-
1
-
-
1542270493
-
Protein kinase C in disease
-
Newton A.C. (Ed), Humana Press Inc, Totowa, NJ
-
Fields A.P., and Gustafson W.C. Protein kinase C in disease. In: Newton A.C. (Ed). Methods in Molecular Biology, vol 233. Protein kinase C protocols (2003), Humana Press Inc, Totowa, NJ 519-537
-
(2003)
Methods in Molecular Biology, vol 233. Protein kinase C protocols
, pp. 519-537
-
-
Fields, A.P.1
Gustafson, W.C.2
-
2
-
-
0035657643
-
Protein kinase C inhibitors as novel anticancer drugs
-
Goekjian P.G., and Jirousek M.R. Protein kinase C inhibitors as novel anticancer drugs. Expert Opin Invest Drugs 10 (2001) 2117-2140
-
(2001)
Expert Opin Invest Drugs
, vol.10
, pp. 2117-2140
-
-
Goekjian, P.G.1
Jirousek, M.R.2
-
3
-
-
1542619344
-
Protein kinase C isozymes as potential targets for anticancer therapy
-
Hofmann J. Protein kinase C isozymes as potential targets for anticancer therapy. Curr Cancer Drug Targets 4 (2004) 125-146
-
(2004)
Curr Cancer Drug Targets
, vol.4
, pp. 125-146
-
-
Hofmann, J.1
-
4
-
-
0023764824
-
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
-
Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334 (1988) 661-665
-
(1988)
Nature
, vol.334
, pp. 661-665
-
-
Nishizuka, Y.1
-
5
-
-
0027322679
-
Protein kinase C isoenzymes. Divergence in signal transduction?
-
Hug H., and Sarre T.F. Protein kinase C isoenzymes. Divergence in signal transduction?. Biochem J 291 (1993) 329-343
-
(1993)
Biochem J
, vol.291
, pp. 329-343
-
-
Hug, H.1
Sarre, T.F.2
-
6
-
-
0026510349
-
Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation
-
Hocevar B.A., Morrow D.M., Tykocinski M.L., et al. Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation. J Cell Sci 101 (1992) 671-679
-
(1992)
J Cell Sci
, vol.101
, pp. 671-679
-
-
Hocevar, B.A.1
Morrow, D.M.2
Tykocinski, M.L.3
-
7
-
-
0027180238
-
Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that βII protein kinase C is required for proliferation
-
Murray N.R., Baumgardner G.P., Burns D.J., et al. Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that βII protein kinase C is required for proliferation. J Biol Chem 268 (1993) 15847-15853
-
(1993)
J Biol Chem
, vol.268
, pp. 15847-15853
-
-
Murray, N.R.1
Baumgardner, G.P.2
Burns, D.J.3
-
8
-
-
0023278635
-
Expression and properties of two types of protein kinase C. Alternative splicing from a single gene
-
Ono Y., Kikkawa U., Ogita K., et al. Expression and properties of two types of protein kinase C. Alternative splicing from a single gene. Science 236 (1987) 1116-1120
-
(1987)
Science
, vol.236
, pp. 1116-1120
-
-
Ono, Y.1
Kikkawa, U.2
Ogita, K.3
-
9
-
-
0033577858
-
Overexpression of protein kinase C βII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis
-
Murray N.R., Davidson L.A., Chapkin R.S., et al. Overexpression of protein kinase C βII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. J Cell Biol 145 (1999) 699-711
-
(1999)
J Cell Biol
, vol.145
, pp. 699-711
-
-
Murray, N.R.1
Davidson, L.A.2
Chapkin, R.S.3
-
10
-
-
0035021863
-
Protein kinase C isozymes in colon carcinogenesis. Guilt by omission
-
Black J.D. Protein kinase C isozymes in colon carcinogenesis. Guilt by omission. Gastroenterology 120 (2001) 1868-1872
-
(2001)
Gastroenterology
, vol.120
, pp. 1868-1872
-
-
Black, J.D.1
-
11
-
-
0035866371
-
Elevated protein kinase C beta II is an early promotive event in colon carcinogenesis
-
Gökmen-Polar Y., Murray N.R., Velasco M.A., et al. Elevated protein kinase C beta II is an early promotive event in colon carcinogenesis. Cancer Res 61 (2001) 1375-1381
-
(2001)
Cancer Res
, vol.61
, pp. 1375-1381
-
-
Gökmen-Polar, Y.1
Murray, N.R.2
Velasco, M.A.3
-
12
-
-
2542506202
-
Protein kinase C (PKC) βII induces cell invasion through a Ras/Mek-, PKCiota/Rac 1-dependent signaling pathway
