-
1
-
-
1542547319
-
The ins and outs of protein kinase C
-
A.C. Newton The ins and outs of protein kinase C Methods Mol. Biol. 233 2003 3 7
-
(2003)
Methods Mol. Biol.
, vol.233
, pp. 3-7
-
-
Newton, A.C.1
-
2
-
-
0032104245
-
The extended protein kinase C superfamily
-
H. Mellor, and P.J. Parker The extended protein kinase C superfamily Biochem. J. 332 1998 281 292
-
(1998)
Biochem. J.
, vol.332
, pp. 281-292
-
-
Mellor, H.1
Parker, P.J.2
-
3
-
-
0242321186
-
Divergence and complexities in DAG signaling: Looking beyond PKC
-
C. Yang, and M.G. Kazanietz Divergence and complexities in DAG signaling: looking beyond PKC Trends Pharmacol. Sci. 24 2003 602 608
-
(2003)
Trends Pharmacol. Sci.
, vol.24
, pp. 602-608
-
-
Yang, C.1
Kazanietz, M.G.2
-
4
-
-
1942453351
-
Diacylglycerol's affair with protein kinase C turns 25
-
A.C. Newton Diacylglycerol's affair with protein kinase C turns 25 Trends Pharmacol. Sci. 25 2004 175 177
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 175-177
-
-
Newton, A.C.1
-
5
-
-
1542757480
-
Phorbol esters as probes for the study of protein kinase C function
-
M.G. Kazanietz, and P.S. Lorenzo Phorbol esters as probes for the study of protein kinase C function Methods Mol. Biol. 233 2003 423 439
-
(2003)
Methods Mol. Biol.
, vol.233
, pp. 423-439
-
-
Kazanietz, M.G.1
Lorenzo, P.S.2
-
6
-
-
0023253596
-
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin
-
H. Hennings, P.M. Blumberg, G.R. Pettit, C.L. Herald, R. Shores, and S.H. Yuspa Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin Carcinogenesis 8 1987 1343 1346
-
(1987)
Carcinogenesis
, vol.8
, pp. 1343-1346
-
-
Hennings, H.1
Blumberg, P.M.2
Pettit, G.R.3
Herald, C.L.4
Shores, R.5
Yuspa, S.H.6
-
7
-
-
0027212503
-
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin
-
Z. Szallasi, L. Krsmanovic, and P.M. Blumberg Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin Cancer Res. 53 1993 2507 2512
-
(1993)
Cancer Res.
, vol.53
, pp. 2507-2512
-
-
Szallasi, Z.1
Krsmanovic, L.2
Blumberg, P.M.3
-
8
-
-
0027297104
-
Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes
-
M.G. Kazanietz, L.B. Areces, A. Bahador, H. Mischak, J. Goodnight, J.F. Mushinski, and P.M. Blumberg Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes Mol. Pharmacol. 44 1993 298 307
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 298-307
-
-
Kazanietz, M.G.1
Areces, L.B.2
Bahador, A.3
Mischak, H.4
Goodnight, J.5
Mushinski, J.F.6
Blumberg, P.M.7
-
9
-
-
0024526623
-
The protein kinase C pathway in tumor promotion
-
P.M. Blumberg, G.R. Pettit, B.S. Warren, A. Szallasi, L.D. Schuman, N.A. Sharkey, H. Nakakuma, M.L. Dell'Aquila, and D.J. de Vries The protein kinase C pathway in tumor promotion Progr. Clin. Biol. Res. 298 1989 201 212
-
(1989)
Progr. Clin. Biol. Res.
, vol.298
, pp. 201-212
-
-
Blumberg, P.M.1
Pettit, G.R.2
Warren, B.S.3
Szallasi, A.4
Schuman, L.D.5
Sharkey, N.A.6
Nakakuma, H.7
Dell'Aquila, M.L.8
De Vries, D.J.9
-
10
-
-
0021999845
-
Phospholipid and Ca++ dependency of phorbol ester receptors
-
B. Konig, P.A. Di Nitto, and P.M. Blumberg Phospholipid and Ca++ dependency of phorbol ester receptors J. Cell. Biochem. 27 1985 255 265
-
(1985)
