Resistance to influenza A virus infection by antigen-conjugated CpG oligonucleotides, a novel antigen-specific immunomodulator

Biochemical and Biophysical Research Communications

Volumn 329, Issue 1, 2005, Pages 230-236

  Hayashi, Mieko ^a   Satou, Emi ^a   Ueki, Ryouji ^a   Yano, Mayuka ^a   Miyano Kurosaki, Naoko ^a   Fujii, Masayuki ^b   Takaku, Hiroshi ^a  

^a CHIBA INSTITUTE OF TECHNOLOGY   (Japan)

^b KINKI UNIVERSITY   (Japan)

Author keywords

Antigen conjugated oligonucleotides; Hemagglutinin; Immunostimulatory sequences; Influenza virus; Oligonucleotides; Th1

Indexed keywords

GAMMA INTERFERON; HISTIDYLASPARTYLTYROSYLGLUTAMYLGLUTAMYLLEUCYLARGINYLGLUTAMYLGLUTAMINYL LEUCYLSERYLLYSINE HYDROXIDE; IMMUNOGLOBULIN G2A; IMMUNOMODULATING AGENT; OLIGODEOXYNUCLEOTIDE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; COVALENT BOND; CYTOKINE RELEASE; DRUG CONJUGATION; FEMALE; IMMUNE RESPONSE; IMMUNOMODULATION; INFECTION RESISTANCE; INFLUENZA VIRUS A; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; TH1 CELL;

INFLUENZA A VIRUS; INFLUENZA VIRUS;

EID: 13844299445     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.01.116     Document Type: Article

References (34)

