Wealth of opportunity - The C1 domain as a target for drug development

Current Drug Targets

Volumn 9, Issue 8, 2008, Pages 641-652

  Blumberg, P M ^a   Kedei, N ^a   Lewin, N E ^a   Yang, D ^a   Czifra, G ^a   Pu, Y ^a   Peach, M L ^b   Marquez, V E ^c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Bryostation; C1 domain; Phorbol ester; Protein kinase C; RasGRP

Indexed keywords

AUROTHIOGLUCOSE; BENZOLACTAM DERIVATIVE; BRYOSTATIN 1; DIACYLGLYCEROL; ENZASTAURIN; INDOLACTAM DERIVATIVE; INGENOL 3 ANGELATE; LACTAM DERIVATIVE; LACTONE DERIVATIVE; LIGAND; NATURAL PRODUCT; PEP 005; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTRATIN; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ACTINIC KERATOSIS; ALZHEIMER DISEASE; B CELL LYMPHOMA; CELLULAR DISTRIBUTION; CLINICAL TRIAL; DRUG DESIGN; DRUG DEVELOPMENT; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SKIN CANCER;

CLINICAL TRIALS AS TOPIC; DIACYLGLYCEROL KINASE; DIGLYCERIDES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

EID: 52449093812     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945008785132376     Document Type: Review

References (119)

1. Nishizuka, Y. (1992) Science, 258, 607-614.
2. Rhee, S.G. (2001) Annu. Rev. Biochem., 70, 281-312.
3. Oude Weernink, P.A.; Han, L.; Jakobs, K.H. and Schmidt, M. (2007) Biochim. Biophys. Acta, 1768, 888-900.
4. Hurley, J.H.; Newton, A.C.; Parker, P.J.; Blumberg, P.M. and Nishizuka, Y. (1997) Protein Sci., 6, 477-480.
5. Geiger, M.; Wrulich, O.A.; Jenny, M.; Schwaiger, W.; Grunicke, H.H. and Überall, F. (2003) Cur. Opin. Mol. Therap., 5, 631-641.
6. Colón-González, F. and Kazanietz, M.G., (2006) Biochim. Biophys. Acta, 1761, 827-837.
7. Newton, A.C. and Johnson, J.E. (1998) Biochim. Biophys. Acta, 1376, 155-172.
8. Newton, A.C. (2001) Chem. Rev., 101, 2353-2364.
9. Carmena, D. and Sardini, A. (2007) Biochem. Soc. Trans., 35, 1043-1045.
10. Yang, C. and Kazanietz, M.G. (2003) Trends Pharmacol. Sci., 24, 602-608.
11. Kazanietz, M.G. (2005) Biochim. Biophys. Acta, 1754, 296-304.
12. Rykx, A.; Kimpe, L.D.; Mikhalap, S.; Vantus, T.; Seufferlein, T.; Vandenheede, J.R. and Van Lint, J. (2003) FEBS Lett., 546, 81-86.
13. Wang, Q.J. (2006) Trends Pharmacol. Sci., 27, 317-323.
14. Bruinsma, S.P. and Baranski, T.J. (2007) Cell Cycle, 6, 2440-2444.
15. Stone, J.C. (2006) Biochem. Soc., Trans., 34, 858-861.
16. Kim, R.; Trubetskoy, A.; Suzuki, T.; Jenkins, N.A.; Copeland, N.G. and Lenz, J. (2003) J. Virol., 77, 2056-2062.
17. Luke, C.T.; Oki-Idouchi, C.E.; Cline, J.M. and Lorenzo, P.S. (2007) Cancer Res., 67, 10190-10197.
18. Roberts, D.M.; Anderson, A.L.; Kidaka, M.; Swetenburg, R.L.; Patterson, C.; Stanford, W.L. and Bautch, V.L. (2004) Mol. Cell Biol., 24, 10515-10528.
