메뉴 건너뛰기




Volumn 33, Issue SUPPL. 9, 2006, Pages 15-18

Protein Kinase C-β as a Therapeutic Target in Breast Cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBOPLATIN; CISPLATIN; ENZASTAURIN; GEMCITABINE; LY 379196; PACLITAXEL; PROTEIN KINASE C BETA; PROTEIN KINASE C INHIBITOR; RUBOXISTAURIN; UNCLASSIFIED DRUG;

EID: 33745200542     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2006.03.019     Document Type: Article
Times cited : (45)

References (43)
  • 2
    • 0035657643 scopus 로고    scopus 로고
    • Protein kinase C inhibitors as novel anticancer drugs
    • Goekjian P.G., and Jirousek M.R. Protein kinase C inhibitors as novel anticancer drugs. Expert Opin Invest Drugs 10 (2001) 2117-2140
    • (2001) Expert Opin Invest Drugs , vol.10 , pp. 2117-2140
    • Goekjian, P.G.1    Jirousek, M.R.2
  • 3
    • 1542619344 scopus 로고    scopus 로고
    • Protein kinase C isozymes as potential targets for anticancer therapy
    • Hofmann J. Protein kinase C isozymes as potential targets for anticancer therapy. Curr Cancer Drug Targets 4 (2004) 125-146
    • (2004) Curr Cancer Drug Targets , vol.4 , pp. 125-146
    • Hofmann, J.1
  • 4
    • 0023764824 scopus 로고
    • The molecular heterogeneity of protein kinase C and its implications for cellular regulation
    • Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334 (1988) 661-665
    • (1988) Nature , vol.334 , pp. 661-665
    • Nishizuka, Y.1
  • 5
    • 0027322679 scopus 로고
    • Protein kinase C isoenzymes. Divergence in signal transduction?
    • Hug H., and Sarre T.F. Protein kinase C isoenzymes. Divergence in signal transduction?. Biochem J 291 (1993) 329-343
    • (1993) Biochem J , vol.291 , pp. 329-343
    • Hug, H.1    Sarre, T.F.2
  • 6
    • 0026510349 scopus 로고
    • Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation
    • Hocevar B.A., Morrow D.M., Tykocinski M.L., et al. Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation. J Cell Sci 101 (1992) 671-679
    • (1992) J Cell Sci , vol.101 , pp. 671-679
    • Hocevar, B.A.1    Morrow, D.M.2    Tykocinski, M.L.3
  • 7
    • 0027180238 scopus 로고
    • Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that βII protein kinase C is required for proliferation
    • Murray N.R., Baumgardner G.P., Burns D.J., et al. Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that βII protein kinase C is required for proliferation. J Biol Chem 268 (1993) 15847-15853
    • (1993) J Biol Chem , vol.268 , pp. 15847-15853
    • Murray, N.R.1    Baumgardner, G.P.2    Burns, D.J.3
  • 8
    • 0023278635 scopus 로고
    • Expression and properties of two types of protein kinase C. Alternative splicing from a single gene
    • Ono Y., Kikkawa U., Ogita K., et al. Expression and properties of two types of protein kinase C. Alternative splicing from a single gene. Science 236 (1987) 1116-1120
    • (1987) Science , vol.236 , pp. 1116-1120
    • Ono, Y.1    Kikkawa, U.2    Ogita, K.3
  • 9
    • 0033577858 scopus 로고    scopus 로고
    • Overexpression of protein kinase C βII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis
    • Murray N.R., Davidson L.A., Chapkin R.S., et al. Overexpression of protein kinase C βII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. J Cell Biol 145 (1999) 699-711
    • (1999) J Cell Biol , vol.145 , pp. 699-711
    • Murray, N.R.1    Davidson, L.A.2    Chapkin, R.S.3
  • 10
    • 0035021863 scopus 로고    scopus 로고
    • Protein kinase C isozymes in colon carcinogenesis. Guilt by omission
    • Black J.D. Protein kinase C isozymes in colon carcinogenesis. Guilt by omission. Gastroenterology 120 (2001) 1868-1872
    • (2001) Gastroenterology , vol.120 , pp. 1868-1872
    • Black, J.D.1
  • 11
    • 0035866371 scopus 로고    scopus 로고
    • Elevated protein kinase C beta II is an early promotive event in colon carcinogenesis
    • Gökmen-Polar Y., Murray N.R., Velasco M.A., et al. Elevated protein kinase C beta II is an early promotive event in colon carcinogenesis. Cancer Res 61 (2001) 1375-1381
    • (2001) Cancer Res , vol.61 , pp. 1375-1381
    • Gökmen-Polar, Y.1    Murray, N.R.2    Velasco, M.A.3
  • 12
