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Volumn 24, Issue 24, 2004, Pages 10515-10528

A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHORBOID RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PROTEIN KINASE C; RAS GUANINE RELEASING PROTEIN 3; RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 10044256619     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.24.10515-10528.2004     Document Type: Article
Times cited : (42)

References (82)
  • 1
    • 0035876321 scopus 로고    scopus 로고
    • Assembly of trunk and limb blood vessels involves extensive migration and vasculogenesis of somite-derived angioblasts
    • Ambler, C. A., J. L. Nowicki, A. C. Burke, and V. L. Bautch. 2001. Assembly of trunk and limb blood vessels involves extensive migration and vasculogenesis of somite-derived angioblasts. Dev. Biol. 234:352-364.
    • (2001) Dev. Biol. , vol.234 , pp. 352-364
    • Ambler, C.A.1    Nowicki, J.L.2    Burke, A.C.3    Bautch, V.L.4
  • 2
    • 0037403556 scopus 로고    scopus 로고
    • Stem cell-derived endothelial cells/progenitors migrate and pattern in the embryo using the VEGF signaling pathway
    • Ambler, C. A., G. M. Schmunk, and V. L. Bautch. 2003. Stem cell-derived endothelial cells/progenitors migrate and pattern in the embryo using the VEGF signaling pathway. Dev. Biol. 257:205-219.
    • (2003) Dev. Biol. , vol.257 , pp. 205-219
    • Ambler, C.A.1    Schmunk, G.M.2    Bautch, V.L.3
  • 3
    • 0035945351 scopus 로고    scopus 로고
    • A novel Db1 family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion
    • Bashaw, G. J., H. Hu, C. D. Nobes, and C. S. Goodman. 2001. A novel Db1 family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion. J. Cell Biol. 155:1117-1122.
    • (2001) J. Cell Biol. , vol.155 , pp. 1117-1122
    • Bashaw, G.J.1    Hu, H.2    Nobes, C.D.3    Goodman, C.S.4
  • 4
    • 0036133877 scopus 로고    scopus 로고
    • Embryonic stem cell differentiation and the vascular lineage
    • Bautch, V. L. 2002. Embryonic stem cell differentiation and the vascular lineage. Methods Mol. Biol. 185:117-125.
    • (2002) Methods Mol. Biol. , vol.185 , pp. 117-125
    • Bautch, V.L.1
  • 5
    • 0034653482 scopus 로고    scopus 로고
    • Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A
    • Bautch, V. L., S. D. Redick, A. Scalia, M. Harmaty, P. Carmeliet, and R. Rapoport. 2000. Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A. Blood 95:1979-1987.
    • (2000) Blood , vol.95 , pp. 1979-1987
    • Bautch, V.L.1    Redick, S.D.2    Scalia, A.3    Harmaty, M.4    Carmeliet, P.5    Rapoport, R.6
  • 6
    • 0037451803 scopus 로고    scopus 로고
    • GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila
    • Bernards, A. 2003. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim. Biophys. Acta 1603:47-82.
    • (2003) Biochim. Biophys. Acta , vol.1603 , pp. 47-82
    • Bernards, A.1
  • 10
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee, M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 15
    • 0036340212 scopus 로고    scopus 로고
    • Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation
    • Damert, A., L. Miquerol, M. Gertsenstein, W. Risau, and A. Nagy. 2002. Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation. Development 129:1881-1892.
    • (2002) Development , vol.129 , pp. 1881-1892
    • Damert, A.1    Miquerol, L.2    Gertsenstein, M.3    Risau, W.4    Nagy, A.5
  • 16
    • 0033855011 scopus 로고    scopus 로고
    • Endothelial signal integration in vascular assembly
    • Daniel, T. O., and D. Abrahamson. 2000. Endothelial signal integration in vascular assembly. Annu. Rev. Physiol. 62:649-671.
    • (2000) Annu. Rev. Physiol. , vol.62 , pp. 649-671
    • Daniel, T.O.1    Abrahamson, D.2
  • 17
    • 0041737795 scopus 로고    scopus 로고
    • Signal transduction: Life on Mars, cellularly speaking
    • Di Fiore, P. P. 2003. Signal transduction: life on Mars, cellularly speaking. Nature 424:624-625.
    • (2003) Nature , vol.424 , pp. 624-625
    • Di Fiore, P.P.1
  • 20
    • 0029955128 scopus 로고    scopus 로고
    • Control of ras activation
    • Downward, J. 1996. Control of ras activation. Cancer Surv. 27:87-100.
