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Volumn 10, Issue 3, 2004, Pages 197-203

Antiviral chemotherapeutic agents against respiratory viruses: Where are we now and what's in the pipeline?

Author keywords

Antiviral agents; Neuraminidase inhibitors; Respiratory viruses

Indexed keywords

AMANTADINE; ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; CELL ADHESION MOLECULE; OSELTAMIVIR; PROTEINASE; RIBAVIRIN; RIMANTADINE; SIALIDASE; SIALIDASE INHIBITOR; VIRUS ENZYME; ZANAMIVIR;

EID: 1942468738     PISSN: 10705287     EISSN: None     Source Type: Journal    
DOI: 10.1097/00063198-200405000-00009     Document Type: Review
Times cited : (67)

References (88)
  • 1
    • 0037403079 scopus 로고    scopus 로고
    • The role of antivirals in the control of influenza
    • Monto AS: The role of antivirals in the control of influenza. Vaccine 2003, 21:1796-1800. An excellent article providing an understanding of the issues around the use of antiviral drugs for influenza virus infections.
    • (2003) Vaccine , vol.21 , pp. 1796-1800
    • Monto, A.S.1
  • 2
    • 0037463658 scopus 로고    scopus 로고
    • The economic burden of non-influenza-related viral respiratory tract infection in the United States
    • Fendrick A, Monto A, Nightengale B, et al.: The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch Intern Med 2003, 163:487-494.
    • (2003) Arch Intern Med , vol.163 , pp. 487-494
    • Fendrick, A.1    Monto, A.2    Nightengale, B.3
  • 4
    • 0037429119 scopus 로고    scopus 로고
    • Respiratory consequences of rhinovirus infection
    • Greenberg S: Respiratory consequences of rhinovirus infection. Arch Intern Med 2003, 163:278-284.
    • (2003) Arch Intern Med , vol.163 , pp. 278-284
    • Greenberg, S.1
  • 5
    • 0034953901 scopus 로고    scopus 로고
    • A newly discovered human metapneumovirus isolated from young children with respiratory tract disease
    • van den Hoogen B, de Jong JC, Groen J, et al.: A newly discovered human metapneumovirus isolated from young children with respiratory tract disease. Nat Med 2001, 7:719-724.
    • (2001) Nat Med , vol.7 , pp. 719-724
    • Van Den Hoogen, B.1    De Jong, J.C.2    Groen, J.3
  • 6
    • 0242717589 scopus 로고    scopus 로고
    • Coronavirus as a possible cause of severe acute respiratory syndrome
    • April
    • Peiris J, Lai S, Poon L, et al.: Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet [serial online] April 2003:8.
    • (2003) Lancet [Serial Online] , pp. 8
    • Peiris, J.1    Lai, S.2    Poon, L.3
  • 7
    • 0013165966 scopus 로고    scopus 로고
    • Identification of severe acute respiratory syndrome in Canada
    • Poutanen SM, Low DE, Henry B, et al.: Identification of severe acute respiratory syndrome in Canada. N Engl J Med 2003, 348:1995-2005.
    • (2003) N Engl J Med , vol.348 , pp. 1995-2005
    • Poutanen, S.M.1    Low, D.E.2    Henry, B.3
  • 8
    • 0013255608 scopus 로고    scopus 로고
    • A cluster of cases of severe acute respiratory syndrome in Hong Kong
    • Tsang KW, Ho PL, Ooi GC, et al.: A cluster of cases of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003, 348:1977-1985.
    • (2003) N Engl J Med , vol.348 , pp. 1977-1985
    • Tsang, K.W.1    Ho, P.L.2    Ooi, G.C.3
  • 9
    • 0030817237 scopus 로고    scopus 로고
    • Influenza vaccination in 22 developed countries: An update to 1995
    • Fedson D, Hirota Y, Shin H, et al.: Influenza vaccination in 22 developed countries: an update to 1995. Vaccine 1997, 15:1506-1511.
    • (1997) Vaccine , vol.15 , pp. 1506-1511
    • Fedson, D.1    Hirota, Y.2    Shin, H.3
  • 10
    • 0028896397 scopus 로고
    • Hyperimmune globulins in prevention and treatment of respiratory syncytial virus infections
    • Hemming VG, Prince GA, Groothuis JR, et al.: Hyperimmune globulins in prevention and treatment of respiratory syncytial virus infections. Clin Microbiol Rev 1995, 8:22-33.
