-
1
-
-
0018760747
-
Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin
-
Van Duuren BL, Tseng SS, Segal A, Smith AC, Melchionne S, Seidman I: Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin. Cancer Res (1979) 39(7 Pt 1):2644-2646.
-
(1979)
Cancer Res.
, vol.39
, Issue.7 PART 1
, pp. 2644-2646
-
-
Van Duuren, B.L.1
Tseng, S.S.2
Segal, A.3
Smith, A.C.4
Melchionne, S.5
Seidman, I.6
-
2
-
-
0024412493
-
The protein kinase C family: Heterogeneity and its implications
-
Kikkawa U, Kishimoto A, Nishizuka Y: The protein kinase C family: Heterogeneity and its implications. Annu Rev Biochem (1989) 58:31-44.
-
(1989)
Annu. Rev. Biochem.
, vol.58
, pp. 31-44
-
-
Kikkawa, U.1
Kishimoto, A.2
Nishizuka, Y.3
-
3
-
-
0028811653
-
Protein kinase C: Structure, function and regulation
-
Newton AC: Protein kinase C: Structure, function and regulation. J Biol Chem (1995) 270(48):28495-28498.
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.48
, pp. 28495-28498
-
-
Newton, A.C.1
-
4
-
-
0023764824
-
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
-
(6184)
-
Nishizuka Y: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (1988) 334(6184):661-665.
-
(1988)
Nature
, vol.334
, pp. 661-665
-
-
Nishizuka, Y.1
-
5
-
-
0037303088
-
Discovery and prospect of protein kinase C research: Epilogue
-
Nishizuka Y: Discovery and prospect of protein kinase C research: Epilogue. J Biochem (2003) 133(2):155-158.
-
(2003)
J. Biochem.
, vol.133
, Issue.2
, pp. 155-158
-
-
Nishizuka, Y.1
-
6
-
-
0034903846
-
Toward the identification of selective modulators of protein kinase C (PKC) isozymes: Establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding
-
Shindo M, Irie K, Nakahara A, Ohigashi H, Konishi H, Kikkawa U, Fukuda H, Wender PA: Toward the identification of selective modulators of protein kinase C (PKC) isozymes: Establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding. Bioorg Med Chem (2001) 9(8):2073-2081.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, Issue.8
, pp. 2073-2081
-
-
Shindo, M.1
Irie, K.2
Nakahara, A.3
Ohigashi, H.4
Konishi, H.5
Kikkawa, U.6
Fukuda, H.7
Wender, P.A.8
-
7
-
-
0034665675
-
MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells
-
Kawashima T, Hirose K, Satoh T, Kaneko A, Ikeda Y, Kaziro Y, Nosaka T, Kitamura T: MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood (2000) 96(6):2116-2124.
-
(2000)
Blood
, vol.96
, Issue.6
, pp. 2116-2124
-
-
Kawashima, T.1
Hirose, K.2
Satoh, T.3
Kaneko, A.4
Ikeda, Y.5
Kaziro, Y.6
Nosaka, T.7
Kitamura, T.8
-
8
-
-
0036209077
-
Novel 'nonkinase' phorbol ester receptors: The C1 domain connection
-
Kazanietz MG: Novel 'nonkinase' phorbol ester receptors: The C1 domain connection. Mol Pharmacol (2002) 61(4):759-767.
-
(2002)
Mol. Pharmacol.
, vol.61
, Issue.4
, pp. 759-767
-
-
Kazanietz, M.G.1
-
9
-
-
0036905264
-
Move over protein kinase C, you've got company: Alternative cellular effectors of diacylglycerol and phorbol esters
-
Brose N, Rosenmund C: Move over protein kinase C, you've got company: Alternative cellular effectors of diacylglycerol and phorbol esters. J Cell Sci (2002) 115(23):4399-4411.
-
(2002)
J. Cell Sci.
, vol.115
, Issue.23
, pp. 4399-4411
-
-
Brose, N.1
Rosenmund, C.2
-
10
-
-
0038754049
-
Phorboll esters and neurotransmitter release: More than just protein kinase C?
-
Silinsky EM, Searl TJ: Phorboll esters and neurotransmitter release: More than just protein kinase C? Br J Pharmacol (2003) 138(7):1191-1201.
-
(2003)
Br. J. Pharmacol.
, vol.138
, Issue.7
, pp. 1191-1201
-
-
Silinsky, E.M.1
Searl, T.J.2
-
11
-
-
1842394775
-
Competitive inhibition by diacylglycerol of specific phorbol ester binding
-
Sharkey NA, Leach KL, Blumberg PM: Competitive inhibition by diacylglycerol of specific phorbol ester binding. Proc Natl Acad Sci USA (1984) 81(2):607-610.