    • (1996) Cancer Surv. , vol.27 , pp. 87-100
    • Downward, J.1
  • 21
    • 0025941560 scopus 로고
    • Isolation and characterization of an established endothelial cell line from transgenic mouse hemangiomas
    • Dubois, N. A., L. C. Kolpack, R. Wang, R. G. Azizkhan, and V. L. Bautch. 1991. Isolation and characterization of an established endothelial cell line from transgenic mouse hemangiomas. Exp. Cell Res. 196:302-313.
    • (1991) Exp. Cell Res. , vol.196 , pp. 302-313
    • Dubois, N.A.1    Kolpack, L.C.2    Wang, R.3    Azizkhan, R.G.4    Bautch, V.L.5
  • 22
    • 0032524389 scopus 로고    scopus 로고
    • RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
    • Ebinu, J. O., D. A. Bottorff, E. Y. Chan, S. L. Stang, R. J. Dunn, and J. C. Stone. 1998. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science 280:1082-1086.
    • (1998) Science , vol.280 , pp. 1082-1086
    • Ebinu, J.O.1    Bottorff, D.A.2    Chan, E.Y.3    Stang, S.L.4    Dunn, R.J.5    Stone, J.C.6
  • 26
    • 0032559597 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces endothelial fenestrations in vitro
    • Esser, S., K. Wolburg, H. Wolburg, G. Breier, T. Kurzchalia, and W. Risau. 1998. Vascular endothelial growth factor induces endothelial fenestrations in vitro. J. Cell Biol. 140:947-959.
    • (1998) J. Cell Biol. , vol.140 , pp. 947-959
    • Esser, S.1    Wolburg, K.2    Wolburg, H.3    Breier, G.4    Kurzchalia, T.5    Risau, W.6
  • 29
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara, N., H. P. Gerber, and J. LeCouter. 2003. The biology of VEGF and its receptors. Nat. Med. 9:669-676.
    • (2003) Nat. Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 30
    • 0141988568 scopus 로고    scopus 로고
    • Fundamental concepts of the angiogenic process
    • Folkman, J. 2003. Fundamental concepts of the angiogenic process. Curr. Mol. Med. 3:643-651.
    • (2003) Curr. Mol. Med. , vol.3 , pp. 643-651
    • Folkman, J.1
  • 31
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong, G. H., J. Rossant, M. Gertsenstein, and M. L. Breitman. 1995. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 32
    • 0028963912 scopus 로고
    • Gene knock-out technology: A methodological overview for the interested novice
    • Galli-Taliadoros, L. A., J. D. Sedgwick, S. A. Wood, and H. Korner. 1995. Gene knock-out technology: a methodological overview for the interested novice. J. Immunol. Methods 181:1-15.
    • (1995) J. Immunol. Methods , vol.181 , pp. 1-15
    • Galli-Taliadoros, L.A.1    Sedgwick, J.D.2    Wood, S.A.3    Korner, H.4
  • 35
    • 0026587657 scopus 로고
    • Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
    • Guy, C. T., R. D. Cardiff, and W. J. Muller. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol. Cell. Biol. 12:954-961.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 954-961
    • Guy, C.T.1    Cardiff, R.D.2    Muller, W.J.3
  • 37
  • 38
    • 0042386426 scopus 로고    scopus 로고
    • Differential αv integrin-mediated Ras-ERK signaling during two pathways of angiogenesis
    • Hood, J. D., R. Frausto, W. B. Kiosses, M. A. Schwartz, and D. A. Cheresh. 2003. Differential αv integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. J. Cell Biol. 162:933-943.
    • (2003) J. Cell Biol. , vol.162 , pp. 933-943
    • Hood, J.D.1    Frausto, R.2    Kiosses, W.B.3    Schwartz, M.A.4    Cheresh, D.A.5
  • 39
    • 33751269676 scopus 로고    scopus 로고
    • Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability
    • Huang, Q., and Y. Yuan. 1997. Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability. Am. J. Physiol. 273:H2442-H2451.
    • (1997) Am. J. Physiol. , vol.273
    • Huang, Q.1    Yuan, Y.2
  • 42
    • 0036530222 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division
    • Kearney, J. B., C. A. Ambler, K. A. Monaco, N. Johnson, R. G. Rapoport, and V. L. Bautch. 2002. Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division. Blood 99:2397-2407.