19. Brose, N.; Rosenmund, C. and Rettig, J. (2000) Cur. Opin. Neurobiol., 10, 303-311.
20. Silinsky, E.M. and Searl, T.J. (2003) Br. J. Pharmacol., 138, 1191-1201.
21. Topham, M.K. (2006) J. Cell Biochem., 97, 474-484.
22. Leung, T.; Chen, Z.Q.; Tan, I.; Manser, E. and Lim, L. (1998) Mol. Cell Biol., 18, 130-140.
23. Gaggioli, C.; Hooper, S.; Hidalgo-Carcedo, C.; Grosse, R.; Marshall, J.F.; Harrington, K. and Sahai, E. (2007) Nat. Cell Biol., 9, 1392-1400.
24. Griner, E.M. and Kazanietz, M.G. (2007) Nat. Rev. Cancer, 7, 281-294.
25. Podar, K., Raab, M.S., Chauhan, D. and Anderson, K.C. (2007) Expert Opin. Invest. Drugs, 16, 1693-1707.
26. Fields, A.P. and Regala, R.P. (2007) Pharmacol. Res., 55, 487-497.
27. Teicher, B.A. (2007) Clin. Cancer Res., 12, 5336-5345.
28. Shipp, M.A.; Ross, K.N.; Tamayo, P.; Weng, A.P.; Kutok, J.L.; Aguiar, R.C.T.; Gaasenbeek, M.; Angelo, M.; Reich, M.; Pinkus, G.S.; Ray, T.S.; Koval, M.A.; Last, K.W.; Norton, A.; Lister, T.A.; Mesirov, J.; Neuberg, D.S.; Lander, E. S.; Aster, J.C. and Golub, T. R. (2002) Nat. Med., 8, 68-74.
29. Espinosa, I.; Briones, J.; Bordes, R.; Brunet, S.; Martino, R.; Sureda, A.; Prat, J. and Sierra, J. (2006) Ann. Hematol., 85, 597-603.
30. Robertson, M.J.; Kahl, B.S.; Vose, J.M.; Vos, S.D.; Laughlin, M.; Flynn, P.J.; Rowland, K.; Cruz, J.C.; Goldberg, S.L.; Musib, L.; Darstein C.; Enas, N.; Kutok, J.L.; Aster, J.C.; Neuberg, D.; Savage, K.J.; LaCasce, A.; Thornton, D.; Slapak, C.A. and Shipp, M.A. (2007) J. Clin. Oncol., 25, 1741-1746.
31. Ma, S and Rosen, S.T. (2007) Curr. Opin. Oncol., 19, 590-595.
32. Regala, R.P.; Weems, C.; Jamieson, L.; Khoor, A.; Edell, E.S.; Lohse, C.M. and Fields, A.P. (2005) Cancer Res., 65, 8905-8911.
33. Stallings-Mann, M.; Jamieson, L.; Regala, R.P.; Weems, C.; Murray, N.R. and Fields, A.P. (2006) Cancer Res., 66, 1767-1774.
34. Adolf, W.; Chanai, S. and Hecker, E. (1983) J. Sci. Soc Thailand., 9, 81-88.
35. Ogbourne, S.M.; Hampson, P.; Lord, J.M.; Parsons, P.; Witte, P.A. and Suhbier, A. (2007) Anticancer Drugs, 18, 357-362.
36. Kortmansky J. and Schwartz, G.K. (2003) Cancer Invest. 21, 924-936.
37. Kulkosky, J.; Culnan, D.M.; Roman, J.; Dornadula, G.; Schnell, M.; Boyd, M.R. and Pomerantz, R.J. (2001) Blood, 98, 3006-3015.
38. Hezareh M. (2005) Drug News Perspect., 18, 496-500.
39. Schaar, D.; Goodell, L.; Aisner, J.; Cui, X.X.; Han, Z.T.; Chang, R.; Martin, J.; Grospe, S.; Dudek, L.; Riley, J.; Manago, J.; Lin, Y.; Rubin, E.H.; Conney, A.; Strair, R.K. (2006) Cancer Chemother. Pharmacol., 57, 789-795.
