Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 14, 1997, Pages 7509-7514

  Ghetie, Maria Ana ^a   Podar, Erika M ^a   Ilgen, Amy ^b   Gordon, Brian E ^c   Uhr, Jonathan W ^a   Vitetta, Ellen S ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c CAROLINAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD20 ANTIGEN; CD22 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; MONOCLONAL ANTIBODY;

ANTIBODY SPECIFICITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER IMMUNOTHERAPY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; DIMERIZATION; HUMANS; IMMUNOGLOBULIN G; TUMOR CELLS, CULTURED;

EID: 0030806221     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.14.7509     Document Type: Article

References (52)

1. Herlyn, D. & Koprowski, H. (1982) Proc. Natl. Acad. Sci. USA 79, 4761-4765.
2. Riethmüller, G., Schnider-Gadicke, E., Schlimok, G., Schmiegel, W. & Raab, R. (1994) Lancet 343, 1174-1177.
3. Dyer, M. J. S., Hale, G., Hayhoe, F. G. J. & Waldmann, H. (1989) Blood 73, 1431-1439.
4. Hale, G., Clarke, M. R., Marcus, R., Winter, G., Dyer, M. J. S., Phillips, J. M., Riechmann, L. & Waldman, H. (1988) Lancet ii, 1394-1399.
5. Hooijberg, E., van den Berk, P. C. M., Sein, J. J., Wijdenes, J., Hart, A. A. M., de Boer, R. W., Melief, C. J. M. & Hekman, A. (1995) Cancer Res. 55, 840-846.
6. Hooijberg, E., Sein, J. J., van den Berk, P. C. M., Hart, A. A. M., van der Valk, M. A., Kast, W. M., Melief, C. J. M. & Hekman, A. (1995) Cancer Res. 55, 2627-2634.
7. Morrison, S. L. & Oi, V. T. (1989) Adv. Immunol. 44, 65-91.
8. Adair, J. R. (1992) Immunol. Rev. 130, 5-40.
9. Hale, G., Clark, M. & Waldmann, H. (1985) J. Immunol. 134, 3056-3061.
10. Kaminski, M. S., Kitamura, K., Maloney, D. G., Campbell, M. J. & Levy, R. (1986) J. Immunol. 136, 1123-1130.
11. Denkers, E. Y., Badger, C. C., Ledbetter, J. A. & Bernstein, I. D. (1995) J. Immunol. 135, 2183-2186.
12. Dillman, R. O. (1994) J. Clin. Oncol. 12, 1497-1515.
13. Ghetie, M., Ghetie, V. & Vitetta, E. S. (1996) Exp. Opin. Invest. Drugs 5, 309-321.
14. Hellström, I., Hellström, K. E., Siegall, C. B. & Trail, P. A. (1995) Adv. Pharmacol. 33, 349-388.
15. Qi, Y., Moyana, T., Bresalier, R. & Xiang, J. (1995) Gastroenterology 109, 1950-1957.
16. Guo, Y., Ma, J., Wang, J., Che, X., Narula, J., Bigby, M., Wu, M. & Sy, M. S. (1994) Cancer Res. 54, 1561-1565.
17. Edward, M. (1995) Curr. Opin. Oncol. 7, 185-191.
18. Ghetie, M. A., Tucker, K., Richardson, J., Uhr, J. W. & Vitetta, E. S. (1992) Blood 80, 2315-2320.
19. Ghetie, M. A., Picker, L. J., Richardson, J. A., Tucker, K., Uhr, J. W. & Vitetta, E. S. (1994) Blood 83, 1329-1336.
20. Vitetta, E. S. & Uhr, J. W. (1994) Cancer Res. 54, 5301-5309.
21. Trauth, B. C., Klas, C., Peters, A. M. J., Matzku, S., Moller, P., Falk, W., Debatin, K. & Krammer, P. H. (1989) Science 245, 301-305.
22. Page, D. M. & Defranco, A. (1988) J. Immunol. 140, 3717-3726.
23. Bridges, S. H., Kruisbeek, A. M. & Longo, D. L. (1987) J. Immunol. 139, 4242-4249.
24. Funakoshi, S., Longo, D. L., Beckwith, M., Conley, D. K., Tsarfaty, G., Tsarfaty, I., Armitage, R. J., Fanslow, W. C., Spriggs, M. K. & Murphy, W. J. (1994) Blood 83, 2787-2794.