    • (2002) Blood , vol.99 , pp. 2397-2407
    • Kearney, J.B.1    Ambler, C.A.2    Monaco, K.A.3    Johnson, N.4    Rapoport, R.G.5    Bautch, V.L.6
  • 43
    • 0346220080 scopus 로고    scopus 로고
    • In vitro differentiation of mouse ES cells: Hematopoietic and vascular development
    • Kearney, J. B., and V. L. Bautch. 2003. In vitro differentiation of mouse ES cells: hematopoietic and vascular development. Methods Enzymol. 365:83-98.
    • (2003) Methods Enzymol. , vol.365 , pp. 83-98
    • Kearney, J.B.1    Bautch, V.L.2
  • 44
    • 2942556514 scopus 로고    scopus 로고
    • The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis
    • Kearney, J. B., N. C. Kappas, C. Ellerstrom, F. W. DiPaola, and V. L. Bautch. 2004. The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis. Blood 103:4527-4535.
    • (2004) Blood , vol.103 , pp. 4527-4535
    • Kearney, J.B.1    Kappas, N.C.2    Ellerstrom, C.3    DiPaola, F.W.4    Bautch, V.L.5
  • 46
    • 0034061660 scopus 로고    scopus 로고
    • The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters
    • Lorenzo, P. S., M. Beheshti, G. R. Pettit, J. C. Stone, and P. M. Blumberg. 2000. The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters. Mol. Pharmacol. 57:840-846.
    • (2000) Mol. Pharmacol. , vol.57 , pp. 840-846
    • Lorenzo, P.S.1    Beheshti, M.2    Pettit, G.R.3    Stone, J.C.4    Blumberg, P.M.5
  • 48
    • 0035966004 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation
    • Meadows, K. N., P. Bryant, and K. Pumiglia. 2001. Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J. Biol. Chem. 276:49289-49298.
    • (2001) J. Biol. Chem. , vol.276 , pp. 49289-49298
    • Meadows, K.N.1    Bryant, P.2    Pumiglia, K.3
  • 49
    • 0942301171 scopus 로고    scopus 로고
    • Activated Ras induces a proangiogenic phenotype in primary endothelial cells
    • Meadows, K. N., P. Bryant, P. A. Vincent, and K. M. Pumiglia. 2004. Activated Ras induces a proangiogenic phenotype in primary endothelial cells. Oncogene 23:192-200.
    • (2004) Oncogene , vol.23 , pp. 192-200
    • Meadows, K.N.1    Bryant, P.2    Vincent, P.A.3    Pumiglia, K.M.4
  • 50
    • 0033793921 scopus 로고    scopus 로고
    • Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression
    • Miquerol, L., B. L. Langille, and A. Nagy. 2000. Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression. Development 127:3941-3946.
    • (2000) Development , vol.127 , pp. 3941-3946
    • Miquerol, L.1    Langille, B.L.2    Nagy, A.3
  • 51
    • 0032585352 scopus 로고    scopus 로고
    • Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
    • Nagase, T., K. Ishikawa, M. Suyama, R. Kikuno, M. Hirosawa, N. Miyajima, A. Tanaka, H. Kotani, N. Nomura, and O. Ohara. 1998. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5:355-364.
    • (1998) DNA Res. , vol.5 , pp. 355-364
    • Nagase, T.1    Ishikawa, K.2    Suyama, M.3    Kikuno, R.4    Hirosawa, M.5    Miyajima, N.6    Tanaka, A.7    Kotani, H.8    Nomura, N.9    Ohara, O.10
  • 52
    • 0030053505 scopus 로고    scopus 로고
    • Protein kinase C β 1 overexpression augments phorbol ester-induced increase in endothelial permeability
    • Nagpala, P. G., A. B. Malik, P. T. Vuong, and H. Lum. 1996. Protein kinase C β 1 overexpression augments phorbol ester-induced increase in endothelial permeability. J. Cell. Physiol. 166:249-255.
    • (1996) J. Cell. Physiol. , vol.166 , pp. 249-255
    • Nagpala, P.G.1    Malik, A.B.2    Vuong, P.T.3    Lum, H.4
  • 53
    • 0347593996 scopus 로고    scopus 로고
    • Requirement for Ras guanine nucleolide releasing protein 3 in coupling phospholipase C-γ2 to Ras in B cell receptor signaling
    • Oh-hora, M., S. Johmura, A. Hashimoto, M. Hikida, and T. Kurosaki. 2003. Requirement for Ras guanine nucleolide releasing protein 3 in coupling phospholipase C-γ2 to Ras in B cell receptor signaling. J. Exp. Med. 198:1841-1851.