    • 2542506202 scopus 로고    scopus 로고
    • Protein kinase C (PKC) βII induces cell invasion through a Ras/Mek-, PKCiota/Rac 1-dependent signaling pathway
    • Zhang J., Anastasiadis P.Z., Liu Y., et al. Protein kinase C (PKC) βII induces cell invasion through a Ras/Mek-, PKCiota/Rac 1-dependent signaling pathway. J Biol Chem 279 (2004) 22118-22123
    • (2004) J Biol Chem , vol.279 , pp. 22118-22123
    • Zhang, J.1    Anastasiadis, P.Z.2    Liu, Y.3
  • 13
    • 0031938826 scopus 로고    scopus 로고
    • Down-regulation of protein kinase C alpha detected in human colorectal cancer
    • Suga K., Sugimoto I., Ito H., et al. Down-regulation of protein kinase C alpha detected in human colorectal cancer. Biochem Mol Biol Int 44 (1998) 523-528
    • (1998) Biochem Mol Biol Int , vol.44 , pp. 523-528
    • Suga, K.1    Sugimoto, I.2    Ito, H.3
  • 14
    • 0033866819 scopus 로고    scopus 로고
    • Morphodensitometric analysis of protein kinase C beta (II) expression in rat colon. Modulation by diet and relation to in situ cell proliferation and apoptosis
    • Davidson L.A., Brown R.E., Chang W.C., et al. Morphodensitometric analysis of protein kinase C beta (II) expression in rat colon. Modulation by diet and relation to in situ cell proliferation and apoptosis. Carcinogenesis 21 (2000) 1513-1519
    • (2000) Carcinogenesis , vol.21 , pp. 1513-1519
    • Davidson, L.A.1    Brown, R.E.2    Chang, W.C.3
  • 15
    • 0034655130 scopus 로고    scopus 로고
    • Adenoma-specific alterations of protein kinase C expression in Apc(MIN) mice
    • Klein I.K., Ritland S.R., Burgart L.J., et al. Adenoma-specific alterations of protein kinase C expression in Apc(MIN) mice. Cancer Res 60 (2000) 2077-2080
    • (2000) Cancer Res , vol.60 , pp. 2077-2080
    • Klein, I.K.1    Ritland, S.R.2    Burgart, L.J.3
  • 16
    • 18244409933 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
    • Shipp M.A., Ross K.N., Tamayo P., et al. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 8 (2002) 68-74
    • (2002) Nat Med , vol.8 , pp. 68-74
    • Shipp, M.A.1    Ross, K.N.2    Tamayo, P.3
  • 17
    • 0036177115 scopus 로고    scopus 로고
    • Targeting protein kinase C. New therapeutic opportunities against high-grade malignant gliomas?
    • da Rocha A.B., Mans D.R., Regner A., et al. Targeting protein kinase C. New therapeutic opportunities against high-grade malignant gliomas?. Oncologist 7 (2002) 17-33
    • (2002) Oncologist , vol.7 , pp. 17-33
    • da Rocha, A.B.1    Mans, D.R.2    Regner, A.3
  • 18
    • 0036344276 scopus 로고    scopus 로고
    • PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
    • Su T.T., Guo B., Kawakami Y., et al. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol 3 (2002) 780-786
    • (2002) Nat Immunol , vol.3 , pp. 780-786
    • Su, T.T.1    Guo, B.2    Kawakami, Y.3
  • 19
    • 0024323584 scopus 로고
    • Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue
    • O'Brian C.A., Vogel V.G., Singletary S.E., et al. Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Res 49 (1989) 3215-3217
    • (1989) Cancer Res , vol.49 , pp. 3215-3217
    • O'Brian, C.A.1    Vogel, V.G.2    Singletary, S.E.3
  • 20
    • 0000939974 scopus 로고    scopus 로고
    • Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue
    • Gordge P.C., Hulme M.J., Clegg R.A., et al. Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue. Eur J Cancer 32A (1996) 2120-2126
    • (1996) Eur J Cancer , vol.32 A , pp. 2120-2126
    • Gordge, P.C.1    Hulme, M.J.2    Clegg, R.A.3
  • 21
    • 0023526075 scopus 로고
    • 2+-dependent protein kinase of human mammary carcinoma cells. Inverse relationship to estrogen receptors
    • 2+-dependent protein kinase of human mammary carcinoma cells. Inverse relationship to estrogen receptors. Int J Cancer 40 (1987) 344-348
    • (1987) Int J Cancer , vol.40 , pp. 344-348
    • Borner, C.1    Wyss, R.2    Regazzi, R.3
  • 22
    • 0026688919 scopus 로고
    • Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells
    • Lee S.A., Karaszkiewicz J.W., and Anderson W.B. Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells. Cancer Res 52 (1992) 3750-3759
