Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection

Infection and Immunity

Volumn 67, Issue 11, 1999, Pages 5658-5663

  Klinman, Dennis M ^a,b   Conover, Jackie ^a   Coban, Cevahir ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 6; OLIGODEOXYNUCLEOTIDE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; FRANCISELLA TULARENSIS; IMMUNE RESPONSE; IMMUNITY; IMMUNOMODULATION; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; LISTERIA MONOCYTOGENES; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE INJURY;

EID: 0032706198     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.11.5658-5663.1999     Document Type: Article

References (30)

1. Ballas, Z. D., W. L. Rasmussen, and A. M. Krieg. 1996. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157:1840-1847.
2. Bird, A. P. 1987. CpG-rich islands and the function of DNA methylation. Trends Genet. 3:342-347.
3. Branda, R. F., A. L. Moore, A. R. Lafayette, L. Mathews, R. Hong, G. Zon, T. Brown, and J. J. McCormack. 1996. Amplification of antibody production by phosphorothioate oligodeoxynucleotides. J. Lab. Clin. Med. 128:329-338.
4. Brazolot Millan, C. L., R. Weeratna, A. M. Krieg, C. A. Siegrist, and H. L. Davis. 1998. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc. Natl. Acad. Sci. USA 95:15553-15558.
5. Cella, M., M. Salio, Y. Sakakibara, H. Langen, I. Julkunen, and A. Lanzavecchia. 1999. Maturation, activation and protection of dendritic cells induced by double stranded RNA. J. Exp. Med. 189:821-829.
6. Cowdery, J. S., J. H. Chace, A. Yi, and A. M. Krieg. 1996. Bacterial DNA induces NK cells to produce IFN gamma in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156:4570-4575.
7. Elkins, K. L., T. R. Rhinehart-Jones, S. Stibitz, J. S. Conover, and D. M. Klinman. 1999. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J. Immunol. 162:2991-2998.
8. Gilkeson, G. S., J. P. Grudier, D. G. Karounos, and D. S. Pisetsky. 1989. Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA. J. Immunol. 142:1482-1486.
9. Halpern, M. D., R. J. Kurlander, and D. S. Pisetsky. 1996. Bacterial DNA induces murine interferon-gamma production by stimulation of IL-12 and tumor necrosis factor-alpha. Cell. Immunol. 167:72-78.
10. Klinman, D. M. 1998. Therapeutic applications of CpG-containing oligode-oxynucleotides. Antisense Nucleic Acid Drug Dev. 8:181-184.
11. Klinman, D. M., K. M. Barnhart, and J. Conover. 1998. CpG motifs as immune adjuvants. Vaccine 17:19-25.
12. Klinman, D. M., and T. B. Nutman. 1994. ELIspot assay to detect cytokine-secreting murine and human cells, p. 6.19.1-6.19.8. In J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober ed., Current protocols in immunology. Greene Publishing Associates, Brooklyn, N.Y.
13. Klinman, D. M., and A. D. Steinberg. 1986. Proliferation of anti-DNA producing NZB B cells in a non-autoimmune environment. J. Immunol. 137: 69-75.
14. Klinman, D. M., A. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFNγ. Proc. Natl. Acad. Sci. USA 93:2879-2883.
15. Kovarik, J., P. Bozzotti, L. Love-Homan, M. Pihlgren, H. L. Davis, P. Lambert, A. M. Krieg, and C. A. Siegrist. 1999. CpG oligonucleotides can circumvent the TH2 polarization of neonatal responses to vaccines but fail to fully redirect TH2 responses established by neonatal priming. J. Immunol. 162:1611-1617.
16. Krieg, A. M., L. L. Homan, A. K. Yi, and J. T. Harty. 1998. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161:2428-2434.
17. Krieg, A. M., A. Yi, S. Matson, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546-548.
18. Marrack, P., and J. Kappler. 1994. Submersion of the immune system by pathogens. Cell 76:323-332.
19. McCluskie, M. J., and H. L. Davis. 1998. CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice. J. Immunol. 161:4463-4466.
20. Medzhitov, R., and C. A. Janeway. 1997. Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9:4-9.
21. Medzhitov, R., and C. A. Janeway. 1998. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91:295-298.
22. Moldoveanu, Z., L. Love-Homan, W. Q. Huang, and A. M. Krieg. 1998. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 16:1216-1224.
23. Razin, A., and J. Friedman. 1981. DNA methylation and its possible biological roles. Prog. Nucleic Acid Res. Mol. Biol. 25:33-52.
24. Roman, M., E. Martin-Orozco, J. S. Goodman, M. Nguyen, Y. Sato, A. Ronaghy, R. S. Kornbluth, D. D. Richman, D. A. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as T helper-1 promoting adjuvants. Nat. Med. 3:849-854.
25. Sato, Y., M. Roman, H. Tighe, D. Lee, M. Corr, M. Nguyen, D. A. Carson, and E. Raz. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352-354.
26. Sedgwick, J. D., and P. G. Holt. 1983. A solid phase immunoenzymatic technique for the enumeration of specific antibody secreting cells. J. Immunol. Methods 57:301-309.
27. Sparwasser, T., T. Meithke, G. Lipford, K. Borschert, H. Hicker, K. Heeg, and H. Wagner. 1997. Bacterial DNA causes septic shock. Nature 386:336-338.
28. Sparwasser, T., T. Miethke, G. Lipford, A. Erdmann, H. Hacker, K. Heeg, and H. Wagner. 1997. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock. Eur. J. Immunol. 27: 1671-1679.
29. Yamamoto, S., T. Yamamoto, T. Katoaka, E. Kuramoto, O. Yano, and T. Tokunaga. 1992. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol. 148:4072-4076.
30. Zimmermann, S., O. Egeter, S. Hausmann, G. B. Lipford, M. Rocken, H. Wagner, and K. Heeg. 1998. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine Leishmaniasis. J. Immunol. 160:3627-3630.