Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells

Nucleic Acids Research

Volumn 31, Issue 17, 2003, Pages 5122-5133

  Marshall, Jason D ^a   Hessel, Edith M ^a   Gregorio, Josh ^a   Abbate, Christina ^a   Yee, Priscilla ^a   Chu, Mabel ^a   Van Nest, Gary ^a   Coffman, Robert L ^a   Fearon, Karen L ^a  

^a Dynavax Technologies Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ETHYLENE GLYCOL; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 6; NUCLEOTIDE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; SPACER DNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE ACTIVATION; CHIMERA; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DNA SEQUENCE; FEMALE; GENE ACTIVITY; GENE INDUCTION; GENE SEQUENCE; HUMAN; HUMAN CELL; HYDROPHILICITY; IMMUNOMODULATION; IMMUNOSTIMULATION; IN VIVO STUDY; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BASE SEQUENCE; CELLS, CULTURED; CPG ISLANDS; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTERFERON-ALPHA; INTERFERONS; LEUKOCYTES, MONONUCLEAR; LUNG; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; OLIGONUCLEOTIDES; RNA, MESSENGER; THIONUCLEOTIDES;

ANIMALIA;

EID: 0344012220     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg700     Document Type: Article

References (39)

1. Yamamoto, S., Yamamoto, T. and Tokunaga, T. (2000) Oligodeoxyribonucleotides with 5′-ACGT-3′ or 5′-TCGA-3′ sequence induce production of interferons. Curr. Topics Microbiol. Immunol., 247, 23-39.
2. Santeliz, J.V., Van Nest, G., Traquina, P., Larsen, E. and Wills-Karp, M. (2002) Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J. Allergy Clin. Immunol., 109, 455-462.
3. Hafner, M., Zawatzky, R., Hirtreiter, C., Buurman, W.A., Echtenacher, B., Hehlgans, T. and Mannel, D.N. (2001) Antimetastatic effect of CpG DNA mediated by type I IFN. Cancer Res., 61, 5523-5528.
4. Merad, M., Sugie, T., Engleman, E.G. and Fong, L. (2002) In vivo manipulation of dendritic cells to induce therapeutic immunity. Blood, 99, 1676-1682.
5. Verthelyi, D., Kenney, R.T., Seder, R.A., Gam, A.A., Friedag, B. and Klinman, D.M. (2002) CpG oligodeoxynucleotides as vaccine adjuvants in primates. J. Immunol., 168, 1659-1663.
6. Dieudonne, F., Vital Durand, D., Eiden, J., Tuck, S., Van Nest, G.E.R., Hamilton, R., Creticos, P.S. and Andre, C. (2001) ISS linked to Amb a 1 allergen (AIC) stimulates IgG response to Amb a 1 by ragweed-allergic humans. J. Allergy Clin. Immunol., 107, 933.
7. Halperin, S.A., Van Nest, G., Smith, B., Abtahi, S., Whiley, H. and Eiden, J.J. (2003) A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimmulatory phosphorothioate oligonucleotide adjuvant. Vaccine, 21, 2461-2467.
8. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K. et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature, 408, 740-745.
9. Martin-Orozco, E., Kobayashi, H., Van Uden, J., Nguyen, M.D., Kornbluth, R.S. and Raz, E. (1999) Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences. Int. Immunol., 11, 1111-1118.
10. Chu, R.S., Askew, D., Noss, E.H., Tobian, A., Krieg, A.M. and Harding, C.V. (1999) CpG oligodeoxynucleotides down-regulate macrophage class II MHC antigen processing. J. Immunol., 163, 1188-1194.
11. Gilliet, M., Boonstra, A., Paturel, C., Antonenko, S., Xu, X.L., Trinchieri, G., O'Garra, A. and Liu, Y.J. (2002) The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med., 195, 953-958.
12. Asselin-Paturel, C., Boonstra, A., Dalod, M., Durand, I., Yessaad, N., Dezutter-Dambuyant, C., Vicari, A., O'Garra, A., Biron, C., Briere, F. et al. (2001) Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol., 19, 19.
13. Krug, A., Towarowski, A., Britsch, S., Rothenfusser, S., Hornung, V., Bals, R., Giese, T., Engelmann, H., Endress, S., Krieg, A.M. et al. (2001) Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol., 31, 3026-3037.
14. Zarember, K.A. and Godowski, P.J. (2002) Tissue expression of human Toll-like Receptors and differential regulation of Toll-like Receptor mRNAs is leukocytes in response to microbes, their products and cytokines. J. Immunol., 168, 554-561.
15. Bauer, M., Redecke, V., Ellwart, J.W., Scherer, B., Kremer, J.P., Wagner, H. and Lipford, G.B. (2001) Bacterial CpG-DNA triggers activation and maturation of human CD11c(-), CD123(+) dendritic cells. J. Immunol., 166, 5000-5007.
16. Verthelyi, D., Ishii, K.J., Gursel, M., Takeshita, F. and Klinman, D.M. (2001) Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J. Immunol., 166, 2372-2377.