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.81
, Issue.2
, pp. 607-610
-
-
Sharkey, N.A.1
Leach, K.L.2
Blumberg, P.M.3
-
12
-
-
0022332395
-
Kinetic evidence that 1,2-diolein inhibits phorbol ester binding to protein kinase C via a competitive mechanism
-
Sharkey NA, Blumberg PM: Kinetic evidence that 1,2-diolein inhibits phorbol ester binding to protein kinase C via a competitive mechanism. Biochem Biophys Res Commun (1985) 133(3):1051-1056.
-
(1985)
Biochem. Biophys. Res. Commun.
, vol.133
, Issue.3
, pp. 1051-1056
-
-
Sharkey, N.A.1
Blumberg, P.M.2
-
13
-
-
0029670030
-
Protein kinase Cα contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities
-
Slater SJ, Ho C, Kelly MB, Larkin JD, Taddeo FJ, Yeager MD, Stubbs CD: Protein kinase Cα contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities. J Biol Chem (1996) 271(9):4627-4631.
-
(1996)
J. Biol. Chem.
, vol.271
, Issue.9
, pp. 4627-4631
-
-
Slater, S.J.1
Ho, C.2
Kelly, M.B.3
Larkin, J.D.4
Taddeo, F.J.5
Yeager, M.D.6
Stubbs, C.D.7
-
14
-
-
0037059451
-
Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane
-
(5553)
-
Baron L, Malhotra V: Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane. Science (2002) 295(5553):325-328.
-
(2002)
Science
, vol.295
, pp. 325-328
-
-
Baron, L.1
Malhotra, V.2
-
15
-
-
0032538616
-
Dissimilar phorbol ester binding properties of the individual cysteine-rich motifs of protein kinase D
-
Iglesias T, Matthews S, Rozengurt E: Dissimilar phorbol ester binding properties of the individual cysteine-rich motifs of protein kinase D. FEBS Lett (1998) 437(1-2):19-23.
-
(1998)
FEBS Lett.
, vol.437
, Issue.1-2
, pp. 19-23
-
-
Iglesias, T.1
Matthews, S.2
Rozengurt, E.3
-
16
-
-
0035377312
-
Role of hydrophobic residues in the C1b domain of protein kinase C δ on ligand and phospholipid interactions
-
Wang QJ, Fang TW, Nacro K, Marquez VE, Wang S, Blumberg PM: Role of hydrophobic residues in the C1b domain of protein kinase C δ on ligand and phospholipid interactions. J Biol Chem (2001) 276(22):19580-19587.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.22
, pp. 19580-19587
-
-
Wang, Q.J.1
Fang, T.W.2
Nacro, K.3
Marquez, V.E.4
Wang, S.5
Blumberg, P.M.6
-
17
-
-
0031050299
-
Taxonomy and function of C1 protein kinase C homology domains
-
Hurley JH, Newton AC, Parker PJ, Blumberg PM, Nishizuka Y: Taxonomy and function of C1 protein kinase C homology domains. Protein Sci (1997) 6(2):477-480.
-
(1997)
Protein Sci.
, vol.6
, Issue.2
, pp. 477-480
-
-
Hurley, J.H.1
Newton, A.C.2
Parker, P.J.3
Blumberg, P.M.4
Nishizuka, Y.5
-
18
-
-
10344252920
-
Molecular genetics and structural genomics of the human protein kinase C gene module
-
research0014.1-0014.10
-
Kofler K, Erdel M, Utermann G, Baier G: Molecular genetics and structural genomics of the human protein kinase C gene module. Genome Biol (2002) 3(3):research0014.1-0014.10.
-
(2002)
Genome Biol.
, vol.3
, Issue.3
-
-
Kofler, K.1
Erdel, M.2
Utermann, G.3
Baier, G.4
-
19
-
-
0034025493
-
Eyes wide shut: Protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters
-
Kazanietz MG: Eyes wide shut: Protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. Mol Carcinog (2000) 28(1):5-11.
-
(2000)
Mol. Carcinog.
, vol.28
, Issue.1
, pp. 5-11
-
-
Kazanietz, M.G.1
-
20
-
-
0037337159
-
Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
-
Newton AC: Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm. Biochem J (2003) 370(2):361-371.
-
(2003)
Biochem. J.
, vol.370
, Issue.2
, pp. 361-371
-
-
Newton, A.C.1
-
21
-
-
0035990921
-
Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity
-
Irie K, Nakahara A, Nakagawa Y, Ohigashi H, Shindo M, Fukuda H, Konishi H, Kikkawa U, Kashiwagi K, Saito N: Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Pharmacol Ther (2002) 93(2-3):271-281.
-
(2002)
Pharmacol. Ther.
, vol.93
, Issue.2-3
, pp. 271-281
-
-
Irie, K.1
Nakahara, A.2
Nakagawa, Y.3
Ohigashi, H.4
Shindo, M.5
Fukuda, H.6
Konishi, H.7
Kikkawa, U.8
Kashiwagi, K.9
Saito, N.10
-
22
-
-
0034607989
-
Identification and characterization of a new family of guanine nucleotide exchange factors for the Ras-related GTPase Ral
-
Rebhun JF, Chen H, Quilliam LA: Identification and characterization of a new family of guanine nucleotide exchange factors for the Ras-related GTPase Ral. J Biol Chem (2000) 275(18):13406-13410.