    • (1992) Cancer Res , vol.52 , pp. 3750-3759
    • Lee, S.A.1    Karaszkiewicz, J.W.2    Anderson, W.B.3
  • 23
    • 0033581954 scopus 로고    scopus 로고
    • Increased protein kinase Cδ in mammary tumor cells. relationship to transformation and metastasic progression
    • Kiley S.C., Clark K.J., Duddy S.K., et al. Increased protein kinase Cδ in mammary tumor cells. relationship to transformation and metastasic progression. Oncogene 18 (1999) 6748-6757
    • (1999) Oncogene , vol.18 , pp. 6748-6757
    • Kiley, S.C.1    Clark, K.J.2    Duddy, S.K.3
  • 24
    • 0033168515 scopus 로고    scopus 로고
    • Protein Kinase Cδ involvement in mammary tumor cell metastasis
    • Kiley S.C., Clark K.J., Goodnough M., et al. Protein Kinase Cδ involvement in mammary tumor cell metastasis. Cancer Res 59 (1999) 3230-3238
    • (1999) Cancer Res , vol.59 , pp. 3230-3238
    • Kiley, S.C.1    Clark, K.J.2    Goodnough, M.3
  • 25
    • 5644271449 scopus 로고    scopus 로고
    • Protein kinase C alpha expression in breast and ovarian cancer
    • Lahn M., Köhler G., Sundell K., et al. Protein kinase C alpha expression in breast and ovarian cancer. Oncology 67 (2004) 1-10
    • (2004) Oncology , vol.67 , pp. 1-10
    • Lahn, M.1    Köhler, G.2    Sundell, K.3
  • 26
    • 0028903545 scopus 로고
    • MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype
    • Ways D.K., Kukoly C.A., deVente J., et al. MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J Clin Invest 95 (1995) 1906-1915
    • (1995) J Clin Invest , vol.95 , pp. 1906-1915
    • Ways, D.K.1    Kukoly, C.A.2    deVente, J.3
  • 27
    • 0031812220 scopus 로고    scopus 로고
    • Protein kinase C and its isoforms in human breast cancer cells. Relationship to the invasive phenotype
    • Morse-Gaudio M., Connolly J.M., and Rose D.P. Protein kinase C and its isoforms in human breast cancer cells. Relationship to the invasive phenotype. Int J Oncol 12 (1998) 1349-1354
    • (1998) Int J Oncol , vol.12 , pp. 1349-1354
    • Morse-Gaudio, M.1    Connolly, J.M.2    Rose, D.P.3
  • 28
    • 0029851475 scopus 로고    scopus 로고
    • Induction of a less aggressive breast cancer phenotype by protein kinase C-α and β-overexpression
    • Manni A., Buckwalter E., Etindi R., et al. Induction of a less aggressive breast cancer phenotype by protein kinase C-α and β-overexpression. Cell Growth Differ 7 (1996) 1187-1198
    • (1996) Cell Growth Differ , vol.7 , pp. 1187-1198
    • Manni, A.1    Buckwalter, E.2    Etindi, R.3
  • 29
    • 18844427567 scopus 로고    scopus 로고
    • Upregulation of PKCδ contributes to antiestrogen resistance in mammary tumor cells
    • Nabha S.M., Glaros S., Hong M., et al. Upregulation of PKCδ contributes to antiestrogen resistance in mammary tumor cells. Oncogene 24 (2005) 3166-3176
    • (2005) Oncogene , vol.24 , pp. 3166-3176
    • Nabha, S.M.1    Glaros, S.2    Hong, M.3
  • 30
    • 0029060644 scopus 로고
    • Regulation of alternative splicing of protein kinase C beta by insulin
    • Chalfant C.E., Mishak H., Watson J.E., et al. Regulation of alternative splicing of protein kinase C beta by insulin. J Biol Chem 270 (1995) 13326-13332
    • (1995) J Biol Chem , vol.270 , pp. 13326-13332
    • Chalfant, C.E.1    Mishak, H.2    Watson, J.E.3
  • 31
    • 2642709170 scopus 로고    scopus 로고
    • Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
    • Xia P., Aiello L.P., Ishii H., et al. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 98 (1996) 2018-2026
    • (1996) J Clin Invest , vol.98 , pp. 2018-2026
    • Xia, P.1    Aiello, L.P.2    Ishii, H.3
  • 32
    • 0033118228 scopus 로고    scopus 로고
    • VEGF activates protein kinase C-dependent, but Ras independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
    • Takahashi T., Ueno H., and Shibuya M. VEGF activates protein kinase C-dependent, but Ras independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18 (1999) 2221-2230
    • (1999) Oncogene , vol.18 , pp. 2221-2230
    • Takahashi, T.1    Ueno, H.2    Shibuya, M.3
  • 33
    • 0348049834 scopus 로고    scopus 로고
