Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

Cell

Volumn 110, Issue 6, 2002, Pages 775-787

  Ogiso, Hideo ^a,b   Ishitani, Ryuichiro ^a,c   Nureki, Osamu ^a,c,d   Fukai, Shuya ^a,c,d   Yamanaka, Mari ^b   Kim, Jae Hoon ^b   Saito, Kazuki ^a,b   Sakamoto, Ayako ^a   Inoue, Mio ^a   Shirouzu, Mikako ^a,d   Yokoyama, Shigeyuki ^a,b,c,d  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d RIKEN HARIMA INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

EID: 18644386251     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00963-7     Document Type: Article

References (62)

1. Abe Y., Odaka M., Inagaki F., Lax I., Schlessinger J., Kohda D. Disulfide bond structure of human epidermal growth factor receptor. J. Biol. Chem. 273:1998;11150-11157.
2. Aritomi M., Kunishima N., Okamoto T., Kuroki R., Ota Y., Morikawa K. Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme. Nature. 401:1999;713-717.
3. Bajaj M., Waterfield M.D., Schlessinger J., Taylor W.R., Blundell T. On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors. Biochim. Biophys. Acta. 916:1987;220-226.
4. Barbacci E.G., Guarino B.C., Stroh J.G., Singleton D.H., Rosnack K.J., Moyer J.D., Andrews G.C. The structural basis for the specificity of epidermal growth factor and heregulin binding. J. Biol. Chem. 270:1995;9585-9589.
5. Brown P.M., Debanne M.T., Grothe S., Bergsma D., Caron M., Kay C., O'Connor-McCourt M.D. The extracellular domain of the epidermal growth factor receptor. Studies on the affinity and stoichiometry of binding, receptor dimerization and a binding-domain mutant. Eur. J. Biochem. 225:1994;223-233.
6. Brunger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.S., Kuszewski J., Nilges M., Pannu N.S.et al. Crystallography and NMR system. a new software suit for macromolecular structure determination Acta Crystallogr. D. 54:1998;905-921.
7. Campion S.R., Matsunami R.K., Engler D.A., Niyogi S.K. Biochemical properties of site-directed mutants of human epidermal growth factor. importance of solvent-exposed hydrophobic residues of the amino-terminal domain in receptor binding Biochemistry. 29:1990;9988-9993.
8. Carpenter G., Cohen S. Epidermal growth factor. Annu. Rev. Biochem. 48:1979;193-216.
9. Carpenter G., Cohen S. Epidermal growth factor. J. Biol. Chem. 265:1990;7709-7712.
10. CCP4 The CCP4 (Collaborative Computational Project 4) suite. programs for protein crystallography Acta Crystallogr. D. 50:1994;760-763.
11. de Vos A.M., Ultsch M., Kossiakoff A.A. Human growth hormone and extracellular domain of its receptor. crystal structure of the complex Science. 255:1992;306-312.
12. Degenhardt M., Weber W., Eschenburg S., Dierks K., Funari S.S., Rapp G., Betzel C. Crystallization and preliminary X-ray crystallographic analysis of the EGF receptor ectodomain. Acta Crystallogr. D. 54:1998;999-1001.
13. Derynck R., Roberts A.B., Winkler M.E., Chen E.Y., Goeddel D.V. Human transforming growth factor-α precursor structure and expression in E. coli Cell. 38:1984;287-297.
14. Domagala T., Konstantopoulos N., Smyth F., Jorissen R.N., Fabri L., Geleick D., Lax I., Schlessinger J., Sawyer W., Howlett G.J.et al. Stoichiometry, kinetic and binding analysis of the interaction between epidermal growth factor (EGF) and the extracellular domain of the EGF receptor. Growth Factors. 18:2000;11-29.
15. Downward J., Yarden Y., Mayes E., Scrace G., Totty N., Stockwell P., Ullrich A., Schlessinger J., Waterfield M.D. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature. 307:1984;521-527.
16. Elleman T.C., Domagala T., McKern N.M., Nerrie M., Lonnqvist B., Adams T.E., Lewis J., Lovrecz G.O., Hoyne P.A., Richards K.M.et al. Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain. Biochemistry. 40:2001;8930-8939.
17. Engler D.A., Campion S.R., Hauser M.R., Cook J.S., Niyogi S.K. Critical functional requirement for the guanidinium group of the arginine 41 side chain of human epidermal growth factor as revealed by mutagenic inactivation and chemical reactivation. J. Biol. Chem. 267:1992;2274-2281.