-
(2000)
J. Biol. Chem.
, vol.275
, Issue.18
, pp. 13406-13410
-
-
Rebhun, J.F.1
Chen, H.2
Quilliam, L.A.3
-
23
-
-
0037067713
-
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of detective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function
-
Yang Y, Li L, Wong GW, Krilis SA, Madhusudhan MS, Sali A, Stevens RL: RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of detective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. J Biol Chem (2002) 277(28):25756-25774.
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.28
, pp. 25756-25774
-
-
Yang, Y.1
Li, L.2
Wong, G.W.3
Krilis, S.A.4
Madhusudhan, M.S.5
Sali, A.6
Stevens, R.L.7
-
24
-
-
0034644772
-
Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor
-
Clyde-Smith J, Silins G, Gartside M, Grimmond S, Etheridge M, Apolloni A, Hayward N, Hancock JF: Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. J Biol Chem (2000) 275(41):32260-32267.
-
(2000)
J. Biol. Chem.
, vol.275
, Issue.41
, pp. 32260-32267
-
-
Clyde-Smith, J.1
Silins, G.2
Gartside, M.3
Grimmond, S.4
Etheridge, M.5
Apolloni, A.6
Hayward, N.7
Hancock, J.F.8
-
25
-
-
0032524389
-
RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
-
(5366)
-
Ebinu JO, Bottorff DA, Chan EY, Stang SL, Dunn RJ Stone JC: RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science (1998) 280(5366):1082-1086.
-
(1998)
Science
, vol.280
, pp. 1082-1086
-
-
Ebinu, J.O.1
Bottorff, D.A.2
Chan, E.Y.3
Stang, S.L.4
Dunn, R.J.5
Stone, J.C.6
-
26
-
-
0035853782
-
Activation of the Rap1 guanine nucleotide exchange gene, CaIDAG-GEF I, in BXH-2 murine myeloid leukemia
-
Dupuy AJ, Morgan K, von Lintig FC, Shen H, Acar H, Hasz DE, Jenkins NA, Copeland NG, Boss GR, Largaespada DA: Activation of the Rap1 guanine nucleotide exchange gene, CaIDAG-GEF I, in BXH-2 murine myeloid leukemia. J Biol Chem (2001) 276(15):11804-11811.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.15
, pp. 11804-11811
-
-
Dupuy, A.J.1
Morgan, K.2
von Lintig, F.C.3
Shen, H.4
Acar, H.5
Hasz, D.E.6
Jenkins, N.A.7
Copeland, N.G.8
Boss, G.R.9
Largaespada, D.A.10
-
27
-
-
0034061660
-
The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters
-
Lorenzo PS, Beheshti M, Pettit GR, Stone JC, Blumberg PM: The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters. Mol Pharmacol (2000) 57(5):840-846.
-
(2000)
Mol. Pharmacol.
, vol.57
, Issue.5
, pp. 840-846
-
-
Lorenzo, P.S.1
Beheshti, M.2
Pettit, G.R.3
Stone, J.C.4
Blumberg, P.M.5
-
28
-
-
0035117119
-
Phorbol esters modulate the Ras exchange factor RasGRP3
-
Lorenzo PS, Kung JW, Bottorff DA, Garfield SH, Stone JC, Blumberg PM: Phorbol esters modulate the Ras exchange factor RasGRP3. Cancer Res (2001) 61(3):943-949.
-
(2001)
Cancer Res.
, vol.61
, Issue.3
, pp. 943-949
-
-
Lorenzo, P.S.1
Kung, J.W.2
Bottorff, D.A.3
Garfield, S.H.4
Stone, J.C.5
Blumberg, P.M.6
-
29
-
-
0346364657
-
Amino acid properties and consequences of substitutions
-
Barnes MR, Gray IC (Eds), John Wiley & Sons Ltd, West Sussex, UK
-
Betts MJ, Russell RB: Amino acid properties and consequences of substitutions. In: Bioinformatics for Geneticists. Barnes MR, Gray IC (Eds), John Wiley & Sons Ltd, West Sussex, UK (2003).
-
(2003)
Bioinformatics for Geneticists
-
-
Betts, M.J.1
Russell, R.B.2
-
30
-
-
0030764306
-
NMR structure of a protein kinase C-γ phorbol-binding domain and study of protein-lipid micelle interactions
-
Xu RX, Pawelczyk T, Xia T-H, Brown SC: NMR structure of a protein kinase C-γ phorbol-binding domain and study of protein-lipid micelle interactions. Biochemistry (1997) 36(35 ):10709-10717.
