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Volumn 71, Issue 3, 1996, Pages 187-204

Dopamine and serotonin receptors: Amino acid sequences, and clinical role in neuroleptic parkinsonism

Author keywords

Antipsychotic drug; Catalepsy; Clozapine; Dopamine D4 receptor; Parkinsonism; Serotonin 2 receptor

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR; FLUPHENAZINE; HALOPERIDOL; LEVODOPA; LOXAPINE; MELPERONE; MOLINDONE; NEUROLEPTIC AGENT; OLANZAPINE; PERLAPINE; QUETIAPINE; RACLOPRIDE; RADIOLIGAND; REMOXIPRIDE; RISPERIDONE; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; SERTINDOLE; THIORIDAZINE; TRIFLUOPERAZINE;

EID: 0029841131     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.71.187     Document Type: Review
Times cited : (46)

References (140)
  • 4
    • 0025881062 scopus 로고
    • Three-dimensional models of neurotransmitter G-binding protein-coupled receptors
    • Hibert MF, Trumpp-Kallmeyer S, Bruinvels A and Hoflack J: Three-dimensional models of neurotransmitter G-binding protein-coupled receptors. Mol Pharmacol 40, 8-15 (1991)
    • (1991) Mol Pharmacol , vol.40 , pp. 8-15
    • Hibert, M.F.1    Trumpp-Kallmeyer, S.2    Bruinvels, A.3    Hoflack, J.4
  • 5
    • 0025863465 scopus 로고
    • Pivotal role for aspartate-80 in the regulation of dopa- Mine D2 receptor affinity for drugs and inhibition of adenylyl cyclase
    • Neve KA, Cox BA, Henningsen RA, Spanoyannis A and Neve RL: Pivotal role for aspartate-80 in the regulation of dopa- mine D2 receptor affinity for drugs and inhibition of adenylyl cyclase. Mol Pharmacol 39, 733-739 (1991)
    • (1991) Mol Pharmacol , vol.39 , pp. 733-739
    • Neve, K.A.1    Cox, B.A.2    Henningsen, R.A.3    Spanoyannis, A.4    Neve, R.L.5
  • 6
    • 0027986462 scopus 로고
    • 2-adrenergic receptor-G-protein interactions
    • 2-adrenergic receptor-G-protein interactions. J Biol Chem 269, 29557-29564 (1994)
    • (1994) J Biol Chem , vol.269 , pp. 29557-29564
    • Ceresa, B.P.1    Limbird, L.E.2
  • 12
    • 0027996410 scopus 로고
    • Molecular biology of serotonin (5-HT) receptors
    • Peroutka SJ: Molecular biology of serotonin (5-HT) receptors. Synapse 18, 241-260 (1994)
    • (1994) Synapse , vol.18 , pp. 241-260
    • Peroutka, S.J.1
  • 14
    • 0029003491 scopus 로고
    • New players in the 5-HT receptor field: Genes and knockouts
    • Lucas JJ and Hen R: New players in the 5-HT receptor field: genes and knockouts. Trends Pharmacol Sci 16, 246-252 (1995)
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 246-252
    • Lucas, J.J.1    Hen, R.2
  • 16
    • 0016287562 scopus 로고
    • Dopamine receptor-block and nigral fiber-impulse blockade by major tranquilizers
    • Seeman P, Wong M and Lee T: Dopamine receptor-block and nigral fiber-impulse blockade by major tranquilizers. Fed Proc 33, 246 (1974)
    • (1974) Fed Proc , vol.33 , pp. 246
    • Seeman, P.1    Wong, M.2    Lee, T.3
  • 17
    • 0010686493 scopus 로고
    • Brain receptors for antipsychotic drugs and dopamine: Direct binding assays
    • Seeman P, Chau-Wong M, Tedesco J and Wong K: Brain receptors for antipsychotic drugs and dopamine: Direct binding assays. Proc Natl Acad Sci USA 72, 4376-4380 (1975)
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 4376-4380
    • Seeman, P.1    Chau-Wong, M.2    Tedesco, J.3    Wong, K.4
  • 18
    • 0017255979 scopus 로고
    • Dopamine receptor binding predicts clinical and pharmacological potencies of anti-schizophrenic drugs
    • Creese I, Burt DR and Snyder SH: Dopamine receptor binding predicts clinical and pharmacological potencies of anti-schizophrenic drugs. Science 192, 481-483 (1976)
    • (1976) Science , vol.192 , pp. 481-483
    • Creese, I.1    Burt, D.R.2    Snyder, S.H.3
  • 19
    • 0026481115 scopus 로고
    • Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2, clozapine occupies D4
    • Seeman P: Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2, clozapine occupies D4. Neuropsychopharmacology 7, 261-284 (1992)
    • (1992) Neuropsychopharmacology , vol.7 , pp. 261-284
    • Seeman, P.1
  • 21
    • 0026357347 scopus 로고
    • Effects of antipsychotic drugs on serotonin receptors
    • Meltzer HY and Nash JF: Effects of antipsychotic drugs on serotonin receptors. Pharmacol Rev 43, 587-604 (1991)
    • (1991) Pharmacol Rev , vol.43 , pp. 587-604
    • Meltzer, H.Y.1    Nash, J.F.2
  • 22
    • 0024468417 scopus 로고
    • Clinical studies on the mechanism of action of clozapine: The dopamine-serotonin hypothesis of schizophrenia
    • Meltzer HY: Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology (Berlin) 99, S18-S27 (1989)
    • (1989) Psychopharmacology (Berlin) , vol.99
    • Meltzer, H.Y.1
  • 23
    • 0028888599 scopus 로고
    • The role of serotonin in schizophrenia and the place of serotonin-dopamine antagonist antipsychotics
    • Meltzer HY: The role of serotonin in schizophrenia and the place of serotonin-dopamine antagonist antipsychotics. J Clin Psychopharmacol 15, Supp 1, 2S-3S (1995)
    • (1995) J Clin Psychopharmacol , vol.15 , Issue.1 SUPPL.
    • Meltzer, H.Y.1
  • 24
    • 4243577554 scopus 로고
    • Finely balanced 5HT2/D2-antagonism: A crucial factor for the treatment of schizophrenia
    • Leysen JE, Megens AAHH, Janssen PMF and Schotte A: Finely balanced 5HT2/D2-antagonism: A crucial factor for the treatment of schizophrenia. Neuropsychopharmacology 10, Supp 3, 467S (1994)
    • (1994) Neuropsychopharmacology , vol.10 , Issue.3 SUPPL.
    • Leysen, J.E.1    Megens, A.A.H.H.2    Janssen, P.M.F.3    Schotte, A.4
  • 25
    • 0028870605 scopus 로고
    • The evolution of the serotonin-dopamine antagonist concept
    • Huttunen M: The evolution of the serotonin-dopamine antagonist concept. J Clin Psychopharmacol 15, Supp 1, 4S-10S (1995)
    • (1995) J Clin Psychopharmacol , vol.15 , Issue.1 SUPPL.
    • Huttunen, M.1
  • 28
    • 0029612808 scopus 로고
    • Therapeutic receptor-blocking concentrations of neuroleptics
    • Seeman P: Therapeutic receptor-blocking concentrations of neuroleptics. Int Clin Psychopharmacol 10, Supp 3, 5-13 (1995)
    • (1995) Int Clin Psychopharmacol , vol.10 , Issue.3 SUPPL. , pp. 5-13
    • Seeman, P.1
  • 33
    • 0026458521 scopus 로고
    • Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum
    • Kawagoe KT, Garris PA, Wiedemann DJ and Wightman RM: Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum. Neuroscience 51, 55-64 (1992)
    • (1992) Neuroscience , vol.51 , pp. 55-64
    • Kawagoe, K.T.1    Garris, P.A.2    Wiedemann, D.J.3    Wightman, R.M.4
  • 37
    • 0028920801 scopus 로고
    • Plasma clozapine levels and the treatment of L-DOPA-induced psychosis in Parkinson's disease
    • Meltzer HY, Kennedy J, Dai J, Parsa M and Riley D: Plasma clozapine levels and the treatment of L-DOPA-induced psychosis in Parkinson's disease. Neuropsychopharmacology 12, 39-45 (1995)
    • (1995) Neuropsychopharmacology , vol.12 , pp. 39-45
    • Meltzer, H.Y.1    Kennedy, J.2    Dai, J.3    Parsa, M.4    Riley, D.5
  • 39
    • 4243652088 scopus 로고
    • The mechanism of antipsychotic drug action examined by PET in schizophrenic patients
    • Nordström A-L: The mechanism of antipsychotic drug action examined by PET in schizophrenic patients. Neuropsychopharmacology 10, Supp 3, Part 1, 695S (1994)
    • (1994) Neuropsychopharmacology , vol.10 , Issue.SUPP 3 AND PART 1
    • Nordström, A.-L.1
  • 43
    • 0000514829 scopus 로고
    • Dopamine receptors. Clinical correlates
    • Edited by Bloom FE and Kupfer DJ, Raven Press, New York