J. Cell. Biochem.
, vol.27
, pp. 255-265
-
-
Konig, B.1
Di Nitto, P.A.2
Blumberg, P.M.3
-
11
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
J.A. Le Good, W.H. Ziegler, D.B. Parekh, D.R. Alessi, P. Cohen, and P.J. Parker Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1 Science 281 1998 2042 2045
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
Le Good, J.A.1
Ziegler, W.H.2
Parekh, D.B.3
Alessi, D.R.4
Cohen, P.5
Parker, P.J.6
-
13
-
-
0030987070
-
Regulation of protein kinase C
-
A.C. Newton Regulation of protein kinase C Curr. Opin. Cell Biol. 9 1997 161 167
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 161-167
-
-
Newton, A.C.1
-
14
-
-
0343692517
-
Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cdelta: Possible correlation with tumor-promoting activity
-
K. Bogi, P.S. Lorenzo, Z. Szallasi, P. Acs, G.S. Wagner, and P.M. Blumberg Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cdelta: possible correlation with tumor-promoting activity Cancer Res. 58 1998 1423 1428
-
(1998)
Cancer Res.
, vol.58
, pp. 1423-1428
-
-
Bogi, K.1
Lorenzo, P.S.2
Szallasi, Z.3
Acs, P.4
Wagner, G.S.5
Blumberg, P.M.6
-
15
-
-
0034168037
-
Protein kinase C-mediated regulation of the cell cycle
-
J.D. Black Protein kinase C-mediated regulation of the cell cycle Front. Biosci. 5 2000 D406 D423
-
(2000)
Front. Biosci.
, vol.5
-
-
Black, J.D.1
-
16
-
-
3042647350
-
Protein kinase C and prostate carcinogenesis: Targeting the cell cycle and apoptotic mechanisms
-
M.V. Gavrielides, A.F. Frijhoff, C.J. Conti, and M.G. Kazanietz Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms Curr. Drug Targets 5 2004 431 443
-
(2004)
Curr. Drug Targets
, vol.5
, pp. 431-443
-
-
Gavrielides, M.V.1
Frijhoff, A.F.2
Conti, C.J.3
Kazanietz, M.G.4
-
17
-
-
0030795939
-
Linking protein kinase C to cell-cycle control
-
E. Livneh, and D.D. Fishman Linking protein kinase C to cell-cycle control Eur. J. Biochem. 248 1997 1 9
-
(1997)
Eur. J. Biochem.
, vol.248
, pp. 1-9
-
-
Livneh, E.1
Fishman, D.D.2
-
18
-
-
26644461205
-
Phorbol ester induced G1 phase arrest selectively mediated by a PKCdelta-dependent induction of p21
-
M. Nakagawa, J.L. Oliva, D. Kothapalli, A. Fournier, R.K. Assoian, and M.G. Kazanietz Phorbol ester induced G1 phase arrest selectively mediated by a PKCdelta-dependent induction of p21 J. Biol. Chem. 2005 (in press)
-
(2005)
J. Biol. Chem.
-
-
Nakagawa, M.1
Oliva, J.L.2
Kothapalli, D.3
Fournier, A.4
Assoian, R.K.5
Kazanietz, M.G.6
-
19
-
-
0027418816
-
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
-
H. Mischak, J.A. Goodnight, W. Kolch, G. Martiny-Baron, C. Schaechtle, M.G. Kazanietz, P.M. Blumberg, J.H. Pierce, and J.F. Mushinski Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity J. Biol. Chem. 268 1993 6090 6096
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 6090-6096
-
-
Mischak, H.1
Goodnight, J.A.2
Kolch, W.3
Martiny-Baron, G.4
Schaechtle, C.5
Kazanietz, M.G.6
Blumberg, P.M.7
Pierce, J.H.8
Mushinski, J.F.9
-
20
-
-
0033571747
-
Transgenic mice overexpressing protein kinase Cdelta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
-
P.J. Reddig, N.E. Dreckschmidt, H. Ahrens, R. Simsiman, C.P. Tseng, J. Zou, T.D. Oberley, and A.K. Verma Transgenic mice overexpressing protein kinase Cdelta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate Cancer Res. 59 1999 5710 5718
-
(1999)
Cancer Res.
