Conjugation of ligands at the 5′-end of CpG DNA affects immunostimulatory activity

Bioconjugate Chemistry

Volumn 13, Issue 5, 2002, Pages 966-974

  Kandimalla, Ekambar R ^a   Bhagat, Lakshmi ^a   Yu, Dong ^a   Cong, Yanping ^a   Tang, Jimmy ^a   Agrawal, Sudhir ^a  

^a HYBRIDON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; IMMUNE SYSTEM; LIGANDS; OLIGONUCLEOTIDES;

% REDUCTIONS; CELLULAR UPTAKE; CLINICAL TRIAL; DINUCLEOTIDES; IMMUNE RESPONSE; IMMUNOSTIMULATORY ACTIVITIES; LONG OLIGONUCLEOTIDE; MONONUCLEOTIDES; PHOSPHOROTHIOATES; VERTEBRATE IMMUNE SYSTEM;

DNA;

BACTERIA (MICROORGANISMS); VERTEBRATA;

CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; CROSS LINKING REAGENT; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOLOGICAL ADJUVANT; LIGAND; OLIGODEOXYRIBONUCLEOTIDE; OLIGONUCLEOTIDE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; CYTOLOGY; DNA FLANKING REGION; DRUG EFFECT; FEMALE; IMMUNE SYSTEM; IMMUNOLOGY; MACROPHAGE; METABOLISM; MOUSE; SECRETION; SPLEEN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

3' FLANKING REGION; 5' FLANKING REGION; ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL LINE; CROSS-LINKING REAGENTS; CYTOKINES; FEMALE; IMMUNE SYSTEM; LIGANDS; MACROPHAGES; MICE; MICE, INBRED BALB C; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDES; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036738536     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0200374     Document Type: Article

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