-
1
-
-
0035876321
-
Assembly of trunk and limb blood vessels involves extensive migration and vasculogenesis of somite-derived angioblasts
-
Ambler, C. A., J. L. Nowicki, A. C. Burke, and V. L. Bautch. 2001. Assembly of trunk and limb blood vessels involves extensive migration and vasculogenesis of somite-derived angioblasts. Dev. Biol. 234:352-364.
-
(2001)
Dev. Biol.
, vol.234
, pp. 352-364
-
-
Ambler, C.A.1
Nowicki, J.L.2
Burke, A.C.3
Bautch, V.L.4
-
2
-
-
0037403556
-
Stem cell-derived endothelial cells/progenitors migrate and pattern in the embryo using the VEGF signaling pathway
-
Ambler, C. A., G. M. Schmunk, and V. L. Bautch. 2003. Stem cell-derived endothelial cells/progenitors migrate and pattern in the embryo using the VEGF signaling pathway. Dev. Biol. 257:205-219.
-
(2003)
Dev. Biol.
, vol.257
, pp. 205-219
-
-
Ambler, C.A.1
Schmunk, G.M.2
Bautch, V.L.3
-
3
-
-
0035945351
-
A novel Db1 family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion
-
Bashaw, G. J., H. Hu, C. D. Nobes, and C. S. Goodman. 2001. A novel Db1 family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion. J. Cell Biol. 155:1117-1122.
-
(2001)
J. Cell Biol.
, vol.155
, pp. 1117-1122
-
-
Bashaw, G.J.1
Hu, H.2
Nobes, C.D.3
Goodman, C.S.4
-
4
-
-
0036133877
-
Embryonic stem cell differentiation and the vascular lineage
-
Bautch, V. L. 2002. Embryonic stem cell differentiation and the vascular lineage. Methods Mol. Biol. 185:117-125.
-
(2002)
Methods Mol. Biol.
, vol.185
, pp. 117-125
-
-
Bautch, V.L.1
-
5
-
-
0034653482
-
Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A
-
Bautch, V. L., S. D. Redick, A. Scalia, M. Harmaty, P. Carmeliet, and R. Rapoport. 2000. Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A. Blood 95:1979-1987.
-
(2000)
Blood
, vol.95
, pp. 1979-1987
-
-
Bautch, V.L.1
Redick, S.D.2
Scalia, A.3
Harmaty, M.4
Carmeliet, P.5
Rapoport, R.6
-
6
-
-
0037451803
-
GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila
-
Bernards, A. 2003. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim. Biophys. Acta 1603:47-82.
-
(2003)
Biochim. Biophys. Acta
, vol.1603
, pp. 47-82
-
-
Bernards, A.1
-
7
-
-
0028349997
-
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
-
Brannan, C. I., A. S. Perkins, K. S. Vogel, N. Ratner, M. L. Nordlund, S. W. Reid, A. M. Buchberg, N. A. Jenkins, L. F. Parada, and N. G. Copeland. 1994. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 8:1019-1029.
-
(1994)
Genes Dev.
, vol.8
, pp. 1019-1029
-
-
Brannan, C.I.1
Perkins, A.S.2
Vogel, K.S.3
Ratner, N.4
Nordlund, M.L.5
Reid, S.W.6
Buchberg, A.M.7
Jenkins, N.A.8
Parada, L.F.9
Copeland, N.G.10
-
8
-
-
3042630992
-
PKCδ associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters
-
Brodie, C., R. Steinhart, G. Kazimirsky, H. Rubinfeld, T. Hyman, J. N. Ayres, G. M. Hur, A. Toth, D. Yang, S. H. Garfield, J. C. Stone, and P. M. Blumberg. 2004. PKCδ associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters. Mol. Pharmacol. 66:76-84.
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 76-84
-
-
Brodie, C.1
Steinhart, R.2
Kazimirsky, G.3
Rubinfeld, H.4
Hyman, T.5
Ayres, J.N.6
Hur, G.M.7
Toth, A.8
Yang, D.9
Garfield, S.H.10
Stone, J.C.11
Blumberg, P.M.12
-
9
-
-
0026487867
-
Vascular permeability factor mRNA and protein expression in human kidney
-
Brown, L. F., B. Berse, K. Tognazzi, E. J. Manseau, L. Van de Water, D. R. Senger, H. F. Dvorak, and S. Rosen. 1992. Vascular permeability factor mRNA and protein expression in human kidney. Kidney Int. 42:1457-1461.
-
(1992)
Kidney Int.
, vol.42
, pp. 1457-1461
-
-
Brown, L.F.1
Berse, B.2
Tognazzi, K.3
Manseau, E.J.4
Van De Water, L.5
Senger, D.R.6
Dvorak, H.F.7
Rosen, S.8
-
10
-
-
0035856980
-
Biochemistry and molecular cell biology of diabetic complications
-
Brownlee, M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820.