40. Manning, G.; Whyte, D.B.; Martinez, R.; Hunter, T. and Sudarsanam, S. (2002) Science, 298, 1912-1934.
41. Sledge, G.W. Jr. and Gökmen-Polar, Y. (2006) Semin. Oncol., 33, S15-18.
42. Blumberg, P.M.; Delclos, K.B. and Jaken, S. (1983) in Organ and Species Specificity in Chemical Carcinogenesis, (Langenbach, R., Newnow, S., and Rice, J., Eds.), Plenum Press, New York, pp. 201-229.
43. Lorenzo, P.S.; Beheshti, M.; Pettit, G.R.; Stone, J.C. and Blumberg, P.M. (2000) Mol. Pharmacol., 57, 840-846.
44. Szallasi, Z.; Smith, C.B.; Pettit, G.R. and Blumberg, P.M. (1994) J. Biol. Chem., 269, 2118-2124.
45. Szallasi, Z.; Denning, M.F.; Smith, C.B.; Dlugosz, A.A.; Yuspa, S.H.; Pettit, G.R. and Blumberg, P.M. (1994) Mol. Pharmacol., 46, 840-850.
46. Fürstenberger, G. and Hecker, E. (1972) Planta Med., 22, 241-266.
47. Slaga, T.J.; Fischer, S.M.; Nelson, K. and Gleason, G.L. (1980) Proc. Natl. Acad. Sci. U.S.A., 77, 3659-3663.
48. Hennings, H.; Shores, R.; Mitchell, P.; Spangler, E.F. and Yuspa, S.H. (1985) Carcinogenesis, 6, 1607-1610.
49. Gustafson, K.R.; Cardellina, J.H. II; McMahon, J.B.; Gulakowski, R.J.; Ishitoya, J.; Szallasi, Z.; Lewin, N.E.; Blumberg, P.M.; Weislow, O.S.; Beutler, J.A.; Buckheit, R.W. Jr.; Cragg, G.M.; Cox, P.A.; Bader, J.P. and Boyd, M.R. (1992) J. Med. Chem., 35, 1978-1986.
50. Szallasi, Z. and Blumberg, P.M. (1991) Cancer Res., 51, 5355-5360.
51. Szallasi, Z.; Krausz, K. and Blumberg, P.M. (1992) Carcinogenesis, 13, 2161-2167.
52. Szallasi, Z.; Krsmanovic, L. and Blumberg, P.M. (1993) Cancer Res., 53, 2507-2512.
53. Perletti, G. and Terrian, D.M. (2006) Cur. Pharmaceut. Design, 12, 3117-3133.
54. Mischak, H.; Goodnight, J.A.; Kolch, W.; Martiny-Baron, G.; Schaechtle, C.; Kazanietz, M.G.; Blumberg, P.M.; Pierce, J.H. and Mushinski, J.F. (1993) J. Biol. Chem., 268, 6090-6096.
55. Verma, A.K.; Wheeler, D.L.; Aziz, M.H. and Manoharan, H. (2006) Mol. Carcinogen., 45, 381-388.
56. Yoshida, K. (2007) Cell. Signal., 19, 892-901.
57. Reyland, M.E. (2007) Biochem. Soc. Trans., 35, 1001-1004.
58. Brodie, C. and Blumberg, P.M. (2003) Apoptosis, 8, 19-27.
59. Reddig, P.J.; Dreckschmidt, N.E.; Ahrens, H.; Simsiman, R.; Tseng, C.P.; Zou, J.; Oberley, T.D. and Verma, A.K. (1999) Cancer Res., 59, 5710-5718.
