RasGRP1 overexpression in the epidermis of transgenic mice contributes to tumor progression during multistage skin carcinogenesis

Cancer Research

Volumn 67, Issue 21, 2007, Pages 10190-10197

  Luke, Courtney T ^a   Oki Idouchi, Carolyn E ^a   Cline, J Mark ^b   Lorenzo, Patricia S ^a  

^a UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; CYTOKERATIN 5; DIACYLGLYCEROL; GUANINE NUCLEOTIDE EXCHANGE FACTOR; KERATIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PROTEIN RASGRP1; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CELL ISOLATION; CONTROLLED STUDY; EPIDERMIS; EPIDERMIS CELL; HISTOPATHOLOGY; KERATINOCYTE; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SECOND MESSENGER; SIGNAL TRANSDUCTION; SKIN CARCINOGENESIS; SKIN PAPILLOMA; SQUAMOUS CELL CARCINOMA; TRANSGENIC MOUSE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; DISEASE PROGRESSION; EPIDERMIS; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; KERATINOCYTES; MALE; MICE; MICE, TRANSGENIC; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

EID: 35949004382     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-2375     Document Type: Article

References (35)

1. Springett GM, Kawasaki H, Spriggs DR. Non-kinase second-messenger signaling: new pathways with new promise. Bioessays 2004;26:730-8.
2. Brose N, Betz A, Wegmeyer H. Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals. Curr Opin Neurobiol 2004;14:328-40.
3. Colon-Gonzalez F, Kazanietz MG. C1 domains exposed: from diacylglycerol binding to protein-protein interactions. Biochim Biophys Acta 2006;1761:827-37.
4. Lorenzo PS, Beheshti M, Pettit GR, et al. The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters. Mol Pharmacol 2000;57:840-6.
5. Lorenzo PS, Kung JW, Bottorff DA, et al. Phorbol esters modulate the Ras exchange factor RasGRP3. Cancer Res 2001;61:943-9.
6. Irie K, Masuda A, Shindo M, et al. Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s. Bioorg Med Chem 2004;12:4575-83.
7. Dower NA, Stang SL, Bottorff DA, et al. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol 2000;1:317-21.
8. Ebinu JO, Stang SL, Teixeira C, et al. RasGRP links T-cell receptor signaling to Ras. Blood 2000;95:3199-203.
9. Coughlin JJ, Stang SL, Dower NA, et al. RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J Immunol 2005;175:7179-84.
10. Pierret P, Dunn RJ, Djordjevic B, et al. Distribution of Ras guanyl releasing protein (RasGRP) mRNA in the adult rat central nervous system. J Neurocytol 2000;29:485-97.
11. Liu Y, Zhu M, Nishida K, et al. An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med 2007;204:93-103.
12. Yamashita S, Mochizuki N, Ohba Y, et al. CalDAG-GEFIII activation of Ras, R-Ras, and Rap1. J Biol Chem 2000;275:25488-93.
13. Rambaratsingh RA, Stone JC, Blumberg PM, et al. RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes. J Biol Chem 2003;278:52792-801.
14. Tuthill MC, Oki CE, Lorenzo PS. Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes. Mol Cancer Ther 2006;5:602-10.
15. Sharkey NA, Leach KL, Blumberg PM. Competitive inhibition by diacylglycerol of specific phorbol ester binding. Proc Natl Acad Sci U S A 1984;81:607-10.
16. Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 2007;7:281.
17. Angel JM, Caballero M, DiGiovanni J. Identification of novel genetic loci contributing to 12-O-tetradecanoylphorbol-13-acetate skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice. Cancer Res 2003;63:2747-51.
18. Riggs PK, Angel JM, Abel EL, et al. Differential gene expression in epidermis of mice sensitive and resistant to phorbol ester skin tumor promotion. Mol Carcinog 2005;44:122-36.
19. Oki-Idouchi CE, Lorenzo PS. Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin. Cancer Res 2007;67:276-80.
20. Nelson MA, Futscher BW, Kinsella T, et al. Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors. Proc Natl Acad Sci U S A 1992;89:6398-402.
21. Quintanilla M, Brown K, Ramsden M, et al. Carcinogen-specific mutation and amplification of Haras during mouse skin carcinogenesis. Nature 1986;322:78-80.
22. Hennings H, Glick AB, Lowry DT, et al. FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis 1993;14:2353-8.
23. Dajee M, Tarutani M, Deng H, et al. Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene 2002;21:1527-38.
24. Bremner R, Balmain A. Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 1990;61:407-17.
25. Bianchi AB, Aldaz CM, Conti CJ. Nonrandom duplication of the chromosome bearing a mutated Haras-1 allele in mouse skin tumors. Proc Natl Acad Sci U S A 1990;87:6902-6.
26. Singh A, Sowjanya AP, Ramakrishna G. The wild-type Ras: road ahead. FASEB J 2005;19:161-9.
27. Wang XJ, Greenhalgh DA, Roop DR. Transgenic coexpression of v-Ha-Ras and transforming growth factor a increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-Ras activation. Mol Carcinog 2000;27:200-9.
28. DiGiovanni J, Beltran L, Rupp A, et al. Further analysis of c-Ha-ras mutations in papillomas initiated by several polycyclic aromatic hydrocarbons and papillomas from uninitiated, promoter-treated skin in SENCAR mice. Mol Carcinog 1993;8:272-9.
29. Sutter C, Greenhalgh DA, Ueda M, et al. SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene. Carcinogenesis 1994;15:1975-8.
30. Argyris TS. Tumor promotion by regenerative epidermal hyperplasia in mouse skin. J Cutan Pathol 1982;9:1-18.
31. DiGiovanni J. Multistage carcinogenesis in mouse skin. Pharmacol Ther 1992;54:63-128.
32. Leder A, Kuo A, Cardiff RD, et al. v-Ha-ras transgene abrogates the initiation stepin mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc Natl Acad Sci U S A 1990;87:9178-82.
33. van der Schroeff JG, Evers LM, Boot AJ, et al. Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin. J Invest Dermatol 1990;94:423-5.
34. Lieu FM, Yamanishi K, Konishi K, et al. Low incidence of Ha-ras oncogene mutations in human epidermal tumors. Cancer Lett 1991;59:231-5.
35. Khavari PA. Modelling cancer in human skin tissue. Nat Rev Cancer 2006;6:270-80.