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Volumn 9, Issue 9, 2008, Pages 1561-1594

Broad-spectrum drugs against viral agents

Author keywords

CpG; Cytokine; Influenza; Poly (ICLC); TLR

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; AMPHOTERICIN B; AMPLIGEN; ANTIVIRUS AGENT; CARBOXYMETHYLCELLULOSE POLYCYTIDYLIC POLYINOSINIC ACID POLYLYSINE; CASTANOSPERMINE; CHLOROQUINE; CPG OLIGODEOXYNUCLEOTIDE; DOUBLE STRANDED RNA; ENERGIX B; FOSCARNET; HEPATITIS VACCINE; INFLUENZA VACCINE; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN; OLIGONUCLEOTIDE; POLYINOSINIC POLYCYTIDYLIC ACID; RECOMBINANT ALPHA INTERFERON A; RECOMBINANT BETA INTERFERON; RECOMBINANT GAMMA INTERFERON; RETINOIC ACID; RIBAVIRIN; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG; VENEZUELAN EQUINE ENCEPHALITIS VIRUS VACCINE; VIRUS VACCINE; ZIDOVUDINE;

EID: 53549090456     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms9091561     Document Type: Review
Times cited : (11)

References (217)
  • 1
    • 33144461911 scopus 로고    scopus 로고
    • Avian influenza virus infections in humans
    • Wong, S.S.; Yuen, K.Y. Avian influenza virus infections in humans. Chest 2006, 129, 156-168.
    • (2006) Chest , vol.129 , pp. 156-168
    • Wong, S.S.1    Yuen, K.Y.2
  • 2
    • 1842856069 scopus 로고    scopus 로고
    • Seed viruses containing novel avian HA and NA antigens for prevention against potential influenza pandemic
    • Li, S.; Perdue, M.L.; Patzer, E. Seed viruses containing novel avian HA and NA antigens for prevention against potential influenza pandemic. Dev. Biol. (Basel) 2002, 110, 135-141.
    • (2002) Dev. Biol. (Basel) , vol.110 , pp. 135-141
    • Li, S.1    Perdue, M.L.2    Patzer, E.3
  • 3
    • 1942468738 scopus 로고    scopus 로고
    • Antiviral chemotherapeutic agents against respiratory viruses: Where are we now and what's in the pipeline?
    • Brooks, M.J.; Sasadeusz, J.J.; Tannock, G.A. Antiviral chemotherapeutic agents against respiratory viruses: where are we now and what's in the pipeline? Curr. Opin. Pulm. Med. 2004, 10, 197-203.
    • (2004) Curr. Opin. Pulm. Med , vol.10 , pp. 197-203
    • Brooks, M.J.1    Sasadeusz, J.J.2    Tannock, G.A.3
  • 4
    • 7644241814 scopus 로고    scopus 로고
    • Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium
    • Matrosovich, M.N.; Matrosovich, T.Y.; Gray, T.; Roberts, N.A.; Klenk, H.D. Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium. J. Virol. 2004, 78, 12665-12667.
    • (2004) J. Virol , vol.78 , pp. 12665-12667
    • Matrosovich, M.N.1    Matrosovich, T.Y.2    Gray, T.3    Roberts, N.A.4    Klenk, H.D.5
  • 5
    • 84856100845 scopus 로고    scopus 로고
    • accessed 25 Feb 2008
    • WHO http://www.who.int/csr/disease/avian_influenza/en/, accessed 25 Feb 2008.
    • WHO http
  • 8
    • 25844438380 scopus 로고    scopus 로고
    • Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: A cause for concern
    • Bright, R.A.; Medina, M.J.; Xu, X.; Perez-Oronoz, G.; Wallis, T.R.; Davis, X.M.; Povinelli, L.; Cox, N.J.; Klimov, A.I. Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet 2005, 366, 1175-1181.
    • (2005) Lancet , vol.366 , pp. 1175-1181
    • Bright, R.A.1    Medina, M.J.2    Xu, X.3    Perez-Oronoz, G.4    Wallis, T.R.5    Davis, X.M.6    Povinelli, L.7    Cox, N.J.8    Klimov, A.I.9
  • 9
    • 0042208151 scopus 로고    scopus 로고
    • Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2
    • Ashkar, A.A.; Bauer, S.; Mitchell, W.J.; Vieira, J.; Rosenthal, K.L., Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2. J. Virol. 2003, 77, 8948-8956.
    • (2003) J. Virol , vol.77 , pp. 8948-8956
    • Ashkar, A.A.1    Bauer, S.2    Mitchell, W.J.3    Vieira, J.4    Rosenthal, K.L.5
  • 12
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg, A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 2002, 20, 709-760.
    • (2002) Annu. Rev. Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 16
    • 33646453915 scopus 로고    scopus 로고
    • Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
    • Weber, F.; Wagner, V.; Rasmussen, S.B.; Hartmann, R.; Paludan, S.R. Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J. Virol. 2006, 80, 5059-5064.
    • (2006) J. Virol , vol.80 , pp. 5059-5064
    • Weber, F.1    Wagner, V.2    Rasmussen, S.B.3    Hartmann, R.4    Paludan, S.R.5
  • 17
    • 14044267522 scopus 로고    scopus 로고
    • Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to doublestranded RNA and influenza A virus
    • Guillot, L.; Le Goffic, R.; Bloch, S.; Escriou, N.; Akira, S.; Chignard, M.; Si-Tahar, M., Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to doublestranded RNA and influenza A virus. J. Biol. Chem. 2005, 280, 5571-5580.
    • (2005) J. Biol. Chem , vol.280 , pp. 5571-5580
    • Guillot, L.1    Le Goffic, R.2    Bloch, S.3    Escriou, N.4    Akira, S.5    Chignard, M.6    Si-Tahar, M.7
  • 18
    • 28044445881 scopus 로고    scopus 로고
    • Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
    • Chan, M.C.; Cheung, C.Y.; Chui, W.H.; Tsao, S.W.; Nicholls, J.M.; Chan, Y.O.; Chan, R.W.; Long, H.T.; Poon, L.L.; Guan, Y.; et al. Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir. Res. 2005, 6, 135-147.
    • (2005) Respir. Res , vol.6 , pp. 135-147
    • Chan, M.C.1    Cheung, C.Y.2    Chui, W.H.3    Tsao, S.W.4    Nicholls, J.M.5    Chan, Y.O.6    Chan, R.W.7    Long, H.T.8    Poon, L.L.9    Guan, Y.10
  • 19
    • 3042711969 scopus 로고    scopus 로고
    • CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: Induction of cytokine release and cytotoxicity against tumors and dendritic cells
    • Sivori, S.; Falco, M.; Delia Chiesa, M.; Carlomagno, S.; Vitale, M.; Moretta, L.; Moretta, A. CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc. Natl. Acad. Sci. USA 2004, 101, 10116-10121.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 10116-10121
    • Sivori, S.1    Falco, M.2    Delia Chiesa, M.3    Carlomagno, S.4    Vitale, M.5    Moretta, L.6    Moretta, A.7
  • 20
    • 0037234342 scopus 로고    scopus 로고
    • Virus-cell interactions in the induction of type 1 interferon by influenza virus in mouse spleen cells
    • Miller, J.L.; Anders, E.M. Virus-cell interactions in the induction of type 1 interferon by influenza virus in mouse spleen cells. J. Gen. Virol. 2003, 84(Pt 1), 193-202.
    • (2003) J. Gen. Virol , vol.84 , Issue.PART 1 , pp. 193-202
    • Miller, J.L.1    Anders, E.M.2
  • 21
    • 3442875541 scopus 로고    scopus 로고
    • Activation of mast cells by doublestranded RNA: Evidence for activation through Toll-like receptor 3
    • Kulka, M.; Alexopoulou, L.; Flavell, R.A.; Metcalfe, D.D. Activation of mast cells by doublestranded RNA: evidence for activation through Toll-like receptor 3. J. Allergy Clin. Immunol. 2004, 114, 174-182.
    • (2004) J. Allergy Clin. Immunol , vol.114 , pp. 174-182
    • Kulka, M.1    Alexopoulou, L.2    Flavell, R.A.3    Metcalfe, D.D.4
  • 22
  • 23
    • 1642370060 scopus 로고    scopus 로고
    • Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells
    • Coccia, E.M.; Severa, M.; Giacomini, E.; Monneron, D.; Remoli, M.E.; Julkunen, I.; Cella, M.; Lande, R.; Uze, G. Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells. Eur. J. Immunol. 2004, 34, 796-805.
    • (2004) Eur. J. Immunol , vol.34 , pp. 796-805
    • Coccia, E.M.1    Severa, M.2    Giacomini, E.3    Monneron, D.4    Remoli, M.E.5    Julkunen, I.6    Cella, M.7    Lande, R.8    Uze, G.9
  • 25
    • 0022407722 scopus 로고
    • Prophylactic and therapeutic efficacy of poly(I,C)-LC against Rift Valley fever virus infection in mice
    • Kende, M. Prophylactic and therapeutic efficacy of poly(I,C)-LC against Rift Valley fever virus infection in mice. J. Biol. Response Mod. 1985, 4, 503-511.
    • (1985) J. Biol. Response Mod , vol.4 , pp. 503-511
    • Kende, M.1
  • 26
    • 34547828326 scopus 로고    scopus 로고
    • Involvement of Toll-like receptors in the immune response of nasal polyp epithelial cells
    • Wang, J.; Matsukura, S.; Watanabe, S.; Adachi, M.; Suzaki, H. Involvement of Toll-like receptors in the immune response of nasal polyp epithelial cells. Clin. Immunol. 2007, 124, 345-352.
    • (2007) Clin. Immunol , vol.124 , pp. 345-352
    • Wang, J.1    Matsukura, S.2    Watanabe, S.3    Adachi, M.4    Suzaki, H.5
  • 27
    • 2942579665 scopus 로고    scopus 로고
    • Double-stranded RNA activates RANTES gene transcription through co-operation of nuclear factor-kappaB and interferon regulatory factors in human airway epithelial cells
    • Ieki, K.; Matsukura, S.; Kokubu, F.; Kimura, T.; Kuga, H.; Kawaguchi, M.; Odaka, M.; Suzuki, S.; Watanabe, S.; Takeuchi, H.; et al. Double-stranded RNA activates RANTES gene transcription through co-operation of nuclear factor-kappaB and interferon regulatory factors in human airway epithelial cells. Clin. Exp. Allergy 2004, 34, 745-752.
    • (2004) Clin. Exp. Allergy , vol.34 , pp. 745-752
    • Ieki, K.1    Matsukura, S.2    Kokubu, F.3    Kimura, T.4    Kuga, H.5    Kawaguchi, M.6    Odaka, M.7    Suzuki, S.8    Watanabe, S.9    Takeuchi, H.10
  • 28
    • 33746801581 scopus 로고    scopus 로고
    • Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells
    • Matsukura, S.; Kokubu, F.; Kurokawa, M.; Kawaguchi, M.; Ieki, K.; Kuga, H.; Odaka, M.; Suzuki, S.; Watanabe, S.; Takeuchi, H.; et al. Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells. Clin. Exp. Allergy 2006, 36, 1049-1062.