    • (2003) J. Exp. Med. , vol.198 , pp. 1841-1851
    • Oh-Hora, M.1    Johmura, S.2    Hashimoto, A.3    Hikida, M.4    Kurosaki, T.5
  • 54
    • 0036364408 scopus 로고    scopus 로고
    • A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases
    • Quilliam, L. A., J. F. Rebhun, and A. F. Castro. 2002. A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. Prog. Nucleic Acid Res. Mol. Biol. 71:391-444.
    • (2002) Prog. Nucleic Acid Res. Mol. Biol. , vol.71 , pp. 391-444
    • Quilliam, L.A.1    Rebhun, J.F.2    Castro, A.F.3
  • 55
    • 0034634534 scopus 로고    scopus 로고
    • Identification of guanine nucleotide exchange factors (GEFs) for the Rapl GTPase. Regulation of MR-GEF by M-Ras-GTP interaction
    • Rebhun, J. F., A. F. Castro, and L. A. Quilliam. 2000. Identification of guanine nucleotide exchange factors (GEFs) for the Rapl GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. J. Biol. Chem. 275:34901-34908.
    • (2000) J. Biol. Chem. , vol.275 , pp. 34901-34908
    • Rebhun, J.F.1    Castro, A.F.2    Quilliam, L.A.3
  • 57
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau, W. 1997. Mechanisms of angiogenesis. Nature 386:671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 58
    • 0033840069 scopus 로고    scopus 로고
    • Coexpression of neuropilin-1, FIk1, and VEGF164 in developing and mature mouse kidney glomeruli
    • Robert, B., X. Zhao, and D. R. Abrahamson. 2000. Coexpression of neuropilin-1, FIk1, and VEGF164 in developing and mature mouse kidney glomeruli. Am. J. Physiol. Renal Physiol. 279:F275-F282.
    • (2000) Am. J. Physiol. Renal Physiol. , vol.279
    • Robert, B.1    Zhao, X.2    Abrahamson, D.R.3
  • 59
    • 1942437424 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation
    • Roberts, D. M., J. B. Kearney, J. H. Johnson, M. P. Rosenberg, R. Kumar, and V. L. Bautch. 2004. The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation. Am. J. Pathol. 164:1531-1535.
    • (2004) Am. J. Pathol. , vol.164 , pp. 1531-1535
    • Roberts, D.M.1    Kearney, J.B.2    Johnson, J.H.3    Rosenberg, M.P.4    Kumar, R.5    Bautch, V.L.6
  • 60
    • 0029010434 scopus 로고
    • Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
    • Roberts, W. G., and G. E. Palade. 1995. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J. Cell Sci. 108:2369-2379.
    • (1995) J. Cell Sci. , vol.108 , pp. 2369-2379
    • Roberts, W.G.1    Palade, G.E.2
  • 61
    • 0027310879 scopus 로고
    • Whole-mount in situ hybridization in the mouse embryo: Gene expression in three dimensions
    • Rosen, B., and R. S. Beddington. 1993. Whole-mount in situ hybridization in the mouse embryo: gene expression in three dimensions. Trends Genet. 9:162-167.
    • (1993) Trends Genet. , vol.9 , pp. 162-167
    • Rosen, B.1    Beddington, R.S.2
  • 62
    • 0037108152 scopus 로고    scopus 로고
    • Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    • Ruhrberg, C., H. Gerhardt, M. Golding, R. Watson, S. Ioannidou, H. Fujisawa, C. Betsholtz, and D. T. Shima. 2002. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev. 16:2684-2698.
    • (2002) Genes Dev. , vol.16 , pp. 2684-2698
    • Ruhrberg, C.1    Gerhardt, H.2    Golding, M.3    Watson, R.4    Ioannidou, S.5    Fujisawa, H.6    Betsholtz, C.7    Shima, D.T.8
  • 64
    • 0141996422 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2: Its unique signaling and specific ligand, VEGF-E
    • Shibuya, M. 2003. Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E. Cancer Sci. 94:751-756.