-
(1997)
Biochemistry
, vol.36
, Issue.35
, pp. 10709-10717
-
-
Xu, R.X.1
Pawelczyk, T.2
Xia, T.-H.3
Brown, S.C.4
-
31
-
-
0029102822
-
Residues in the second cysteine-rich region of protein kinase C δ relevant to phorbol ester binding as revealed by site-directed mutagenesis
-
Kazanietz MG, Wang S, Milne GW, Lewin NE, Liu HL, Blumberg PM: Residues in the second cysteine-rich region of protein kinase C δ relevant to phorbol ester binding as revealed by site-directed mutagenesis. J Biol Chem (1995) 270(37):21852-21859.
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.37
, pp. 21852-21859
-
-
Kazanietz, M.G.1
Wang, S.2
Milne, G.W.3
Lewin, N.E.4
Liu, H.L.5
Blumberg, P.M.6
-
32
-
-
0042237772
-
Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3
-
Teixeira C, Stang SL, Zheng Y, Beswick NS, Stone JC: Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. Blood (2003) 102(4):1414-1420.
-
(2003)
Blood
, vol.102
, Issue.4
, pp. 1414-1420
-
-
Teixeira, C.1
Stang, S.L.2
Zheng, Y.3
Beswick, N.S.4
Stone, J.C.5
-
33
-
-
0016063911
-
The genetics of Caenorhabditis elegans
-
Brenner S: The genetics of Caenorhabditis elegans. Genetics (1974) 77(1):71-94.
-
(1974)
Genetics
, vol.77
, Issue.1
, pp. 71-94
-
-
Brenner, S.1
-
34
-
-
0028791349
-
Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins
-
Brose N, Hofmann K, Hats Y, Sudhof TC: Mammalian homologues; of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins. J Biol Chem (1995) 270(42):25273-25280.
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.42
, pp. 25273-25280
-
-
Brose, N.1
Hofmann, K.2
Hats, Y.3
Sudhof, T.C.4
-
35
-
-
0034235922
-
Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform
-
Koch H, Hofmann K, Brose N: Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform. Biochem J (2000) 349(1):247-253.
-
(2000)
Biochem. J.
, vol.349
, Issue.1
, pp. 247-253
-
-
Koch, H.1
Hofmann, K.2
Brose, N.3
-
36
-
-
0033617742
-
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
-
Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res (1999) 6(3):197-205.
-
(1999)
DNA Res.
, vol.6
, Issue.3
, pp. 197-205
-
-
Kikuno, R.1
Nagase, T.2
Ishikawa, K.3
Hirosawa, M.4
Miyajima, N.5
Tanaka, A.6
Kotani, H.7
Nomura, N.8
Ohara, O.9
-
37
-
-
0026053020
-
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 of Caenorhabditis elegans
-
Maruyama IN, Brenner S: A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 of Caenorhabditis elegans. Proc Natl Acad Sci USA (1991) 88(13):5729-5733.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, Issue.13
, pp. 5729-5733
-
-
Maruyama, I.N.1
Brenner, S.2
-
38
-
-
18544399674
-
Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release
-
Betz A, Ashery U, Rickmann M, Augustin I, Neher E, Sudhof TC, Rettig J, Brose N: Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. Neuron (1998) 21(1):123-136.
-
(1998)
Neuron
, vol.21
, Issue.1
, pp. 123-136
-
-
Betz, A.1
Ashery, U.2
Rickmann, M.3
Augustin, I.4
Neher, E.5
Sudhof, T.C.6
Rettig, J.7
Brose, N.8
-
39
-
-
0037524470
-
Protein kinase D: A family affair
-
Rykx A, De Kimpe L, Mikhalap S, Vantus T, Seufferlein T, Vandenheede JR, Van Lint J: Protein kinase D: A family affair. FEBS Lett (2003) 546(1):81-86.
-
(2003)
FEBS Lett.
, vol.546
, Issue.1
, pp. 81-86
-
-
Rykx, A.1
De Kimpe, L.2
Mikhalap, S.3
Vantus, T.4
Seufferlein, T.5
Vandenheede, J.R.6
Van Lint, J.7
-
40
-
-
0032855089
-
Dynamic redistribution of protein kinase D (PKD) as revealed by a GFP-PKD fusion protein: Dissociation from PKD activation
-
Matthews S, Iglesias T, Cantrell D, Rozengurt E: Dynamic redistribution of protein kinase D (PKD) as revealed by a GFP-PKD fusion protein: Dissociation from PKD activation. FEBS Lett (1999) 457(3):515-521.
-
(1999)
FEBS Lett.