-
(2001)
Nature
, vol.414
, pp. 813-820
-
-
Brownlee, M.1
-
11
-
-
0343920277
-
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
-
Carmeliet, P., V. Ferreira, G. Breier, S. Pollefeyt, L. Kieckens, M. Gertsenstein, M. Fahrig, A. Vandenhoeck, K. Harpal, C. Eberhardt, C. Declercq, J. Pawling, L. Moons, D. Collen, W. Risau, and A. Nagy. 1996. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435-439.
-
(1996)
Nature
, vol.380
, pp. 435-439
-
-
Carmeliet, P.1
Ferreira, V.2
Breier, G.3
Pollefeyt, S.4
Kieckens, L.5
Gertsenstein, M.6
Fahrig, M.7
Vandenhoeck, A.8
Harpal, K.9
Eberhardt, C.10
Declercq, C.11
Pawling, J.12
Moons, L.13
Collen, D.14
Risau, W.15
Nagy, A.16
-
12
-
-
0034644772
-
Characterization of Ras-GRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor
-
Clyde-Smith, J., G. Silins, M. Gartside, S. Grimmond, M. Etheridge, A. Apolloni, N. Hayward, and J. F. Hancock. 2000. Characterization of Ras-GRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. J. Biol. Chem. 275:32260-32267.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 32260-32267
-
-
Clyde-Smith, J.1
Silins, G.2
Gartside, M.3
Grimmond, S.4
Etheridge, M.5
Apolloni, A.6
Hayward, N.7
Hancock, J.F.8
-
13
-
-
4644221351
-
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
-
Crittenden, J. R., W. Bergmeier, Y. Zhang, C. L. Piffath, Y. Liang, D. D. Wagner, D. E. Housman, and A. M. Graybiel. 2004. CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat. Med. 10:982-986.
-
(2004)
Nat. Med.
, vol.10
, pp. 982-986
-
-
Crittenden, J.R.1
Bergmeier, W.2
Zhang, Y.3
Piffath, C.L.4
Liang, Y.5
Wagner, D.D.6
Housman, D.E.7
Graybiel, A.M.8
-
14
-
-
0642306485
-
VEGF-receptor signal transduction
-
Cross, M. J., J. Dixelius, T. Matsumoto, and L. Claesson-Welsh. 2003. VEGF-receptor signal transduction. Trends Biochem. Sci. 28:488-494.
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 488-494
-
-
Cross, M.J.1
Dixelius, J.2
Matsumoto, T.3
Claesson-Welsh, L.4
-
15
-
-
0036340212
-
Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation
-
Damert, A., L. Miquerol, M. Gertsenstein, W. Risau, and A. Nagy. 2002. Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation. Development 129:1881-1892.
-
(2002)
Development
, vol.129
, pp. 1881-1892
-
-
Damert, A.1
Miquerol, L.2
Gertsenstein, M.3
Risau, W.4
Nagy, A.5
-
16
-
-
0033855011
-
Endothelial signal integration in vascular assembly
-
Daniel, T. O., and D. Abrahamson. 2000. Endothelial signal integration in vascular assembly. Annu. Rev. Physiol. 62:649-671.
-
(2000)
Annu. Rev. Physiol.
, vol.62
, pp. 649-671
-
-
Daniel, T.O.1
Abrahamson, D.2
-
17
-
-
0041737795
-
Signal transduction: Life on Mars, cellularly speaking
-
Di Fiore, P. P. 2003. Signal transduction: life on Mars, cellularly speaking. Nature 424:624-625.
-
(2003)
Nature
, vol.424
, pp. 624-625
-
-
Di Fiore, P.P.1
-
18
-
-
0033573895
-
VEGF stimulates MARK through a pathway that is unique for receptor tyrosine kinases
-
Doanes, A. M., D. D. Hegland, R. Sethi, I. Kovesdi, J. T. Bruder, and T. Finkel. 1999. VEGF stimulates MARK through a pathway that is unique for receptor tyrosine kinases. Biochem. Biophys. Res. Commun. 255:545-548.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.255
, pp. 545-548
-
-
Doanes, A.M.1
Hegland, D.D.2
Sethi, R.3
Kovesdi, I.4
Bruder, J.T.5
Finkel, T.6
-
19
-
-
0034303371
-
RasGRP is essential for mouse thymocyte differentiation and TCR signaling
-
Dower, N. A., S. L. Stang, D. A. Bottorff, J. O. Ebinu, P. Dickie, H. L. Ostergaard, and J. C. Stone. 2000. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat. Immunol. 1:317-321.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 317-321
-
-
Dower, N.A.1
Stang, S.L.2
Bottorff, D.A.3
Ebinu, J.O.4
Dickie, P.5
Ostergaard, H.L.6
Stone, J.C.7
-
20
-
-
0029955128
-
Control of ras activation
-
Downward, J. 1996. Control of ras activation. Cancer Surv. 27:87-100.
-
(1996)
Cancer Surv.