, vol.59
, pp. 5710-5718
-
-
Reddig, P.J.1
Dreckschmidt, N.E.2
Ahrens, H.3
Simsiman, R.4
Tseng, C.P.5
Zou, J.6
Oberley, T.D.7
Verma, A.K.8
-
21
-
-
0033951214
-
Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion
-
P.J. Reddig, N.E. Dreckschmidt, J. Zou, S.E. Bourguignon, T.D. Oberley, and A.K. Verma Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion Cancer Res. 60 2000 595 602
-
(2000)
Cancer Res.
, vol.60
, pp. 595-602
-
-
Reddig, P.J.1
Dreckschmidt, N.E.2
Zou, J.3
Bourguignon, S.E.4
Oberley, T.D.5
Verma, A.K.6
-
22
-
-
0033577858
-
Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis
-
N.R. Murray, L.A. Davidson, R.S. Chapkin, W. Clay Gustafson, D.G. Schattenberg, and A.P. Fields Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis J. Cell Biol. 145 1999 699 711
-
(1999)
J. Cell Biol.
, vol.145
, pp. 699-711
-
-
Murray, N.R.1
Davidson, L.A.2
Chapkin, R.S.3
Clay Gustafson, W.4
Schattenberg, D.G.5
Fields, A.P.6
-
23
-
-
1542275216
-
Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells
-
J.A. Clark, A.R. Black, O.V. Leontieva, M.R. Frey, M.A. Pysz, L. Kunneva, A. Woloszynska-Read, D. Roy, and J.D. Black Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells J. Biol. Chem. 279 2004 9233 9247
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 9233-9247
-
-
Clark, J.A.1
Black, A.R.2
Leontieva, O.V.3
Frey, M.R.4
Pysz, M.A.5
Kunneva, L.6
Woloszynska-Read, A.7
Roy, D.8
Black, J.D.9
-
24
-
-
0033233483
-
Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
-
L. Li, P.S. Lorenzo, K. Bogi, P.M. Blumberg, and S.H. Yuspa Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector Mol. Cell. Biol. 19 1999 8547 8558
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 8547-8558
-
-
Li, L.1
Lorenzo, P.S.2
Bogi, K.3
Blumberg, P.M.4
Yuspa, S.H.5
-
25
-
-
0034875172
-
Involvement of protein kinase C-delta in DNA damage-induced apoptosis
-
A. Basu, M.D. Woolard, and C.L. Johnson Involvement of protein kinase C-delta in DNA damage-induced apoptosis Cell Death Differ. 8 2001 899 908
-
(2001)
Cell Death Differ.
, vol.8
, pp. 899-908
-
-
Basu, A.1
Woolard, M.D.2
Johnson, C.L.3
-
26
-
-
0036144679
-
Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C
-
M.F. Denning, Y. Wang, S. Tibudan, S. Alkan, B.J. Nickoloff, and J.Z. Qin Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C Cell Death Differ. 9 2002 40 52
-
(2002)
Cell Death Differ.
, vol.9
, pp. 40-52
-
-
Denning, M.F.1
Wang, Y.2
Tibudan, S.3
Alkan, S.4
Nickoloff, B.J.5
Qin, J.Z.6
-
27
-
-
12644268232
-
Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis
-
T. Ghayur, M. Hugunin, R.V. Talanian, S. Ratnofsky, C. Quinlan, Y. Emoto, P. Pandey, R. Datta, Y. Huang, S. Kharbanda, H. Allen, R. Kamen, W. Wong, and D. Kufe Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis J. Exp. Med. 184 1996 2399 2404
-
(1996)
J. Exp. Med.
, vol.184
, pp. 2399-2404
-
-
Ghayur, T.1
Hugunin, M.2
Talanian, R.V.3
Ratnofsky, S.4
Quinlan, C.5
Emoto, Y.6
Pandey, P.7
Datta, R.8
Huang, Y.9
Kharbanda, S.10
Allen, H.11
Kamen, R.12
Wong, W.13
Kufe, D.14
-
28
-
-
0037246123
-
Regulation of cell apoptosis by protein kinase C delta
-
C. Brodie, and P.M. Blumberg Regulation of cell apoptosis by protein kinase C delta Apoptosis 8 2003 19 27
-
(2003)
Apoptosis
, vol.8
, pp. 19-27
-
-
Brodie, C.1
Blumberg, P.M.2
-
29
-
-
0032523941
-
12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase
-
M. Garzotto, M. White-Jones, Y. Jiang, D. Ehleiter, W.C. Liao, A. Haimovitz-Friedman, Z. Fuks, and R. Kolesnick 12-O-tetradecanoylphorbol-13- acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase Cancer Res. 58 1998 2260 2264
-
(1998)
Cancer Res.