    • (2006) Clin. Exp. Allergy , vol.36 , pp. 1049-1062
    • Matsukura, S.1    Kokubu, F.2    Kurokawa, M.3    Kawaguchi, M.4    Ieki, K.5    Kuga, H.6    Odaka, M.7    Suzuki, S.8    Watanabe, S.9    Takeuchi, H.10
  • 29
    • 1842737584 scopus 로고    scopus 로고
    • Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia
    • Auch, C.J.; Saha, R.N.; Sheikh, F.G.; Liu, X.; Jacobs, B.L.; Pahan, K. Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia. FEBS Lett. 2004, 563, 223-228.
    • (2004) FEBS Lett , vol.563 , pp. 223-228
    • Auch, C.J.1    Saha, R.N.2    Sheikh, F.G.3    Liu, X.4    Jacobs, B.L.5    Pahan, K.6
  • 30
    • 0021119535 scopus 로고
    • Vaccine adjuvant effects, and immune response, to synthetic polymers MVE and poly ICLC
    • Chirigos, M.A.; Welker, R.; Schlick, E.; Saito, T.; Ruffmann, R. Vaccine adjuvant effects, and immune response, to synthetic polymers MVE and poly ICLC. Prog. Clin. Biol. Res. 1984, 161, 467-479.
    • (1984) Prog. Clin. Biol. Res , vol.161 , pp. 467-479
    • Chirigos, M.A.1    Welker, R.2    Schlick, E.3    Saito, T.4    Ruffmann, R.5
  • 32
    • 0028849128 scopus 로고
    • Prophylactic and therapeutic efficacies of poly(IC.LC) against respiratory influenza A virus infection in mice
    • Wong, J.P.; Saravolac, E.G.; Sabuda, D.; Levy, H.B.; Kende, M. Prophylactic and therapeutic efficacies of poly(IC.LC) against respiratory influenza A virus infection in mice. Antimicrob. Agents Chemother. 1995, 39, 2574-2576.
    • (1995) Antimicrob. Agents Chemother , vol.39 , pp. 2574-2576
    • Wong, J.P.1    Saravolac, E.G.2    Sabuda, D.3    Levy, H.B.4    Kende, M.5
  • 35
    • 0025269757 scopus 로고    scopus 로고
    • Sakurai, M; Iigo, M.; Sasaki, Y.; Nakagawa, K.; Fujiwara, Y.; Tamura, T.; Ohe, Y.; Bungo, M.; Saijo, N. Lack of correlation between interferon levels induced by polyribonucleotides and their antimetastatic effect. Oncology 1990, 47, 251-256.
    • Sakurai, M; Iigo, M.; Sasaki, Y.; Nakagawa, K.; Fujiwara, Y.; Tamura, T.; Ohe, Y.; Bungo, M.; Saijo, N. Lack of correlation between interferon levels induced by polyribonucleotides and their antimetastatic effect. Oncology 1990, 47, 251-256.
  • 36
    • 0021934543 scopus 로고
    • A comparison of interferon responses to poly ICLC in males and females
    • Bever, C.T., Jr.; McFarlin, D.E.; Levy, H.B. A comparison of interferon responses to poly ICLC in males and females. J. Interferon Res. 1985, 5, 423-428.
    • (1985) J. Interferon Res , vol.5 , pp. 423-428
    • Bever Jr., C.T.1    McFarlin, D.E.2    Levy, H.B.3
  • 37
    • 0026857436 scopus 로고
    • A comparison of interferon responses to poly ICLC in males and females
    • Bever, C.T., Jr.; McFarlin, D.E.; Levy, H.B. A comparison of interferon responses to poly ICLC in males and females. J. Interferon Res. 1992, Spec No, 85-90.
    • (1992) J. Interferon Res , Issue.SPEC 85-90
    • Bever Jr., C.T.1    McFarlin, D.E.2    Levy, H.B.3
  • 39
    • 0017651306 scopus 로고
    • Successful prophylaxis against rabies in mice and Rhesus monkeys: The interferon system and vaccine
    • Baer, G.M.; Shaddock, J.H.; Moore, S.A.; Yager, P.A.; Baron, S.S.; Levy, H.B. Successful prophylaxis against rabies in mice and Rhesus monkeys: the interferon system and vaccine. J. Infect. Dis. 1977, 136, 286-291.
    • (1977) J. Infect. Dis , vol.136 , pp. 286-291
    • Baer, G.M.1    Shaddock, J.H.2    Moore, S.A.3    Yager, P.A.4    Baron, S.S.5    Levy, H.B.6
  • 41
    • 14844290876 scopus 로고    scopus 로고
    • Prophylaxis of acute respiratory virus infections using nucleic acid-based drugs
    • Wong, J.P.; Nagata, L.P.; Christopher, M.E.; Salazar, A.M.; Dale, R.M. Prophylaxis of acute respiratory virus infections using nucleic acid-based drugs. Vaccine 2005, 23, 2266-2268.
    • (2005) Vaccine , vol.23 , pp. 2266-2268
    • Wong, J.P.1    Nagata, L.P.2    Christopher, M.E.3    Salazar, A.M.4    Dale, R.M.5
  • 42
    • 4544368487 scopus 로고    scopus 로고
    • Induction of antiviral immunity by double-stranded RNA in a marine invertebrate
    • Robalino, J.; Browdy, C.L.; Prior, S.; Metz, A.; Parnell, P.; Gross, P.; Warr, G. Induction of antiviral immunity by double-stranded RNA in a marine invertebrate. J. Virol. 2004, 78, 10442-10448.
    • (2004) J. Virol , vol.78 , pp. 10442-10448
    • Robalino, J.1    Browdy, C.L.2    Prior, S.3    Metz, A.4    Parnell, P.5    Gross, P.6    Warr, G.7
  • 43
    • 0017372280 scopus 로고
    • Effect of a nuclease-resistant derivative of polyriboinosinic- polyribocytidylic acid complex on yellow fever in rhesus monkeys (Macaca mulatta)
    • Stephen, E.L.; Sammons, M.L.; Pannier, W.L.; Baron, S.; Spertzel, R.O.; Levy, H.B. Effect of a nuclease-resistant derivative of polyriboinosinic- polyribocytidylic acid complex on yellow fever in rhesus monkeys (Macaca mulatta). J. Infect. Dis. 1977, 136, 122-126.
    • (1977) J. Infect. Dis , vol.136 , pp. 122-126
    • Stephen, E.L.1    Sammons, M.L.2    Pannier, W.L.3    Baron, S.4    Spertzel, R.O.5    Levy, H.B.6
  • 44
    • 0018411888 scopus 로고
    • Protective and toxic effects of a nuclease-resistant derivative of polyriboinosinic- polyribocytidylic acid on Venezuelan equine encephalomyelitis virus in rhesus monkeys
    • Stephen, EX.; Hilmas, D.E.; Levy, H.B.; Spertzel, R.O. Protective and toxic effects of a nuclease-resistant derivative of polyriboinosinic- polyribocytidylic acid on Venezuelan equine encephalomyelitis virus in rhesus monkeys. J. Infect. Dis. 1979, 139, 267-272.
    • (1979) J. Infect. Dis , vol.139 , pp. 267-272
    • Stephen, E.X.1    Hilmas, D.E.2    Levy, H.B.3    Spertzel, R.O.4
  • 45
    • 0022634346 scopus 로고
    • The effects of polyinosinic: Polycytidylic acid (pI:C) on the GVH reaction: immunopathological observations
    • Peres, A.; Seemayer, T.A.; Lapp, W.S. The effects of polyinosinic: polycytidylic acid (pI:C) on the GVH reaction: immunopathological observations. Clin. Immunol. Immunopathol. 1986, 39, 102-111.
    • (1986) Clin. Immunol. Immunopathol , vol.39 , pp. 102-111
    • Peres, A.1    Seemayer, T.A.2    Lapp, W.S.3
  • 46
    • 53549135604 scopus 로고    scopus 로고
    • Carter, W.A.; Strayer, D.U.S. Patent Application #20,050,137,154, 2004.
    • Carter, W.A.; Strayer, D.U.S. Patent Application #20,050,137,154, 2004.
  • 47
    • 0345003929 scopus 로고    scopus 로고
    • Liposomemediated immunotherapy against respiratory influenza virus infection using double-stranded RNApoly ICLC
    • Wong, J.P.; Yang, H.; Nagata, L.; Kende, M.; Levy, H.; Schnell, G.; Blasetti, K. Liposomemediated immunotherapy against respiratory influenza virus infection using double-stranded RNApoly ICLC. Vaccine 1999, 17, 1788-1795.
    • (1999) Vaccine , vol.17 , pp. 1788-1795
    • Wong, J.P.1    Yang, H.2    Nagata, L.3    Kende, M.4    Levy, H.5    Schnell, G.6    Blasetti, K.7
  • 48
    • 0022407722 scopus 로고
    • Prophylactic and therapeutic efficacy of poly(I,C)-LC against Rift Valley fever virus infection in mice
    • Kende, M. Prophylactic and therapeutic efficacy of poly(I,C)-LC against Rift Valley fever virus infection in mice. J. Biol. Response Mod. 1985, 4, 503-511.
    • (1985) J. Biol. Response Mod , vol.4 , pp. 503-511
    • Kende, M.1
  • 49
    • 0023635774 scopus 로고
    • Ranking of prophylactic efficacy of poly(ICLC) against Rift Valley fever virus infection in mice by incremental relative risk of death
    • Kende, M.; Lupton, H.W.; Rill, W.L.; Gibbs, P.; Levy, H.B.; Canonico, P.G. Ranking of prophylactic efficacy of poly(ICLC) against Rift Valley fever virus infection in mice by incremental relative risk of death. Antimicrob. Agents Chemother. 1987, 31, 1194-1198.
    • (1987) Antimicrob. Agents Chemother , vol.31 , pp. 1194-1198
    • Kende, M.1    Lupton, H.W.2    Rill, W.L.3    Gibbs, P.4    Levy, H.B.5    Canonico, P.G.6
  • 50
    • 34247615468 scopus 로고    scopus 로고
    • Correlation between breakdown of the blood-brain barrier and disease outcome of viral encephalitis in mice
    • Olsen, A.L.; Morrey, J.D.; Smee, D.F.; Sidwell, R.W. Correlation between breakdown of the blood-brain barrier and disease outcome of viral encephalitis in mice. Antiviral Res. 2007, 75, 104-112.
    • (2007) Antiviral Res , vol.75 , pp. 104-112
    • Olsen, A.L.1    Morrey, J.D.2    Smee, D.F.3    Sidwell, R.W.4
  • 51
    • 33845445764 scopus 로고    scopus 로고
    • Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice
    • Barnard, D.L.; Day, C.W.; Bailey, K.; Heiner, M.; Montgomery, R.; Lauridsen, L.; Chan, P.K.; Sidwell, R.W. Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice. Antivir. Chem. Chemother. 2006, 17, 275-284.
    • (2006) Antivir. Chem. Chemother , vol.17 , pp. 275-284
    • Barnard, D.L.1    Day, C.W.2    Bailey, K.3    Heiner, M.4    Montgomery, R.5    Lauridsen, L.6    Chan, P.K.7    Sidwell, R.W.8
  • 52
    • 2342506498 scopus 로고    scopus 로고
    • Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models
    • Morrey, J.D.; Day, C.W.; Julander, J.G.; Blatt, L.M.; Smee, D.F.; Sidwell, R.W. Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models. Antivir. Chem. Chemother. 2004, 15, 101-109.