    • (1995) Clin Microbiol Rev , vol.8 , pp. 22-33
    • Hemming, V.G.1    Prince, G.A.2    Groothuis, J.R.3
  • 11
    • 0034966673 scopus 로고    scopus 로고
    • Antiviral drugs: Current state of the art
    • De Clercq E: Antiviral drugs: current state of the art. J Clin Virol 2001, 22:73-89.
    • (2001) J Clin Virol , vol.22 , pp. 73-89
    • De Clercq, E.1
  • 12
    • 0032828474 scopus 로고    scopus 로고
    • Ribavirin in ventilated respiratory syncytial virus bronchiolitis
    • Guerguerian A-M, Gauthier M, Lebel MH, et al.: Ribavirin in ventilated respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med 1999, 160:829-834.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 829-834
    • Guerguerian, A.-M.1    Gauthier, M.2    Lebel, M.H.3
  • 14
    • 0026612385 scopus 로고
    • Influenza virus M2 protein has ion channel activity
    • Pinto L, Holsinger L, Lamb R: Influenza virus M2 protein has ion channel activity. Cell 1992, 69:517-528.
    • (1992) Cell , vol.69 , pp. 517-528
    • Pinto, L.1    Holsinger, L.2    Lamb, R.3
  • 15
    • 0002988267 scopus 로고
    • The action of adamantanamines against influenza A viruses: Inhibition of the M2 ion channel protein
    • Hay A: The action of adamantanamines against influenza A viruses: inhibition of the M2 ion channel protein. Semin Virol 1992, 3:21-30.
    • (1992) Semin Virol , vol.3 , pp. 21-30
    • Hay, A.1
  • 16
    • 0018875646 scopus 로고
    • Plaque inhibition assay for drug susceptibility testing of influenza viruses
    • Hayden FG, Cote KM, Douglas RG: Plaque inhibition assay for drug susceptibility testing of influenza viruses. Antimicrob Agents Chemother 1980, 17:865-870.
    • (1980) Antimicrob Agents Chemother , vol.17 , pp. 865-870
    • Hayden, F.G.1    Cote, K.M.2    Douglas, R.G.3
  • 17
    • 0023361667 scopus 로고
    • Rimantidine hydrochloride and amantadine hydrochloride use in influenza A infections
    • Tominack R, Hayden F: Rimantidine hydrochloride and amantadine hydrochloride use in influenza A infections. Infect Dis Clin North Am 1987, 1:459-478.
    • (1987) Infect Dis Clin North Am , vol.1 , pp. 459-478
    • Tominack, R.1    Hayden, F.2
  • 18
    • 0019997609 scopus 로고
    • A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection
    • Dolin R, Reichman R, Madore H, et al.: A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. N Engl J Med 1982, 307:580-584.
    • (1982) N Engl J Med , vol.307 , pp. 580-584
    • Dolin, R.1    Reichman, R.2    Madore, H.3
  • 21
    • 0019516791 scopus 로고
    • Successful treatment of naturally occurring influenza A/USSR/77 H1N1
    • Van Voris L, Betts R, Hayden F, et al.: Successful treatment of naturally occurring influenza A/USSR/77 H1N1. J Am Med Assoc 1981, 245:1128-1131.
    • (1981) J Am Med Assoc , vol.245 , pp. 1128-1131
    • Van Voris, L.1    Betts, R.2    Hayden, F.3
  • 22
    • 0022612664 scopus 로고
    • Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults
    • Hayden F, Monto A: Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults. Antimicrob Agents Chemother 1986, 29:339-341.
    • (1986) Antimicrob Agents Chemother , vol.29 , pp. 339-341
    • Hayden, F.1    Monto, A.2
  • 23
    • 0033788325 scopus 로고    scopus 로고
    • Incidence of rimantadine-resistant influenza a viruses in sentinel surveillance sites and nursing homes in Niigata, Japan
    • Masuda H, Suzuki H, Saito R, et al.: Incidence of rimantadine-resistant influenza A viruses in sentinel surveillance sites and nursing homes in Niigata, Japan. Microbiol Immunol 2000, 44:833-839.
    • (2000) Microbiol Immunol , vol.44 , pp. 833-839
    • Masuda, H.1    Suzuki, H.2    Saito, R.3
  • 24
    • 0020633096 scopus 로고
    • Structure of the catalytic and antigenic sites in influenza virus neuraminidase
    • Colman P, Varghese J, Laver W: Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature 1983, 303:41-44.
