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Volumn 160, Issue 8, 1998, Pages 3627-3630

Cutting edge: CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; INTERLEUKIN 12; INTERLEUKIN 4; N6 (1 IMINOETHYL)LYSINE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; UNCLASSIFIED DRUG; OLIGODEOXYRIBONUCLEOTIDE; PRIMER DNA;

EID: 0032521881     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (409)

References (30)
  • 2
    • 0030273086 scopus 로고    scopus 로고
    • Immune activation by bacterial DNA: A new genetic code
    • Pisetsky, D. S. 1996. Immune activation by bacterial DNA: a new genetic code. Immunity 5:303.
    • (1996) Immunity , vol.5 , pp. 303
    • Pisetsky, D.S.1
  • 3
    • 0030240062 scopus 로고    scopus 로고
    • Macrophages ingest and are activated by bacterial DNA
    • Stacey, K. J., M. J. Sweet, and D. A. Hume. 1996. Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157:2116.
    • (1996) J. Immunol. , vol.157 , pp. 2116
    • Stacey, K.J.1    Sweet, M.J.2    Hume, D.A.3
  • 6
    • 0026464967 scopus 로고
    • DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth
    • Yamamoto, S., T. Yamamoto, S. Shimada, E. Kuramoto, O. Yano, T. Kataoka, and T. Tokunaga. 1992. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immunol. 36:983.
    • (1992) Microbiol. Immunol. , vol.36 , pp. 983
    • Yamamoto, S.1    Yamamoto, T.2    Shimada, S.3    Kuramoto, E.4    Yano, O.5    Kataoka, T.6    Tokunaga, T.7
  • 7
    • 0030850462 scopus 로고    scopus 로고
    • CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
    • Lipford, G. B., M. Bauer, C. Blank, R. Reiter, H. Wagner, and K. Heeg. 1997. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol. 27:2340.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2340
    • Lipford, G.B.1    Bauer, M.2    Blank, C.3    Reiter, R.4    Wagner, H.5    Heeg, K.6
  • 8
    • 0030589385 scopus 로고    scopus 로고
    • Rapid immune activation by CpG motifs in bacterial DNA: Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway
    • Yi, A. K., D. M. Klinman, T. L. Martin, S. Matson, and A. M. Krieg. 1996. Rapid immune activation by CpG motifs in bacterial DNA: systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J. Immunol. 157:5394.
    • (1996) J. Immunol. , vol.157 , pp. 5394
    • Yi, A.K.1    Klinman, D.M.2    Martin, T.L.3    Matson, S.4    Krieg, A.M.5
  • 11
    • 0024236111 scopus 로고
    • Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens
    • Scott, P., P. Natovitz, R. L. Coffman, E. Pearce, and A. Sher. 1988. Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med. 168:1675.
    • (1988) J. Exp. Med. , vol.168 , pp. 1675
    • Scott, P.1    Natovitz, P.2    Coffman, R.L.3    Pearce, E.4    Sher, A.5
  • 13
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 151
    • Reiner, S.L.1    Locksley, R.M.2
  • 14
    • 0026539390 scopus 로고
    • Murine epidermal Langerhans cells are potent stimulators of an antigen-specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis
    • Will, A., C. Blank, M. Röllinghoff, and H. Moll. 1992. Murine epidermal Langerhans cells are potent stimulators of an antigen-specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis. Eur. J. Immunol. 22:1341.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1341
    • Will, A.1    Blank, C.2    Röllinghoff, M.3    Moll, H.4
  • 15
    • 0028339765 scopus 로고
    • Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo
    • Röcken, M., J. Urban, and E. M. Shevach. 1994. Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo. J. Exp. Med. 179:1885.
    • (1994) J. Exp. Med. , vol.179 , pp. 1885
    • Röcken, M.1    Urban, J.2    Shevach, E.M.3
  • 16
    • 0023257259 scopus 로고
    • Vaccination against cutaneous leishmaniasis in a murine model: Induction of protective immunity with a soluble extract of promastigotes
    • Scott, P., E. Pearce, P. Natovitz, and A. Sher. 1987. Vaccination against cutaneous leishmaniasis in a murine model: induction of protective immunity with a soluble extract of promastigotes. J. Immunol. 139:221.