    • Seeman P: Dopamine receptors. Clinical correlates. In Psychopharmacology: The Fourth Generation of Progress, Edited by Bloom FE and Kupfer DJ, pp 295-302, Raven Press, New York (1995)
    • (1995) Psychopharmacology: the Fourth Generation of Progress , pp. 295-302
    • Seeman, P.1
  • 44
    • 0024595594 scopus 로고
    • 3H]-raclopride: Implications for positron emission tomography of the human brain
    • 3H]-raclopride: implications for positron emission tomography of the human brain. Synapse 3, 96-97 (1989)
    • (1989) Synapse , vol.3 , pp. 96-97
    • Seeman, P.1    Guan, H.-C.2    Niznik, H.B.3
  • 51
  • 56
    • 0015609958 scopus 로고
    • Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system
    • Andén N-E and Stock G: Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system. J Pharm Pharmacol 25, 346-348 (1973)
    • (1973) J Pharm Pharmacol , vol.25 , pp. 346-348
    • Andén, N.-E.1    Stock, G.2
  • 57
    • 0021361110 scopus 로고
    • Homovanillic acid in caudate and pre-frontal cortex following neuroleptics
    • Bowers MB Jr: Homovanillic acid in caudate and pre-frontal cortex following neuroleptics. Eur J Pharmacol 99, 103-105 (1984)
    • (1984) Eur J Pharmacol , vol.99 , pp. 103-105
    • Bowers Jr., M.B.1
  • 60
    • 0025003934 scopus 로고
    • Atypical neuroleptics: Role of multiple receptors, endogenous dopamine, and receptor linkage
    • Seeman P: Atypical neuroleptics: role of multiple receptors, endogenous dopamine, and receptor linkage. Acta Psychiatry Scand 82, Supp 358, 14-20 (1990)
    • (1990) Acta Psychiatry Scand , vol.82 , Issue.358 SUPPL. , pp. 14-20
    • Seeman, P.1
  • 61
    • 0024469128 scopus 로고
    • Sterically hindered 5,1-dicarbo analogues of clozapine as potential chiral antipsychotic agents
    • Rupard JH, de Paulis T, Janowsky A and Smith HE: Sterically hindered 5,1-dicarbo analogues of clozapine as potential chiral antipsychotic agents. J Med Chem 32, 2261-2268 (1989)
    • (1989) J Med Chem , vol.32 , pp. 2261-2268
    • Rupard, J.H.1    De Paulis, T.2    Janowsky, A.3    Smith, H.E.4
  • 62
    • 0023812652 scopus 로고
    • Clozapine for the treatment-resistant schizophrenic
    • Kane J, Honigfeld G, Singer J, Meltzer H and the Clozaril Collaborative Study Group: Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatry 45, 789-796 (1988)
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 789-796
    • Kane, J.1    Honigfeld, G.2    Singer, J.3    Meltzer, H.4
  • 65
    • 0011300722 scopus 로고
    • Systemic and intracortical administration of ritanserin increases in vivo dopamine release in rat prefrontal cortex
    • Pehek EA: Systemic and intracortical administration of ritanserin increases in vivo dopamine release in rat prefrontal cortex. Schizophrenia Res 15, 161 (1995)
    • (1995) Schizophrenia Res , vol.15 , pp. 161
    • Pehek, E.A.1
  • 66
    • 0000149016 scopus 로고
    • 5HT2-Receptor antagonists can attenuate submaximal haloperidol-induced catalepsy in rats
    • Bligh-Glover W, Jaskiw GE, Vrtunski B, Ubogy D and Meltzer HY: 5HT2-Receptor antagonists can attenuate submaximal haloperidol-induced catalepsy in rats. Schizophrenia Res 15, 153-154 (1995)
    • (1995) Schizophrenia Res , vol.15 , pp. 153-154
    • Bligh-Glover, W.1    Jaskiw, G.E.2    Vrtunski, B.3    Ubogy, D.4    Meltzer, H.Y.5
  • 67
    • 0026701850 scopus 로고
    • Antagonism by 8-OH-DPAT, but not ritanserin, of catalepsy induced by SCH 23390 in the rat
    • Wadenberg M-L: Antagonism by 8-OH-DPAT, but not ritanserin, of catalepsy induced by SCH 23390 in the rat. J Neural Transm 89, 49-59 (1992)
    • (1992) J Neural Transm , vol.89 , pp. 49-59
    • Wadenberg, M.-L.1
  • 68
    • 0011300285 scopus 로고
    • Clozapine's inability to induce experimental catalepsy is not altered by changes in serotonergic transmission