, vol.58
, pp. 2260-2264
-
-
Garzotto, M.1
White-Jones, M.2
Jiang, Y.3
Ehleiter, D.4
Liao, W.C.5
Haimovitz-Friedman, A.6
Fuks, Z.7
Kolesnick, R.8
-
30
-
-
0029834880
-
Persistent membrane translocation of protein kinase C alpha during 12-0-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells
-
C.T. Powell, N.J. Brittis, D. Stec, H. Hug, W.D. Heston, and W.R. Fair Persistent membrane translocation of protein kinase C alpha during 12-0-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells Cell Growth Differ. 7 1996 419 428
-
(1996)
Cell Growth Differ.
, vol.7
, pp. 419-428
-
-
Powell, C.T.1
Brittis, N.J.2
Stec, D.3
Hug, H.4
Heston, W.D.5
Fair, W.R.6
-
31
-
-
0035035730
-
RB activation and repression of C-MYC transcription precede apoptosis of human prostate epithelial cells
-
X. Zhao, and M.L. Day RB activation and repression of C-MYC transcription precede apoptosis of human prostate epithelial cells Urology 57 2001 860 865
-
(2001)
Urology
, vol.57
, pp. 860-865
-
-
Zhao, X.1
Day, M.L.2
-
32
-
-
0039765390
-
Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta
-
T. Fujii, M.L. Garcia-Bermejo, J.L. Bernabo, J. Caamano, M. Ohba, T. Kuroki, L. Li, S.H. Yuspa, and M.G. Kazanietz Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta J. Biol. Chem. 275 2000 7574 7582
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 7574-7582
-
-
Fujii, T.1
Garcia-Bermejo, M.L.2
Bernabo, J.L.3
Caamano, J.4
Ohba, M.5
Kuroki, T.6
Li, L.7
Yuspa, S.H.8
Kazanietz, M.G.9
-
33
-
-
18544378008
-
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.[erratum appears in J Biol. Chem. 2004 May 28;279(22):23846]
-
M.L. Garcia-Bermejo, F.C. Leskow, T. Fujii, Q. Wang, P.M. Blumberg, M. Ohba, T. Kuroki, K.C. Han, J. Lee, V.E. Marquez, and M.G. Kazanietz Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.[erratum appears in J Biol. Chem. 2004 May 28;279(22):23846] J. Biol. Chem. 277 2002 645 655
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 645-655
-
-
Garcia-Bermejo, M.L.1
Leskow, F.C.2
Fujii, T.3
Wang, Q.4
Blumberg, P.M.5
Ohba, M.6
Kuroki, T.7
Han, K.C.8
Lee, J.9
Marquez, V.E.10
Kazanietz, M.G.11
-
34
-
-
0141594871
-
Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway
-
Y. Tanaka, M.V. Gavrielides, Y. Mitsuuchi, T. Fujii, and M.G. Kazanietz Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway J. Biol. Chem. 278 2003 33753 33762
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 33753-33762
-
-
Tanaka, Y.1
Gavrielides, M.V.2
Mitsuuchi, Y.3
Fujii, T.4
Kazanietz, M.G.5
-
35
-
-
0037089018
-
Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer
-
D. Wu, T.L. Foreman, C.W. Gregory, M.A. McJilton, G.G. Wescott, O.H. Ford, R.F. Alvey, J.L. Mohler, and D.M. Terrian Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer Cancer Res. 62 2002 2423 2429
-
(2002)
Cancer Res.