, vol.457
, Issue.3
, pp. 515-521
-
-
Matthews, S.1
Iglesias, T.2
Cantrell, D.3
Rozengurt, E.4
-
42
-
-
0038052927
-
Regulation of protein kinase Cν by the B-cell antigen receptor
-
Matthews SA, Dayalu R, Thompson LJ, Scharenberg AM: Regulation of protein kinase Cν by the B-cell antigen receptor. J Biol Chem (2003) 278(11):9086-9091.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.11
, pp. 9086-9091
-
-
Matthews, S.A.1
Dayalu, R.2
Thompson, L.J.3
Scharenberg, A.M.4
-
43
-
-
0029964752
-
Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway
-
Zugaza JL, Sinnet-Smith J, Van Lint J, Rozengurt E: Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway. EMBO J (1996) 16(22):6220-6230.
-
(1996)
EMBO J.
, vol.16
, Issue.22
, pp. 6220-6230
-
-
Zugaza, J.L.1
Sinnet-Smith, J.2
Van Lint, J.3
Rozengurt, E.4
-
44
-
-
0030856559
-
Bryostatin 1 induces biphasic activation of protein kinase D in intact cells
-
Matthews SA, Pettit GR, Rozengurt E: Bryostatin 1 induces biphasic activation of protein kinase D in intact cells. J Biol Chem (1997) 772(32):20245-20250.
-
(1997)
J. Biol. Chem.
, vol.772
, Issue.32
, pp. 20245-20250
-
-
Matthews, S.A.1
Pettit, G.R.2
Rozengurt, E.3
-
45
-
-
0030771317
-
Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway
-
Zugaza JL, Waldron RT, Sinnett-Smith J, Rozengurt E: Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway. J Biol Chem (1997) 272(38):23952-23960.
-
(1997)
J. Biol. Chem.
, vol.272
, Issue.38
, pp. 23952-23960
-
-
Zugaza, J.L.1
Waldron, R.T.2
Sinnett-Smith, J.3
Rozengurt, E.4
-
46
-
-
0242712991
-
Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases
-
Sturany S, Van Lint J, Müller F, Wilda M, Hameister H, Höecker M, Brey A, Gern U, Vandenheede J, Gress T, Adler G, Senfferlein T: Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases. J Biol Chem (2001) 276(5):3310-3318.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.5
, pp. 3310-3318
-
-
Sturany, S.1
Van Lint, J.2
Müller, F.3
Wilda, M.4
Hameister, H.5
Höecker, M.6
Brey, A.7
Gern, U.8
Vandenheede, J.9
Gress, T.10
Adler, G.11
Senfferlein, T.12
-
47
-
-
0028979464
-
Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester
-
Zhang G, Kazanietz MG, Blumberg PM, Hurley JH: Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester. Cell (1995) 81(6):917-924.
-
(1995)
Cell
, vol.81
, Issue.6
, pp. 917-924
-
-
Zhang, G.1
Kazanietz, M.G.2
Blumberg, P.M.3
Hurley, J.H.4
-
48
-
-
0027282112
-
rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes
-
rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes. Mol Cell Biol (1993) 13(8):4986-4998.
-
(1993)
Mol. Cell Biol.
, vol.13
, Issue.8
, pp. 4986-4998
-
-
Hall, C.1
Sin, W.C.2
Teo, M.3
Michael, G.J.4
Smith, P.5
Dong, J.M.6
Lim, H.H.7
Manser, E.8
Spurr, N.K.9
Jones, T.A.10
Lim, L.11
-
49
-
-
0027456496
-
Germ cell β-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis
-
Leung T, How BE, Manser E, Lim L: Germ cell β-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis. J Biol Chem (1993) 268(6):3813-3816.
-
(1993)
J. Biol. Chem.
, vol.268
, Issue.6
, pp. 3813-3816
-
-
Leung, T.1
How, B.E.2
Manser, E.3
Lim, L.4
-
50
-
-
0028180706
-
Cerebellar β2-chimaerin, a GTPase-activating protein for p21 Ras-related Rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain
-
Leung T, How BE, Manser E, Lim L: Cerebellar β2-chimaerin, a GTPase-activating protein for p21 Ras-related Rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain. J Biol Chem (1994) 269(17):12888-12892.
-
(1994)
J. Biol. Chem.
, vol.269
, Issue.17
, pp. 12888-12892
-
-
Leung, T.1
How, B.E.2
Manser, E.3
Lim, L.4
-
51
-
-
0025600435
-
Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor
-
Ahmed S, Kozma R, Monfries C, Hall C, Lim HH, Smith P, Lim L: Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor. Biochem J (1990) 272(3):767-773.
-
(1990)
Biochem. J.
, vol.272
, Issue.3
, pp. 767-773
-
-
Ahmed, S.1
Kozma, R.2
Monfries, C.3
Hall, C.4
Lim, H.H.5
Smith, P.6
Lim, L.7
-
52
-
-
0028144758
-
Close similarity of baculovirus-expressed n-chimaerin and protein kinase C α as phorbol ester receptors
-
Areces LB, Kazanietz MG, Blumberg PM: Close similarity of baculovirus-expressed n-chimaerin and protein kinase C α as phorbol ester receptors. J Biol Chem (1994) 269(30):19553-19558.