60. Gökmen-Polar, Y.; Murray, N.R.; Velasco, M.A.; Gatalica, Z. and Fields, A.P. (2001) Cancer Res., 61, 1375-1381.
61. Leitges, M. (2007) Biochem. Soc. Trans., 35, 1018-1020.
62. Teixeira, C.; Stang, S.L.; Zheng, Y.; Beswick, N.S. and Stone, J.C. (2003) Blood, 102, 1414-1420.
63. Brodie, C.; Steinhart, R.; Kazimirsky, G.; Rubinfeld, H.; Hyman, T.; Ayres, J.A.; Hur, G.M.; Toth, A.; Yang, D.; Garfield, S.H.; Stone, J.C. and Blumberg, P.M. (2004) Mol. Pharmacol., 66, 76-84.
64. Aiba, Y.; Oh-hora, M.; Kiyonaka, S.; Kimura, Y.; Hijikata, A.; Mori, Y. and Kurosaki, T. (2004) Proc. Natl. Acad. Sci. U.S.A., 101, 16612-16617.
65. Zheng, Y.; Liu, H.; Coughlin, J.; Zheng, J.; Li, L. and Stone, J.C. (2005) Blood, 105, 3648-3654.
66. Stope, M.B.; vom Dorp, F.; Szatkowski, D.; Böhm, A.; Keiper, M.; Nolte, J.; Oude Weernick, P.A.; Rosskopf, D.; Evellin, S.; Jakobs, K.H. and Schmidt, M. (2004) Mol. Cell Biol., 24, 4664-4676.
67. Topham, M.K. and Prescott, S.M. (2001) J. Cell Biochem., 152, 1135-1143.
68. Luo, B.; Prescott, S.M. and Topham, M.K. (2003) J. Cell Biol., 160, 929-937.
69. Jones, D.R.; Sanjuan, M.A.; Stone, J.C. and Merida, I. (2002) FASEB J. 16, 595-597.
70. Regier, D.S.; Higbee, J.; Lund, K.M.; Sakane, F.; Prescott, S.M. and Topham, M.K. (2005) Proc. Natl. Acad. Sci. U.S.A., 102, 7595-7600.
71. Zayed, S.; Sorg, B. and Hecker, E. (1984) Planta Med., 50, 65-69.
72. Adolf, W. and Hecker, E. (1975) Z. Krebsforsch., 84, 325-344.
73. Braun, D.C.; Cao, Y.; Wang, S.; Garfield, S.; Hur, G.M. and Blumberg, P.M. (2005) Mol. Cancer Ther., 4, 141-150.
74. Murphy, T.V.; Prountzos, C.; Kotsonis, P.; Iannazzo, L. and Majewski, H. (1999) Eur. J. Pharmacol., 381, 77-84.
75. Oancea, E. and Meyer, T. (1998) Cell, 95, 307-318.
76. Martiny-Baron, G. and Fabbro, D., (2007) Pharmacol. Rev., 55, 477-486.
77. a Ohmori, S.; Shirai, Y.; Sakai, N.; Fujii, M.; Konishi, H.; Kikkawa, U. and Saito, N. (1998) Mol. Cell Biol., 18, 5263-5271.
78. Wang, Q.C.; Bhattacharyya, D.K.; Garfield, S.; Marquez, V.E. and Blumberg, P.M. (1999) J. Biol. Chem., 274, 37233-37239.
79. Wang, Q.J.; Fang, T.W.; Fenick, D.; Garfield, S.; Bienfait, B., Marquez, V.E. and Blumberg, P.M. (2000) J. Biol. Chem., 275, 12136-12146.
80. Gallegos, L.L.; Kunkel, M.T. and Newton, A.C. (2006) J. Biol. Chem., 281, 30947-30956.
81. Hasler, C.M.; Acs, G. and Blumberg, P.M. (1992) Cancer Res., 52, 202-208.
82. Yeh, E.; Sharkey, N.A. and Blumberg, P.M. (1987) Phytother. Res., 1, 135-139.
83. Zhang, G.; Kazanietz, M.G.; Blumberg, P.M. and Hurley, J.H. (1995) Cell, 81, 917-924.
84. Tamamura, H.; Sigano, D.M.; Lewin, N.E.; Blumberg, P.M. and Marquez, V.E. (2004) J. Med. Chem., 47, 644-655.
85. Kang, J.H.; Peach, M.L.; Pu, Y.; Lewin, N.E.; Nicklaus, M.C.; Blumberg, P.M. and Marquez, V.E. (2005) J. Med. Chem., 48, 5738-5748.