    • (1983) Nature , vol.303 , pp. 41-44
    • Colman, P.1    Varghese, J.2    Laver, W.3
  • 25
    • 0020629047 scopus 로고
    • Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution
    • Varghese J, Laver G, Colman P: Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution. Nature 1983, 303:35-80.
    • (1983) Nature , vol.303 , pp. 35-80
    • Varghese, J.1    Laver, G.2    Colman, P.3
  • 26
    • 0027287506 scopus 로고
    • Rational design of potent sialidase-based inhibitors of influenza virus replication
    • von Itzstein M, Wu W, Kok G, et al.: Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 1993, 363:418-423.
    • (1993) Nature , vol.363 , pp. 418-423
    • Von Itzstein, M.1    Wu, W.2    Kok, G.3
  • 27
    • 0032512327 scopus 로고    scopus 로고
    • Randomised trial of efficacy and safety of inhaled zanamivir in the treatment of influenza A and B virus infections
    • MIST. Management of Influenza in the Southern Hemisphere Trialists: Randomised trial of efficacy and safety of inhaled zanamivir in the treatment of influenza A and B virus infections. Lancet 1998, 352:1877-1881.
    • (1998) Lancet , vol.352 , pp. 1877-1881
  • 28
    • 0033495482 scopus 로고    scopus 로고
    • Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza A and B virus infection
    • Monto A, Fleming D, Henry D, et al.: Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza A and B virus infection. J Infect Dis 1999, 180:254-261.
    • (1999) J Infect Dis , vol.180 , pp. 254-261
    • Monto, A.1    Fleming, D.2    Henry, D.3
  • 29
    • 0005849036 scopus 로고    scopus 로고
    • Rapid antiviral effect of inhaled zanamivir in the treatment of naturally occurring influenza in otherwise healthy adults
    • Boivin G, Goyette N, Hardy I, et al.: Rapid antiviral effect of inhaled zanamivir in the treatment of naturally occurring influenza in otherwise healthy adults. J Infect Dis 2000, 181:1471-1474.
    • (2000) J Infect Dis , vol.181 , pp. 1471-1474
    • Boivin, G.1    Goyette, N.2    Hardy, I.3
  • 30
    • 0034078730 scopus 로고    scopus 로고
    • Zanamivir for treatment of symptomatic influenza A and B infections in children five to twelve years of age: A randomized controlled trial
    • Hedrick J, Barzilai A, Behre U, et al.: Zanamivir for treatment of symptomatic influenza A and B infections in children five to twelve years of age: a randomized controlled trial. Pediatr Infect Dis J 2000, 19:410-417.
    • (2000) Pediatr Infect Dis J , vol.19 , pp. 410-417
    • Hedrick, J.1    Barzilai, A.2    Behre, U.3
  • 31
    • 0035931304 scopus 로고    scopus 로고
    • Zanamivir for treatment of influenza A and B in high-risk patients: A pooled analysis of randomized controlled trials
    • Lalezari J, Campion K, Keene O, et al.: Zanamivir for treatment of influenza A and B in high-risk patients: a pooled analysis of randomized controlled trials. Arch Intern Med 2001, 161:212-217.
    • (2001) Arch Intern Med , vol.161 , pp. 212-217
    • Lalezari, J.1    Campion, K.2    Keene, O.3
  • 32
    • 0033532975 scopus 로고    scopus 로고
    • Zanamivir in the prevention of influenza among healthy adults, a randomised controlled trial
    • Monto A, Robinson D, Herlocher M, et al.: Zanamivir in the prevention of influenza among healthy adults, a randomised controlled trial. JAMA 1999, 282:31-35.
    • (1999) JAMA , vol.282 , pp. 31-35
    • Monto, A.1    Robinson, D.2    Herlocher, M.3
  • 33
    • 1942444983 scopus 로고    scopus 로고
    • FDA/CDER Web site accessed 4 August, 2003
    • FDA. Relenza (zanamivir). In.: FDA/CDER Web site accessed 4 August, 2003; 2001.
    • (2001) Relenza (Zanamivir)
  • 34
    • 0034594874 scopus 로고    scopus 로고
    • Respiratory distress associated with zanamivir
    • Williamson J, Pegram P: Respiratory distress associated with zanamivir. N Engl J Med 2000, 342:661-662.