, vol.62
, pp. 2423-2429
-
-
Wu, D.1
Foreman, T.L.2
Gregory, C.W.3
McJilton, M.A.4
Wescott, G.G.5
Ford, O.H.6
Alvey, R.F.7
Mohler, J.L.8
Terrian, D.M.9
-
36
-
-
0345549478
-
Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells
-
M.A. McJilton, C. Van Sikes, G.G. Wescott, D. Wu, T.L. Foreman, C.W. Gregory, D.A. Weidner, O. Harris Ford, A. Morgan Lasater, J.L. Mohler, and D.M. Terrian Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells Oncogene 22 2003 7958 7968
-
(2003)
Oncogene
, vol.22
, pp. 7958-7968
-
-
McJilton, M.A.1
Van Sikes, C.2
Wescott, G.G.3
Wu, D.4
Foreman, T.L.5
Gregory, C.W.6
Weidner, D.A.7
Harris Ford, O.8
Morgan Lasater, A.9
Mohler, J.L.10
Terrian, D.M.11
-
37
-
-
14044266895
-
Phorbol ester-induced apoptosis of C4-2 cells requires both a unique and a redundant protein kinase C signaling pathway
-
L. Yin, N. Bennani-Baiti, and C.T. Powell Phorbol ester-induced apoptosis of C4-2 cells requires both a unique and a redundant protein kinase C signaling pathway J. Biol. Chem. 280 2005 5533 5541
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 5533-5541
-
-
Yin, L.1
Bennani-Baiti, N.2
Powell, C.T.3
-
38
-
-
0036209077
-
Novel "nonkinase" phorbol ester receptors: The C1 domain connection. [erratum appears in Mol. Pharmacol. 2002 May; 61(5):1265]
-
M.G. Kazanietz Novel "nonkinase" phorbol ester receptors: the C1 domain connection. [erratum appears in Mol. Pharmacol. 2002 May; 61(5):1265] Mol. Pharmacol. 61 2002 759 767
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 759-767
-
-
Kazanietz, M.G.1
-
39
-
-
0029102822
-
Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis
-
M.G. Kazanietz, S. Wang, G.W. Milne, N.E. Lewin, H.L. Liu, and P.M. Blumberg Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis J. Biol. Chem. 270 1995 21852 21859
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 21852-21859
-
-
Kazanietz, M.G.1
Wang, S.2
Milne, G.W.3
Lewin, N.E.4
Liu, H.L.5
Blumberg, P.M.6
-
40
-
-
0028979464
-
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol este
-
G. Zhang, M.G. Kazanietz, P.M. Blumberg, and J.H. Hurley Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol este Cell 81 1995 917 924
-
(1995)
Cell
, vol.81
, pp. 917-924
-
-
Zhang, G.1
Kazanietz, M.G.2
Blumberg, P.M.3
Hurley, J.H.4
-
41
-
-
0035980111
-
Membrane targeting by C1 and C2 domains
-
W. Cho Membrane targeting by C1 and C2 domains J. Biol. Chem. 276 2001 32407 32410
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32407-32410
-
-
Cho, W.1
-
42
-
-
3142733752
-
Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta
-
R.V. Stahelin, M.A. Digman, M. Medkova, B. Ananthanarayanan, J.D. Rafter, H.R. Melowic, and W. Cho Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta J. Biol. Chem. 279 2004 29501 29512
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 29501-29512
-
-
Stahelin, R.V.1
Digman, M.A.2
Medkova, M.3
Ananthanarayanan, B.4
Rafter, J.D.5
Melowic, H.R.6
Cho, W.7
-
43
-
-
0141679354
-
Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C
-
J. Giorgione, M. Hysell, D.F. Harvey, and A.C. Newton Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C Biochemistry 42 2003 11194 11202
-
(2003)
Biochemistry
, vol.42
, pp. 11194-11202
-
-
Giorgione, J.1
Hysell, M.2
Harvey, D.F.3
Newton, A.C.4
-
44
-
-
0025070316
-
Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene
-
C. Hall, C. Monfries, P. Smith, H.H. Lim, R. Kozma, S. Ahmed, V. Vanniasingham, T. Leung, and L. Lim Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene J. Mol. Biol. 211 1990 11 16
-
(1990)