    • (2004) Antivir. Chem. Chemother , vol.15 , pp. 101-109
    • Morrey, J.D.1    Day, C.W.2    Julander, J.G.3    Blatt, L.M.4    Smee, D.F.5    Sidwell, R.W.6
  • 53
    • 0023259706 scopus 로고
    • Enhanced therapeutic efficacy of poly(ICLC) and ribavirin combinations against Rift Valley fever virus infection in mice
    • Kende, M.; Lupton, H.W.; Rill, W.L.; Levy, H.B.; Canonico, P.G. Enhanced therapeutic efficacy of poly(ICLC) and ribavirin combinations against Rift Valley fever virus infection in mice.. Antimicrob. Agents Chemother. 1987, 31, 986-990.
    • (1987) Antimicrob. Agents Chemother , vol.31 , pp. 986-990
    • Kende, M.1    Lupton, H.W.2    Rill, W.L.3    Levy, H.B.4    Canonico, P.G.5
  • 54
    • 0022455887 scopus 로고
    • Treatment of advanced ovarian cancer with polyinosinic-polycytidylic lysine carboxymethylcellulose (poly(ICLC]
    • Rettenmaier, M.A.; Berman, M.L.; DiSaia, P.J. Treatment of advanced ovarian cancer with polyinosinic-polycytidylic lysine carboxymethylcellulose (poly(ICLC]. Gynecol. Oncol. 1986, 24, 359-361.
    • (1986) Gynecol. Oncol , vol.24 , pp. 359-361
    • Rettenmaier, M.A.1    Berman, M.L.2    DiSaia, P.J.3
  • 55
  • 56
    • 38449123291 scopus 로고    scopus 로고
    • Cross-Protection against H5N1 Influenza Virus Infection Is Afforded by Intranasal Inoculation with Seasonal Trivalent Inactivated Influenza Vaccine
    • Ichinohe, T.; Tamura, S.; Kawaguchi, A.; Ninomiya, A.; Imai, M.; Itamura, S.; Odagiri, T.; Tashiro, M.; Takahashi, H.; Sawa, H.; et al. Cross-Protection against H5N1 Influenza Virus Infection Is Afforded by Intranasal Inoculation with Seasonal Trivalent Inactivated Influenza Vaccine. J. Infect. Dis. 2007, 196, 1313-1320.
    • (2007) J. Infect. Dis , vol.196 , pp. 1313-1320
    • Ichinohe, T.1    Tamura, S.2    Kawaguchi, A.3    Ninomiya, A.4    Imai, M.5    Itamura, S.6    Odagiri, T.7    Tashiro, M.8    Takahashi, H.9    Sawa, H.10
  • 57
    • 35148824709 scopus 로고    scopus 로고
    • Intranasal immunization with H5N1 vaccine plus Poly LPoly C(12)U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge
    • Ichinohe, T.; Kawaguchi, A.; Tamura, S.; Takahashi, H.; Sawa, H.; Ninomiya, A.; Imai, M.; Itamura, S.; Odagiri, T.; Tashiro, M.; et al. Intranasal immunization with H5N1 vaccine plus Poly LPoly C(12)U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge. Microbes Infect. 2007, 9, 1333-1340.
    • (2007) Microbes Infect , vol.9 , pp. 1333-1340
    • Ichinohe, T.1    Kawaguchi, A.2    Tamura, S.3    Takahashi, H.4    Sawa, H.5    Ninomiya, A.6    Imai, M.7    Itamura, S.8    Odagiri, T.9    Tashiro, M.10
  • 58
    • 0035168318 scopus 로고    scopus 로고
    • All-trans-retinoic acid and polyriboinosinic: Polyribocytidylic acid in combination potentiate specific antibody production and cell-mediated immunity
    • DeCicco, K.L.; Youngdahl, J.D.; Ross, A.C. All-trans-retinoic acid and polyriboinosinic: Polyribocytidylic acid in combination potentiate specific antibody production and cell-mediated immunity. Immunology 2001, 104, 341-348.
    • (2001) Immunology , vol.104 , pp. 341-348
    • DeCicco, K.L.1    Youngdahl, J.D.2    Ross, A.C.3
  • 59
    • 0018759735 scopus 로고
    • Adjuvant effects of low doses of a nuclease-resistant derivative of polyinosinic acid. polycytidylic acid on antibody responses of monkeys to inactivated Venezuelan equine encephalomyelitis virus vaccine
    • Harrington, D.G.; Crabbs, C.L.; Hilmas, D.E.; Brown, J.R.; Higbee, G.A.; Cole, F.E.J.; Levy, H.B. Adjuvant effects of low doses of a nuclease-resistant derivative of polyinosinic acid. polycytidylic acid on antibody responses of monkeys to inactivated Venezuelan equine encephalomyelitis virus vaccine.. Infect. Immun. 1979, 24, 160-166.
    • (1979) Infect. Immun , vol.24 , pp. 160-166
    • Harrington, D.G.1    Crabbs, C.L.2    Hilmas, D.E.3    Brown, J.R.4    Higbee, G.A.5    Cole, F.E.J.6    Levy, H.B.7
  • 60
    • 0017087553 scopus 로고
    • Modified polyriboinosinicpolyribocytidylic acid, an irnmunological adjuvant
    • Houston, W.E.; Crabbs, C.L.; Stephen, EX.; Levy, H.B. Modified polyriboinosinicpolyribocytidylic acid, an irnmunological adjuvant. Infect. Immun. 1976, 14, 318-319.
    • (1976) Infect. Immun , vol.14 , pp. 318-319
    • Houston, W.E.1    Crabbs, C.L.2    Stephen, E.X.3    Levy, H.B.4
  • 61
    • 0033057053 scopus 로고    scopus 로고
    • Studies on hepatic oxidative stress and antioxidant defence system during chloroquine/poly ICLC treatment of Plasmodium yoelii nigeriensis infected mice
    • Siddiqi, N.J.; Puri, S.K.; Dutta, G.P.; Maheshwari, R.K.; Pandey, V.C. Studies on hepatic oxidative stress and antioxidant defence system during chloroquine/poly ICLC treatment of Plasmodium yoelii nigeriensis infected mice. Mol. Cell. Biochem. 1999, 194, 179-183.
    • (1999) Mol. Cell. Biochem , vol.194 , pp. 179-183
    • Siddiqi, N.J.1    Puri, S.K.2    Dutta, G.P.3    Maheshwari, R.K.4    Pandey, V.C.5
  • 62
    • 0024538723 scopus 로고
    • In vitro evaluation of mismatched doublestranded RNA (ampligen) for combination therapy in the treatment of acquired immunodeficiency syndrome
    • Montefiori, D.C.; Robinson, W.E.J.; Mitchell, W.M. In vitro evaluation of mismatched doublestranded RNA (ampligen) for combination therapy in the treatment of acquired immunodeficiency syndrome. AIDS Res. Hum. Retroviruses 1989, 5, 193-203.
    • (1989) AIDS Res. Hum. Retroviruses , vol.5 , pp. 193-203
    • Montefiori, D.C.1    Robinson, W.E.J.2    Mitchell, W.M.3
  • 63
    • 13744258583 scopus 로고    scopus 로고
    • Differential induction of antiviral effects against West Nile virus in primary mouse macrophages derived from flavivirus-susceptible and congenic resistant mice by alpha/beta interferon and poly(I-C)
    • Pantelic, L.; Sivakumaran, H.; Urosevic, N. Differential induction of antiviral effects against West Nile virus in primary mouse macrophages derived from flavivirus-susceptible and congenic resistant mice by alpha/beta interferon and poly(I-C). J. Virol. 2005, 79, 1753-1764.
    • (2005) J. Virol , vol.79 , pp. 1753-1764
    • Pantelic, L.1    Sivakumaran, H.2    Urosevic, N.3
  • 64
    • 0028931769 scopus 로고
    • Treatment of intracranial alphavirus infections in mice by a combination of specific antibodies and an interferon inducer
    • Coppenhaver, D.H.; Singh, I.P.; Sarzotti, M.; Levy, H.B.; Baron, S. Treatment of intracranial alphavirus infections in mice by a combination of specific antibodies and an interferon inducer. Am. J. Trop. Med. Hyg. 1995, 52, 34-40.
    • (1995) Am. J. Trop. Med. Hyg , vol.52 , pp. 34-40
    • Coppenhaver, D.H.1    Singh, I.P.2    Sarzotti, M.3    Levy, H.B.4    Baron, S.5
  • 65
    • 0026642507 scopus 로고
    • Polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose in combination with interleukin 2 in patients with cancer: Clinical and immunological effects
    • Ewel, C.H.; Urba, W.J.; Kopp, W.C.; Smith, J.W., 2nd; Steis, R.G.; Rossio, J.L.; Longo, D.L.; Jones, M.J.; Alvord, W.G.; Pinsky, CM.; et al. Polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose in combination with interleukin 2 in patients with cancer: clinical and immunological effects. Cancer Res. 1992, 52, 3005-3010.
    • (1992) Cancer Res , vol.52 , pp. 3005-3010
    • Ewel, C.H.1    Urba, W.J.2    Kopp, W.C.3    Smith 2nd, J.W.4    Steis, R.G.5    Rossio, J.L.6    Longo, D.L.7    Jones, M.J.8    Alvord, W.G.9    Pinsky, C.M.10
  • 66
    • 0018922185 scopus 로고
    • Modified polyriboinosinicpolyribocytidylic acid complex: Induction of serum interferon, fever, and hypotension in rabbits
    • Gatmaitan, B.G.; Legaspi, R.C.; Levy, H.B.; Lerner, A.M. Modified polyriboinosinicpolyribocytidylic acid complex: induction of serum interferon, fever, and hypotension in rabbits. Antimicrob. Agents Chemother. 1980, 17, 49-54.
    • (1980) Antimicrob. Agents Chemother , vol.17 , pp. 49-54
    • Gatmaitan, B.G.1    Legaspi, R.C.2    Levy, H.B.3    Lerner, A.M.4
  • 67
    • 1542328794 scopus 로고    scopus 로고
    • Intratracheal double-stranded RNA plus interferon-gamma: A model for analysis of the acute phase response to respiratory viral infections
    • Traynor, T.R.; Majde, J.A.; Bohnet, S.G.; Krueger, J.M. Intratracheal double-stranded RNA plus interferon-gamma: a model for analysis of the acute phase response to respiratory viral infections. Life Sci. 2004, 74, 2563-2576.
    • (2004) Life Sci , vol.74 , pp. 2563-2576
    • Traynor, T.R.1    Majde, J.A.2    Bohnet, S.G.3    Krueger, J.M.4
  • 68
    • 0017108014 scopus 로고
    • A phase I-II trial of multiple-dose polyriboinosic- polyribocytidylic acid in patieonts with leukemia or solid tumors
    • Robinson, R.A.; DeVita, V.T.; Levy, H.B.; Baron, S.; Hubbard, S.P.; Levine, A.S. A phase I-II trial of multiple-dose polyriboinosic- polyribocytidylic acid in patieonts with leukemia or solid tumors. J. Natl. Cancer Inst. 1976, 57, 599-602.
    • (1976) J. Natl. Cancer Inst , vol.57 , pp. 599-602
    • Robinson, R.A.1    DeVita, V.T.2    Levy, H.B.3    Baron, S.4    Hubbard, S.P.5    Levine, A.S.6
  • 70
    • 0022350787 scopus 로고
    • Phase II trial of poly(I,C)-LC, an interferon inducer, in the treatment of children with acute leukemia and neuroblastoma: A report from the Children's Cancer Study Group
    • Lampkin, B.C.; Levine, A.S.; Levy, H.; Krivit, W.; Hammond, D. Phase II trial of poly(I,C)-LC, an interferon inducer, in the treatment of children with acute leukemia and neuroblastoma: A report from the Children's Cancer Study Group. J. Biol. Response Mod. 1985, 4, 531-537.