    • Jaskiw GE, Ubogy D and Meltzer HY: Clozapine's inability to induce experimental catalepsy is not altered by changes in serotonergic transmission. Soc Neurosci Abstr 20, 225 (1994)
    • (1994) Soc Neurosci Abstr , vol.20 , pp. 225
    • Jaskiw, G.E.1    Ubogy, D.2    Meltzer, H.Y.3
  • 71
    • 0011381786 scopus 로고
    • The effect of a serotonin S2 antagonist, ritanserine, and an anticholinergic benztropine on haloperidol-induced dystonia in nonhuman primates
    • Casey DE: The effect of a serotonin S2 antagonist, ritanserine, and an anticholinergic benztropine on haloperidol-induced dystonia in nonhuman primates. Am Coll Neuropsychopharmacol (Abstr) 30, 127 (1991)
    • (1991) Am Coll Neuropsychopharmacol (Abstr) , vol.30 , pp. 127
    • Casey, D.E.1
  • 72
    • 0027254315 scopus 로고
    • Serotonergic and dopaminergic aspects of neuroleptic-induced extrapyramidal syndromes in nonhuman primates
    • Casey DE: Serotonergic and dopaminergic aspects of neuroleptic-induced extrapyramidal syndromes in nonhuman primates. Psychopharmacology (Berlin) 112, S55-S59 (1993)
    • (1993) Psychopharmacology (Berlin) , vol.112
    • Casey, D.E.1
  • 73
    • 0029584169 scopus 로고
    • Motor and mental aspects of extrapyramidal syndromes
    • Casey DE: Motor and mental aspects of extrapyramidal syndromes. Int Clin Psychopharmacol 10, Supp 3, 105-114 (1995)
    • (1995) Int Clin Psychopharmacol , vol.10 , Issue.3 SUPPL. , pp. 105-114
    • Casey, D.E.1
  • 74
    • 0000011766 scopus 로고
    • The nonhuman primate model: Focus on dopamine D2 and sertonin mechanisms
    • Edited by Fog R, Gerlach J and Hemmingsen R, Munksgaard, Copenhagen
    • Casey DE: The nonhuman primate model: Focus on dopamine D2 and sertonin mechanisms. In Schizophrenia, Alfred Benzon Symposium 38, Edited by Fog R, Gerlach J and Hemmingsen R, pp 287-297, Munksgaard, Copenhagen (1995)
    • (1995) Schizophrenia, Alfred Benzon Symposium , vol.38 , pp. 287-297
    • Casey, D.E.1
  • 75
    • 0023920285 scopus 로고
    • 1A receptor agonist, blocks haloperidol-induced catalepsy by an action on raphe nuclei medianus and dorsalis
    • 1A receptor agonist, blocks haloperidol-induced catalepsy by an action on raphe nuclei medianus and dorsalis. Neuropharmacology 27, 515-518 (1988)
    • (1988) Neuropharmacology , vol.27 , pp. 515-518
    • Invernizzi, R.W.1    Cervo, L.2    Samanin, R.3
  • 77
    • 0025242104 scopus 로고
    • The effect of serotonergic agents on haloperidol-induced catalepsy
    • Hicks PB: The effect of serotonergic agents on haloperidol-induced catalepsy. Life Sci 47, 1609-1615 (1990)
    • (1990) Life Sci , vol.47 , pp. 1609-1615
    • Hicks, P.B.1
  • 78
    • 0026032408 scopus 로고
    • Antipsychotic-like profile of combined treatment with raclopride and 8-OHDPAT in the rat: Enhancement of antipsychotic-like effects without catalepsy
    • Wadenberg ML and Ahlenius S: Antipsychotic-like profile of combined treatment with raclopride and 8-OHDPAT in the rat: enhancement of antipsychotic-like effects without catalepsy. J Neural Transm 83, 43-53 (1991)
    • (1991) J Neural Transm , vol.83 , pp. 43-53
    • Wadenberg, M.L.1    Ahlenius, S.2
  • 79
    • 0011300280 scopus 로고
    • The effect of 8-OH-DPAT on haloperidol-induced dystonia in nonhuman primates
    • Casey DE: The effect of 8-OH-DPAT on haloperidol-induced dystonia in nonhuman primates. Am Coll Neuropsychopharmacol (Abstr) 32, 109 (1992)
    • (1992) Am Coll Neuropsychopharmacol (Abstr) , vol.32 , pp. 109
    • Casey, D.E.1
  • 80
    • 0027527435 scopus 로고
    • Serotonergic involve- Ment in haloperidol-induced catalepsy
    • Neal-Beliveau BS, Joyce JN and Lucki I: Serotonergic involve- ment in haloperidol-induced catalepsy. J Pharmacol Exp Ther 265, 207-217 (1993)