J. Mol. Biol.
, vol.211
, pp. 11-16
-
-
Hall, C.1
Monfries, C.2
Smith, P.3
Lim, H.H.4
Kozma, R.5
Ahmed, S.6
Vanniasingham, V.7
Leung, T.8
Lim, L.9
-
45
-
-
0036905264
-
Move over protein kinase C, you've got company: Alternative cellular effectors of diacylglycerol and phorbol esters
-
N. Brose, and C. Rosenmund Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters J. Cell Sci. 115 2002 4399 4411
-
(2002)
J. Cell Sci.
, vol.115
, pp. 4399-4411
-
-
Brose, N.1
Rosenmund, C.2
-
46
-
-
0034025493
-
Eyes wide shut: Protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters
-
M.G. Kazanietz Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters Mol. Carcinog. 28 2000 5 11
-
(2000)
Mol. Carcinog.
, vol.28
, pp. 5-11
-
-
Kazanietz, M.G.1
-
47
-
-
0027282112
-
Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes
-
C. Hall, W.C. Sin, M. Teo, G.J. Michael, P. Smith, J.M. Dong, H.H. Lim, E. Manser, N.K. Spurr, T.A. Jones, and L. Lim Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes Mol. Cell. Biol. 13 1993 4986 4998
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 4986-4998
-
-
Hall, C.1
Sin, W.C.2
Teo, M.3
Michael, G.J.4
Smith, P.5
Dong, J.M.6
Lim, H.H.7
Manser, E.8
Spurr, N.K.9
Jones, T.A.10
Lim, L.11
-
48
-
-
0027456496
-
Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis
-
T. Leung, B.E. How, E. Manser, and L. Lim Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis J. Biol. Chem. 268 1993 3813 3816
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 3813-3816
-
-
Leung, T.1
How, B.E.2
Manser, E.3
Lim, L.4
-
49
-
-
0028180706
-
Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain
-
T. Leung, B.E. How, E. Manser, and L. Lim Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain J. Biol. Chem. 269 1994 12888 12892
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 12888-12892
-
-
Leung, T.1
How, B.E.2
Manser, E.3
Lim, L.4
-
50
-
-
0025873083
-
Bcr encodes a GTPase-activating protein for p21rac
-
D. Diekmann, S. Brill, M.D. Garrett, N. Totty, J. Hsuan, C. Monfries, C. Hall, L. Lim, and A. Hall Bcr encodes a GTPase-activating protein for p21rac Nature 351 1991 400 402
-
(1991)
Nature
, vol.351
, pp. 400-402
-
-
Diekmann, D.1
Brill, S.2
Garrett, M.D.3
Totty, N.4
Hsuan, J.5
Monfries, C.6
Hall, C.7
Lim, L.8
Hall, A.9
-
51
-
-
0027258578
-
A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. the p21rac-GTPase activating protein n-chimaerin
-
S. Ahmed, J. Lee, R. Kozma, A. Best, C. Monfries, and L. Lim A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin J. Biol. Chem. 268 1993 10709 10712
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 10709-10712
-
-
Ahmed, S.1
Lee, J.2
Kozma, R.3
Best, A.4
Monfries, C.5
Lim, L.6
-
52
-
-
0028201009
-
Breakpoint cluster region gene product-related domain of n-chimaerin. Discrimination between Rac-binding and GTPase-activating residues by mutational analysis
-
S. Ahmed, J. Lee, L.P. Wen, Z. Zhao, J. Ho, A. Best, R. Kozma, and L. Lim Breakpoint cluster region gene product-related domain of n-chimaerin. Discrimination between Rac-binding and GTPase-activating residues by mutational analysis J. Biol. Chem. 269 1994 17642 17648
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 17642-17648
-
-
Ahmed, S.1
Lee, J.2
Wen, L.P.3
Zhao, Z.4
Ho, J.5
Best, A.6
Kozma, R.7
Lim, L.8
-
53
-
-
0142169536
-
Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor
-
M.J. Caloca, H. Wang, and M.G. Kazanietz Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor Biochem. J. 375 2003 313 321
-
(2003)
Biochem. J.