-
Zhang J., Anastasiadis P.Z., Liu Y., et al. Protein kinase C (PKC) βII induces cell invasion through a Ras/Mek-, PKCiota/Rac 1-dependent signaling pathway. J Biol Chem 279 (2004) 22118-22123
-
(2004)
J Biol Chem
, vol.279
, pp. 22118-22123
-
-
Zhang, J.1
Anastasiadis, P.Z.2
Liu, Y.3
-
13
-
-
0031938826
-
Down-regulation of protein kinase C alpha detected in human colorectal cancer
-
Suga K., Sugimoto I., Ito H., et al. Down-regulation of protein kinase C alpha detected in human colorectal cancer. Biochem Mol Biol Int 44 (1998) 523-528
-
(1998)
Biochem Mol Biol Int
, vol.44
, pp. 523-528
-
-
Suga, K.1
Sugimoto, I.2
Ito, H.3
-
14
-
-
0033866819
-
Morphodensitometric analysis of protein kinase C beta (II) expression in rat colon. Modulation by diet and relation to in situ cell proliferation and apoptosis
-
Davidson L.A., Brown R.E., Chang W.C., et al. Morphodensitometric analysis of protein kinase C beta (II) expression in rat colon. Modulation by diet and relation to in situ cell proliferation and apoptosis. Carcinogenesis 21 (2000) 1513-1519
-
(2000)
Carcinogenesis
, vol.21
, pp. 1513-1519
-
-
Davidson, L.A.1
Brown, R.E.2
Chang, W.C.3
-
15
-
-
0034655130
-
Adenoma-specific alterations of protein kinase C expression in Apc(MIN) mice
-
Klein I.K., Ritland S.R., Burgart L.J., et al. Adenoma-specific alterations of protein kinase C expression in Apc(MIN) mice. Cancer Res 60 (2000) 2077-2080
-
(2000)
Cancer Res
, vol.60
, pp. 2077-2080
-
-
Klein, I.K.1
Ritland, S.R.2
Burgart, L.J.3
-
16
-
-
18244409933
-
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
-
Shipp M.A., Ross K.N., Tamayo P., et al. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 8 (2002) 68-74
-
(2002)
Nat Med
, vol.8
, pp. 68-74
-
-
Shipp, M.A.1
Ross, K.N.2
Tamayo, P.3
-
17
-
-
0036177115
-
Targeting protein kinase C. New therapeutic opportunities against high-grade malignant gliomas?
-
da Rocha A.B., Mans D.R., Regner A., et al. Targeting protein kinase C. New therapeutic opportunities against high-grade malignant gliomas?. Oncologist 7 (2002) 17-33
-
(2002)
Oncologist
, vol.7
, pp. 17-33
-
-
da Rocha, A.B.1
Mans, D.R.2
Regner, A.3
-
18
-
-
0036344276
-
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
-
Su T.T., Guo B., Kawakami Y., et al. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol 3 (2002) 780-786
-
(2002)
Nat Immunol
, vol.3
, pp. 780-786
-
-
Su, T.T.1
Guo, B.2
Kawakami, Y.3
-
19
-
-
0024323584
-
Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue
-
O'Brian C.A., Vogel V.G., Singletary S.E., et al. Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Res 49 (1989) 3215-3217
-
(1989)
Cancer Res
, vol.49
, pp. 3215-3217
-
-
O'Brian, C.A.1
Vogel, V.G.2
Singletary, S.E.3
-
20
-
-
0000939974
-
Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue
-
Gordge P.C., Hulme M.J., Clegg R.A., et al. Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue. Eur J Cancer 32A (1996) 2120-2126
-
(1996)
Eur J Cancer
, vol.32 A
, pp. 2120-2126
-
-
Gordge, P.C.1
Hulme, M.J.2
Clegg, R.A.3
-
21
-
-
0023526075
-
2+-dependent protein kinase of human mammary carcinoma cells. Inverse relationship to estrogen receptors
-
2+-dependent protein kinase of human mammary carcinoma cells. Inverse relationship to estrogen receptors. Int J Cancer 40 (1987) 344-348
-
(1987)
Int J Cancer
, vol.40
, pp. 344-348
-
-
Borner, C.1
Wyss, R.2
Regazzi, R.3
-
22
-
-
0026688919
-
Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells
-
Lee S.A., Karaszkiewicz J.W., and Anderson W.B. Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells. Cancer Res 52 (1992) 3750-3759
-
(1992)
Cancer Res
, vol.52
, pp. 3750-3759
-
-
Lee, S.A.1
Karaszkiewicz, J.W.2
Anderson, W.B.3
-
23
-
-
0033581954
-
Increased protein kinase Cδ in mammary tumor cells. relationship to transformation and metastasic progression