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 207-217
    • Neal-Beliveau, B.S.1    Joyce, J.N.2    Lucki, I.3
  • 108
    • 0026602337 scopus 로고
    • Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclcase
    • Levy FO, Gudermann T, Birnbaumer M, Kaumann AJ and Birnbaumer L: Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclcase. FEBS Lett 296, 201-206 (1992)
    • (1992) FEBS Lett , vol.296 , pp. 201-206
    • Levy, F.O.1    Gudermann, T.2    Birnbaumer, M.3    Kaumann, A.J.4    Birnbaumer, L.5
  • 120
    • 0011373382 scopus 로고
    • Construction and characterization of stable mammalian cell lines expressing human D4 dopamine receptors
    • Owolabi J, Martin A, Rampersad V, Hoo K and Kamboj RK: Construction and characterization of stable mammalian cell lines expressing human D4 dopamine receptors. Can J Physiol Pharmacol 72, Supp 1, 383 (1994)
    • (1994) Can J Physiol Pharmacol , vol.72 , Issue.1 SUPPL. , pp. 383
    • Owolabi, J.1    Martin, A.2    Rampersad, V.3    Hoo, K.4    Kamboj, R.K.5
  • 123
    • 0011345223 scopus 로고
    • Über eine neue chemische Gruppe stark wirksamer Neuroleptica. 5. Mittelung über siebengliederige Heterocylclen
    • in German
    • Stille G, Lauener H, Eichenberger E, Hunziker F and Schmutz J: Über eine neue chemische Gruppe stark wirksamer Neuroleptica. 5. Mittelung über siebengliederige Heterocylclen. Arzneimittelforschung 15, 841-843 (1965) (in German)
    • (1965) Arzneimittelforschung , vol.15 , pp. 841-843
    • Stille, G.1    Lauener, H.2    Eichenberger, E.3    Hunziker, F.4    Schmutz, J.5
  • 124
    • 0015603545 scopus 로고
    • Absicht und Zufall in der Arznmittelforschung, dargelegt am beispiel der trizyklischen Psychopharmaka
    • in German
    • Schmutz J: Absicht und Zufall in der Arznmittelforschung, dargelegt am beispiel der trizyklischen Psychopharmaka. Pharmaceut Acta Helv 48, 117-132 (1973) (in German)
    • (1973) Pharmaceut Acta Helv , vol.48 , pp. 117-132
    • Schmutz, J.1
  • 125
    • 0011375407 scopus 로고
    • Clozapine
    • Edited by Bindra JS and Lednicer D, John Wiley, New York
    • Schmutz J and Eichenberger E: Clozapine. In Chronicles of Drug Discovery, Edited by Bindra JS and Lednicer D, Vol 1, pp 39-59, John Wiley, New York (1992)
    • (1992) Chronicles of Drug Discovery , vol.1 , pp. 39-59
    • Schmutz, J.1    Eichenberger, E.2
  • 130
    • 0027429027 scopus 로고
    • 3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia
    • 3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia. Proc Natl Acad Sci USA 90, 8942-8946 (1993)
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8942-8946
    • Schmauss, C.1    Haroutunian, V.2    Davis, K.L.3    Davidson, M.4
  • 131
    • 0027239630 scopus 로고
    • Expression of the D3 dopamine receptor gene and a novel variant transcript generated by alternative splicing in human peripheral blood lymphocytes
    • Nagai Y, Ueno S, Saeki Y, Soga F and Yanagihara T: Expression of the D3 dopamine receptor gene and a novel variant transcript generated by alternative splicing in human peripheral blood lymphocytes. Biochem Biophys Res Commun 194, 368-374 (1993)
    • (1993) Biochem Biophys Res Commun , vol.194 , pp. 368-374
    • Nagai, Y.1    Ueno, S.2    Saeki, Y.3    Soga, F.4    Yanagihara, T.5
  • 132
    • 0025831076 scopus 로고
    • Alternative transcripts of the rat and human dopamine D3 receptor
    • Snyder LA, Roberts JL and Sealfon SC: Alternative transcripts of the rat and human dopamine D3 receptor. Biochem Biophys Res Commun 180, 1031-1035 (1991)
    • (1991) Biochem Biophys Res Commun , vol.180 , pp. 1031-1035
    • Snyder, L.A.1    Roberts, J.L.2    Sealfon, S.C.3


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