25. Beckwith, M., Urba, W. J., Ferris, D. K., Freter, C. E., Kuhns, D. B., Moratz, C. M. & Longo, D. L. (1991) J. Immunol. 147, 2411-2418.
26. Schreiber, G. J., Hellström, K. E. & Hellström, I. (1992) Cancer Res. 52, 3262-3266.
27. Scott, D. W., Tuttle, J., Livnat, D., Haynes, W., Cogswell, J. & Keng, P. (1985) Cell. Immunol. 93, 124-131.
28. Levy, R. & Miller, R. A. (1990) J. Natl. Cancer Inst. Monogr. 10, 61-68.
29. Hamblin, T. J., Abdul-Ahab, A. K., Gordon, J., Stevenson, F. K. & Stevenson, G. T. (1980) Br. J. Cancer 42, 495-502.
30. Scott, G. K., Dodson, J. M., Montgomery, P. A., Johnson, R. M., Sarup, J. C., Wong, W. L., Ullrich, A., Shepard, M. & Benz, C. C. (1991) J. Biol. Chem. 266, 14300-14305.
31. Marches, R., Racila, E., Tucker, T. F., Picker, L., Mongini, P., Hsueh, R., Vitetta, E. S., Scheuermann, R. H. & Uhr, J. W. (1996) Ther. Immunol. 2, 125-136.
32. Ghetie, V., Thorpe, P. E., Ghetie, M., Knowles, P., Uhr, J. W. & Vitetta, E. S. (1991) J. Immunol. Methods 142, 223-230.
33. Ghetie, M., May, R. D., Till, M., Uhr, J. W., Ghetie, V., Knowles, P. P., Relf, M., Brown, A., Wallace, P. M., Janossy, G., Amlot, P., Vitetta, E. S. & Thorpe, P. E. (1988) Cancer Res. 48, 2610-2617.
34. Fraker, P. J. & Speck, J. C., Jr. (1978) Biochem. Biophys. Res. Commun. 80, 849-857.
35. Coligan, J. E., Kruisbeek, A. M., Margulies, D. H., Shevach, E. M. & Strober, W., eds. (1991) Current Protocols in Immunology, (Wiley-Interscience, New York).
36. Press, O. W., Farr, A. G., Borroz, K. I., Anderson, S. K. & Martin, P. J. (1989) Cancer Res. 49, 4906-4912.
37. Darzynkiewicz, Z., Bruno, S., Del Bino, G., Gorczyca, W., Hotz, M. A., Lassota, P. & Traganos, F. (1992) Cytometry 13, 795-808.
38. Kim, J.-K., Tsen, M., Ghetie, V. & Ward, E. S. (1994) Eur. J. Immunol. 24, 542-548.
39. Perrier, D. & Mayerson, M. (1982) J. Pharmacol. Sci. 71, 372-373.
40. Schumaker, R. C. (1986) Drug Metab. Rev. 17, 331-348.
41. Ghetie, M. A., Richardson, J., Tucker, T., Jones, D., Uhr, J. W. & Vitetta, E. S. (1990) Int. J. Cancer 45, 481-485.
42. Kalbfleisch, J. D. & Prentice, R. L. (1980) The Statistical Analysis of Failure Time Data (Wiley, New York).
43. Shah, S. A., Halloran, P. M., Ferris, C. A., Levine, B. A., Bourret, L. A., Goldmacher, V. S. & Blattler, W. A. (1993) Cancer Res. 53, 1360-1367.
44. Vermes, I., Haanen, C., Steffens-Nakken, H. & Reutelingsperger, C. (1995) J. Immunol. Methods 184, 39-51.
45. Sato, T., Van Dixhoorn, M. G. A., Schroeijers, W. E. M., Van Es, L. A. & Daha, M. R. (1997) Kidney Int. 51, 173-181.
46. Wolff, E. A., Schreiber, G. J., Cosand, W. L. & Raff, H. V. (1993) Cancer Res. 53, 2560-2565.
47. Vervoordeldonk, S. F., Merle, P. A., van Leeuwen, E. F., van der School, C. E., Kr.von dem Borne, A. E. G. & Slaper-Cortenbach, I. C. M. (1994) Blood 83, 1632-1639.
48. Shuford, W., Raff, H. V., Finley, J. W., Esselstyn, J. & Harris, L. J. (1991) Science 252, 724-727.
49. Caron, P. C., Laird, W., Co, M. S., Avdalovic, N. M., Queen, C. & Scheinberg, D. A. (1992) J. Exp. Med. 176, 1191-1195.
50. Greenwood, J., Gorman, S. D., Routledge, E. G., Lloyd, I. S. & Waldmann, H. (1994) Ther. Immunol. 1, 247-255.
51. Shopes, B. (1992) J. Immunol. 148, 2918-2922.
52. Smith, R. I. F. & Morrison, S. L. (1994) Bio/Technology 12, 683-688.