TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-α

International Immunopharmacology

Volumn 7, Issue 8, 2007, Pages 1111-1121

  Ghosh, Tarun K ^a   Mickelson, Dan J ^a   Solberg, Jonathan C ^a   Lipson, Kenneth E ^a   Inglefield, Jon R ^a   Alkan, Sefik S ^a  

^a 3M COMPANY   (United States)

Author keywords

Interferons; Proinflammatory cytokines; Synergism; Toll like receptors

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; FLAGELLIN; GAMMA INTERFERON; IMMUNOLOGIC AGENT; INTERFERON; INTERLEUKIN 12P70; LIPOPOLYSACCHARIDE; LOXORIBINE; OLIGONUCLEOTIDE; RECOMBINANT ALPHA INTERFERON; RECOMBINANT BETA INTERFERON; RECOMBINANT GAMMA INTERFERON; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR 9 AGONIST; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CANCER IMMUNOTHERAPY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENTIATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VACCINATION;

ANTIVIRAL AGENTS; CELLS, CULTURED; CYTOKINES; DRUG ANTAGONISM; DRUG SYNERGISM; GUANOSINE; HUMANS; INTERFERON INDUCERS; INTERFERON TYPE I; INTERFERON TYPE II; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; POLY I-C; RECEPTOR CROSS-TALK; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; ZYMOSAN;

EID: 34250011263     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2007.04.006     Document Type: Article

References (58)

