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Offidani M, Corvatta L, Marconi M, et al. Common and rare side-effects of low-dose thalidomide in multiple myeloma: focus on the dose-minimizing peripheral neuropathy. Eur J Haematol 2004; 72:403-409. This describes a series of 59 patients treated with thalidomide alone or in combination with oral melphalan. The incidence of neuropathy is similar to the other studies. In addition, the authors report that in patients with advanced multiple myeloma a thalidomide dose of 150 mg/day minimizes peripheral neuropathy without compromising treatment efficacy.
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(2004)
Eur J Haematol
, vol.72
, pp. 403-409
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Offidani, M.1
Corvatta, L.2
Marconi, M.3
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54
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20044386503
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Neurological toxicity of long-term (>1 yr) thalidomide therapy in patients with multiple myeloma
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Tosi P, Zamagni E, Cellini C, et al. Neurological toxicity of long-term (>1 yr) thalidomide therapy in patients with multiple myeloma. Eur J Haematol 2005; 74:212-216. This study examined the long-term toxicity profile of 40 patients with multiple myeloma who received 200-400 mg/day of thalidomide for longer than 12 months. Seventy-five percent developed neurotoxicity and the severity appeared to be correlated more with duration of disease rather than the dose of thalidomide.
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(2005)
Eur J Haematol
, vol.74
, pp. 212-216
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Tosi, P.1
Zamagni, E.2
Cellini, C.3
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55
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5044222306
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Pyridoxine-induced toxicity in rats: A stereological quantification of the sensory neuropathy
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Perry TA, Weerasuriya A, Mouton PR, et al. Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy. Exp Neurol 2004; 190:133-144. This study used stereological and electrophysiological techniques to measure the morphological and physiological changes in dorsal root ganglia and sciatic nerve after pyridoxine intoxication.
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(2004)
Exp Neurol
, vol.190
, pp. 133-144
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Perry, T.A.1
Weerasuriya, A.2
Mouton, P.R.3
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56
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0034870443
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Pyridoxine-induced neuropathy in rats: A sensory neuropathy that responds to 4-methylcatechol
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Callizot N, Warter JM, Poindron P. Pyridoxine-induced neuropathy in rats: a sensory neuropathy that responds to 4-methylcatechol. Neurobiol Dis 2001; 8:626-635.
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(2001)
Neurobiol Dis
, vol.8
, pp. 626-635
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Callizot, N.1
Warter, J.M.2
Poindron, P.3
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58
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21344469223
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Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma
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Jagannath S, Durie BG, Wolf J, et al. Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. Br J Haematol 2005; 129:776-783. This study described 32 consecutive patients with previously untreated symptomatic multiple myeloma who received bortezomib, alone or in combination with dexamethasone. The most common side effect was sensory neuropathy, occurring in 31% of patients.
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(2005)
Br J Haematol
, vol.129
, pp. 776-783
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Jagannath, S.1
Durie, B.G.2
Wolf, J.3
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59
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0037973279
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A phase 2 study of bortezomib in relapsed, refractory myeloma
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Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003; 348:2609-2617.
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(2003)
N Engl J Med
, vol.348
, pp. 2609-2617
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Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
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60
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11144242919
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Oxaliplatin-associated neuropathy: A review
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Cersosimo RJ. Oxaliplatin-associated neuropathy: a review. Ann Pharmacother 2005; 39:128-135. This is a good review of the incidence, mechanism, signs, symptoms, and management of oxaliplatin-induced neurotoxicity.
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(2005)
Ann Pharmacother
, vol.39
, pp. 128-135
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Cersosimo, R.J.1
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61
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21444451972
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Oxaliplatin-induced neurotoxicity and the development of neuropathy
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Krishnan AV, Goldstein D, Friedlander M, Kieman MC. Oxaliplatin-induced neurotoxicity and the development of neuropathy. Muscle Nerve 2005; 32:51-60. This was a clinical, and electrophysiological study of 16 patients with neuropathy from oxaliplatin. Besides standard nerve conduction, nerve excitability studies were also performed on these patients. The authors suggest that changes in nerve excitability and refractoriness can possibly explain some of the acute manifestation of this neuropathy.
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(2005)
Muscle Nerve
, vol.32
, pp. 51-60
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Krishnan, A.V.1
Goldstein, D.2
Friedlander, M.3
Kieman, M.C.4
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62
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0036321899
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Differences in membrane properties of axonal and demyelinating Guillain-Barré syndromes
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Kuwabara S, Ogawara K, Sung JY, et al. Differences in membrane properties of axonal and demyelinating Guillain-Barré syndromes. Ann Neurol 2002; 52:180-187.
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(2002)
Ann Neurol
, vol.52
, pp. 180-187
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Kuwabara, S.1
Ogawara, K.2
Sung, J.Y.3
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63
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20244376916
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A phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days
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Zhuang SH, Agrawal M, Edgerly M, et al. A phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days. Cancer 2005; 103:1932-1938. This was a phase I study of ixabepilone in 26 patients. Only mild non-dose limiting peripheral neuropathy is reported.
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(2005)
Cancer
, vol.103
, pp. 1932-1938
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Zhuang, S.H.1
Agrawal, M.2
Edgerly, M.3
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64
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20144388068
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Neuropathy associated with leflunomide: A case series
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Martin K, Bentaberry F, Dumoulin C, et al. Neuropathy associated with leflunomide: a case series. Ann Rheum Dis 2005; 64:649-650. This reports on a case-series of 14 patients who developed neuropathy after they were treated with leflunomide for rheumatoid arthritis.
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(2005)
Ann Rheum Dis
, vol.64
, pp. 649-650
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Martin, K.1
Bentaberry, F.2
Dumoulin, C.3
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