18. Garrett T.P., McKern N.M., Lou M., Frenkel M.J., Bentley J.D., Lovrecz G.O., Elleman T.C., Cosgrove L.J., Ward C.W. Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor. Nature. 394:1998;395-399.
19. Garrett T.P.J., McKern N.M., Lou M., Elleman T.C., Adams T.E., Lovrecz G.O., Zhu H.-J., Walker F., Frenkel M.J., Hoyne P.A.et al. Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor-α Cell. 110:2002;763-773. this issue,
20. Graus-Porta D., Beerli R.R., Daly J.M., Hynes N.E. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 16:1997;1647-1655.
21. Groenen L.C., Nice E.C., Burgess A.W. Structure-function relationships for the EGF/TGF-α family of mitogens. Growth Factors. 11:1994;235-257.
22. Gunther N., Betzel C., Weber W. The secreted form of the epidermal growth factor receptor. Characterization and crystallization of the receptor-ligand complex. J. Biol. Chem. 265:1990;22082-22085.
23. Haley J.D., Hsuan J.J., Waterfield M.D. Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors. Oncogene. 4:1989;273-283.
24. Harvey T.S., Wilkinson A.J., Tappin M.J., Cooke R.M., Campbell I.D. The solution structure of human transforming growth factor α Eur. J. Biochem. 198:1991;555-562.
25. Huang H.S., Nagane M., Klingbeil C.K., Lin H., Nishikawa R., Ji X.D., Huang C.M., Gill G.N., Wiley H.S., Cavenee W.K. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J. Biol. Chem. 272:1997;2927-2935.
26. Jones T.A., Zou J.Y., Cowan S.W., Kjeldgaard Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A. 47:1991;110-119.
27. Kim J.-H., Saito K., Yokoyama S. Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin. Eur. J. Biochem. 269:2002;2323-2329.
28. Kohda D., Inagaki F. Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions. Biochemistry. 31:1992;11928-11939.
29. Kohda D., Odaka M., Lax I., Kawasaki H., Suzuki K., Ullrich A., Schlessinger J., Inagaki F. A 40-kDa epidermal growth factor/transforming growth factor α-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor. J. Biol. Chem. 268:1993;1976-1981.
30. Koide H., Muto Y., Kasai H., Hoshi K., Takusari H., Kohri K., Takahashi S., Sasaki T., Tsukumo K., Miyake T.et al. Recognition of an antiparallel beta-sheet structure of human epidermal growth factor by its receptor. Site-directed mutagenesis studies of Ala-30 and Asn-32. FEBS Lett. 302:1992;39-42. a.
31. Koide H., Muto Y., Kasai H., Kohri K., Hoshi K., Takahashi S., Tsukumo K., Sasaki T., Oka T., Miyake T.et al. A site-directed mutagenesis study on the role of isoleucine-23 of human epidermal growth factor in the receptor binding. Biochim. Biophys. Acta. 1120:1992;257-261. b.
32. Lax I., Bellot F., Howk R., Ullrich A., Givol D., Schlessinger J. Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules. EMBO J. 8:1989;421-427.
33. Lemmon M.A., Bu Z., Ladbury J.E., Zhou M., Pinchasi D., Lax I., Engelman D.M., Schlessinger J. Two EGF molecules contribute additively to stabilization of the EGFR dimer. EMBO J. 16:1997;281-294.
34. Lu H.S., Chai J.J., Li M., Huang B.R., He C.H., Bi R.C. Crystal structure of human epidermal growth factor and its dimerization. J. Biol. Chem. 276:2001;34913-34917.
35. Marquardt H., Hunkapiller M.W., Hood L.E., Todaro G.J. Rat transforming growth factor type 1. structure and relation to epidermal growth factor Science. 223:1984;1079-1082.
36. McInnes C., Grothe S., O'Connor-McCourt M., Sykes B.D. NMR study of the differential contributions of residues of transforming growth factor alpha to association with its receptor. Protein Eng. 13:2000;143-147.
37. Muthuswamy S.K., Gilman M., Brugge J.S. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol. Cell. Biol. 19:1999;6845-6857.
38. Navaza J. AMoRe. an automated package for molecular replacement Acta Crystallogr. A. 50:1994;157-163.
39. Odaka M., Kohda D., Lax I., Schlessinger J., Inagaki F. Ligand-binding enhances the affinity of dimerization of the extracellular domain of the epidermal growth factor receptor. J. Biochem. (Tokyo). 122:1997;116-121.
