Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C)

Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2003, Pages 1571-1579

  Sigano, Dina M ^a   Peach, Megan L ^a   Nacro, Kassoum ^a,c   Choi, Yongseok ^a   Lewin, Nancy E ^b   Nicklaus, Marc C ^a   Blumberg, Peter M ^b   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c ALBANY MOLECULAR RESEARCH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; DIACYLGLYCEROL LACTONE DERIVATIVE; GLYCEROL; ISOENZYME; LACTONE DERIVATIVE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENTROPY; ENZYME BINDING; HYDROGEN BOND; PROTEIN BINDING; SN 1 BINDING MODE; SN 2 BINDING MODE; STRUCTURE ACTIVITY RELATION;

DIGLYCERIDES; HYDROGEN BONDING; LACTONES; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE C; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037464480     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020476o     Document Type: Article

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