    • (1987) J. Immunol. , vol.139 , pp. 221
    • Scott, P.1    Pearce, E.2    Natovitz, P.3    Sher, A.4
  • 18
    • 0029976423 scopus 로고    scopus 로고
    • Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase
    • Stenger, S., N. Donhauser, H. Thüring, M. Röllinghoff, and C. Bogdan. 1996. Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase. J. Exp. Med. 183:1501.
    • (1996) J. Exp. Med. , vol.183 , pp. 1501
    • Stenger, S.1    Donhauser, N.2    Thüring, H.3    Röllinghoff, M.4    Bogdan, C.5
  • 19
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R beta2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-12R beta2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817.
    • (1997) J. Exp. Med. , vol.185 , pp. 817
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 21
    • 0031114125 scopus 로고    scopus 로고
    • Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness
    • Launois, P., K. G. Swihart, G. Milon, and J. A. Louis. 1997. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J. Immunol. 158:3317.
    • (1997) J. Immunol. , vol.158 , pp. 3317
    • Launois, P.1    Swihart, K.G.2    Milon, G.3    Louis, J.A.4
  • 22
    • 0025133974 scopus 로고
    • Cure of murine leishmaniasis with anti-IL-4 monoclonal antibody: Evidence for a T cell-dependent, interferon-gamma-independent mechanism
    • Sadick, M. D., F. P. Heinzel, B. J. Holaday, R. T. Pu, R. S. Dawkins, and R. M. Locksley. 1990. Cure of murine leishmaniasis with anti-IL-4 monoclonal antibody: evidence for a T cell-dependent, interferon-gamma-independent mechanism. J. Exp. Med. 171:115.
    • (1990) J. Exp. Med. , vol.171 , pp. 115
    • Sadick, M.D.1    Heinzel, F.P.2    Holaday, B.J.3    Pu, R.T.4    Dawkins, R.S.5    Locksley, R.M.6
  • 25
    • 0028934155 scopus 로고
    • Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and pentostam
    • Nabors, G. S., L. C. C. Afonso, J. P. Farrell, and P. Scott. 1995. Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and pentostam. Proc. Natl. Acad. Sci. USA 92:3142.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3142
    • Nabors, G.S.1    Afonso, L.C.C.2    Farrell, J.P.3    Scott, P.4
  • 26
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas, Z. K., W. L. Rasmussen, and A. M. Krieg. 1996. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157:1840.
    • (1996) J. Immunol. , vol.157 , pp. 1840
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 27
    • 0031081724 scopus 로고    scopus 로고
    • Modulating ongoing Th2-cell responses in experimental leishmaniasis
    • Nabors, G. S. 1997. Modulating ongoing Th2-cell responses in experimental leishmaniasis. Parasitol. Today 13:76.
    • (1997) Parasitol. Today , vol.13 , pp. 76
    • Nabors, G.S.1
  • 28
    • 0030940348 scopus 로고    scopus 로고
    • + T cells, interleukin 4 production is cytokine-autonomous, whereas interferon-gamma production is cytokine-dependent
    • + T cells, interleukin 4 production is cytokine-autonomous, whereas interferon-gamma production is cytokine-dependent. Proc. Natl. Acad. Sci. USA 94:3189.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3189
    • Hu-Li, J.1    Huang, H.2    Ryan, J.3    Paul, W.E.4
  • 29
    • 0030859053 scopus 로고    scopus 로고
    • Successful therapy of chronic, non-healing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production
    • Li, J., S. Sutterwala, and J. P. Farrell. 1997. Successful therapy of chronic, non-healing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production. Infect. Immun. 65: 3225.
    • (1997) Infect. Immun. , vol.65 , pp. 3225
    • Li, J.1    Sutterwala, S.2    Farrell, J.P.3
  • 30
    • 0031156982 scopus 로고    scopus 로고
    • Microbial products induce autoimmune disease by an IL-12-dependent pathway
    • Segal, B. M., D. M. Klinman, and E. M. Shevach. 1997. Microbial products induce autoimmune disease by an IL-12-dependent pathway. J. Immunol. 158: 5087.
    • (1997) J. Immunol. , vol.158 , pp. 5087
    • Segal, B.M.1    Klinman, D.M.2    Shevach, E.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.