-
(1994)
J. Biol. Chem.
, vol.269
, Issue.30
, pp. 19553-19558
-
-
Areces, L.B.1
Kazanietz, M.G.2
Blumberg, P.M.3
-
53
-
-
0030611884
-
β2-Chimaerin is a high affinity receptor for the phorbor ester tumor promoters
-
Caloca MJ, Fernandez N, Lewin NE, Ching D, Modali R, Blumberg PM, Kazanietz MG: β2-Chimaerin is a high affinity receptor for the phorbor ester tumor promoters. J Biol Chem (1997) 272(42):26488-26496.
-
(1997)
J. Biol. Chem.
, vol.272
, Issue.42
, pp. 26488-26496
-
-
Caloca, M.J.1
Fernandez, N.2
Lewin, N.E.3
Ching, D.4
Modali, R.5
Blumberg, P.M.6
Kazanietz, M.G.7
-
54
-
-
0025873083
-
Bcr encodes a GTPase-activating protein for p21rac
-
(6325)
-
Diekmann D, Brill S, Garret MD, Totty N, Hsuan J, Monfries C, Hall C, Lim L, Hall A: Bcr encodes a GTPase-activating protein for p21rac. Nature (1991) 351(6325):400-402.
-
(1991)
Nature
, vol.351
, pp. 400-402
-
-
Diekmann, D.1
Brill, S.2
Garret, M.D.3
Totty, N.4
Hsuan, J.5
Monfries, C.6
Hall, C.7
Lim, L.8
Hall, A.9
-
55
-
-
0027258578
-
A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin
-
Ahmed S, Lee J, Kozma R, Best A, Monfries C, Lim L: A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin. J Biol Chem (1993) 268(15):10709-10712.
-
(1993)
J. Biol. Chem.
, vol.268
, Issue.15
, pp. 10709-10712
-
-
Ahmed, S.1
Lee, J.2
Kozma, R.3
Best, A.4
Monfries, C.5
Lim, L.6
-
56
-
-
0037040248
-
Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): Evidence for a novel anchoring mechanism involving the chimaerin C1 domain
-
Wang H, Kazanietz MG: Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): Evidence for a novel anchoring mechanism involving the chimaerin C1 domain. J Biol Chem (2002) 277(6):4541-4550.
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.6
, pp. 4541-4550
-
-
Wang, H.1
Kazanietz, M.G.2
-
57
-
-
0142169536
-
Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of β2-chimaerin, a 'non-protein kinase C' phorbol ester receptor
-
Caloca MJ, Wang H, Kazanietz MG: Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of β2-chimaerin, a 'non-protein kinase C' phorbol ester receptor. Biochem J (2003) 375(2):313-321.
-
(2003)
Biochem. J.
, vol.375
, Issue.2
, pp. 313-321
-
-
Caloca, M.J.1
Wang, H.2
Kazanietz, M.G.3
-
58
-
-
0035947687
-
Phorbol esters and related analogs regulate the subcellular localization of -chimaerin, a non-protein kinase C phorbol ester receptor
-
Caloca MJ, Wang H, Delemos A, Wang S, Kazanietz MG: Phorbol esters and related analogs regulate the subcellular localization of -chimaerin, a non-protein kinase C phorbol ester receptor. J Biol Chem (2001) 276(21):18303-18312.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.21
, pp. 18303-18312
-
-
Caloca, M.J.1
Wang, H.2
Delemos, A.3
Wang, S.4
Kazanietz, M.G.5
-
59
-
-
0038375063
-
Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the β2-chimaerin GAP domain
-
Menna PL, Skilton G, Leskow FC, Alonso DF, Gomez DE, Kazanietz MG: Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the β2-chimaerin GAP domain. Cancer Res (2003) 63(9):2284-2291.
-
(2003)
Cancer Res.
, vol.63
, Issue.9
, pp. 2284-2291
-
-
Menna, P.L.1
Skilton, G.2
Leskow, F.C.3
Alonso, D.F.4
Gomez, D.E.5
Kazanietz, M.G.6
-
60
-
-
0029133178
-
Identification and characterization of human β2-chimaerin: Association with malignant transformation in astrocytoma
-
Yuan S, Miller DW, Barnett GH, Hahn JF, Williams BRG: Identification and characterization of human β2-chimaerin: Association with malignant transformation in astrocytoma. Cancer Res (1995) 55(15):3456-3461.
-
(1995)
Cancer Res.