86. Bertolini, T.M.; Giorgione, J.; Harvey, D.F. and Newton, A.C. (2003) J. Org. Chem., 68, 5028-5036.
87. Yamatsugu, K.; Motoki, R.; Kanai, M. and Shbasaki, M. (2006) Chem. Asian J., 1, 314-321.
88. Stark, G.R. and Bartlett, P.A. (1983) Pharmacol. Ther., 23, 45-78.
89. Nowak, I. (2007) Curr. Top. Med. Chem., 7, 355-362.
90. Sridhar, J.; Wei, Z.L.; Nowak, I.; Lewin, N.E.; Ayres, J.A.; Pearce, L.V.; Blumberg, P.M. and Kozikowski, A.P. (2003) J. Med. Chem., 46, 4196-4204.
91. Giorgione, J.; Hysell, M.; Harvey, D.F. and Newton, A.C. (2003) Biochemistry, 42, 11194-11202.
92. Bittova, L.; Stahelin, R. and Cho, W. (2001) J. Biol. Chem. 276, 4218-4226.
93. Stahelin, R.V.; Digman, M.A.; Medkova, M.; Ananthanarayanan, B.; Rafter, J.D.; Melowic, H.R. and Cho, W. (2004) J. Biol. Chem. 279, 501-512.
94. Stahelin, R.V.; Digman, M.A.; Medkova, M.; Ananthanarayanan, B.; Melowic, H.R.; Rafter, J.D. and Cho, W. (2005) J. Biol. Chem., 280, 19784-19793.
95. Malolanarashimhan, K.; Kedei, N.; Sigano, D.M.; Kelley, J.A.; Lai, C.C.; Lewin, N.E.; Surawski, R.J.; Pavlyukovets, V.A.; Garfield, S.H.; Wincovitch, S.; Blumberg, P.M. and Marquez, V.E. (2007) J. Med. Chem., 50, 962-978, 2007.
96. Pak, Y.; Enyedy, I.; Varady, J.; Kung, J.W.; Lorenzo, P.S.; Blumberg, P.M. and Wang, S. (2001) J. Med. Chem., 44, 1690-1701.
97. Kimura, K.; Mizutani, M.Y.; Tomioka, N.; Endo, Y.; Shudo, K. and Itai, A. (1999) Chem. Pharm. Bull., 47, 1134-1137.
98. Marquez, V.E. and Blumberg, P.M. (2003) Acc. Chem. Res., 36, 434-443.
99. Sigano, D.M.; Peach, M.L.; Nacro, K.; Choi, Y.; Lewin, N.E.; Nicklaus, M.C.; Blumberg, P.M. and Marquez, V.E. (2003) J. Med. Chem., 46, 1571-1579.
100. Irie, K.; Masuda, A.; Shindo, M.; Nakagawa, Y. and Ohigashi, H. (2004) Bioorg. Med. Chem., 12, 4575-4583.
101. Pu, Y.; Perry, N.A.; Yang, D.; Lewin, N.E.; Kedei, N.; Braun, D.C.; Choi, S.H.; Blumberg, P.M.; Garfield, S.H.; Stone, J.C.; Duan, D. and Marquez, V.E. (2005) J. Biol. Chem., 280, 27329-27338.
102. Canagarajah, B.; Leskow, F.C.; Ho, J.Y.S.; Mischak, H.; Saidi, L.F.; Kazanietz, M.G. and Hurley, J.H. (2004) Cell, 119, 407-418.
