; STRUCTURAL BASES; STRUCTURAL DETERMINANTS; STRUCTURAL SIMILARITIES; STRUCTURE-ACTIVITY RELATIONSHIPS; TRANSMEMBRANE;

BINDING SITES;

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ADRENALIN; ADRENERGIC RECEPTOR; ALPRENOLOL; ATYPICAL ANTIPSYCHOTIC AGENT; BETA 2 ADRENERGIC RECEPTOR; CARAZOLOL; CARVEDILOL; CHLORPROMAZINE; CLOZAPINE; DIHYDROALPRENOLOL; FORMOTEROL; G PROTEIN COUPLED RECEPTOR; ISOPRENALINE; LABETALOL; METOPROLOL; PROPRANOLOL; RISPERIDONE; SALBUTAMOL;

CONFORMATIONAL TRANSITION; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW;

ADRENERGIC BETA-AGONISTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; EPINEPHRINE; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; THERMODYNAMICS;

EID: 54449098286     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800891r     Document Type: Review

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