    • (1985) J. Biol. Response Mod , vol.4 , pp. 531-537
    • Lampkin, B.C.1    Levine, A.S.2    Levy, H.3    Krivit, W.4    Hammond, D.5
  • 71
    • 0022396818 scopus 로고
    • Phase II trial of a complex polyriboinosinic-polyribocytidylic acid with poly-L-lysine and carboxymethyl cellulose in the treatment of children with acute leukemia and neuroblastoma: A report from the Children's Cancer Study Group
    • Lampkin, B.C.; Levine, A.S.; Levy, H.; Krivit, W.; Hammond, D. Phase II trial of a complex polyriboinosinic-polyribocytidylic acid with poly-L-lysine and carboxymethyl cellulose in the treatment of children with acute leukemia and neuroblastoma: a report from the Children's Cancer Study Group. Cancer Res. 1985, 45(11 Pt2), 5904-5909.
    • (1985) Cancer Res , vol.45 , Issue.11 PT2 , pp. 5904-5909
    • Lampkin, B.C.1    Levine, A.S.2    Levy, H.3    Krivit, W.4    Hammond, D.5
  • 75
    • 0022345774 scopus 로고
    • An Eastern Cooperative Oncology Group phase I-II pilot study of polyriboinosinic-polyribocytidylic acid poly-L-lysine complex in patients with metastatic malignant melanoma
    • Hawkins, M.J.; Levin, M.; Borden, E.C. An Eastern Cooperative Oncology Group phase I-II pilot study of polyriboinosinic-polyribocytidylic acid poly-L-lysine complex in patients with metastatic malignant melanoma. J. Biol. Response Mod. 1985, 4, 664-668.
    • (1985) J. Biol. Response Mod , vol.4 , pp. 664-668
    • Hawkins, M.J.1    Levin, M.2    Borden, E.C.3
  • 76
    • 0023874664 scopus 로고
    • Cortisol induction by poly ICLC: Implications for clinical trials of interferon
    • Bever, C.T., Jr.; McFarland, H.F.; Levy, H.B.; McFarlin, D.E. Cortisol induction by poly ICLC: implications for clinical trials of interferon. Ann. Neurol. 1988, 23, 196-199.
    • (1988) Ann. Neurol , vol.23 , pp. 196-199
    • Bever Jr., C.T.1    McFarland, H.F.2    Levy, H.B.3    McFarlin, D.E.4
  • 77
    • 0035092809 scopus 로고    scopus 로고
    • Toxicity and response evaluation of the interferon inducer poly ICLC administered at low dose in advanced renal carcinoma and relapsed or refractory lymphoma: A report of two clinical trials of the Eastern Cooperative Oncology Group
    • Giantonio, B.J.; Hochster, H.; Blum, R.; Wiernik, P.H.; Hudes, G.R.; Kirkwood, J.; Trump, D.; Oken, M.M. Toxicity and response evaluation of the interferon inducer poly ICLC administered at low dose in advanced renal carcinoma and relapsed or refractory lymphoma: a report of two clinical trials of the Eastern Cooperative Oncology Group. Invest. New Drugs 2001, 19, 89-92.
    • (2001) Invest. New Drugs , vol.19 , pp. 89-92
    • Giantonio, B.J.1    Hochster, H.2    Blum, R.3    Wiernik, P.H.4    Hudes, G.R.5    Kirkwood, J.6    Trump, D.7    Oken, M.M.8
  • 79
    • 0344401448 scopus 로고
    • A comparison of immune modulating effects of interferon and interferon inducers
    • Openheim, J, Pick, A, Eds, Academic Press: New York
    • Levy, H.B.; Riley, F.L. A comparison of immune modulating effects of interferon and interferon inducers. In Lymphokines, Openheim, J., Pick, A., Eds.; Academic Press: New York, 1983; Vol. 8, pp 303-322.
    • (1983) Lymphokines , vol.8 , pp. 303-322
    • Levy, H.B.1    Riley, F.L.2
  • 81
    • 8644253352 scopus 로고    scopus 로고
    • Effect of increasing thiolation of the polycytidylic acid strand of poly Lpoly C on the alpha, beta and gamma interferon-inducing properties, antiviral and antiproliferative activities
    • Chadha, K.C.; Dembinski, W.E.; Dunn, C.B.; Aradi, J.; Bardos, T.J.; Dunn, J.A.; Ambrus, J.L., Sr. Effect of increasing thiolation of the polycytidylic acid strand of poly Lpoly C on the alpha, beta and gamma interferon-inducing properties, antiviral and antiproliferative activities. Antiviral Res. 2004, 64, 171-177.
    • (2004) Antiviral Res , vol.64 , pp. 171-177
    • Chadha, K.C.1    Dembinski, W.E.2    Dunn, C.B.3    Aradi, J.4    Bardos, T.J.5    Dunn, J.A.6    Ambrus Sr., J.L.7
  • 82
    • 0344012220 scopus 로고    scopus 로고
    • Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells
    • Marshall, J.D.; Hessel, E.M.; Gregorio, J.; Abbate, C.; Yee, P.; Chu, M.; Van Nest, G.; Coffman, R.L.; Fearon, K.L. Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells. Nucleic Acids Res. 2003, 31, 5122-5133.
    • (2003) Nucleic Acids Res , vol.31 , pp. 5122-5133
    • Marshall, J.D.1    Hessel, E.M.2    Gregorio, J.3    Abbate, C.4    Yee, P.5    Chu, M.6    Van Nest, G.7    Coffman, R.L.8    Fearon, K.L.9
  • 84
    • 8444219651 scopus 로고    scopus 로고
    • Identification of CpG oligodeoxynucleotide sequences that induce IFN-gamma production in canine peripheral blood mononuclear cells
    • Kurata, K.; Iwata, A.; Masuda, K.; Sakaguchi, M.; Ohno, K.; Tsujimoto, H. Identification of CpG oligodeoxynucleotide sequences that induce IFN-gamma production in canine peripheral blood mononuclear cells. Vet. Immunol. Immunopathol. 2004, 102, 441-450.
    • (2004) Vet. Immunol. Immunopathol , vol.102 , pp. 441-450
    • Kurata, K.1    Iwata, A.2    Masuda, K.3    Sakaguchi, M.4    Ohno, K.5    Tsujimoto, H.6
  • 87
    • 2442450672 scopus 로고    scopus 로고
    • Direct evidence that toll-like receptor 9 (TLR9) functionally binds plasmid DNA by specific cytosinephosphate-guanine motif recognition
    • Cornelie, S.; Hoebeke, J.; Schacht, A.M.; Bertin, B.; Vicogne, J.; Capron, M.; Riveau, G. Direct evidence that toll-like receptor 9 (TLR9) functionally binds plasmid DNA by specific cytosinephosphate-guanine motif recognition. J. Biol. Chem. 2004, 279, 15124-15129.
    • (2004) J. Biol. Chem , vol.279 , pp. 15124-15129
    • Cornelie, S.1    Hoebeke, J.2    Schacht, A.M.3    Bertin, B.4    Vicogne, J.5    Capron, M.6    Riveau, G.7
  • 88
    • 2942549527 scopus 로고    scopus 로고
    • Use of CpG oligodeoxynucleotides as immune adjuvants
    • Klinman, D.M.; Currie, D.; Gursel, I.; Verthelyi, D. Use of CpG oligodeoxynucleotides as immune adjuvants. Immunol. Rev. 2004, 199, 201-216.
    • (2004) Immunol. Rev , vol.199 , pp. 201-216
    • Klinman, D.M.1    Currie, D.2    Gursel, I.3    Verthelyi, D.4
  • 89
    • 7944219649 scopus 로고    scopus 로고
    • Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides
    • Ishii, K.J.; Gursel, I.; Gursel, M.; Klinman, D.M. Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides. Curr. Opin. Mol. Ther. 2004, 6, 166-174.
    • (2004) Curr. Opin. Mol. Ther , vol.6 , pp. 166-174
    • Ishii, K.J.1    Gursel, I.2    Gursel, M.3    Klinman, D.M.4
  • 90
    • 0033406341 scopus 로고    scopus 로고
    • CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway
    • Yi, A.K.; Peckham, D.W.; Ashman, R.F.; Krieg, A.M. CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway. Int. Immunol. 1999, 11, 2015-2024.
    • (1999) Int. Immunol , vol.11 , pp. 2015-2024
    • Yi, A.K.1    Peckham, D.W.2    Ashman, R.F.3    Krieg, A.M.4
  • 91
    • 0033529891 scopus 로고    scopus 로고
    • Hartmann, G.; Weiner, G.J.; Krieg, A.M. CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. Proc. Natl. Acad. Sci. USA 1999, 96, 9305-9310.
    • Hartmann, G.; Weiner, G.J.; Krieg, A.M. CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. Proc. Natl. Acad. Sci. USA 1999, 96, 9305-9310.
  • 92
    • 0038142387 scopus 로고    scopus 로고
    • A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    • Bernasconi, N.L.; Onai, N.; Lanzavecchia, A. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 2003, 101, 4500-4504.
    • (2003) Blood , vol.101 , pp. 4500-4504
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 93
    • 0037407691 scopus 로고    scopus 로고
    • Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells
    • Kerkmann, M.; Rothenfusser, S.; Hornung, V.; Towarowski, A.; Wagner, M.; Sarris, A.; Giese, T.; Endres, S.; Hartmann, G. Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J. Immunol. 2003, 170, 4465-4474.
    • (2003) J. Immunol , vol.170 , pp. 4465-4474
    • Kerkmann, M.1    Rothenfusser, S.2    Hornung, V.3    Towarowski, A.4    Wagner, M.5    Sarris, A.6    Giese, T.7    Endres, S.8    Hartmann, G.9
  • 94
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung, V.; Rothenfusser, S.; Britsch, S.; Krug, A.; Jahrsdorfer, B.; Giese, T.; Endres, S.; Hartmann, G., Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 2002, 168, 4531-4537.
    • (2002) J. Immunol , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 95
    • 11144232881 scopus 로고    scopus 로고
    • Toll-like receptor 9 regulates tumor necrosis factoralpha expression by different mechanisms. Implications for osteoclastogenesis
    • Amcheslavsky, A.; Zou, W.; Bar-Shavit, Z. Toll-like receptor 9 regulates tumor necrosis factoralpha expression by different mechanisms. Implications for osteoclastogenesis. J. Biol. Chem. 2004, 279, 54039-54045.
    • (2004) J. Biol. Chem , vol.279 , pp. 54039-54045
    • Amcheslavsky, A.1    Zou, W.2    Bar-Shavit, Z.3
  • 96
    • 0027325137 scopus 로고
    • Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides
    • Zhao, Q.; Matson, S.; Herrera, C.J.; Fisher, E.; Yu, H.; Krieg, A.M., Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides. Antisense Res. Dev. 1993, 3, 53-66.
    • (1993) Antisense Res. Dev , vol.3 , pp. 53-66
    • Zhao, Q.1    Matson, S.2    Herrera, C.J.3    Fisher, E.4    Yu, H.5    Krieg, A.M.6
  • 98
    • 0026920673 scopus 로고
    • Cellular uptake and subcellular distribution of phosphorothioate oligonucleotides into cultured cells
    • Iversen, P.L.; Zhu, S.; Meyer, A.; Zon, G. Cellular uptake and subcellular distribution of phosphorothioate oligonucleotides into cultured cells. Antisense Res. Dev. 1992, 2, 211-222.
    • (1992) Antisense Res. Dev , vol.2 , pp. 211-222
    • Iversen, P.L.1    Zhu, S.2    Meyer, A.3    Zon, G.4
  • 99
    • 0042667064 scopus 로고    scopus 로고
    • Hierarchical recognition of CpG motifs expressed by immunostimulatory oligodeoxynucleotides
    • Klinman, D.M.; Currie, D. Hierarchical recognition of CpG motifs expressed by immunostimulatory oligodeoxynucleotides. Clin. Exp. Immunol. 2003, 133, 227-232.
    • (2003) Clin. Exp. Immunol , vol.133 , pp. 227-232
    • Klinman, D.M.1    Currie, D.2
  • 100
    • 0037407856 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection
    • Verthelyi, D.; Gursel, M.; Kenney, R.T.; Lifson, J.D.; Liu, S.; Mican, J.; Klinman, D.M. CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection. J. Immunol. 2003, 170, 4717-4723.
    • (2003) J. Immunol , vol.170 , pp. 4717-4723
    • Verthelyi, D.1    Gursel, M.2    Kenney, R.T.3    Lifson, J.D.4    Liu, S.5    Mican, J.6    Klinman, D.M.7
  • 101
    • 0032168355 scopus 로고    scopus 로고
    • CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
    • Krieg, A.M.; Love-Homan, L.; Yi, A.K.; Harty, J.T. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 1998, 161, 2428-2434.
    • (1998) J. Immunol , vol.161 , pp. 2428-2434
    • Krieg, A.M.1    Love-Homan, L.2    Yi, A.K.3    Harty, J.T.4
  • 102
    • 7444242674 scopus 로고    scopus 로고
    • Induction of systemic THl-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist
    • Krieg, A.M.; Efler, S.M.; Wittpoth, M.; Al Adhami, M.J.; Davis, H.L. Induction of systemic THl-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist. J. Immunother. 2004, 27, 460-471.
    • (2004) J. Immunother , vol.27 , pp. 460-471
    • Krieg, A.M.1    Efler, S.M.2    Wittpoth, M.3    Al Adhami, M.J.4    Davis, H.L.5
  • 103
    • 53549114336 scopus 로고    scopus 로고
    • Broad-spectrum antiviral defence against influenza viruses using nucleic acid-based immunomodulators
    • Wong, J. P, Ed, Transworld Research Network: Trivandrum
    • Christopher, M.E.; Wong, J.P. Broad-spectrum antiviral defence against influenza viruses using nucleic acid-based immunomodulators. In Recent Developments on the Avian Influenza (H5N1) Crisis, Wong, J. P., Ed.; Transworld Research Network: Trivandrum, 2006; pp 85-118.
    • (2006) Recent Developments on the Avian Influenza (H5N1) Crisis , pp. 85-118
    • Christopher, M.E.1    Wong, J.P.2
  • 104
    • 0038653486 scopus 로고    scopus 로고
    • An immunostimulatory oligodeoxynucleotide containing a cytidine-guanosine motif protects senescence-accelerated mice from lethal influenza virus by augmenting the T helper type 1 response
    • Dong, L.; Mori, I.; Hossain, M.J.; Liu, B.; Kimura, Y. An immunostimulatory oligodeoxynucleotide containing a cytidine-guanosine motif protects senescence-accelerated mice from lethal influenza virus by augmenting the T helper type 1 response. J. Gen. Virol. 2003, 84(Pt6), 1623-1628.
    • (2003) J. Gen. Virol , vol.84 , Issue.PT6 , pp. 1623-1628
    • Dong, L.1    Mori, I.2    Hossain, M.J.3    Liu, B.4    Kimura, Y.5
  • 106
    • 0035885126 scopus 로고    scopus 로고
    • Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides
    • Gursel, I.; Gursel, M.; Ishii, K.J.; Klinman, D.M. Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides. J. Immunol. 2001, 167, 3324-3328.
    • (2001) J. Immunol , vol.167 , pp. 3324-3328
    • Gursel, I.1    Gursel, M.2    Ishii, K.J.3    Klinman, D.M.4
  • 107
    • 0033558121 scopus 로고    scopus 로고
    • Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
    • Elkins, K.L.; Rhinehart-Jones, T.R.; Stibitz, S.; Conover, J.S.; Klinman, D.M. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J. Immunol. 1999, 162, 2291-2298.
    • (1999) J. Immunol , vol.162 , pp. 2291-2298
    • Elkins, K.L.1    Rhinehart-Jones, T.R.2    Stibitz, S.3    Conover, J.S.4    Klinman, D.M.5
  • 108
    • 0031948647 scopus 로고    scopus 로고
    • Therapeutic applications of CpG-containing oligodeoxynucleotides
    • Klinman, D.M. Therapeutic applications of CpG-containing oligodeoxynucleotides. Antisense Nucleic Acid Drug Dev. 1998, 8, 181-184.
    • (1998) Antisense Nucleic Acid Drug Dev , vol.8 , pp. 181-184
    • Klinman, D.M.1
  • 109
    • 0032706198 scopus 로고    scopus 로고
    • Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection
    • Klinman, D.M.; Conover, J.; Coban, C. Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection. Infect. Immun. 1999, 67, 5658-5663.
    • (1999) Infect. Immun , vol.67 , pp. 5658-5663
    • Klinman, D.M.1    Conover, J.2    Coban, C.3
  • 111
    • 0035865054 scopus 로고    scopus 로고
    • Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
    • Verthelyi, D.; Ishii, K.J.; Gursel, M.; Takeshita, F.; Klinman, D.M. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol. 2001, 166, 2372-2377.
    • (2001) J. Immunol , vol.166 , pp. 2372-2377
    • Verthelyi, D.1    Ishii, K.J.2    Gursel, M.3    Takeshita, F.4    Klinman, D.M.5
  • 112
    • 0032521881 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
    • Zimmermann, S.; Egeter, O.; Hausmann, S.; Lipford, G.B.; Rocken, M.; Wagner, H.; Heeg, K. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 1998, 160, 3627-3630.
    • (1998) J. Immunol , vol.160 , pp. 3627-3630
    • Zimmermann, S.1    Egeter, O.2    Hausmann, S.3    Lipford, G.B.4    Rocken, M.5    Wagner, H.6    Heeg, K.7
  • 114
    • 0033179892 scopus 로고    scopus 로고
    • Immune recognition of foreign DNA: A cure for bioterrorism?
    • Klinman, D.M.; Verthelyi, D.; Takeshita, F.; Ishii, K.J. Immune recognition of foreign DNA: A cure for bioterrorism? Immunity 1999, 11, 123-129.
    • (1999) Immunity , vol.11 , pp. 123-129
    • Klinman, D.M.1    Verthelyi, D.2    Takeshita, F.3    Ishii, K.J.4
  • 115
    • 0035117252 scopus 로고    scopus 로고
    • Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice
    • Gramzinski, R.A.; Doolan, D.L.; Sedegah, M.; Davis, H.L.; Krieg, A.M.; Hoffman, S.L. Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect. Immun. 2001, 69, 1643-1649.
    • (2001) Infect. Immun , vol.69 , pp. 1643-1649
    • Gramzinski, R.A.1    Doolan, D.L.2    Sedegah, M.3    Davis, H.L.4    Krieg, A.M.5    Hoffman, S.L.6
  • 116
    • 0036828062 scopus 로고    scopus 로고
    • Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs
    • Olbrich, A.R.; Schimmer, S.; Heeg, K.; Schepers, K.; Schumacher, T.N.; Dittmer, U. Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs. J. Virol. 2002, 76, 11397-11404.
    • (2002) J. Virol , vol.76 , pp. 11397-11404
    • Olbrich, A.R.1    Schimmer, S.2    Heeg, K.3    Schepers, K.4    Schumacher, T.N.5    Dittmer, U.6
  • 117
    • 0036827534 scopus 로고    scopus 로고
    • Pyles, R.B.; Higgins, D.; Chalk, C; Zalar, A.; Eiden, J.; Brown, C; Van Nest, G.; Stanberry, L.R. Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection. J. Virol. 2002, 76, 11387-11396.
    • Pyles, R.B.; Higgins, D.; Chalk, C; Zalar, A.; Eiden, J.; Brown, C; Van Nest, G.; Stanberry, L.R. Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection. J. Virol. 2002, 76, 11387-11396.
  • 118
    • 0037143011 scopus 로고    scopus 로고
    • Postexposure prophylaxis against prion disease with a stimulator of innate immunity
    • Sethi, S.; Lipford, G.; Wagner, H.; Kretzschmar, H. Postexposure prophylaxis against prion disease with a stimulator of innate immunity. Lancet 2002, 360, 229-230.
    • (2002) Lancet , vol.360 , pp. 229-230
    • Sethi, S.1    Lipford, G.2    Wagner, H.3    Kretzschmar, H.4
  • 120
    • 0031800888 scopus 로고    scopus 로고
    • Moldoveanu, Z.; Love-Homan, L.; Huang, W.Q.; Krieg, A.M. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 1998, 16, 1216-1224.
    • Moldoveanu, Z.; Love-Homan, L.; Huang, W.Q.; Krieg, A.M. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 1998, 16, 1216-1224.
  • 121
    • 0034668209 scopus 로고    scopus 로고
    • Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants
    • McCluskie, M.J.; Davis, H.L. Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants. Vaccine 2000, 19, 413-422.
    • (2000) Vaccine , vol.19 , pp. 413-422
    • McCluskie, M.J.1    Davis, H.L.2
  • 122
    • 13844299445 scopus 로고    scopus 로고
    • Resistance to influenza A virus infection by antigen-conjugated CpG oligonucleotides, a novel antigen-specific immunomodulator
    • Hayashi, M.; Satou, E.; Ueki, R.; Yano, M.; Miyano-Kurosaki, N.; Fujii, M.; Takaku, H. Resistance to influenza A virus infection by antigen-conjugated CpG oligonucleotides, a novel antigen-specific immunomodulator. Biochem. Biophys. Res. Commun. 2005, 329, 230-236.
    • (2005) Biochem. Biophys. Res. Commun , vol.329 , pp. 230-236
    • Hayashi, M.1    Satou, E.2    Ueki, R.3    Yano, M.4    Miyano-Kurosaki, N.5    Fujii, M.6    Takaku, H.7
  • 126
    • 0037726807 scopus 로고    scopus 로고
    • A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
    • Halperin, S.A.; Van Nest, G.; Smith, B.; Abtahi, S.; Whiley, H.; Eiden, J.J. A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine 2003, 21, 2461-2467.
    • (2003) Vaccine , vol.21 , pp. 2461-2467
    • Halperin, S.A.1    Van Nest, G.2    Smith, B.3    Abtahi, S.4    Whiley, H.5    Eiden, J.J.6
  • 127
    • 11244280803 scopus 로고    scopus 로고
    • Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: Increased interferon-alpha/betainducible gene expression, without significant toxicity
    • Friedberg, J.W.; Kim, H.; McCauley, M.; Hessel, E.M.; Sims, P.; Fisher, D.C.; Nadler, L.M.; Coffman, R.L.; Freedman, A.S. Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/betainducible gene expression, without significant toxicity. Blood 2005, 105, 489-495.
    • (2005) Blood , vol.105 , pp. 489-495
    • Friedberg, J.W.1    Kim, H.2    McCauley, M.3    Hessel, E.M.4    Sims, P.5    Fisher, D.C.6    Nadler, L.M.7    Coffman, R.L.8    Freedman, A.S.9
  • 130
    • 0142185281 scopus 로고    scopus 로고
    • Technology evaluation: CpG-7909, Coley
    • Paul, S. Technology evaluation: CpG-7909, Coley. Curr. Opin. Mol. Ther. 2003, 5, 553-559.
    • (2003) Curr. Opin. Mol. Ther , vol.5 , pp. 553-559
    • Paul, S.1
  • 131
    • 11344257404 scopus 로고    scopus 로고
    • CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study
    • Cooper, C.L.; Davis, H.L.; Morris, M.L.; Efler, S.M.; Adhami, M.A.; Krieg, A.M.; Cameron, D.W.; Heathcote, J. CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study. J. Clin. Immunol. 2004, 24, 693-701.
    • (2004) J. Clin. Immunol , vol.24 , pp. 693-701
    • Cooper, C.L.1    Davis, H.L.2    Morris, M.L.3    Efler, S.M.4    Adhami, M.A.5    Krieg, A.M.6    Cameron, D.W.7    Heathcote, J.8
  • 132
    • 11844299863 scopus 로고    scopus 로고
    • Biphasic lipid vesicles (Biphasix) enhance the adjuvanticity of CpG oligonucleotides following systemic and mucosal administration
    • Babiuk, S.; Baca-Estrada, M.E.; Middleton, D.M.; Hecker, R.; Babiuk, L.A.; Foldvari, M. Biphasic lipid vesicles (Biphasix) enhance the adjuvanticity of CpG oligonucleotides following systemic and mucosal administration. Curr. Drug. Deliv. 2004, 1, 9-15.
    • (2004) Curr. Drug. Deliv , vol.1 , pp. 9-15
    • Babiuk, S.1    Baca-Estrada, M.E.2    Middleton, D.M.3    Hecker, R.4    Babiuk, L.A.5    Foldvari, M.6
  • 136
    • 35348955182 scopus 로고    scopus 로고
    • Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus
    • Kwissa, M.; Amara, R.R.; Robinson, H.L.; Moss, B.; Alkan, S.; Jabbar, A.; Villinger, F.; Pulendran, B. Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus. J. Exp. Med. 2007, 204, 2733-2746.
    • (2007) J. Exp. Med , vol.204 , pp. 2733-2746
    • Kwissa, M.1    Amara, R.R.2    Robinson, H.L.3    Moss, B.4    Alkan, S.5    Jabbar, A.6    Villinger, F.7    Pulendran, B.8
  • 137
    • 10744224734 scopus 로고    scopus 로고
    • Kumar, S.; Jones, T.R.; Oakley, M.S.; Zheng, H.; Kuppusamy, S.P.; Taye, A.; Krieg, A.M.; Stowers, A.W.; Kaslow, D.C.; Hoffman, S.L. CpG oligodeoxynucleotide and Montanide ISA 51 adjuvant combination enhanced the protective efficacy of a subunit malaria vaccine. Infect. Immun. 2004, 72, 949-957.
    • Kumar, S.; Jones, T.R.; Oakley, M.S.; Zheng, H.; Kuppusamy, S.P.; Taye, A.; Krieg, A.M.; Stowers, A.W.; Kaslow, D.C.; Hoffman, S.L. CpG oligodeoxynucleotide and Montanide ISA 51 adjuvant combination enhanced the protective efficacy of a subunit malaria vaccine. Infect. Immun. 2004, 72, 949-957.
  • 138
    • 0030900680 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma
    • Wooldridge, J.E.; Ballas, Z.; Krieg, A.M.; Weiner, G.J. Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood 1997, 89, 2994-2998.
    • (1997) Blood , vol.89 , pp. 2994-2998
    • Wooldridge, J.E.1    Ballas, Z.2    Krieg, A.M.3    Weiner, G.J.4
  • 139
    • 0038330766 scopus 로고    scopus 로고
    • DNA as a vaccine adjuvant
    • Klinman, D.M. CpG DNA as a vaccine adjuvant. Expert Rev. Vaccines 2003, 2, 305-315.
    • (2003) Expert Rev. Vaccines , vol.2 , pp. 305-315
    • Klinman, D.M.C.1
  • 140
    • 0028600632 scopus 로고
    • Humoral and cellular immunity to an encoded protein induced by direct DNA injection
    • Katsumi, A.; Emi, N.; Abe, A.; Hasegawa, Y.; Ito, M.; Saito, H. Humoral and cellular immunity to an encoded protein induced by direct DNA injection. Hum. Gene Ther. 1994, 5, 1335-1339.
    • (1994) Hum. Gene Ther , vol.5 , pp. 1335-1339
    • Katsumi, A.1    Emi, N.2    Abe, A.3    Hasegawa, Y.4    Ito, M.5    Saito, H.6
  • 143
    • 0031156982 scopus 로고    scopus 로고
    • Microbial products induce autoimmune disease by an IL-12-dependent pathway
    • Segal, B.M.; Klinman, D.M.; Shevach, E.M. Microbial products induce autoimmune disease by an IL-12-dependent pathway. J. Immunol. 1997, 158, 5087-5090.
    • (1997) J. Immunol , vol.158 , pp. 5087-5090
    • Segal, B.M.1    Klinman, D.M.2    Shevach, E.M.3
  • 144
    • 0034043957 scopus 로고    scopus 로고
    • CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo
    • Segal, B.M.; Chang, J.T.; Shevach, E.M. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. J. Immunol. 2000, 164, 5683-5688.
    • (2000) J. Immunol , vol.164 , pp. 5683-5688
    • Segal, B.M.1    Chang, J.T.2    Shevach, E.M.3
  • 145
    • 0033605250 scopus 로고    scopus 로고
    • Chlamydia infections and heart disease linked through antigenic mimicry
    • Bachmaier, K.; Neu, N.; de la Maza, L.M.; Pal, S.; Hessel, A.; Penninger, J.M. Chlamydia infections and heart disease linked through antigenic mimicry. Science 1999, 283, 1335-1339.
    • (1999) Science , vol.283 , pp. 1335-1339
    • Bachmaier, K.1    Neu, N.2    de la Maza, L.M.3    Pal, S.4    Hessel, A.5    Penninger, J.M.6
  • 146
    • 0037637548 scopus 로고    scopus 로고
    • Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis
    • Zeuner, R.A.; Verthelyi, D.; Gursel, M.; Ishii, K.J.; Klinman, D.M. Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis. Arthritis Rheum. 2003, 48, 1701-1707.
    • (2003) Arthritis Rheum , vol.48 , pp. 1701-1707
    • Zeuner, R.A.1    Verthelyi, D.2    Gursel, M.3    Ishii, K.J.4    Klinman, D.M.5
  • 147
    • 0029934754 scopus 로고    scopus 로고
    • Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides
    • Cowdery, J.S.; Chace, J.H.; Yi, A.K.; Krieg, A.M. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 1996, 156, 4570-4575.
    • (1996) J. Immunol , vol.156 , pp. 4570-4575
    • Cowdery, J.S.1    Chace, J.H.2    Yi, A.K.3    Krieg, A.M.4
  • 148
    • 0029771599 scopus 로고    scopus 로고
    • Oligodeoxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: Dependence on phosphorothioate modification and reversal by heparin
    • Hartmann, G.; Krug, A.; Waller-Fontaine, K.; Endres, S. Oligodeoxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: dependence on phosphorothioate modification and reversal by heparin. Mol. Med. 1996, 2, 429-438.
    • (1996) Mol. Med , vol.2 , pp. 429-438
    • Hartmann, G.1    Krug, A.2    Waller-Fontaine, K.3    Endres, S.4
  • 151
    • 2942631177 scopus 로고    scopus 로고
    • Enhanced hepatitis C virus NS3 specific Thl immune responses induced by co-delivery of protein antigen and CpG with cationic liposomes
    • Jiao, X.; Wang, R.Y.; Qiu, Q.; Alter, H.J.; Shih, J.W. Enhanced hepatitis C virus NS3 specific Thl immune responses induced by co-delivery of protein antigen and CpG with cationic liposomes. J. Gen. Virol. 2004, 85(Pt6), 1545-1553.
    • (2004) J. Gen. Virol , vol.85 , Issue.PT6 , pp. 1545-1553
    • Jiao, X.1    Wang, R.Y.2    Qiu, Q.3    Alter, H.J.4    Shih, J.W.5
  • 152
    • 0034893986 scopus 로고    scopus 로고
    • Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles
    • Mui, B.; Raney, S.G.; Semple, S.C.; Hope, M.J. Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles. J. Pharmacol. Exp. Ther. 2001, 298, 1185-1192.
    • (2001) J. Pharmacol. Exp. Ther , vol.298 , pp. 1185-1192
    • Mui, B.1    Raney, S.G.2    Semple, S.C.3    Hope, M.J.4
  • 153
    • 2542576435 scopus 로고    scopus 로고
    • Changes in gene expression induced by phosphorothioate oligodeoxynucleotides (including G3139) in PC3 prostate carcinoma cells are recapitulated at least in part by treatment with interferon-beta and -gamma
    • Benimetskaya, L.; Wittenberger, T.; Stein, C.A.; Hofmann, H.P.; Weller, C; Lai, J.C.; Miller, P.; Gekeler, V. Changes in gene expression induced by phosphorothioate oligodeoxynucleotides (including G3139) in PC3 prostate carcinoma cells are recapitulated at least in part by treatment with interferon-beta and -gamma. Clin. Cancer Res. 2004, 10, 3678-3688.
    • (2004) Clin. Cancer Res , vol.10 , pp. 3678-3688
    • Benimetskaya, L.1    Wittenberger, T.2    Stein, C.A.3    Hofmann, H.P.4    Weller, C.5    Lai, J.C.6    Miller, P.7    Gekeler, V.8
  • 154
    • 0037073639 scopus 로고    scopus 로고
    • Enhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres
    • Diwan, M.; Tafaghodi, M.; Samuel, J. Enhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres. J. Control. Release 2002, 85, 247-262.
    • (2002) J. Control. Release , vol.85 , pp. 247-262
    • Diwan, M.1    Tafaghodi, M.2    Samuel, J.3
  • 156
    • 0036738536 scopus 로고    scopus 로고
    • Conjugation of ligands at the 5′-end of CpG DNA affects immunostimulatory activity
    • Kandimalla, E.R.; Bhagat, L.; Yu, D.; Cong, Y.; Tang, J.; Agrawal, S. Conjugation of ligands at the 5′-end of CpG DNA affects immunostimulatory activity. Bioconjug. Chem. 2002, 13, 966-974.
    • (2002) Bioconjug. Chem , vol.13 , pp. 966-974
    • Kandimalla, E.R.1    Bhagat, L.2    Yu, D.3    Cong, Y.4    Tang, J.5    Agrawal, S.6
  • 157
    • 10744227784 scopus 로고    scopus 로고
    • A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif
    • Kandimalla, E.R.; Bhagat, L.; Zhu, F.G.; Yu, D.; Cong, Y.P.; Wang, D.; Tang, J.X.; Tang, J.Y.; Knetter, C.F.; Lien, E.; et al. A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif. Proc. Natl. Acad. Sci. USA 2003, 100, 14303-14308.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 14303-14308
    • Kandimalla, E.R.1    Bhagat, L.2    Zhu, F.G.3    Yu, D.4    Cong, Y.P.5    Wang, D.6    Tang, J.X.7    Tang, J.Y.8    Knetter, C.F.9    Lien, E.10
  • 158
    • 33845579097 scopus 로고    scopus 로고
    • Diebold, S.S.; Massacrier, C; Akira, S.; Paturel, C; Morel, Y.; Reis e Sousa, C. Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur. J. Immunol. 2006, 36, 3256-3267.
    • Diebold, S.S.; Massacrier, C; Akira, S.; Paturel, C; Morel, Y.; Reis e Sousa, C. Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur. J. Immunol. 2006, 36, 3256-3267.
  • 159
    • 33750813795 scopus 로고    scopus 로고
    • Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition
    • Wang, J.P.; Liu, P.; Latz, E.; Golenbock, D.T.; Finberg, R.W.; Libraty, D.H. Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition. J. Immunol. 2006, 177, 7114-7121.
    • (2006) J. Immunol , vol.177 , pp. 7114-7121
    • Wang, J.P.1    Liu, P.2    Latz, E.3    Golenbock, D.T.4    Finberg, R.W.5    Libraty, D.H.6
  • 163
    • 47249162826 scopus 로고    scopus 로고
    • Analysis of the neuroinflammatory response to TLR7 stimulation in the brain: Comparison of multiple TLR7 and/or TLR8 agonists
    • Butchi, N.B.; Pourciau, S.; Du, M.; Morgan, T.W.; Peterson, K.E. Analysis of the neuroinflammatory response to TLR7 stimulation in the brain: comparison of multiple TLR7 and/or TLR8 agonists. J. Immunol. 2008, 180, 7604-7612.
    • (2008) J. Immunol , vol.180 , pp. 7604-7612
    • Butchi, N.B.1    Pourciau, S.2    Du, M.3    Morgan, T.W.4    Peterson, K.E.5
  • 165
    • 42149167357 scopus 로고    scopus 로고
    • TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages
    • Gantier, M.P.; Tong, S.; Behlke, M.A.; Xu, D.; Phipps, S.; Foster, P.S.; Williams, B.R. TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. J. Immunol. 2008, 180, 2117-2124.
    • (2008) J. Immunol , vol.180 , pp. 2117-2124
    • Gantier, M.P.1    Tong, S.2    Behlke, M.A.3    Xu, D.4    Phipps, S.5    Foster, P.S.6    Williams, B.R.7
  • 170
    • 39349090624 scopus 로고    scopus 로고
    • Nucleic acid recognition receptors in autoimmunity
    • Krug, A. Nucleic acid recognition receptors in autoimmunity. Handb. Exp. Pharmacol. 2008, 183, 129-151.
    • (2008) Handb. Exp. Pharmacol , vol.183 , pp. 129-151
    • Krug, A.1
  • 171
    • 36048962438 scopus 로고    scopus 로고
    • Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    • Deane, J.A.; Pisitkun, P.; Barrett, R.S.; Feigenbaum, L.; Town, T.; Ward, J.M.; Flavell, R.A.; Bolland, S. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007, 27, 801-810.
    • (2007) Immunity , vol.27 , pp. 801-810
    • Deane, J.A.1    Pisitkun, P.2    Barrett, R.S.3    Feigenbaum, L.4    Town, T.5    Ward, J.M.6    Flavell, R.A.7    Bolland, S.8
  • 172
    • 37549066665 scopus 로고    scopus 로고
    • Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
    • Barrat, F.J.; Meeker, T.; Chan, J.H.; Guiducci, C; Coffman, R.L. Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur. J. Immunol. 2007, 37, 3582-3586.
    • (2007) Eur. J. Immunol , vol.37 , pp. 3582-3586
    • Barrat, F.J.1    Meeker, T.2    Chan, J.H.3    Guiducci, C.4    Coffman, R.L.5
  • 174
    • 1842585032 scopus 로고    scopus 로고
    • Human and avian influenza viruses target different cell types in cultures of human airway epithelium
    • Matrosovich, M.N.; Matrosovich, T.Y.; Gray, T.; Roberts, N.A.; Klenk, H.D. Human and avian influenza viruses target different cell types in cultures of human airway epithelium. Proc. Natl. Acad. Sci. USA 2004, 101, 4620-4624.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4620-4624
    • Matrosovich, M.N.1    Matrosovich, T.Y.2    Gray, T.3    Roberts, N.A.4    Klenk, H.D.5
  • 175
    • 85047689738 scopus 로고    scopus 로고
    • Avian influenza and sialic acid receptors: More than meets the eye?
    • Olofsson, S.; Kumlin, U.; Dimock, K.; Arnberg, N. Avian influenza and sialic acid receptors: more than meets the eye? Lancet Infect. Dis. 2005, 5, 184-188.
    • (2005) Lancet Infect. Dis , vol.5 , pp. 184-188
    • Olofsson, S.1    Kumlin, U.2    Dimock, K.3    Arnberg, N.4
  • 176
    • 0029861167 scopus 로고    scopus 로고
    • Inhibitory effects of recombinant manganese superoxide dismutase on influenza virus infections in mice
    • Sidwell, R.W.; Huffman, J.H.; Bailey, K.W.; Wong, M.H.; Nimrod, A.; Panet, A. Inhibitory effects of recombinant manganese superoxide dismutase on influenza virus infections in mice. Antimicrob. Agents Chemother. 1996, 40, 2626-2631.
    • (1996) Antimicrob. Agents Chemother , vol.40 , pp. 2626-2631
    • Sidwell, R.W.1    Huffman, J.H.2    Bailey, K.W.3    Wong, M.H.4    Nimrod, A.5    Panet, A.6
  • 177
    • 0024375781 scopus 로고
    • Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD
    • Oda, T.; Akaike, T.; Hamamoto, T.; Suzuki, F.; Hirano, T.; Maeda, H. Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD. Science 1989, 244, 974-976.
    • (1989) Science , vol.244 , pp. 974-976
    • Oda, T.1    Akaike, T.2    Hamamoto, T.3    Suzuki, F.4    Hirano, T.5    Maeda, H.6
  • 180
    • 0029861191 scopus 로고    scopus 로고
    • Influenza virus neuraminidase activates latent transforming growth factor beta
    • Schultz-Cherry, S.; Hinshaw, V.S. Influenza virus neuraminidase activates latent transforming growth factor beta. J. Virol. 1996, 70, 8624-8629.
    • (1996) J. Virol , vol.70 , pp. 8624-8629
    • Schultz-Cherry, S.1    Hinshaw, V.S.2
  • 181
    • 22044438960 scopus 로고    scopus 로고
    • Predominant contribution of IFN-beta expression to apoptosis induction in human uterine cervical fibroblast cells by influenza-virus infection
    • Ohyama, K.; Sano, T.; Toyoda, H. Predominant contribution of IFN-beta expression to apoptosis induction in human uterine cervical fibroblast cells by influenza-virus infection. Biol. Pharm. Bull. 2004, 27, 1750-1757.
    • (2004) Biol. Pharm. Bull , vol.27 , pp. 1750-1757
    • Ohyama, K.1    Sano, T.2    Toyoda, H.3
  • 182
    • 0037381149 scopus 로고    scopus 로고
    • Local immune responses to influenza virus infection in mice with a targeted disruption of perforin gene
    • Liu, B.; Mori, I.; Hossain, M.J.; Dong, L.; Chen, Z.; Kimura, Y. Local immune responses to influenza virus infection in mice with a targeted disruption of perforin gene. Microb. Pathog. 2003, 34, 161-167.
    • (2003) Microb. Pathog , vol.34 , pp. 161-167
    • Liu, B.1    Mori, I.2    Hossain, M.J.3    Dong, L.4    Chen, Z.5    Kimura, Y.6
  • 184
    • 0036239484 scopus 로고    scopus 로고
    • Protective cross-reactive cellular immunity to lethal A/Goose/Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8(+) T cells expressing gamma interferon
    • Seo, S.H.; Peiris, M.; Webster, R.G. Protective cross-reactive cellular immunity to lethal A/Goose/Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8(+) T cells expressing gamma interferon. J. Virol. 2002, 76, 4886-4890.
    • (2002) J. Virol , vol.76 , pp. 4886-4890
    • Seo, S.H.1    Peiris, M.2    Webster, R.G.3
  • 185
    • 0037038866 scopus 로고    scopus 로고
    • Induction of pro inflammatory cytokines in human macrophages by influenza A (H5N1) viruses: A mechanism for the unusual severity of human disease?
    • Cheung, C.Y.; Poon, L.L.; Lau, A.S.; Luk, W.; Lau, Y.L.; Shortridge, K.F.; Gordon, S.; Guan, Y.; Peiris, J.S. Induction of pro inflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet 2002, 360, 1831-1837.
    • (2002) Lancet , vol.360 , pp. 1831-1837
    • Cheung, C.Y.1    Poon, L.L.2    Lau, A.S.3    Luk, W.4    Lau, Y.L.5    Shortridge, K.F.6    Gordon, S.7    Guan, Y.8    Peiris, J.S.9
  • 186
    • 0033982808 scopus 로고    scopus 로고
    • Distinct pathogenesis of Hong Kong-origin H5N1 viruses in mice compared to that of other highly pathogenic H5 avian influenza viruses
    • Dybing, J.K.; Schultz-Cherry, S.; Swayne, D.E.; Suarez, D.L.; Perdue, M.L. Distinct pathogenesis of Hong Kong-origin H5N1 viruses in mice compared to that of other highly pathogenic H5 avian influenza viruses. J. Virol. 2000, 74, 1443-1450.
    • (2000) J. Virol , vol.74 , pp. 1443-1450
    • Dybing, J.K.1    Schultz-Cherry, S.2    Swayne, D.E.3    Suarez, D.L.4    Perdue, M.L.5
  • 187
    • 23744449807 scopus 로고    scopus 로고
    • Infection of the endothelium by influenza viruses
    • Klenk, H.D. Infection of the endothelium by influenza viruses. Thromb. Haemost. 2005, 94, 262-265.
    • (2005) Thromb. Haemost , vol.94 , pp. 262-265
    • Klenk, H.D.1
  • 190
    • 18744380336 scopus 로고    scopus 로고
    • Vascular endothelial growth factor mRNA and protein expression in airway epithelial cell lines in vitro
    • Koyama, S.; Sato, E.; Tsukadaira, A.; Haniuda, M.; Numanami, H.; Kurai, M.; Nagai, S.; Izumi, T. Vascular endothelial growth factor mRNA and protein expression in airway epithelial cell lines in vitro. Eur. Respir. J. 2002, 20, 1449-1456.
    • (2002) Eur. Respir. J , vol.20 , pp. 1449-1456
    • Koyama, S.1    Sato, E.2    Tsukadaira, A.3    Haniuda, M.4    Numanami, H.5    Kurai, M.6    Nagai, S.7    Izumi, T.8
  • 191
    • 8844261873 scopus 로고    scopus 로고
    • Productive infection in the murine central nervous system with avian influenza virus A (H5N1) after intranasal inoculation
    • Iwasaki, T.; Itamura, S.; Nishimura, H.; Sato, Y.; Tashiro, M.; Hashikawa, T.; Kurata, T. Productive infection in the murine central nervous system with avian influenza virus A (H5N1) after intranasal inoculation. Acta. Neuropathol. 2004, 108, 485-492.