17. Marshall, J.D., Fearon, K., Abbate, C., Subramanian, S., Yee, P., Gregorio, J., Coffman, R.L. and Van Nest, G. (2003) Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions. J. Leuko. Biol., 73, 781-792.
18. Klinman, D.M., Yi, A.K., Beaucage, S.L., Conover, J. and Krieg, A.M. (1996) CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12 and interferon gamma. Proc. Natl Acad. Sci. USA, 93, 2879-2883.
19. Kuramoto, E., Yano, O., Kimura, Y., Baba, M., Makino, T., Yamamoto, S., Yamamoto, T., Kataoka, T. and Tokunaga, T. (1992) Oligonucleotide sequences required for natural killer cell activation. Jpn J. Cancer Res., 83, 1128-1131.
20. Sato, Y., Roman, M., Tighe, H., Lee, D., Corr, M., Nguyen, M.D., Silverman, G.J., Lotz, M., Carson, D.A. and Raz, E. (1996) Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science, 273, 352-354.
21. Bauer, S., Kirschning, C.J., Hacker, H., Redecke, V., Hausmann, S., Akira, S., Wagner, H. and Lipford, G.B. (2001) Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl Acad. Sci. USA, 24, 24.
22. Fearon, K., Marshall, J.D., Abbate, C., Subramanian, S., Yee, P., Gregorio, J., Teshima, G., Ott, G., Tuck, S., Van Nest, G. et al. (2003) A minimal human immunostimulatory CpG motif that potently induces IFN-γ and IFN-α production. Eur. J. Immunol., 33, 2114-2122.
23. Tang, J.Y., Han, Y., Tang, J.X. and Zhang, Z. (2000) Large-scale synthesis of oligonucleotide phosphorothioates using 3-amino-1,2,4-dithiazole-5-thione as an efficient sulfur-transfer reagent. Org. Process Res. Dev., 4, 194-198.
24. Tighe, H., Takabayashi, K., Schwartz, D., Van Nest, G., Tuck, S., Eiden, J.J., Kagey-Sobotka, A., Creticos, P.S., Lichtenstein, L.M., Spiegelberg, H.L. et al. (2000) Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity. J. Allergy Clin. Immunol., 106, 124-134.
25. Inman, J.K. (1975) Thymus-independent antigens: the preparation of covalent, hapten-ficoll conjugates. J. Immunol., 114, 704-709.
26. Lee, A.C., Powell, J.E., Tregear, G.W., Niall, H.D. and Stevens, V.C. (1980) A method for preparing beta-hCG COOH peptide-carrier conjugates of predictable composition. Mol. Immunol., 17, 749-756.
27. Singh, R. (1994) A sensitive assay for maleimide groups. Bioconjug. Chem., 5, 348-351.
28. Krieg, A.M., Yi, A.K., Matson, S., Waldschmidt, T.J., Bishop, G.A., Teasdale, R., Koretzky, G.A. and Klinman, D.M. (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature, 374, 546-549.
29. Jung, J., Yi, A.K., Zhang, X., Choe, J., Li, L. and Choi, Y.S. (2002) Distinct response of human B cell subpopulations in recognition of an innate immune signal, CpG DNA. J. Immunol., 169, 2368-2373.
30. Bernasconi, N.L., Onai, N. and Lanzavecchia, A. (2003) A role for Toll-like receptors in acquired immunity: upregulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood, 101, 4500-4504.
31. Grunig, G., Warnock, M., Wakil, A.E., Venkayya, R., Brombacher, F., Rennick, D.M., Sheppard, D., Mohrs, M., Donaldson, D.D., Locksley, R.M. et al. (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Science, 282, 2261-2263.
32. Hurst, S.D., Muchamuel, T., Gorman, D.M., Gilbert, J.M., Clifford, T., Kwan, S., Menon, S., Seymour, B., Jackson, C., Kung, T.T. et al. (2002) New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J. Immunol., 169, 443-453.
33. Krieg, A.M. (2002) CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol., 20, 709-760.
34. Hartmann, G. and Krieg, A.M. (2000) Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J. Immunol., 164, 944-953.
35. Krug, A., Rothenfusser, S., Hornung, V., Jahrsdorfer, B., Blackwell, S., Ballas, Z.K., Endres, S., Krieg, A.M. and Hartmann, G. (2001) Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur. J. Immunol., 31, 2154-2163.
36. Lee, S.W., Song, M.K., Baek, K.H., Park, Y., Kim, J.K., Lee, C.H., Cheong, H.K., Cheong, C. and Sung, Y.C. (2000) Effects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentials. J. Immunol., 165, 3631-3639.
37. Chuang, T.H., Lee, J., Kline, L., Mathison, J.C. and Ulevitch, R.J. (2002) Toll-like receptor 9 mediates CpG-DNA signaling. J. Leukoc. Biol., 71, 538-544.
38. Yu, D., Kandimalla, E.R., Bhagat, L., Tang, J.Y., Cong, Y., Tang, J. and Agrawal, S. (2002) 'Immunomers'-novel 3′-3′-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents. Nucleic Acids Res., 30, 4460-4469.
39. Bhagat, L., Zhu, F.G., Yu, D., Tang, J., Wang, H., Kandimalla, E.R., Zhang, R. and Agrawal, S. (2003) CpG penta- and hexadeoxyribonucleotides as potent immunomodulatory agents. Biochem. Biophys. Res. Commun., 300, 853-861.