1. J.P. Messina, G.S. Gilkeson, and D.S. Pisetsky Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA J. Vriol. 147 1991 1759 1764
2. S. Yamamoto, S. Shimada, E. Kuramoto, O. Yano, T. Kataoka, and T. Tokunaga DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth Microbiol. Immunol. 36 1992 983 997
3. A.M. Krieg, A.K. Yi, S. Matson, T.J. Waldchmidt, G.A. Bishop, R. Teasdale, G.A. Koretzky, and D.M. Klinman CpG motifs in bacterial DNA trigger direct B-cell activation Nature 374 1995 546 549
4. J.K. Stacey, M.J. Sweet, and D.A. Hume Macrophages ingest and are activated by bacterial DNA J. Immunol. 157 1996 2116 2122
5. S. Sun, H. Kishimoto, and J. Sprent NA as an adjuvant: Capacity of insect DNA and synthetic oligodeoxynucleotides to augment T-cell responses to specific antigen J. Exp. Med. 187 1998 1145 1150
6. P.S. Walker, T. Scharton-Kersten, A.M. Krieg, L. Love-Homan, E.D. Rowton, M.C. Udey, and J.C. Voge Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms Proc. Natl. Acad. Sci. USA 96 1999 6970 6975
7. A.M. Krieg Now I know my CpGs Trends Microbiol. 9 2001 249 252
8. J.S. Wild, and S. Sur CpG oligonucleotide modulation of allergic inflammation Allergy 56 2001 365 376
9. B.R. Blazar, A.M. Krieg, and P.A. Taylor Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients Blood 98 2001 1217 1225
10. A. Oxenius, M. Martinic, H. Hengartner, and P. Klenerman CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines J. Virol. 73 1999 4120 4126
11. E. Malanchere-Bres, P.J. Payette, M. Mancini, P. Tiollais, H.L. Davis, and M.L. Michel CpG oligodeoxynucleotides with hepatitis B surface antigen (HBsAg) for vaccination in HBsAg-transgenic mice J. Virol. 75 2001 6482 6491
12. H.L. Davis, C.L. Cooper, M.L. Morris, S.M. Efler, D.E. Cameron, and J. Heathcote CpG ODN is safe and highly effective in humans as adjuvant to HBV vaccine: Preliminary results of phase I trial with CpG ODN 7909 Third Annu. Conf. Vaccine Res. Suppl. 25 2000 47
13. S. Zimmermann, O. Egeter, S. Hausmann, G.B. Lipford, M. Rocken, H. Wagner, and K. Heeg CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis J. Immunol. 160 1998 3627 3630
14. R.S. Chu, O.S. Targoni, A.M. Krieg, P.V. Lehmann, and C.V. Harding CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity J. Exp. Med. 186 1997 1623 1631
15. M. Roman, E. Martin-Orozco, J.S. Goodman, M.D. Nguyen, Y. Sato, A. Ronaghy, R.S. Kornbluth, D.D. Richman, D.A. Carson, and E. Raz Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants Nature Med. 8 1997 849 854
16. K. Heeg, and S. Zimmermann CpG DNA as a Th1 trigger Int. Arch. Allergy Immunol. 121 2000 87 97
17. A.M. Krieg Immune effects and mechanism of action of CpG motifs Vaccine 19 2000 618 622
18. M.J. McCluski, and H.L. Davis CpG DNA as mucosal adjuvant Vaccine 18 1999 231 237
19. A.A. Horner, N. Cinman, A. Ronaghy, and E. Raz Mucosal adjuvanticity of immunostimulatory DNA sequences Springer Semin. Immunopath. 22 2000 133 146
20. Z. Moldoveanu, L. Love-Homan, W.Q. Huang, and A.M. Krieg CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus Vaccine 116 1998 1216 1224
21. H.J. Cho, K. Takabayashi, P.M. Cheng, M.D. Nguyen, M. Corr, S. Tuck, and E. Raz Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism Nat. Biotechnol. 18 2000 509 514
22. A.M. Krieg, and H.L. Davis Enhancing vaccines with immune stimulatory CPG DNA Curr. Opin. Mol. Ther. 3 2001 15 24
23. L. Dong, I. Mori, M.J. Hossain, B. Liu, and Y. Kimura An immunostimulatory oligodeoxynucleotide containing a cytidine-guanosine motif protects senescence-accelerated mice from lethal influenza virus by augmenting the T helper type 1 response J. Gen. Virol. 84 2003 1623 1628
24. H. Shirota, K. Sano, T. Kikuchi, G. Tamura, and K. Shirato Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator J. Immunol. 164 2000 5575 5582
25. A.A. Horner, J.H. Van Uden, J.M. Zubeldia, D. Broide, and E. Raz DNA-based immunotherapeutics for the treatment of allergic disease Immunol. Rev. 179 2001 102 118
26. Z.K. Ballas, A.M. Krieg, T. Warren, W. Rasmussen, H.L. Davis, M. Waldschmidt, and G.J. Weiner Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs J. Immunol. 167 2001 4878 4886
27. Y. Kawarada, R. Ganss, N. Garbi, T. Sacher, B. Arnold, and G.J. Hammerling NK- and CD8(+) T cell-mediated eradication of established tumors by peritumoral injection of CpG-containing oligodeoxynucleotides J. Immunol. 167 2001 5247 5253
28. C.C. Pak, M. Krumbiegel, and R. Blumenthal Intermediates in influenza PR/8 hemagglutinin-induced membrane fusion J. Gen. Virol. 75 1994 395 399
29. G. Hartmann, R.D. Weeratna, Z.R. Ballas, P. Payette, S. Blackwell, L. Suparto, W.L. Rasmussen, M. Waldschimidt, D. Sajuthi, R.H. Purcell, H.L. Davis, and A.M. Krieg Delineation of a CpG phosphorothioate oligodeoxyribonucleotide for activating primate immune responses in vitro and in vivo J. Immunol. 164 2000 1617 1624
30. K. Tobita, A. Sugiura, C. Enomoto, and M. Furuyama Plaque assay and primary isolation of influenza A viruses in an established line of canine kidney cells (MDCK) in the presence of trypsin Med. Microbiol. Immunol. 162 1975 9 14
31. T. Mizuta, M. Fujiwara, T. Hatta, T. Abe, N. Miyano-Kurosaki, S. Shigeta, T. Yokota, and H. Takaku Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A Nat. Biotech. 17 1999 583 587
32. J.T. Qiu, B. Liu, C. Tian, G.N. Pavlakis, and X.F. Yu Enhancement of primary and secondary cellular immune responses against human immunodeficiency virus type1 gag by using DNA expression vectors that target Gag antigen to the secretory pathway J. Virol. 74 2003 5997 6005
33. P.J. Lewis, van Drunen Littel-vanden Hurk, L.A. Babiuk, Altering the cellular location of an antigen expressed by a DNA-based vaccine modulates the immune response, J. Virol. 73 (1999) 10214-10223
34. T. Abe, H. Takahashi, H. Hamazaki, N. Miyano-Kurosaki, Y. Matsuura, and H. Takaku Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice J. Immunol. 171 2003 1133 1139