SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit

FASEB Journal

Volumn 15, Issue 3, 2001, Pages 645-658

  Botchkareva, Natalia V ^a   Khlgatian, Mary ^a   Longley, B Jack ^b   Botchkarev, Vladimir A ^a   Gilchrest, Barbara A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Columbia University ^*  (United States)

Author keywords

Hair cycle; Hair follicle; Melanocyte; Stem cell

Indexed keywords

MELANIN; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DEPIGMENTATION; FEMALE; GENE EXPRESSION; GENE MUTATION; HAIR; HAIR FOLLICLE; MELANOCYTE; MOUSE; NONHUMAN; PIGMENTATION; PRIORITY JOURNAL; REGENERATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES, MONOCLONAL; EPIDERMIS; FEMALE; HAIR COLOR; HAIR FOLLICLE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MELANOCYTES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; OXIDOREDUCTASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; SIGNAL TRANSDUCTION; STEM CELL FACTOR;

ANIMALIA;

EID: 0035088316     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0368com     Document Type: Article

References (69)

1. Growth of the hair
2. Principles of hair cycle control
3. The biology of hair follicles
4. Analysis of apoptosis during hair follicle regression (catagen)
5. Growth of the hair follicle: A cycling and regenerating biological system
6. The fate of hair follicle melanocytes during the hair growth cycle
7. Differential expression and activity of melanogenesis-related proteins during induced hair growth in mice
8. Melanogenesis during the anagen-catagen-telogen transformation of the murine hair cycle
9. The melanocytes and the hair follicle
10. Different populations of melanocytes are present in hair follicles and epidermis
11. Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis
12. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells
13. Enzymatic control of pigmentation in mammals
14. Mechanisms of ultraviolet light-induced pigmentation
15. Biology of melanocytes
16. Signaling pathways mediating melanogenesis
17. Biochemical control of melanogenesis and melanosomal organization
18. Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice
19. The tyrosinase gene family: Interactions of melanogenic proteins to regulate melanogenesis
20. A cDNA encoding tyrosinase-related protein maps to the mouse brown locus
21. A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus
22. Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth
23. Molecular and development genetics of mouse coat color
24. What controls melanogenesis?
25. The kit ligand, stem cell factor
26. Development of melanocytes from neural crest progenitors
27. Distinct stages of melanocyte differentiation revealed by analysis of nonuniform pigmentation patterns
28. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
29. Stem cell factor is encoded at the S1 locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
30. In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: Two distinct waves of c-kit-dependency during melanocyte development
31. Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors
32. Murine cutaneous mastocytosis and epidermal melanocytosis induced by keratinocyte expression of transgenic stem cell factor
33. Dermal papilla cells derived from beard hair follicles secrete more stem cell factor (SCF) iu culture than scalp cells or dermal fibroblasts
34. Intraepithelial c-kit expression during murine hair follicle development and cycling: A role for stem cell factor in epithelial biology
35. Telogen skin contains an inhibitor of hair growth
36. A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis
37. Hair cycle-dependent plasticity of skin and hair follicle innervation in normal murine skin
38. DNA staining for fluorescence and laser confocal microscopy
39. A new role for neurotrophins: Involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control
40. Double immunofluorescent staining using two unconjugated primary antisera raised in the same species
41. The trk family of receptors mediates nerve growth factor and neurotrophin-3 effects in melanocytes
42. A new role for neurotrophin-3: Involvement in the control of hair follicle regression (catagen)
43. Tyrosinases from two different loci are expressed by normal and by transformed melanocytes
44. TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor
45. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 act as "epitheliotrophins" in murine skin
46. c-kit and SCF expression in murine skin: A role in hair follicle development and cycling
47. Mode of redifferentiation and melanogenesis of melanocytes in mouse hair follicles
48. Do hair bulb melanocytes undergo apoptosis during hair follicle regression (catagen)?
49. Proliferating activity of the hair follicle melanocytes at the early and anagen III stages in the hair growth cycle: Detection by immunohistochemistry for bromodeoxyuridine combined with DOPA reaction cytochemistry
50. Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo
51. The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis
52. The regulation of normal melanocyte proliferation
53. Coordinated mRNA expression of c-Kit with tyrosinase and TRP-1 in melanin pigmentation of normal and malignant human melanocytes and transient activation of tyrosinase by Kit/SCF-R
54. MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
55. c-Kit triggers dual phosphorylations which couple activation and degradation of the essential melanocyte factor Mi
56. Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes
57. Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: Pivotal role of M boxes (GTCATGTGCT) and of microphthalmia
58. Effects of monoclonal anti-c-kit antibody (ACK2) on melanocytes in newborn mice
59. Removal of stem cell factor or addition of monoclonal anti-c-KIT antibody induces apoptosis in murine melanocyte precursors
60. Pharmacological disruption of hair follicle pigmentation by cyclophosphamide as a model for studying the melanocyte response to and recovery from cytotoxic drug damage in situ
61. Production of POMC, CRH-R1, MC 1, and MC2 receptor mRNA and expression of tyrosinase gene in relation to hair cycle and dexamethasone treatment in the C57BL/6 mouse skin
62. Hair cycle-dependent production of ACTH in mouse skin
63. Developmentally regulated expression of alpha-MSH and MC-1 receptor in C57BL/6 mouse skin suggests functions beyond pigmentation
64. Endothelin-1 of keratinocyte origin is a mediator of melanocyte dendricity
65. Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte development
66. Assessment of cell proliferation in murine tissues with a polyclonal antiserum against the murine Ki-67 protein
67. High levels of p53 protein in UV-irradiated normal human skin
68. Mammalian tyrosinase: Biosynthesis, processing, and modulation by melanocyte-stimulating hormone
69. A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase