Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands

Journal of Medicinal Chemistry

Volumn 47, Issue 12, 2004, Pages 3248-3254

  Duan, Dehui ^a   Lewin, Nancy E ^b   Sigano, Dina M ^a   Blumberg, Peter M ^b   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (HYDROXYMETHYL) 5 [(4 METHOXYPHENOXY)METHYL] 3,4,5 TRIHYDROFURAN 2 ONE; DIACYLGLYCEROL DERIVATIVE; LACTONE DERIVATIVE; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG; ZINC CHLORIDE;

ARTICLE; CATALYSIS; COMBINATORIAL CHEMISTRY; DRUG CONFORMATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

BINDING, COMPETITIVE; COMBINATORIAL CHEMISTRY TECHNIQUES; DIGLYCERIDES; ISOENZYMES; LACTONES; LIGANDS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2542540617     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030610k     Document Type: Article

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