-
Kiley S.C., Clark K.J., Duddy S.K., et al. Increased protein kinase Cδ in mammary tumor cells. relationship to transformation and metastasic progression. Oncogene 18 (1999) 6748-6757
-
(1999)
Oncogene
, vol.18
, pp. 6748-6757
-
-
Kiley, S.C.1
Clark, K.J.2
Duddy, S.K.3
-
24
-
-
0033168515
-
Protein Kinase Cδ involvement in mammary tumor cell metastasis
-
Kiley S.C., Clark K.J., Goodnough M., et al. Protein Kinase Cδ involvement in mammary tumor cell metastasis. Cancer Res 59 (1999) 3230-3238
-
(1999)
Cancer Res
, vol.59
, pp. 3230-3238
-
-
Kiley, S.C.1
Clark, K.J.2
Goodnough, M.3
-
25
-
-
5644271449
-
Protein kinase C alpha expression in breast and ovarian cancer
-
Lahn M., Köhler G., Sundell K., et al. Protein kinase C alpha expression in breast and ovarian cancer. Oncology 67 (2004) 1-10
-
(2004)
Oncology
, vol.67
, pp. 1-10
-
-
Lahn, M.1
Köhler, G.2
Sundell, K.3
-
26
-
-
0028903545
-
MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype
-
Ways D.K., Kukoly C.A., deVente J., et al. MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J Clin Invest 95 (1995) 1906-1915
-
(1995)
J Clin Invest
, vol.95
, pp. 1906-1915
-
-
Ways, D.K.1
Kukoly, C.A.2
deVente, J.3
-
27
-
-
0031812220
-
Protein kinase C and its isoforms in human breast cancer cells. Relationship to the invasive phenotype
-
Morse-Gaudio M., Connolly J.M., and Rose D.P. Protein kinase C and its isoforms in human breast cancer cells. Relationship to the invasive phenotype. Int J Oncol 12 (1998) 1349-1354
-
(1998)
Int J Oncol
, vol.12
, pp. 1349-1354
-
-
Morse-Gaudio, M.1
Connolly, J.M.2
Rose, D.P.3
-
28
-
-
0029851475
-
Induction of a less aggressive breast cancer phenotype by protein kinase C-α and β-overexpression
-
Manni A., Buckwalter E., Etindi R., et al. Induction of a less aggressive breast cancer phenotype by protein kinase C-α and β-overexpression. Cell Growth Differ 7 (1996) 1187-1198
-
(1996)
Cell Growth Differ
, vol.7
, pp. 1187-1198
-
-
Manni, A.1
Buckwalter, E.2
Etindi, R.3
-
29
-
-
18844427567
-
Upregulation of PKCδ contributes to antiestrogen resistance in mammary tumor cells
-
Nabha S.M., Glaros S., Hong M., et al. Upregulation of PKCδ contributes to antiestrogen resistance in mammary tumor cells. Oncogene 24 (2005) 3166-3176
-
(2005)
Oncogene
, vol.24
, pp. 3166-3176
-
-
Nabha, S.M.1
Glaros, S.2
Hong, M.3
-
30
-
-
0029060644
-
Regulation of alternative splicing of protein kinase C beta by insulin
-
Chalfant C.E., Mishak H., Watson J.E., et al. Regulation of alternative splicing of protein kinase C beta by insulin. J Biol Chem 270 (1995) 13326-13332
-
(1995)
J Biol Chem
, vol.270
, pp. 13326-13332
-
-
Chalfant, C.E.1
Mishak, H.2
Watson, J.E.3
-
31
-
-
2642709170
-
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
-
Xia P., Aiello L.P., Ishii H., et al. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 98 (1996) 2018-2026
-
(1996)
J Clin Invest
, vol.98
, pp. 2018-2026
-
-
Xia, P.1
Aiello, L.P.2
Ishii, H.3
-
32
-
-
0033118228
-
VEGF activates protein kinase C-dependent, but Ras independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
-
Takahashi T., Ueno H., and Shibuya M. VEGF activates protein kinase C-dependent, but Ras independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18 (1999) 2221-2230
-
(1999)
Oncogene
, vol.18
, pp. 2221-2230
-
-
Takahashi, T.1
Ueno, H.2
Shibuya, M.3
-
33
-
-
0348049834
-
VEGF signaling. integration and multi-tasking in endothelial cell biology
-
Zachary I. VEGF signaling. integration and multi-tasking in endothelial cell biology. Biochem Soc Trans 6 (2003) 1171-1177
-
(2003)
Biochem Soc Trans
, vol.6
, pp. 1171-1177
-
-
Zachary, I.1
-
34
-
-
0033199874
-
Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis
-