    • (2004) Acta. Neuropathol , vol.108 , pp. 485-492
    • Iwasaki, T.1    Itamura, S.2    Nishimura, H.3    Sato, Y.4    Tashiro, M.5    Hashikawa, T.6    Kurata, T.7
  • 193
    • 2442446901 scopus 로고    scopus 로고
    • The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses
    • Seo, S.H.; Hoffmann, E.; Webster, R.G. The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses. Virus Res. 2004, 103, 107-113.
    • (2004) Virus Res , vol.103 , pp. 107-113
    • Seo, S.H.1    Hoffmann, E.2    Webster, R.G.3
  • 194
    • 0034051290 scopus 로고    scopus 로고
    • Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans
    • Tumpey, T.M.; Lu, X.; Morken, T.; Zaki, S.R.; Katz, J.M. Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans. J. Virol. 2000, 74, 6105-6116.
    • (2000) J. Virol , vol.74 , pp. 6105-6116
    • Tumpey, T.M.1    Lu, X.2    Morken, T.3    Zaki, S.R.4    Katz, J.M.5
  • 197
    • 0024848284 scopus 로고
    • Macrophage inflammatory proteins 1 and 2: Members of a novel superfamily of cytokines
    • Wolpe, S.D.; Cerami, A. Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines. FASEB J. 1989, 3, 2565-2573.
    • (1989) FASEB J , vol.3 , pp. 2565-2573
    • Wolpe, S.D.1    Cerami, A.2
  • 198
    • 0032950857 scopus 로고    scopus 로고
    • Annual review prize lecture cytokines - killers in the brain?
    • Rothwell, N.J. Annual review prize lecture cytokines - killers in the brain? J. Physiol. 1999, 514(Pt 1), 3-17.
    • (1999) J. Physiol , vol.514 , Issue.PART 1 , pp. 3-17
    • Rothwell, N.J.1
  • 199
    • 20444436368 scopus 로고    scopus 로고
    • Human infection by avian influenza A H5N1
    • Yuen, K.Y.; Wong, S.S. Human infection by avian influenza A H5N1. Hong Kong Med. J. 2005, 11, 189-199.
    • (2005) Hong Kong Med. J , vol.11 , pp. 189-199
    • Yuen, K.Y.1    Wong, S.S.2
  • 201
    • 34547619982 scopus 로고    scopus 로고
    • Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection
    • Salomon, R.; Hoffmann, E.; Webster, R.G. Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. Proc. Natl. Acad. Sci. USA. 2007, 104, 12479-12481.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 12479-12481
    • Salomon, R.1    Hoffmann, E.2    Webster, R.G.3
  • 203
    • 33846937311 scopus 로고    scopus 로고
    • TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses
    • Heer, A.K.; Shamshiev, A.; Donda, A.; Uematsu, S.; Akira, S.; Kopf, M.; Marsland, B.J. TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses. J. Immunol. 2007, 178, 2182-2191.
    • (2007) J. Immunol , vol.178 , pp. 2182-2191
    • Heer, A.K.1    Shamshiev, A.2    Donda, A.3    Uematsu, S.4    Akira, S.5    Kopf, M.6    Marsland, B.J.7
  • 204
    • 34250011263 scopus 로고    scopus 로고
    • TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha
    • Ghosh, T.K.; Mickelson, D.J.; Solberg, J.C.; Lipson, K.E.; Inglefield, J.R.; Alkan, S.S. TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha. Int. Immunopharmacol. 2007, 7, 1111-1121.
    • (2007) Int. Immunopharmacol , vol.7 , pp. 1111-1121
    • Ghosh, T.K.1    Mickelson, D.J.2    Solberg, J.C.3    Lipson, K.E.4    Inglefield, J.R.5    Alkan, S.S.6
  • 205
    • 34548423284 scopus 로고    scopus 로고
    • Negative regulation of TLR9-mediated IFN-alpha induction by a small-molecule, synthetic TLR7 ligand
    • Marshall, J.D.; Heeke, D.S.; Gesner, M.L.; Livingston, B.; Van Nest, G. Negative regulation of TLR9-mediated IFN-alpha induction by a small-molecule, synthetic TLR7 ligand. J. Leukoc. Biol. 2007, 82, 497-508.
    • (2007) J. Leukoc. Biol , vol.82 , pp. 497-508
    • Marshall, J.D.1    Heeke, D.S.2    Gesner, M.L.3    Livingston, B.4    Van Nest, G.5
  • 206
    • 33947661319 scopus 로고    scopus 로고
    • Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C- oligodeoxynucleotide-induced IFN-alpha production
    • Berghöfer, B.; Haley, G.; Frommer, T.; Bein, G.; Hackstein, H. Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C- oligodeoxynucleotide-induced IFN-alpha production. J. Immunol. 2007, 178, 4072-4079.
    • (2007) J. Immunol , vol.178 , pp. 4072-4079
    • Berghöfer, B.1    Haley, G.2    Frommer, T.3    Bein, G.4    Hackstein, H.5
  • 207
    • 33846000646 scopus 로고    scopus 로고
    • The functional effects of physical interactions among Toll-like receptors 7, 8, and 9
    • Wang, J.; Shao, Y.; Bennett, T.A.; Shankar, R.A.; Wightman, P.D.; Reddy, L.G. The functional effects of physical interactions among Toll-like receptors 7, 8, and 9. J. Biol. Chem. 2006, 281, 37427-37434.
    • (2006) J. Biol. Chem , vol.281 , pp. 37427-37434
    • Wang, J.1    Shao, Y.2    Bennett, T.A.3    Shankar, R.A.4    Wightman, P.D.5    Reddy, L.G.6
  • 208
    • 23244451497 scopus 로고    scopus 로고
    • Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections
    • Guerrero-Plata, A.; Baron, S.; Poast, J.S.; Adegboyega, P.A.; Casola, A.; Garofalo, R.P. Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections. J. Virol. 2005, 79, 10190-10199.
    • (2005) J. Virol , vol.79 , pp. 10190-10199
    • Guerrero-Plata, A.1    Baron, S.2    Poast, J.S.3    Adegboyega, P.A.4    Casola, A.5    Garofalo, R.P.6
  • 209
    • 20244366104 scopus 로고    scopus 로고
    • Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus
    • Schlender, J.; Hornung, V.; Finke, S.; Gunthner-Biller, M.; Marozin, S.; Brzozka, K.; Moghim, S.; Endres, S.; Hartmann, G.; Conzelmann, K.K. Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus. J. Virol. 2005, 79, 5507-5515.
    • (2005) J. Virol , vol.79 , pp. 5507-5515
    • Schlender, J.1    Hornung, V.2    Finke, S.3    Gunthner-Biller, M.4    Marozin, S.5    Brzozka, K.6    Moghim, S.7    Endres, S.8    Hartmann, G.9    Conzelmann, K.K.10
  • 210
    • 0036838909 scopus 로고    scopus 로고
    • Cutting edge: Impaired Toll-like receptor expression and function in aging
    • Renshaw, M.; Rockwell, J.; Engleman, C.; Gewirtz, A.; Katz, J.; Sambhara, S. Cutting edge: impaired Toll-like receptor expression and function in aging. J. Immunol. 2002, 169, 4697-4701.
    • (2002) J. Immunol , vol.169 , pp. 4697-4701
    • Renshaw, M.1    Rockwell, J.2    Engleman, C.3    Gewirtz, A.4    Katz, J.5    Sambhara, S.6
  • 211
    • 0027322975 scopus 로고
    • Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with L-lysine and carboxymethylcellulose, maleic anhydride divinyl ether and colony stimulating factor 1
    • Kunder, S.C.; Wu, L.; Morahan, P.S. Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with L-lysine and carboxymethylcellulose, maleic anhydride divinyl ether and colony stimulating factor 1. Antiviral Res. 1993, 21, 233-245.
    • (1993) Antiviral Res , vol.21 , pp. 233-245
    • Kunder, S.C.1    Wu, L.2    Morahan, P.S.3
  • 212
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Thl) immunity
    • Chu, R.S.; Targoni, O.S.; Krieg, A.M.; Lehmann, P.V.; Harding, C.V. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Thl) immunity. J. Exp. Med. 1997, 186, 1623-1631.
    • (1997) J. Exp. Med , vol.186 , pp. 1623-1631
    • Chu, R.S.1    Targoni, O.S.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 213
    • 0035218374 scopus 로고    scopus 로고
    • DNA functions as an effective adjuvant for the induction of immune responses in aged mice
    • Manning, B.M.; Enioutina, E.Y.; Visic, D.M.; Knudson, A.D.; Daynes, R.A. CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice. Exp. Gerontol. 2001, 37, 107-126.
    • (2001) Exp. Gerontol , vol.37 , pp. 107-126
    • Manning, B.M.1    Enioutina, E.Y.2    Visic, D.M.3    Knudson, A.D.4    Daynes, R.A.C.5
  • 214
    • 0036746072 scopus 로고    scopus 로고
    • CpG-DNA stimulates cellular and humoral immunity and promotes Thl differentiation in aged BALB/c mice
    • Maletto, B.; Ropolo, A.; Moron, V.; Pistoresi-Palencia, M.C. CpG-DNA stimulates cellular and humoral immunity and promotes Thl differentiation in aged BALB/c mice. J. Leukoc. Biol. 2002, 72, 447-454.
    • (2002) J. Leukoc. Biol , vol.72 , pp. 447-454
    • Maletto, B.1    Ropolo, A.2    Moron, V.3    Pistoresi-Palencia, M.C.4
  • 215
    • 33947589836 scopus 로고    scopus 로고
    • Nucleic acidbased antiviral drugs against seasonal and avian influenza viruses
    • Wong, J.P.; Christopher, M.E.; Salazar, A.M.; Dale, R.M.; Sun, L.Q.; Wang, M. Nucleic acidbased antiviral drugs against seasonal and avian influenza viruses. Vaccine 2007, 25, 3175-3178.
    • (2007) Vaccine , vol.25 , pp. 3175-3178
    • Wong, J.P.1    Christopher, M.E.2    Salazar, A.M.3    Dale, R.M.4    Sun, L.Q.5    Wang, M.6
  • 216
    • 4143131229 scopus 로고    scopus 로고
    • Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity
    • Whitmore, M.M.; DeVeer, M.J.; Edling, A.; Oates, R.K.; Simons, B.; Lindner, D.; Williams, B.R. Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity. Cancer Res. 2004, 64, 5850-5860.
    • (2004) Cancer Res , vol.64 , pp. 5850-5860
    • Whitmore, M.M.1    DeVeer, M.J.2    Edling, A.3    Oates, R.K.4    Simons, B.5    Lindner, D.6    Williams, B.R.7
  • 217
    • 0347126491 scopus 로고    scopus 로고
    • Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Tolllike receptor agonists
    • Werling, D.; Hope, J.C.; Howard, C.J.; Jungi, T.W. Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Tolllike receptor agonists. Immunology 2004, 111, 41-52.
    • (2004) Immunology , vol.111 , pp. 41-52
    • Werling, D.1    Hope, J.C.2    Howard, C.J.3    Jungi, T.W.4


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