The binding of propranolol at 5-hydroxytryptamine1Dβ T355N mutant receptors may involve formation of two hydrogen bonds to asparagine

Molecular Pharmacology

Volumn 49, Issue 1, 1996, Pages 198-206

  Glennon, Richard A ^a,c   Dukat, Malgorzata ^a   Westkaemper, Richard B ^a   Ismaiel, Abd M ^a   Izzarelli, Darcy G ^b   Parker, Eric M ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 ISOPROPYLAMINOPROPYL)NAPHTHALENE OXALATE; 1 ISOPROPYLAMINO 2 (1 NAPHTHYLOXY)ETHANE OXALATE; DEHYDROXYPROPRANOLOL; DESOXYPROPRANOLOL; DIDESOXOPROPRANOLOL; PROPRANOLOL DERIVATIVE; RECEPTOR SUBTYPE; SEROTONIN 1D RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING COMPETITION; CONFORMATIONAL TRANSITION; DRUG RECEPTOR BINDING; HUMAN; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ADRENERGIC BETA-ANTAGONISTS; AMINO ACID SEQUENCE; ANIMALS; ASPARAGINE; CELL LINE; COMPUTER SIMULATION; HUMANS; HYDROGEN BONDING; MOLECULAR SEQUENCE DATA; MUTATION; PROPRANOLOL; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN;

EID: 0029670964     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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