1. Flo T.H., Halaas O., Torp S., Ryan L., Lien E., Dybdahl B., et al. Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 69 3 (2001) 474-481
2. Bosisio D., Polentarutti N., Sironi M., Bernasconi S., Miyake K., Webb G.R., et al. Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood 99 9 (2002) 3427-3431
3. Visintin A., Mazzoni A., Spitzer J.H., Wyllie D.H., Dower S.K., and Segal D.M. Regulation of Toll-like receptors in human monocytes and dendritic cells. J Immunol 166 1 (2001) 249-255
4. Kasai H., He L.M., Kawamura M., Yang P.T., Deng X.W., Munkanta M., et al. IL-12 Production Induced by Agaricus blazei Fraction H (ABH) Involves Toll-like Receptor (TLR). Evid Based Complement Altern Med 1 3 (2004) 259-267
5. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 5396 (1998) 2085-2088
6. Prinz M., Heikenwalder M., Schwarz P., Takeda K., Akira S., and Aguzzi A. Prion pathogenesis in the absence of Toll-like receptor signalling. EMBO Rep 4 2 (2003) 195-199
7. Lien E., Means T.K., Heine H., Yoshimura A., Kusumoto S., Fukase K., et al. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest 105 4 (2000) 497-504
8. O'Neill L.A., and Greene C. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. J Leukoc Biol 63 6 (1998) 650-657
9. Weigt H., Muhlradt P.F., Larbig M., Krug N., and Braun A. The Toll-like receptor-2/6 agonist macrophage-activating lipopeptide-2 cooperates with IFN-gamma to reverse the Th2 skew in an in vitro allergy model. J Immunol 172 10 (2004) 6080-6086
10. Lund J., Sato A., Akira S., Medzhitov R., and Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198 3 (2003) 513-520
11. Lien E., Sellati T.J., Yoshimura A., Flo T.H., Rawadi G., Finberg R.W., et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 274 47 (1999) 33419-33425
12. Schwandner R., Dziarski R., Wesche H., Rothe M., and Kirschning C.J. Peptidoglycan-and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 274 25 (1999) 17406-17409
13. Underhill D.M., Ozinsky A., Smith K.D., and Aderem A. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Acad Sci U S A 96 25 (1999) 14459-14463
14. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 1 2 (2001) 135-145
15. Compton T., Kurt-Jones E.A., Boehme K.W., Belko J., Latz E., Golenbock D.T., et al. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol 77 8 (2003) 4588-4596
16. Hirschfeld M., Weis J.J., Toshchakov V., Salkowski C.A., Cody M.J., Ward D.C., et al. Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 69 3 (2001) 1477-1482
17. Re F., and Strominger J.L. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 276 40 (2001) 37692-37699
18. Jotwani R., Pulendran B., Agrawal S., and Cutler C.W. Human dendritic cells respond to Porphyromonas gingivalis LPS by promoting a Th2 effector response in vitro. Eur J Immunol 33 11 (2003) 2980-2986
19. Qiao H., Andrade M.V., Lisboa F.A., Morgan K., and Beaven M.A. FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells. Blood 107 2 (2006) 610-618
20. Akira S., and Takeda K. Toll-like receptor signalling. Nat Rev Immunol 4 7 (2004) 499-511
21. Coccia E.M., Severa M., Giacomini E., Monneron D., Remoli M.E., Julkunen I., et al. Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells. Eur J Immunol 34 3 (2004) 796-805
22. Pestka S., Krause C.D., and Walter M.R. Interferons, interferon-like cytokines, and their receptors. Immunol Rev 202 (2004) 8-32
23. Homma T., Kato A., Hashimoto N., Batchelor J., Yoshikawa M., Imai S., et al. Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells. Am J Respir Cell Mol Biol 31 4 (2004) 463-469
24. Toshchakov V., Jones B.W., Perera P.Y., Thomas K., Cody M.J., Zhang S., et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol 3 4 (2002) 392-398
25. Lotz M., Ebert S., Esselmann H., Iliev A.I., Prinz M., Wiazewicz N., et al. Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures. J Neurochem 94 2 (2005) 289-298
26. Tao X., Xu Y., Zheng Y., Beg A.A., and Tong L. An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. Biochem Biophys Res Commun 299 2 (2002) 216-221
27. Sato S., Nomura F., Kawai T., Takeuchi O., Muhlradt P.F., Takeda K., et al. Synergy and cross-tolerance between toll-like receptor (TLR) 2-and TLR4-mediated signaling pathways. J Immunol 165 12 (2000) 7096-7101
28. Underhill D.M., and Ozinsky A. Toll-like receptors: key mediators of microbe detection. Curr Opin Immunol 14 1 (2002) 103-110
29. Thoma-Uszynski S., Stenger S., Takeuchi O., Ochoa M.T., Engele M., Sieling P.A., et al. Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 291 5508 (2001) 1544-1547
30. Bahnson R.R., and Ratliff T.L. In vitro and in vivo anti-tumor activity of recombinant mouse tumor necrosis factor (TNF) in a mouse bladder tumor (MBT-2). J Urol 144 1 (1990) 172-175
31. Decker T., Stockinger S., Karaghiosoff M., Muller M., and Kovarik P. IFNs and STATs in innate immunity to microorganisms. J Clin Invest 109 10 (2002) 1271-1277