103. Stahelin, R.V.; Wang, J.; Blatner, N.R.; Rafter, J.D.; Murray, D. ad Cho, W. (2006) J. Biol. Chem., 280, 36452-36463.
104. Tan, I.; Seow, K.T.; Lim, L. and Leung, T. (2001) Mol. Cell Biol. 21, 2767-2778.
105. Choi, S.H.; Czifra, G.; Kedei, N.; Lewin, N.E.; Lazar, J.; Pu, Y.; Marquez, V.E. and Blumberg, P.M. (2008) J. Biol. Chem., 283, 10543-10549.
106. Marquez, V.E.; Nacro, K.; Benzaria, S.; Lee, J.; Sharma, R.; Teng, K.; Milne, G.W.A.; Bienfait, B.; Wang, S.; Lewin, N.E. and Blumberg, P.M. (1999) Pharmacol. Ther., 82, 251-261.
107. Nacro, K.; Bienfait, B.; Lee, J.; Han, K.C.; Kang, J.H.; Benzaria, S.; Lewin, N.E.; Bhattacharyya, D.K.; Blumberg, P.M. and Marquez, V.E. (2000) J. Med. Chem., 43, 921-944.
108. Kang, J.H.; Siddiqui, M.A.; Sigano, D.M.; Krajewski, K.; Lewin, N.E.; Pu, Y.; Blumberg, P.M.; Lee, J. and Marquez, V.E. (2004) Org. Lett., 6, 2413-2416.
109. Choi, Y.; Pu, Y.; Peach, M.L.; Kang, J.H.; Lewin, N.E.; Sigano, D.M.; Garfield, S.H.; Blumberg, P.M. and Marquez, V.E. (2007) J. Med. Chem., 50, 3465-3481.
110. Duan, D.; Lewin, N.E.; Sigano, D.M.; Blumberg, P.M. and Marquez, V.E. (2004) J. Med. Chem., 47, 3248-3254.
111. Duan, D.; Sigano, D.M.; Kelley, J.A.; Lai, C.; Lewin, N.E.; Kedei, N.; Peach, M.L.; Lee, J.; Abeyweera, T.P.; Rotenberg, S.A.; Kim, H.; Kim, Y.H.; El-Kazzouli, S.; Chung, J.U.; Young, H.A.; Young, M.R.; Baker, A.; Colburn, N.H.; Haimovitz-Friedman, A.; Truman, J.P.; Parrish, D.A.; Deschamps, J.R.; Perry, N.A.; Surawski, R.J.; Blumberg, P.M. and Marquez, V.E. (2008) J. Med. Chem. submitted.
112. Irie, K.; Nakagawa, Y. and Ohigashi, H. (2004) Curr. Pharm. Des., 10, 1371-1385.
113. Irie, K.; Nakagawa, Y. and Ohigashi, H. (2005) Chem. Rec., 5, 185-195.
114. Nakagawa, Y.; Irie, K.; Yanagita, R.C.; Ohigashi, H.; Tsuda, K.I.; Kashiwagi, K. and Saito, N. (2006) J. Med. Chem., 49, 2681-2688.
115. Kozikowski, A.P.; Nowak, I.; Petukhov, P.A.; Etcheberrigaray, R.; Mohamed, A.; Tan, M.; Lewin, N.E.; Hennings, H.; Pearce, L.L. and Blumberg, P.M. (2003) J. Med. Chem., 46, 364-373.
116. Schechtman, D. and Mochly-Rosen, D. (2001) Oncogene, 20, 6339-6347.
117. Wang, H. and Kazanietz, M.G. (2002) J. Biol. Chem., 277, 4541-4550.
118. Yasuda, S.; Kai, M.; Imai, S.; Kanoh, H. and Sakane, F. (2008) Biochem. J., 409, 95-106.
119. Eisenberg, D.; Schwarz, E.; Komarony, M. and Wall, R. (1984) J. Mol. Biol., 179, 125-142.