    • (2000) N Engl J Med , vol.342 , pp. 661-662
    • Williamson, J.1    Pegram, P.2
  • 35
    • 0033579237 scopus 로고    scopus 로고
    • Use of neuraminidase inhibitors for treatment of influenza A and B infections
    • MMWR: Use of neuraminidase inhibitors for treatment of influenza A and B infections. Morbid Mortal Weekly Rep 1999, 48:1-9.
    • (1999) Morbid Mortal Weekly Rep , vol.48 , pp. 1-9
  • 36
    • 0031048319 scopus 로고    scopus 로고
    • Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design synthesis and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity
    • Kim C, Lew W, Williams M, et al.: Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design synthesis and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc 1997, 119:681-690.
    • (1997) J Am Chem Soc , vol.119 , pp. 681-690
    • Kim, C.1    Lew, W.2    Williams, M.3
  • 37
    • 1942541109 scopus 로고    scopus 로고
    • Tamiflu™ (oseltamivir phosphate) capsules
    • Nutley, NJ: Roche Laboratories
    • Roche: Tamiflu™ (oseltamivir phosphate) capsules. In: Product Information. Nutley, NJ: Roche Laboratories; 2000.
    • (2000) Product Information
  • 38
    • 0031919227 scopus 로고    scopus 로고
    • Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection
    • Mendel DB, Tai CY, Escarpe PA, et al.: Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob Agents Chemother 1998, 42:640-646.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 640-646
    • Mendel, D.B.1    Tai, C.Y.2    Escarpe, P.A.3
  • 39
    • 0001926202 scopus 로고    scopus 로고
    • In vitro activity of the neuraminidase inhibitor GS4071 against influenza viruses
    • Atlanta, GA
    • Hayden F, Rollins B: In vitro activity of the neuraminidase inhibitor GS4071 against influenza viruses. In: 10th International Conference on Antiviral Research. Atlanta, GA; 1997:A86.
    • (1997) 10th International Conference on Antiviral Research
    • Hayden, F.1    Rollins, B.2
  • 40
    • 0033651178 scopus 로고    scopus 로고
    • The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses
    • Leneva I, Roberts N, Govorkova E, et al.: The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses. Antiviral Res 2000, 48:101-115.
    • (2000) Antiviral Res , vol.48 , pp. 101-115
    • Leneva, I.1    Roberts, N.2    Govorkova, E.3
  • 41
    • 0034720503 scopus 로고    scopus 로고
    • Efficacy and safety of oseltamivir in treatment of acute influenza: A randomized controlled trial
    • Nicholson K, Aoki F, Osterhaus A, et al.: Efficacy and safety of oseltamivir in treatment of acute influenza: A randomized controlled trial. Lancet 2000, 355:1845-1850.
    • (2000) Lancet , vol.355 , pp. 1845-1850
    • Nicholson, K.1    Aoki, F.2    Osterhaus, A.3
  • 42
    • 17744412173 scopus 로고    scopus 로고
    • Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza
    • Treanor JJ, Hayden FG, Vrooman PS, et al.: Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza. JAMA 2000, 283:1016-1024.
    • (2000) JAMA , vol.283 , pp. 1016-1024
    • Treanor, J.J.1    Hayden, F.G.2    Vrooman, P.S.3
  • 43
    • 0042259159 scopus 로고    scopus 로고
    • Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations
    • Kaiser L, Wat C, Mills T, et al.: Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch Intern Med 2003, 163:1667-1672.
    • (2003) Arch Intern Med , vol.163 , pp. 1667-1672
    • Kaiser, L.1    Wat, C.2    Mills, T.3
  • 45
    • 0032696188 scopus 로고    scopus 로고
    • Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza
    • Hayden F, Atmar R, Schilling M, et al.: Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza. N Engl J Med 1999, 341:1336-1343.
    • (1999) N Engl J Med , vol.341 , pp. 1336-1343
    • Hayden, F.1    Atmar, R.2    Schilling, M.3
  • 46
    • 0035857389 scopus 로고    scopus 로고
    • Effectiveness of oseltamivir in preventing influenza in household contacts: A randomised controlled trial
    • Oseltamivir Post Exposure Prophylaxis Investigator Group
    • Welliver R, Monto A, Carewicz O, et al.: Oseltamivir Post Exposure Prophylaxis Investigator Group. Effectiveness of oseltamivir in preventing influenza in household contacts: a randomised controlled trial. JAMA 2001, 285:748-754.