, vol.55
, Issue.15
, pp. 3456-3461
-
-
Yuan, S.1
Miller, D.W.2
Barnett, G.H.3
Hahn, J.F.4
Williams, B.R.G.5
-
61
-
-
0035976766
-
Diacylglycerol kinase γ is one of the specific receptors of tumor-promoting phorbol esters
-
Shindo M, Irie K, Ohigashi H, Kuriyama M, Saito N: Diacylglycerol kinase γ is one of the specific receptors of tumor-promoting phorbol esters. Biochem Biophys Res Commun (2001) 289(2):451-456.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.289
, Issue.2
, pp. 451-456
-
-
Shindo, M.1
Irie, K.2
Ohigashi, H.3
Kuriyama, M.4
Saito, N.5
-
62
-
-
0037705412
-
Synthesis and phorbol ester binding of the cysteine-rich domains at diacylglycerol kinase (DGK) isozymes. DGKγ and DGKβ are new targets of tumor-promoting phorbol esters
-
Shindo M, Irie K, Masuda A, Ohigashi H, Shirai Y, Miyasaka K, Saito N: Synthesis and phorbol ester binding of the cysteine-rich domains at diacylglycerol kinase (DGK) isozymes. DGKγ and DGKβ are new targets of tumor-promoting phorbol esters. J Biol Chem (2003) 278(20):18448-18454.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.20
, pp. 18448-18454
-
-
Shindo, M.1
Irie, K.2
Masuda, A.3
Ohigashi, H.4
Shirai, Y.5
Miyasaka, K.6
Saito, N.7
-
63
-
-
0034637434
-
Subtype-specific translocation of diacylglycerol kinase α and γ and its correlation with protein kinase C
-
Shirai Y, Segawa S, Kuriyama M, Goto K, Sakai N, Saito N: Subtype-specific translocation of diacylglycerol kinase α and γ and its correlation with protein kinase C. J Biol Chem (2000) 275(32):24760-24766.
-
(2000)
J. Biol. Chem.
, vol.275
, Issue.32
, pp. 24760-24766
-
-
Shirai, Y.1
Segawa, S.2
Kuriyama, M.3
Goto, K.4
Sakai, N.5
Saito, N.6
-
64
-
-
0037085251
-
Molecular cloning and characterization of the human diacylglycerol kinase β (DGKβ) gene: Alternative splicing generates DGKβ isotypes with different properties
-
Caricasole A, Bettini E, Sala C, Roncarati R, Kobayashi N, Caldara F, Goto K, Terstappen GC: Molecular cloning and characterization of the human diacylglycerol kinase β (DGKβ) gene: Alternative splicing generates DGKβ isotypes with different properties. J Biol Chem (2002) 7(7):4790-4796.
-
(2002)
J. Biol. Chem.
, vol.7
, Issue.7
, pp. 4790-4796
-
-
Caricasole, A.1
Bettini, E.2
Sala, C.3
Roncarati, R.4
Kobayashi, N.5
Caldara, F.6
Goto, K.7
Terstappen, G.C.8
-
65
-
-
0033579208
-
Diacylglycerol kinase E, but not ζ selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo
-
Pettitt TR, Wakelam MJ: Diacylglycerol kinase E, but not ζ selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo. J Biol Chem (1999) 274(51):36181-36186.
-
(1999)
J. Biol. Chem.
, vol.274
, Issue.51
, pp. 36181-36186
-
-
Pettitt, T.R.1
Wakelam, M.J.2
-
66
-
-
0036547350
-
Expression of a catalytically inactive form of diacylglycerol kinase α induces sustained signaling through RasGRP
-
Jones DR, Sanjuan MA, Stone JC, Merida I: Expression of a catalytically inactive form of diacylglycerol kinase α induces sustained signaling through RasGRP. FASEB J (2002) 16(6):595-597.
-
(2002)
FASEB J.
, vol.16
, Issue.6
, pp. 595-597
-
-
Jones, D.R.1
Sanjuan, M.A.2
Stone, J.C.3
Merida, I.4
-
67
-
-
0141994860
-
Protein kinase C α phosphorylates and negatively regulates diacylglycerol kinase ζ
-
Luo B, Prescott SM, Topham MK: Protein kinase C α phosphorylates and negatively regulates diacylglycerol kinase ζ. J Biol Chem (2003) 278(41):39547-39547.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.41
, pp. 39547
-
-
Luo, B.1
Prescott, S.M.2
Topham, M.K.3
-
68
-
-
0031962372
-
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization
-
Leung T, Chen XQ, Tan I, Manser E, Lim L: Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. Mol Cell Biol (1998) 118(1):130-140.
-
(1998)
Mol. Cell Biol.
, vol.118
, Issue.1
, pp. 130-140
-
-
Leung, T.1
Chen, X.Q.2
Tan, I.3
Manser, E.4
Lim, L.5
-
69
-
-
0035079891
-
Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase α
-
Tan I, Seow KT, Lim L, Leung T: Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase α. Mol Cell Biol (2001) 21(8):2767-2778.
-
(2001)
Mol. Cell Biol.
, vol.21
, Issue.8
, pp. 2767-2778
-
-
Tan, I.1
Seow, K.T.2
Lim, L.3
Leung, T.4
-
70
-
-
0033853336
-
Phosphorylation of ERM proteins at filopodia induced by Cdc42
-
Nakamura N, Oshiro N, Fukata Y, Amano M, Fukata M, Kuroda S, Matsuura Y, Leung T, Lim L, Kaibuchi K: Phosphorylation of ERM proteins at filopodia induced by Cdc42. Genes Cells (2000) 5(7):571-581.