40. Olayioye M.A., Neve R.M., Lane H.A., Hynes N.E. The ErbB signaling network. receptor heterodimerization in development and cancer EMBO J. 19:2000;3159-3167.
41. Otwinowski Z., Minor W. Processing of X-ray diffraction data collection in oscillation mode. Methods Enzymol. 276:1997;307-326.
42. Pellegrini L., Burke D.F., von Delft F., Mulloy B., Blundell T.L. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature. 407:2000;1029-1034.
43. Plotnikov A.N., Schlessinger J., Hubbard S.R., Mohammadi M. Structural basis for FGF receptor dimerization and activation. Cell. 98:1999;641-650.
44. Plotnikov A.N., Hubbard S.R., Schlessinger J., Mohammadi M. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell. 101:2000;413-424.
45. Sako Y., Minoghchi S., Yanagida T. Single-molecule imaging of EGFR signalling on the surface of living cells. Nat. Cell Biol. 2:2000;168-172.
46. Sato C., Kim J.-H., Abe Y., Saito K., Yokoyama S., Kohda D. Characterization of the N-oligosaccharides attached to the atypical Asn-X-Cys sequence of recombinant human epidermal growth factor receptor. J. Biochem. (Tokyo). 127:2000;65-72.
47. Schlessinger J., Plotnikov A.N., Ibrahimi O.A., Eliseenkova A.V., Yeh B.K., Yayon A., Linhardt R.J., Mohammadi M. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol. Cell. 6:2000;743-750.
48. Stauber D.J., DiGabriele A.D., Hendrickson W.A. Structural interactions of fibroblast growth factor receptor with its ligands. Proc. Natl. Acad. Sci. USA. 97:2000;49-54.
49. Summerfield A.E., Hudnall A.K., Lukas T.J., Guyer C.A., Staros J.V. Identification of residues of the epidermal growth factor receptor proximal to residue 45 of bound epidermal growth factor. J. Biol. Chem. 271:1996;19656-19659.
50. Syed R.S., Reid S.W., Li C., Cheetham J.C., Aoki K.H., Liu B., Zhan H., Osslund T.D., Chirino A.J., Zhang J.et al. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 395:1998;511-516.
51. Tadaki D.K., Niyogi S.K. The functional importance of hydrophobicity of the tyrosine at position 13 of human epidermal growth factor in receptor binding. J. Biol. Chem. 268:1993;10114-10119.
52. Terwilliger T.C. Maximum-likelihood density modification. Acta Crystallogr. D. 56:2000;965-972.
53. Tzahar E., Waterman H., Chen X., Levkowitz G., Karunagaran D., Lavi S., Ratzkin B.J., Yarden Y. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol. Cell. Biol. 16:1996;5276-5287.
54. Ullrich A., Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell. 61:1990;203-212.
55. Ullrich A., Coussens L., Hayflick J.S., Dull T.J., Gray A., Tam A.W., Lee J., Yarden Y., Libermann T.A., Schlessinger J.et al. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature. 309:1984;418-425.
56. Ward C.W., Hoyne P.A., Flegg R.H. Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor. Proteins. 22:1995;141-153.
57. Weeks C.M., Miller R. The design and implementation of SnB v2.0. J. Appl. Crystallogr. 32:1999;120-124.
58. Wiesmann C., Ultsch M.H., Bass S.H., de Vos A.M. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 401:1999;184-188.
59. Woltjer R.L., Lukas T.J., Staros J.V. Direct identification of residues of the epidermal growth factor receptor in close proximity to the amino terminus of bound epidermal growth factor. Proc. Natl. Acad. Sci. USA. 89:1992;7801-7805.
60. Wu D.G., Wang L.H., Sato G.H., West K.A., Harris W.R., Crabb J.W., Sato J.D. Human epidermal growth factor (EGF) receptor sequence recognized by EGF competitive monoclonal antibodies. Evidence for the localization of the EGF-binding site. J. Biol. Chem. 264:1989;17469-17475.
61. Wu D.G., Wang L.H., Chi Y., Sato G.H., Sato J.D. Human epidermal growth factor receptor residue covalently cross-linked to epidermal growth factor. Proc. Natl. Acad. Sci. USA. 87:1990;3151-3155.
62. Yamamoto T., Nishida T., Miyajima N., Kawai S., Ooi T., Toyoshima K. The erbB gene of avian erythroblastosis virus is a member of the src gene family. Cell. 35:1983;71-78.