, vol.375
, pp. 313-321
-
-
Caloca, M.J.1
Wang, H.2
Kazanietz, M.G.3
-
54
-
-
0030611884
-
Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters
-
M.J. Caloca, N. Fernandez, N.E. Lewin, D. Ching, R. Modali, P.M. Blumberg, and M.G. Kazanietz Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters J. Biol. Chem. 272 1997 26488 26496
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 26488-26496
-
-
Caloca, M.J.1
Fernandez, N.2
Lewin, N.E.3
Ching, D.4
Modali, R.5
Blumberg, P.M.6
Kazanietz, M.G.7
-
55
-
-
0035947687
-
Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor
-
M.J. Caloca, H. Wang, A. Delemos, S. Wang, and M.G. Kazanietz Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor J. Biol. Chem. 276 2001 18303 18312
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18303-18312
-
-
Caloca, M.J.1
Wang, H.2
Delemos, A.3
Wang, S.4
Kazanietz, M.G.5
-
56
-
-
0037040248
-
Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): Evidence for a novel anchoring mechanism involving the chimaerin C1 domain
-
H. Wang, and M.G. Kazanietz Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain J. Biol. Chem. 277 2002 4541 4550
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 4541-4550
-
-
Wang, H.1
Kazanietz, M.G.2
-
57
-
-
0032589433
-
Beta2-chimaerin is a novel target for diacylglycerol: Binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain
-
M.J. Caloca, M.L. Garcia-Bermejo, P.M. Blumberg, N.E. Lewin, E. Kremmer, H. Mischak, S. Wang, K. Nacro, B. Bienfait, V.E. Marquez, and M.G. Kazanietz beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain Proc. Natl. Acad. Sci. U. S. A. 96 1999 11854 11859
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 11854-11859
-
-
Caloca, M.J.1
Garcia-Bermejo, M.L.2
Blumberg, P.M.3
Lewin, N.E.4
Kremmer, E.5
Mischak, H.6
Wang, S.7
Nacro, K.8
Bienfait, B.9
Marquez, V.E.10
Kazanietz, M.G.11
-
58
-
-
7044223022
-
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin
-
B. Canagarajah, F.C. Leskow, J.Y. Ho, H. Mischak, L.F. Saidi, M.G. Kazanietz, and J.H. Hurley Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin Cell 119 2004 407 418
-
(2004)
Cell
, vol.119
, pp. 407-418
-
-
Canagarajah, B.1
Leskow, F.C.2
Ho, J.Y.3
Mischak, H.4
Saidi, L.F.5
Kazanietz, M.G.6
Hurley, J.H.7
-
59
-
-
0038375063
-
Role of beta2-chimaerin in the behaviour of murine mammary carcinoma cells in response to extracellular matrix components
-
P.L. Menna, G. Skilton, F.C. Leskow, D.F. Alonso, D.E. Gomez, and M.G. Kazanietz Role of beta2-chimaerin in the behaviour of murine mammary carcinoma cells in response to extracellular matrix components Cancer Res. 63 2003 2284 2291
-
(2003)
Cancer Res.
, vol.63
, pp. 2284-2291
-
-
Menna, P.L.1
Skilton, G.2
Leskow, F.C.3
Alonso, D.F.4
Gomez, D.E.5
Kazanietz, M.G.6
-
60
-
-
21644476814
-
Rac-GAP-dependent inhibition of breast cancer cell proliferation by beta2-chimerin
-
C. Yang, Y. Liu, F. Coluccio Leskow, V.M. Weaver, and M.G. Kazanietz Rac-GAP-dependent inhibition of breast cancer cell proliferation by beta2-chimerin J. Biol. Chem. 280 2005 24363 24370
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 24363-24370
-
-
Yang, C.1
Liu, Y.2
Coluccio Leskow, F.3
Weaver, V.M.4
Kazanietz, M.G.5
-
61
-
-
0029133178
-
Identification and characterization of human beta 2-chimaerin: Association with malignant transformation in astrocytoma
-
S. Yuan, D.W. Miller, G.H. Barnett, J.F. Hahn, and B.R. Williams Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma Cancer Res. 55 1995 3456 3461
-
(1995)
Cancer Res.
, vol.55
, pp. 3456-3461
-
-
Yuan, S.1
Miller, D.W.2
Barnett, G.H.3
Hahn, J.F.4
Williams, B.R.5
-
62
-
-
0034776809
-
Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy
-
O.P. Barry, and M.G. Kazanietz Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy Curr. Pharm. Des. 7 2001 1725 1744
-
(2001)
Curr. Pharm. Des.
