Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes α and δ by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups

Journal of Medicinal Chemistry

Volumn 50, Issue 5, 2007, Pages 962-978

  Malolanarasimhan, Krishnan ^a,c   Kedei, Noemi ^b   Sigano, Dina M ^a   Kelley, James A ^a   Lai, Christopher C ^a   Lewin, Nancy E ^b   Surawski, Robert J ^b   Pavlyukovets, Vladimir A ^b   Garfield, Susan H ^b   Wincovitch, Stephen ^b   Blumberg, Peter M ^b   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; INTERLEUKIN 6; ISOENZYME; LACTONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE C DELTA;

ARTICLE; BINDING SITE; CELL ADHESION; CELL MEMBRANE; CELL PROLIFERATION; COMPARATIVE STUDY; CONFORMATION; CYTOKINE RELEASE; ENZYME BINDING; ENZYME KINETICS; ENZYME PHOSPHORYLATION; FILM; LIPOPHILICITY; MEMBRANE TRANSPORT; MOLECULAR STABILITY;

ANIMALS; BINDING SITES; CELL ADHESION; CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; CRICETINAE; CRICETULUS; DIGLYCERIDES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INTERLEUKIN-6; ISOENZYMES; KINETICS; LACTONES; LIGANDS; MOLECULAR CONFORMATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN TRANSPORT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33847771003     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061289j     Document Type: Article

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