    • (2001) JAMA , vol.285 , pp. 748-754
    • Welliver, R.1    Monto, A.2    Carewicz, O.3
  • 47
    • 0030053758 scopus 로고    scopus 로고
    • Generation and characterization of variants of NWS/G70C influenza virus after in vitro passage in 4-Amino-Neu5Ac2en and 4-Guanidino-Neu5Ac2en
    • McKimm-Breschkin JL, Blick TJ, Sahasrabudhe A, et al.: Generation and characterization of variants of NWS/G70C influenza virus after in vitro passage in 4-Amino-Neu5Ac2en and 4-Guanidino-Neu5Ac2en. Antimicrob Agents Chemother 1996, 40:40-46.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 40-46
    • McKimm-Breschkin, J.L.1    Blick, T.J.2    Sahasrabudhe, A.3
  • 48
    • 0031787185 scopus 로고    scopus 로고
    • Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071
    • Tai CY, Escarpe PA, Sidwell RW, et al.: Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071. Antimicrob Agents Chemother 1998, 42:3234-3241.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 3234-3241
    • Tai, C.Y.1    Escarpe, P.A.2    Sidwell, R.W.3
  • 49
    • 0031911783 scopus 로고    scopus 로고
    • Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors
    • McKimm-Breschkin J, Sahasrabudhe A, Blick T, et al.: Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors. J Virol 1998, 72:2456-2462.
    • (1998) J Virol , vol.72 , pp. 2456-2462
    • McKimm-Breschkin, J.1    Sahasrabudhe, A.2    Blick, T.3
  • 50
    • 0029585928 scopus 로고
    • Generation and characterisation of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en
    • Blick T, Tiong T, Sahasrabudhe A, et al.: Generation and characterisation of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en. Virology 1995, 214:475-484.
    • (1995) Virology , vol.214 , pp. 475-484
    • Blick, T.1    Tiong, T.2    Sahasrabudhe, A.3
  • 51
    • 0031724750 scopus 로고    scopus 로고
    • Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus
    • Gubareva L, Matrosovich M, Brenner M, et al.: Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus. J Infect Dis 1998, 178:1257-1262.
    • (1998) J Infect Dis , vol.178 , pp. 1257-1262
    • Gubareva, L.1    Matrosovich, M.2    Brenner, M.3
  • 52
    • 0036294882 scopus 로고    scopus 로고
    • Current research on respiratory viral infections: Fourth International Symposium
    • Ison MG, Mills J, Openshaw P, et al.: Current research on respiratory viral infections: Fourth International Symposium. Antiviral Res 2002, 55:227-278. A collection of brief reports on the recent developments of both vaccines and antivirals for respiratory virus infections, which serves as an excellent starting point for those wishing to gain an overall perspective on the area.
    • (2002) Antiviral Res , vol.55 , pp. 227-278
    • Ison, M.G.1    Mills, J.2    Openshaw, P.3
  • 53
    • 0035865919 scopus 로고    scopus 로고
    • Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir
    • Gubareva L, Kaiser L, Matrosovich M, et al.: Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir. J Infect Dis 2001, 183:523-531.
    • (2001) J Infect Dis , vol.183 , pp. 523-531
    • Gubareva, L.1    Kaiser, L.2    Matrosovich, M.3
  • 54
    • 0034930675 scopus 로고    scopus 로고
    • Prophylaxis and treatment of influenza virus infection
    • Kandel R, Hartshorn KL: Prophylaxis and treatment of influenza virus infection. BioDrugs 2001, 15:303-323.
    • (2001) BioDrugs , vol.15 , pp. 303-323
    • Kandel, R.1    Hartshorn, K.L.2
  • 55
    • 0015523596 scopus 로고
    • Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1, 2,4-triazole-3-carboxamide
    • Sidwell R, Huffman J, Khare G, et al.: Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science 1972, 177:705-706.
    • (1972) Science , vol.177 , pp. 705-706
    • Sidwell, R.1    Huffman, J.2    Khare, G.3
  • 56
    • 0036182633 scopus 로고    scopus 로고
    • Ribavirin's antiviral mechanism of action: Lethal mutagenesis?
    • Crotty S, Cameron C, Andino R: Ribavirin's antiviral mechanism of action: lethal mutagenesis? J Mol Med 2002, 80:86-95. This paper describes the various suggested mechanisms proposed for the antiviral activity of ribavirin and adds an interesting new theory to the mix.
    • (2002) J Mol Med , vol.80 , pp. 86-95
    • Crotty, S.1    Cameron, C.2    Andino, R.3
  • 57
    • 0032547938 scopus 로고    scopus 로고
    • Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
    • Hepatitis Interventional Therapy Group
    • McHutchison J, Gordon S, Schiff E, et al.: Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med 1998, 339:1485.