    • (2003) Cancer Sci. , vol.94 , pp. 751-756
    • Shibuya, M.1
  • 66
    • 0036841720 scopus 로고    scopus 로고
    • Sphingosine kinase mediates vascular endothelial growth factor-induced activation of Ras and mitogen-activated protein kinases
    • Shu, X., W. Wu, R. D. Mosteller, and D. Broela. 2002. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of Ras and mitogen-activated protein kinases. Mol. Cell. Biol. 22:7758-7768.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7758-7768
    • Shu, X.1    Wu, W.2    Mosteller, R.D.3    Broela, D.4
  • 67
    • 0032535384 scopus 로고    scopus 로고
    • Expression trapping: Identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells
    • Stanford, W. L., G. Caruana, K. A. Vallis, M. Inamdar, M. Hidaka, V. L. Bautch, and A. Bernstein. 1998. Expression trapping: identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells. Blood 92:4622-4631.
    • (1998) Blood , vol.92 , pp. 4622-4631
    • Stanford, W.L.1    Caruana, G.2    Vallis, K.A.3    Inamdar, M.4    Hidaka, M.5    Bautch, V.L.6    Bernstein, A.7
  • 69
    • 0031008750 scopus 로고    scopus 로고
    • The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts
    • Takahashi, T., and M. Shibuya. 1997. The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 14:2079-2089.
    • (1997) Oncogene , vol.14 , pp. 2079-2089
    • Takahashi, T.1    Shibuya, M.2
  • 70
    • 0033118228 scopus 로고    scopus 로고
    • VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
    • Takahashi, T., H. Ueno, and M. Shibuya. 1999. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18:2221-2230.
    • (1999) Oncogene , vol.18 , pp. 2221-2230
    • Takahashi, T.1    Ueno, H.2    Shibuya, M.3
  • 71
    • 0042237772 scopus 로고    scopus 로고
    • Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3
    • Teixeira, C., S. L. Stang, Y. Zheng, N. S. Beswick, and J. C. Stone. 2003. Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. Blood 102:1414-1420.
    • (2003) Blood , vol.102 , pp. 1414-1420
    • Teixeira, C.1    Stang, S.L.2    Zheng, Y.3    Beswick, N.S.4    Stone, J.C.5
  • 76
    • 0031043507 scopus 로고    scopus 로고
    • Mutation in Sosl dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sosl in EGFR signaling and development
    • Wang, D. Z., V. E. Hammond, H. E. Abud, I. Bertoncello, J. W. McAvoy, and D. D. Bowtell. 1997. Mutation in Sosl dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sosl in EGFR signaling and development. Genes Dev. 11:309-320.
    • (1997) Genes Dev. , vol.11 , pp. 309-320
    • Wang, D.Z.1    Hammond, V.E.2    Abud, H.E.3    Bertoncello, I.4    McAvoy, J.W.5    Bowtell, D.D.6
  • 77
    • 0035669720 scopus 로고    scopus 로고
    • Protein kinase C and the development of diabetic vascular complications
    • Way, K. J., N. Katai, and G. L. King. 2001. Protein kinase C and the development of diabetic vascular complications. Diabet. Med. 18:945-959.
    • (2001) Diabet. Med. , vol.18 , pp. 945-959
    • Way, K.J.1    Katai, N.2    King, G.L.3
  • 80
    • 0036845084 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: Relative roles of KDR and Flt-1 receptors
    • Yang, S., K. Toy, G. Ingle, C. Zlot, P. M. Williams, G. Fuh, B. Li, A. de Vos, and M. E. Gerritsen. 2002. Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: relative roles of KDR and Flt-1 receptors. Arterioscler. Thromb. Vasc. Biol. 22:1797-1803.
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 1797-1803
    • Yang, S.1    Toy, K.2    Ingle, G.3    Zlot, C.4    Williams, P.M.5    Fuh, G.6    Li, B.7    De Vos, A.8    Gerritsen, M.E.9
  • 81
    • 0037067713 scopus 로고    scopus 로고
    • RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function
    • Yang, Y., L. Li, G. W. Wong, S. A. Krilis, M. S. Madhusudhan, A. Sali, and R. L. Stevens. 2002. RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. J. Biol. Chem. 277:25756-25774.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25756-25774
    • Yang, Y.1    Li, L.2    Wong, G.W.3    Krilis, S.A.4    Madhusudhan, M.S.5    Sali, A.6    Stevens, R.L.7
  • 82
    • 0035920244 scopus 로고    scopus 로고
    • Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 downmodulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathwavs
    • Zeng, H., H. F. Dvorak, and D. Mukhopadhyay. 2001. Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 downmodulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathwavs. J. Biol. Chem. 276:26969-26979.
    • (2001) J. Biol. Chem. , vol.276 , pp. 26969-26979
    • Zeng, H.1    Dvorak, H.F.2    Mukhopadhyay, D.3


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