, vol.7
, pp. 1725-1744
-
-
Barry, O.P.1
Kazanietz, M.G.2
-
63
-
-
0041802953
-
Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent
-
B.T. Susarla, and M.B. Robinson Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent J. Neurochem. 86 2003 635 645
-
(2003)
J. Neurochem.
, vol.86
, pp. 635-645
-
-
Susarla, B.T.1
Robinson, M.B.2
-
64
-
-
0043016254
-
Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C
-
D.M. Tillman, K. Izeradjene, K.S. Szucs, L. Douglas, and J.A. Houghton Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C Cancer Res. 63 2003 5118 5125
-
(2003)
Cancer Res.
, vol.63
, pp. 5118-5125
-
-
Tillman, D.M.1
Izeradjene, K.2
Szucs, K.S.3
Douglas, L.4
Houghton, J.A.5
-
65
-
-
0036786206
-
Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C
-
D. Yu, M.G. Kazanietz, R.G. Harvey, and T.M. Penning Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C Biochemistry 41 2002 11888 11894
-
(2002)
Biochemistry
, vol.41
, pp. 11888-11894
-
-
Yu, D.1
Kazanietz, M.G.2
Harvey, R.G.3
Penning, T.M.4
-
66
-
-
0028144758
-
Close similarity of baculovirus-expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors
-
L.B. Areces, M.G. Kazanietz, and P.M. Blumberg Close similarity of baculovirus-expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors J. Biol. Chem. 269 1994 19553 19558
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 19553-19558
-
-
Areces, L.B.1
Kazanietz, M.G.2
Blumberg, P.M.3
-
67
-
-
0034796216
-
Adaptor proteins in protein kinase C-mediated signal transduction
-
D. Schechtman, and D. Mochly-Rosen Adaptor proteins in protein kinase C-mediated signal transduction Methods Enzymol. 345 2002 470 489
-
(2002)
Methods Enzymol.
, vol.345
, pp. 470-489
-
-
Schechtman, D.1
Mochly-Rosen, D.2
-
68
-
-
0035117119
-
Phorbol esters modulate the Ras exchange factor RasGRP3
-
P.S. Lorenzo, J.W. Kung, D.A. Bottorff, S.H. Garfield, J.C. Stone, and P.M. Blumberg Phorbol esters modulate the Ras exchange factor RasGRP3 Cancer Res. 61 2001 943 949
-
(2001)
Cancer Res.
, vol.61
, pp. 943-949
-
-
Lorenzo, P.S.1
Kung, J.W.2
Bottorff, D.A.3
Garfield, S.H.4
Stone, J.C.5
Blumberg, P.M.6
-
69
-
-
0347993052
-
RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes
-
R.A. Rambaratsingh, J.C. Stone, P.M. Blumberg, and P.S. Lorenzo RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes J. Biol. Chem. 278 2003 52792 527801
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52792-527801
-
-
Rambaratsingh, R.A.1
Stone, J.C.2
Blumberg, P.M.3
Lorenzo, P.S.4
-
70
-
-
0034061660
-
The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters
-
P.S. Lorenzo, M. Beheshti, G.R. Pettit, J.C. Stone, and P.M. Blumberg The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters Mol. Pharmacol. 57 2000 840 846
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 840-846
-
-
Lorenzo, P.S.1
Beheshti, M.2
Pettit, G.R.3
Stone, J.C.4
Blumberg, P.M.5
-
71
-
-
0000356405
-
Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: Preliminary studies on therapeutic efficacy and toxicity
-
Z.T. Han, X.X. Zhu, R.Y. Yang, J.Z. Sun, G.F. Tian, X.J. Liu, G.S. Cao, H.L. Newmark, A.H. Conney, and R.L. Chang Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity Proc. Natl. Acad. Sci. U. S. A. 95 1998 5357 5361
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 5357-5361
-
-
Han, Z.T.1
Zhu, X.X.2
Yang, R.Y.3
Sun, J.Z.4
Tian, G.F.5
Liu, X.J.6
Cao, G.S.7
Newmark, H.L.8
Conney, A.H.9
Chang, R.L.10
|