    • (1998) N Engl J Med , vol.339 , pp. 1485
    • McHutchison, J.1    Gordon, S.2    Schiff, E.3
  • 58
    • 84944969395 scopus 로고
    • Ribavirin treatment of experimental respiratory syncytial virus infection
    • Hall C, Walsh E, Hruska J, et al.: Ribavirin treatment of experimental respiratory syncytial virus infection. JAMA 1983, 249:2666.
    • (1983) JAMA , vol.249 , pp. 2666
    • Hall, C.1    Walsh, E.2    Hruska, J.3
  • 59
    • 0022630892 scopus 로고
    • Lassa fever. Effective therapy with ribavirin
    • McCormick J, King I, Webb P, et al.: Lassa fever. Effective therapy with ribavirin. N Engl J Med 1986, 314:20-26.
    • (1986) N Engl J Med , vol.314 , pp. 20-26
    • McCormick, J.1    King, I.2    Webb, P.3
  • 60
    • 0020535923 scopus 로고
    • Aerosolized ribavirin treatment of infants with respiratory syncytial virus infection: A randomised double-blind study
    • Hall C, McBride J, Walsh EE, et al.: Aerosolized ribavirin treatment of infants with respiratory syncytial virus infection: a randomised double-blind study. N Engl J Med 1983, 308:1443-1447.
    • (1983) N Engl J Med , vol.308 , pp. 1443-1447
    • Hall, C.1    McBride, J.2    Walsh, E.E.3
  • 61
    • 0022329613 scopus 로고
    • Ribavirin treatment of respiratory syncytial virus infection in infants with underlying cardiopulmonary disease
    • Hall C, McBride J, Gala C, et al.: Ribavirin treatment of respiratory syncytial virus infection in infants with underlying cardiopulmonary disease. JAMA 1985, 254:3047-3051.
    • (1985) JAMA , vol.254 , pp. 3047-3051
    • Hall, C.1    McBride, J.2    Gala, C.3
  • 62
    • 0029870386 scopus 로고    scopus 로고
    • Effectiveness of ribavirin in otherwise well infants with respiratory syncytial virus-associated respiratory failure
    • Moler F, Steinhart C, Ohmit S, Stidham G: Effectiveness of ribavirin in otherwise well infants with respiratory syncytial virus-associated respiratory failure. J Pediatr 1996, 128:422-428.
    • (1996) J Pediatr , vol.128 , pp. 422-428
    • Moler, F.1    Steinhart, C.2    Ohmit, S.3    Stidham, G.4
  • 63
    • 0029832166 scopus 로고    scopus 로고
    • Ribavirin for respiratory syncytial virus lower respiratory tract infection
    • Randolph AG, Wang EE: Ribavirin for respiratory syncytial virus lower respiratory tract infection. Arch Paediatr Adolesc Med 1996, 150:942-947.
    • (1996) Arch Paediatr Adolesc Med , vol.150 , pp. 942-947
    • Randolph, A.G.1    Wang, E.E.2
  • 64
    • 0000089226 scopus 로고    scopus 로고
    • Respiratory syncytial virus
    • Edited by Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, et al. Philadelphia: Lippincott, Williams & Wilkins
    • Collins P, Chanock R, Murphy B: Respiratory syncytial virus. In Field's Virology, edn 4. Edited by Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, et al. Philadelphia: Lippincott, Williams & Wilkins; 2001.
    • (2001) Field's Virology, Edn 4.
    • Collins, P.1    Chanock, R.2    Murphy, B.3
  • 65
    • 0035176383 scopus 로고    scopus 로고
    • Pre-emptive oral ribavirin therapy of paramyxovirus infections after haematopoietic stem cell transplantation: A pilot study
    • Chakrabarti S, Collingham K, Holder K, et al.: Pre-emptive oral ribavirin therapy of paramyxovirus infections after haematopoietic stem cell transplantation: a pilot study. Bone Marrow Transplant 2001, 28:759-763.
    • (2001) Bone Marrow Transplant , vol.28 , pp. 759-763
    • Chakrabarti, S.1    Collingham, K.2    Holder, K.3
  • 66
    • 0035491840 scopus 로고    scopus 로고
    • Preventive and therapeutic strategies for respiratory syncytial virus infection
    • Vujovic O, Mills J: Preventive and therapeutic strategies for respiratory syncytial virus infection. Curr Opin Pharmacol 2001, 1:497-503.