32. Geissler K., Tricot G., Leemhuis T., Walker E., and Broxmeyer H.E. Differentiation-inducing effect of recombinant human tumor necrosis factor alpha and gamma-interferon in vitro on blast cells from patients with acute myeloid leukemia and myeloid blast crisis of chronic myeloid leukemia. Cancer Res 49 11 (1989) 3057-3062
33. Kirkwood J.M., Strawderman M.H., Ernstoff M.S., Smith T.J., Borden E.C., and Blum R.H. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol 14 1 (1996) 7-17
34. Katze M.G., He Y., and Gale Jr. M. Viruses and interferon: a fight for supremacy. Nat Rev Immunol 2 9 (2002) 675-687
35. Fan J., Frey R.S., and Malik A.B. TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase. J Clin Invest 112 8 (2003) 1234-1243
36. Sandor F., Latz E., Re F., Mandell L., Repik G., Golenbock D.T., et al. Importance of extra-and intracellular domains of TLR1 and TLR2 in NFkappa B signaling. J Cell Biol 162 6 (2003) 1099-1110
37. Ghosh T.K., Mickelson D.J., Fink J., Solberg J.C., Hook D., Gupta S.K., et al. Toll Like Receptor (TLR) 2- 9 Agonists-Induced Cytokines and Chemokines: I. Comparison with T cell Receptor-Induced Responses. Cell Immunol 243 1 (2006) 48-57
38. Gorden K.K., Qiu X., Battiste J.J., Wightman P.P., Vasilakos J.P., and Alkan S.S. Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines. J Immunol 177 11 (2006) 8164-8170
39. Gorden K.B., Gorski K.S., Gibson S.J., Kedl R.M., Kieper W.C., Qiu X., et al. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol 174 3 (2005) 1259-1268
40. Wang J., Shao Y., Bennett T.A., Shankar R.A., Wightman P.D., and Reddy L.G. The functional effects of physical interactions among Toll-like receptors 7, 8, and 9. J Biol Chem 281 49 (2006) 37427-37434
41. Flynn J.L., Chan J., Triebold K.J., Dalton D.K., Stewart T.A., and Bloom B.R. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 178 6 (1993) 2249-2254
42. Krutzik S.R., and Modlin R.L. The role of Toll-like receptors in combating mycobacteria. Semin Immunol 16 1 (2004) 35-41
43. Murray H.W. Current and future clinical applications of interferon-gamma in host antimicrobial defense. Intensive Care Med 22 Suppl 4 (1996) S456-S461
44. Salgame P. Host innate and Th1 responses and the bacterial factors that control Mycobacterium tuberculosis infection. Curr Opin Immunol 17 4 (2005) 374-380
45. Brunda M.J., Luistro L., Warrier R.R., Wright R.B., Hubbard B.R., Murphy M., et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 178 4 (1993) 1223-1230
46. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13 (1995) 251-276
47. Germann T., Gately M.K., Schoenhaut D.S., Lohoff M., Mattner F., Fischer S., et al. Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur J Immunol 23 8 (1993) 1762-1770
48. Wu C.Y., Demeure C., Kiniwa M., Gately M., and Delespesse G. IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells. J Immunol 151 4 (1993) 1938-1949
49. Gao J.J., Zuvanich E.G., Xue Q., Horn D.L., Silverstein R., and Morrison D.C. Cutting edge: bacterial DNA and LPS act in synergy in inducing nitric oxide production in RAW 264.7 macrophages. J Immunol 163 8 (1999) 4095-4099
50. Yi A.K., Yoon J.G., Hong S.C., Redford T.W., and Krieg A.M. Lipopolysaccharide and CpG DNA synergize for tumor necrosis factor-alpha production through activation of NF-kappaB. Int Immunol 13 11 (2001) 1391-1404
51. Dalpke A.H., Frey M., Morath S., Hartung T., and Heeg K. Interaction of lipoteichoic acid and CpG-DNA during activation of innate immune cells. Immunobiology 206 4 (2002) 392-407
52. Whitmore M.M., DeVeer M.J., Edling A., Oates R.K., Simons B., Lindner D., et al. Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity. Cancer Res 64 16 (2004) 5850-5860
53. Faure E., Thomas L., Xu H., Medvedev A., Equils O., and Arditi M. Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J Immunol 166 3 (2001) 2018-2024
54. Hadley J.S., Wang J.E., Foster S.J., Thiemermann C., and Hinds C.J. Peptidoglycan of Staphylococcus aureus upregulates monocyte expression of CD14, Toll-like receptor 2 (TLR2), and TLR4 in human blood: possible implications for priming of lipopolysaccharide signaling. Infect Immun 73 11 (2005) 7613-7619
55. Liang M.D., Bagchi A., Warren H.S., Tehan M.M., Trigilio J.A., Beasley-Topliffe L.K., et al. Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide. J Infect Dis 191 6 (2005) 939-948
56. Napolitani G., Rinaldi A., Bertoni F., Sallusto F., and Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 6 8 (2005) 769-776
57. Roelofs M.F., Joosten L.A., Abdollahi-Roodsaz S., van Lieshout A.W., Sprong T., van den Hoogen F.H., et al. The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum 52 8 (2005) 2313-2322
58. Gorski K.S., Waller E.L., Bjornton-Severson J., Hanten J.A., Riter C.L., Kieper W.C., et al. Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists. Int Immunol 18 7 (2006) 1115-1126