-
(2000)
Genes Cells
, vol.5
, Issue.7
, pp. 571-581
-
-
Nakamura, N.1
Oshiro, N.2
Fukata, Y.3
Amano, M.4
Fukata, M.5
Kuroda, S.6
Matsuura, Y.7
Leung, T.8
Lim, L.9
Kaibuchi, K.10
-
71
-
-
0028310840
-
Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C ζ and the vav and c-raf proto-oncogene products
-
Kazanietz MG, Bustelo XR, Barbacid M, Kolch W, Mischak H, Wong G, Pettit GR, Bruns JD, Blumberg PM: Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C ζ and the vav and c-raf proto-oncogene products. J Biol Chem (1994) 269(15):11590-11594.
-
(1994)
J. Biol. Chem.
, vol.269
, Issue.15
, pp. 11590-11594
-
-
Kazanietz, M.G.1
Bustelo, X.R.2
Barbacid, M.3
Kolch, W.4
Mischak, H.5
Wong, G.6
Pettit, G.R.7
Bruns, J.D.8
Blumberg, P.M.9
-
72
-
-
0036301210
-
Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)
-
Zhou M, Horita DA, Waugh DS, Byrd RA, Morrison DK: Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR). J Mol Biol (2002) 315(3):435-446.
-
(2002)
J. Mol. Biol.
, vol.315
, Issue.3
, pp. 435-446
-
-
Zhou, M.1
Horita, D.A.2
Waugh, D.S.3
Byrd, R.A.4
Morrison, D.K.5
-
73
-
-
0028447767
-
Solution structure of a cysteine rich domain of rat protein kinase C
-
Hommel U, Zurini M, Luyten M: Solution structure of a cysteine rich domain of rat protein kinase C. Nat Struct Biol (1994) 1(6):383-387.
-
(1994)
Nat. Struct. Biol.
, vol.1
, Issue.6
, pp. 383-387
-
-
Hommel, U.1
Zurini, M.2
Luyten, M.3
-
74
-
-
0028961287
-
Solution structure of cysteine-rich domain of protein kinase Cα
-
Ichikawa S, Hatanaka H, Takeuchi Y, Ohno S, Inagaki F: Solution structure of cysteine-rich domain of protein kinase Cα. J Biochem (1995) 117(3):566-574.
-
(1995)
J. Biochem.
, vol.117
, Issue.3
, pp. 566-574
-
-
Ichikawa, S.1
Hatanaka, H.2
Takeuchi, Y.3
Ohno, S.4
Inagaki, F.5
-
75
-
-
0001613219
-
Protein kinase C ζ subspecies from rat brain: Its structure, expression, and properties
-
Ono Y, Fujii T, Ogita K, Kikkawa U, Igarashi K, Nishizuka Y: Protein kinase C ζ subspecies from rat brain: Its structure, expression, and properties. Proc Natl Acad Sci USA (1989) 86(9 ):3099-3103.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, Issue.9
, pp. 3099-3103
-
-
Ono, Y.1
Fujii, T.2
Ogita, K.3
Kikkawa, U.4
Igarashi, K.5
Nishizuka, Y.6
-
76
-
-
0027297104
-
Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes
-
Kazanietz MG, Areces LB, Bahador A, Mischak H, Goodnight J, Mushinski JF, Blumberg PM: Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol Pharmacol (1993) 44(2):298-307.
-
(1993)
Mol. Pharmacol.
, vol.44
, Issue.2
, pp. 298-307
-
-
Kazanietz, M.G.1
Areces, L.B.2
Bahador, A.3
Mischak, H.4
Goodnight, J.5
Mushinski, J.F.6
Blumberg, P.M.7
-
77
-
-
0028298476
-
A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells
-
Akimoto K, Mizuno K, Osada S, Hirai S, Tanuma S, Suzuki K, Ohno S: A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. J Biol Chem (1994) 269(17):12677-12683.
-
(1994)
J. Biol. Chem.
, vol.269
, Issue.17
, pp. 12677-12683
-
-
Akimoto, K.1
Mizuno, K.2
Osada, S.3
Hirai, S.4
Tanuma, S.5
Suzuki, K.6
Ohno, S.7
-
78
-
-
0038688782
-
Antisense oligonucleotides for cancer therapy - An overview
-
Stahel RA, Zangemeister-Wittke U: Antisense oligonucleotides for cancer therapy - an overview. Lung Cancer (2003) 41 (Suppl 1):S81-S88.
-
(2003)
Lung Cancer
, vol.41
, Issue.SUPPL. 1
-
-
Stahel, R.A.1
Zangemeister-Wittke, U.2
-
79
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA: The hallmarks of cancer. Cell (2000) 100(1):57-70.
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
|