    • (2001) Curr Opin Pharmacol , vol.1 , pp. 497-503
    • Vujovic, O.1    Mills, J.2
  • 67
    • 0001178031 scopus 로고    scopus 로고
    • Orthomyxoviruses
    • Edited by Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, et al. Philadelphia: Lippincott, Williams & Wilkins
    • Wright PF, Webster RG: Orthomyxoviruses. In Field's Virology, edn 4. Edited by Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, et al. Philadelphia: Lippincott, Williams & Wilkins; 2001.
    • (2001) Field's Virology, Edn 4.
    • Wright, P.F.1    Webster, R.G.2
  • 68
    • 0038681890 scopus 로고    scopus 로고
    • Systematic review of the biology and medical management of syncytial respiratory virus infection
    • Black CP: Systematic review of the biology and medical management of syncytial respiratory virus infection. Respir Care 2003, 48:209-233. A comprehensive analysis of the respiratory disease caused by RSV and the various options for its control.
    • (2003) Respir Care , vol.48 , pp. 209-233
    • Black, C.P.1
  • 69
    • 2442671303 scopus 로고    scopus 로고
    • Reassessment of the indications for ribavirin therapy in respiratory syncytial virus infections
    • AAPC. American Academy of Pediatrics Committee on Infectious Diseases: reassessment of the indications for ribavirin therapy in respiratory syncytial virus infections. Pediatrics 1996, 97:137-140.
    • (1996) Pediatrics , vol.97 , pp. 137-140
  • 70
    • 0033974940 scopus 로고    scopus 로고
    • Respiratory syncytial virus immune globulin treatment of lower respiratory tract infection in pediatric patients undergoing bone marrow transplantation-a compassionate use experience
    • DeVincenzo J, Hirsch R, Fuentes R, et al.: Respiratory syncytial virus immune globulin treatment of lower respiratory tract infection in pediatric patients undergoing bone marrow transplantation-a compassionate use experience. Bone Marrow Transplant 2000, 25:161-165.
    • (2000) Bone Marrow Transplant , vol.25 , pp. 161-165
    • DeVincenzo, J.1    Hirsch, R.2    Fuentes, R.3
  • 71
  • 72
    • 0035087778 scopus 로고    scopus 로고
    • Molecular targets for antiviral agents
    • De Clercq E: Molecular targets for antiviral agents. J Pharmacol Exp Ther 2001, 297:1-10.
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 1-10
    • De Clercq, E.1
  • 73
    • 0000095156 scopus 로고    scopus 로고
    • Picornaviridae: The viruses and their replication
    • Edited by Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, et al. Philadelphia: Lippincott, Willians & Wilkins
    • Racaniello VR: Picornaviridae: the viruses and their replication. In Field's Virology, edn 4. Edited by Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, et al. Philadelphia: Lippincott, Willians & Wilkins; 2001.
    • (2001) Field's Virology, Edn 4
    • Racaniello, V.R.1
  • 74
    • 0031899552 scopus 로고    scopus 로고
    • Approaches to antiviral chemotherapy for acute respiratory infections
    • Shigeta S: Approaches to antiviral chemotherapy for acute respiratory infections. Antivir Chem Chemother 1998, 9:93-107.
    • (1998) Antivir Chem Chemother , vol.9 , pp. 93-107
    • Shigeta, S.1
  • 76
    • 0037405114 scopus 로고    scopus 로고
    • Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein
    • Douglas J, Panis M, Ho E, et al.: Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein. J Virol 2003, 77:5054-5064.
    • (2003) J Virol , vol.77 , pp. 5054-5064
    • Douglas, J.1    Panis, M.2    Ho, E.3
  • 77
    • 0032054629 scopus 로고    scopus 로고
    • CL387626 exhibits marked and unusual antiviral activity against respiratory syncytial virus in tissue culture and in cotton rats
    • Wyde PR, Moore-Poveda DK, O'Hara B, et al.: CL387626 exhibits marked and unusual antiviral activity against respiratory syncytial virus in tissue culture and in cotton rats. Antiviral Res 1998, 38:31-42.