    • VEGF signaling. integration and multi-tasking in endothelial cell biology
    • Zachary I. VEGF signaling. integration and multi-tasking in endothelial cell biology. Biochem Soc Trans 6 (2003) 1171-1177
    • (2003) Biochem Soc Trans , vol.6 , pp. 1171-1177
    • Zachary, I.1
  • 34
    • 0033199874 scopus 로고    scopus 로고
    • Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis
    • Yoshiji H., Kuriyama S., Ways D.K., et al. Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis. Cancer Res 59 (1999) 4413-4418
    • (1999) Cancer Res , vol.59 , pp. 4413-4418
    • Yoshiji, H.1    Kuriyama, S.2    Ways, D.K.3
  • 36
    • 23844521568 scopus 로고    scopus 로고
    • The protein kinase cb-selective inhibitor, enzastaurin (LY317615.HCL), supressess signaling through the Akt pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
    • Graff J.R., McNulty A.M., Hanna K.R., et al. The protein kinase cb-selective inhibitor, enzastaurin (LY317615.HCL), supressess signaling through the Akt pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 65 (2005) 7462-7469
    • (2005) Cancer Res , vol.65 , pp. 7462-7469
    • Graff, J.R.1    McNulty, A.M.2    Hanna, K.R.3
  • 37
    • 0036137647 scopus 로고    scopus 로고
    • Antiangiogenic effects of a protein kinase Cβ-selective small molecule
    • Teicher B.A., Alvarez E., Menon K., et al. Antiangiogenic effects of a protein kinase Cβ-selective small molecule. Cancer Chemother Pharmacol 49 (2002) 69-77
    • (2002) Cancer Chemother Pharmacol , vol.49 , pp. 69-77
    • Teicher, B.A.1    Alvarez, E.2    Menon, K.3
  • 38
    • 0442329299 scopus 로고    scopus 로고
    • LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice
    • Keyes K.A., Mann L., Sherman M., et al. LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice. Cancer Chemother Pharmacol 53 (2004) 133-140
    • (2004) Cancer Chemother Pharmacol , vol.53 , pp. 133-140
    • Keyes, K.A.1    Mann, L.2    Sherman, M.3
  • 39
    • 0036021216 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human breast cancer and ovarian cancer xenografts
    • Teicher B.A., Menon K., Alvarez E., et al. Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human breast cancer and ovarian cancer xenografts. Invest New Drugs 20 (2002) 241-251
    • (2002) Invest New Drugs , vol.20 , pp. 241-251
    • Teicher, B.A.1    Menon, K.2    Alvarez, E.3
  • 40
    • 4243406643 scopus 로고    scopus 로고
    • Phase 1 study of LY317615, a protein kinase Cb inhibitor
    • abstr
    • Herbst R.S., Thornton D.E., Kies M.S., et al. Phase 1 study of LY317615, a protein kinase Cb inhibitor. Proc Am Soc Clin Oncol 21 (2002) 326 abstr
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 326
    • Herbst, R.S.1    Thornton, D.E.2    Kies, M.S.3
  • 41
    • 33745189743 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of enzastaurin HCl, gemcitabine and cisplatin
    • abstr
    • Rademaker-Lakhai J.M. Phase I and pharmacologic study of enzastaurin HCl, gemcitabine and cisplatin. Proc Am Soc Clin Oncol 24 (2004) 3129 abstr
    • (2004) Proc Am Soc Clin Oncol , vol.24 , pp. 3129
    • Rademaker-Lakhai, J.M.1
  • 42
    • 33646555670 scopus 로고    scopus 로고
    • Results from phase II trial of enzastaurin (LY317615) in patients with recurrent high grade gliomas
    • abstr
    • Fine H.A., Royce K.M., Draper D., et al. Results from phase II trial of enzastaurin (LY317615) in patients with recurrent high grade gliomas. Proc Am Soc Clin Oncol 23 (2005) 1504 abstr
    • (2005) Proc Am Soc Clin Oncol , vol.23 , pp. 1504
    • Fine, H.A.1    Royce, K.M.2    Draper, D.3
  • 43
    • 33646563634 scopus 로고    scopus 로고
    • A phase II study of enzastaurin, a protein kinase C-β (PKCβ) inhibitor, in the treatment of relapsed diffuse large B-cell lymphoma (DLBCL)
    • abstr
    • Robertson M., Kahl B., Vose J., et al. A phase II study of enzastaurin, a protein kinase C-β (PKCβ) inhibitor, in the treatment of relapsed diffuse large B-cell lymphoma (DLBCL). Blood 106 (2005) 934 abstr
    • (2005) Blood , vol.106 , pp. 934
    • Robertson, M.1    Kahl, B.2    Vose, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.