Yoshiji H., Kuriyama S., Ways D.K., et al. Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis. Cancer Res 59 (1999) 4413-4418
-
(1999)
Cancer Res
, vol.59
, pp. 4413-4418
-
-
Yoshiji, H.1
Kuriyama, S.2
Ways, D.K.3
-
35
-
-
33745221352
-
-
Presented at the 41st Annual Meeting of the American Society of Clinical Oncology, Orlando, FL May 13-17
-
Miller K.D., Wang M., Gralow J.D., et al. E2100. A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer (2004), Presented at the 41st Annual Meeting of the American Society of Clinical Oncology, Orlando, FL May 13-17
-
(2004)
E2100. A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer
-
-
Miller, K.D.1
Wang, M.2
Gralow, J.D.3
-
36
-
-
23844521568
-
The protein kinase cb-selective inhibitor, enzastaurin (LY317615.HCL), supressess signaling through the Akt pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
-
Graff J.R., McNulty A.M., Hanna K.R., et al. The protein kinase cb-selective inhibitor, enzastaurin (LY317615.HCL), supressess signaling through the Akt pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 65 (2005) 7462-7469
-
(2005)
Cancer Res
, vol.65
, pp. 7462-7469
-
-
Graff, J.R.1
McNulty, A.M.2
Hanna, K.R.3
-
37
-
-
0036137647
-
Antiangiogenic effects of a protein kinase Cβ-selective small molecule
-
Teicher B.A., Alvarez E., Menon K., et al. Antiangiogenic effects of a protein kinase Cβ-selective small molecule. Cancer Chemother Pharmacol 49 (2002) 69-77
-
(2002)
Cancer Chemother Pharmacol
, vol.49
, pp. 69-77
-
-
Teicher, B.A.1
Alvarez, E.2
Menon, K.3
-
38
-
-
0442329299
-
LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice
-
Keyes K.A., Mann L., Sherman M., et al. LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice. Cancer Chemother Pharmacol 53 (2004) 133-140
-
(2004)
Cancer Chemother Pharmacol
, vol.53
, pp. 133-140
-
-
Keyes, K.A.1
Mann, L.2
Sherman, M.3
-
39
-
-
0036021216
-
Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human breast cancer and ovarian cancer xenografts
-
Teicher B.A., Menon K., Alvarez E., et al. Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human breast cancer and ovarian cancer xenografts. Invest New Drugs 20 (2002) 241-251
-
(2002)
Invest New Drugs
, vol.20
, pp. 241-251
-
-
Teicher, B.A.1
Menon, K.2
Alvarez, E.3
-
40
-
-
4243406643
-
Phase 1 study of LY317615, a protein kinase Cb inhibitor
-
abstr
-
Herbst R.S., Thornton D.E., Kies M.S., et al. Phase 1 study of LY317615, a protein kinase Cb inhibitor. Proc Am Soc Clin Oncol 21 (2002) 326 abstr
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 326
-
-
Herbst, R.S.1
Thornton, D.E.2
Kies, M.S.3
-
41
-
-
33745189743
-
Phase I and pharmacologic study of enzastaurin HCl, gemcitabine and cisplatin
-
abstr
-
Rademaker-Lakhai J.M. Phase I and pharmacologic study of enzastaurin HCl, gemcitabine and cisplatin. Proc Am Soc Clin Oncol 24 (2004) 3129 abstr
-
(2004)
Proc Am Soc Clin Oncol
, vol.24
, pp. 3129
-
-
Rademaker-Lakhai, J.M.1
-
42
-
-
33646555670
-
Results from phase II trial of enzastaurin (LY317615) in patients with recurrent high grade gliomas
-
abstr
-
Fine H.A., Royce K.M., Draper D., et al. Results from phase II trial of enzastaurin (LY317615) in patients with recurrent high grade gliomas. Proc Am Soc Clin Oncol 23 (2005) 1504 abstr
-
(2005)
Proc Am Soc Clin Oncol
, vol.23
, pp. 1504
-
-
Fine, H.A.1
Royce, K.M.2
Draper, D.3
-
43
-
-
33646563634
-
A phase II study of enzastaurin, a protein kinase C-β (PKCβ) inhibitor, in the treatment of relapsed diffuse large B-cell lymphoma (DLBCL)
-
abstr
-
Robertson M., Kahl B., Vose J., et al. A phase II study of enzastaurin, a protein kinase C-β (PKCβ) inhibitor, in the treatment of relapsed diffuse large B-cell lymphoma (DLBCL). Blood 106 (2005) 934 abstr
-
(2005)
Blood
, vol.106
, pp. 934
-
-
Robertson, M.1
Kahl, B.2
Vose, J.3
|