    • (1998) Antiviral Res , vol.38 , pp. 31-42
    • Wyde, P.R.1    Moore-Poveda, D.K.2    O'Hara, B.3
  • 78
    • 0036170138 scopus 로고    scopus 로고
    • RFI-641, a potent respiratory syncytial virus inhibitor
    • Huntley C, Weiss W, Gazumyan A, et al.: RFI-641, a potent respiratory syncytial virus inhibitor. Antimicrob Agents Chemother 2002, 46:841-847.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 841-847
    • Huntley, C.1    Weiss, W.2    Gazumyan, A.3
  • 79
    • 0036210594 scopus 로고    scopus 로고
    • In vitro characterisation of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication
    • Kati WM, Montgomery D, Carrick R, et al.: In vitro characterisation of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication. Antimicrob Agents Chemother 2002, 46:1014-1021.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1014-1021
    • Kati, W.M.1    Montgomery, D.2    Carrick, R.3
  • 80
    • 0038209544 scopus 로고    scopus 로고
    • Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: Modifications of essential pyrrolidinone ring substituents
    • Brouillette W, Bajpai S, Ali S, et al.: Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents. Bioorg Med Chem 2003, 11:2739-2749.
    • (2003) Bioorg Med Chem , vol.11 , pp. 2739-2749
    • Brouillette, W.1    Bajpai, S.2    Ali, S.3
  • 81
    • 0037025440 scopus 로고    scopus 로고
    • Synthesis and anti-influenza virus activity of 4-Guanidino-7-substituted- Neu5Ac2en derivatives
    • Honda T, Masuda T, Yoshida S, et al.: Synthesis and anti-influenza virus activity of 4-Guanidino-7-substituted-Neu5Ac2en derivatives. Bioorg Med Chem Lett 2002, 12:1921-1924.
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 1921-1924
    • Honda, T.1    Masuda, T.2    Yoshida, S.3
  • 82
    • 0036061381 scopus 로고    scopus 로고
    • Targeted therapy of respiratory syncytial virus in African green monkeys by intranasally administered 2-5A antisense
    • Leaman D, Longano F, Okicki J, et al.: Targeted therapy of respiratory syncytial virus in African green monkeys by intranasally administered 2-5A antisense. Virology 2002, 292:70-77. This paper describes novel antisense technology that allows the specific cleavage RSV genomic RNA, resulting in a reduction of viral replication in vitro and in vivo.
    • (2002) Virology , vol.292 , pp. 70-77
    • Leaman, D.1    Longano, F.2    Okicki, J.3
  • 83
    • 0032870120 scopus 로고    scopus 로고
    • In vitro antiviral activity of ruprintrivir, a potent inhibitor of human rhinovirus 3C protease
    • Patick A, Binford S, Brothers M, et al.: In vitro antiviral activity of ruprintrivir, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 1999, 43:2444-2450.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 2444-2450
    • Patick, A.1    Binford, S.2    Brothers, M.3
  • 84
    • 0038120984 scopus 로고    scopus 로고
    • Coronavirus main protease (3CLpro) structure: Basis for design of anti-SARS drugs
    • Anand K, Ziebuhr J, Wadhwani P, et al.: Coronavirus main protease (3CLpro) structure: basis for design of anti-SARS drugs. Science 2003, 300:1763-1767.
    • (2003) Science , vol.300 , pp. 1763-1767
    • Anand, K.1    Ziebuhr, J.2    Wadhwani, P.3
  • 85
    • 0032575532 scopus 로고    scopus 로고
    • Novel Anti-respiratory syncytial (RS) viral compounds: Benzodithiin derivatives
    • Watanabe W, Sudo K, Sato R, et al.: Novel Anti-respiratory syncytial (RS) viral compounds: benzodithiin derivatives. Biochem Biophys Res Commun 1998, 249:922-926.
    • (1998) Biochem Biophys Res Commun , vol.249 , pp. 922-926
    • Watanabe, W.1    Sudo, K.2    Sato, R.3
  • 86
    • 0032920404 scopus 로고    scopus 로고
    • Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice
    • Sudo K, Watanabe W, Konno K, et al.: Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice. Antimicrob Agents Chemother 1999, 43:752-757.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 752-757
    • Sudo, K.1    Watanabe, W.2    Konno, K.3
  • 87
    • 0034912960 scopus 로고    scopus 로고
    • Mechanism of selective inhibition of respiratory syncytial virus by a benzodithiin compound (RD3-0028)
    • Sudo K, Konno K, Watanabe W, et al.: Mechanism of selective inhibition of respiratory syncytial virus by a benzodithiin compound (RD3-0028). Microbiol Immunol 2001, 45:531-537.
    • (2001) Microbiol Immunol , vol.45 , pp. 531-537
    • Sudo, K.1    Konno, K.2    Watanabe, W.3


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