, vol.27
, pp. 87-100
-
-
Downward, J.1
-
21
-
-
0025941560
-
Isolation and characterization of an established endothelial cell line from transgenic mouse hemangiomas
-
Dubois, N. A., L. C. Kolpack, R. Wang, R. G. Azizkhan, and V. L. Bautch. 1991. Isolation and characterization of an established endothelial cell line from transgenic mouse hemangiomas. Exp. Cell Res. 196:302-313.
-
(1991)
Exp. Cell Res.
, vol.196
, pp. 302-313
-
-
Dubois, N.A.1
Kolpack, L.C.2
Wang, R.3
Azizkhan, R.G.4
Bautch, V.L.5
-
22
-
-
0032524389
-
RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
-
Ebinu, J. O., D. A. Bottorff, E. Y. Chan, S. L. Stang, R. J. Dunn, and J. C. Stone. 1998. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science 280:1082-1086.
-
(1998)
Science
, vol.280
, pp. 1082-1086
-
-
Ebinu, J.O.1
Bottorff, D.A.2
Chan, E.Y.3
Stang, S.L.4
Dunn, R.J.5
Stone, J.C.6
-
23
-
-
0034658333
-
RasGRP links T-cell receptor signaling to Ras
-
Ebinu, J. O., S. L. Stang, C. Teixeira, D. A. Bottorff, J. Hooton, P. M. Blumberg, M. Barry, R. C. Bleakley, H. L. Ostergaard, and J. C. Stone. 2000. RasGRP links T-cell receptor signaling to Ras. Blood 95:3199-3203.
-
(2000)
Blood
, vol.95
, pp. 3199-3203
-
-
Ebinu, J.O.1
Stang, S.L.2
Teixeira, C.3
Bottorff, D.A.4
Hooton, J.5
Blumberg, P.M.6
Barry, M.7
Bleakley, R.C.8
Ostergaard, H.L.9
Stone, J.C.10
-
25
-
-
0037370325
-
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
-
Eremina, V., M. Sood, J. Haigh, A. Nagy, G. Lajoie, N. Ferrara, H. P. Gerber, Y. Kikkawa, J. H. Miner, and S. E. Quaggin. 2003. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J. Clin. Investig. 111:707-716.
-
(2003)
J. Clin. Investig.
, vol.111
, pp. 707-716
-
-
Eremina, V.1
Sood, M.2
Haigh, J.3
Nagy, A.4
Lajoie, G.5
Ferrara, N.6
Gerber, H.P.7
Kikkawa, Y.8
Miner, J.H.9
Quaggin, S.E.10
-
26
-
-
0032559597
-
Vascular endothelial growth factor induces endothelial fenestrations in vitro
-
Esser, S., K. Wolburg, H. Wolburg, G. Breier, T. Kurzchalia, and W. Risau. 1998. Vascular endothelial growth factor induces endothelial fenestrations in vitro. J. Cell Biol. 140:947-959.
-
(1998)
J. Cell Biol.
, vol.140
, pp. 947-959
-
-
Esser, S.1
Wolburg, K.2
Wolburg, H.3
Breier, G.4
Kurzchalia, T.5
Risau, W.6
-
27
-
-
0035136213
-
Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development
-
Esteban, L. M., C. Vicario-Abejón, P. Fernández-Salguero, A. Fernández-Medarde, N. Swaminathan, K. Yienger, E. Lopez, M. Malumbres, R. McKay, J. M. Ward, A. Pellicer, and E. Santos. 2001. Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development. Mol. Cell. Biol. 21:1444-1452.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1444-1452
-
-
Esteban, L.M.1
Vicario-Abejón, C.2
Fernández-Salguero, P.3
Fernández-Medarde, A.4
Swaminathan, N.5
Yienger, K.6
Lopez, E.7
Malumbres, M.8
McKay, R.9
Ward, J.M.10
Pellicer, A.11
Santos, E.12
-
28
-
-
0030004485
-
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
-
Ferrara, N., K. Carver-Moore, H. Chen, M. Dowd, L. Lu, K. S. O'Shea, L. Powell-Braxton, K. J. Hillan, and M. W. Moore. 1996. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380:439-442.
-
(1996)
Nature
, vol.380
, pp. 439-442
-
-
Ferrara, N.1
Carver-Moore, K.2
Chen, H.3
Dowd, M.4
Lu, L.5
O'Shea, K.S.6
Powell-Braxton, L.7
Hillan, K.J.8
Moore, M.W.9
-
29
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara, N., H. P. Gerber, and J. LeCouter. 2003. The biology of VEGF and its receptors. Nat. Med. 9:669-676.
-
(2003)
Nat. Med.
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
30
-
-
0141988568
-
Fundamental concepts of the angiogenic process
-
Folkman, J. 2003. Fundamental concepts of the angiogenic process. Curr. Mol. Med. 3:643-651.
-
(2003)
Curr. Mol. Med.
, vol.3
, pp. 643-651
-
-
Folkman, J.1
-
31
-
-
0029021660
-
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
-
Fong, G. H., J. Rossant, M. Gertsenstein, and M. L. Breitman. 1995. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66-70.
-
(1995)
Nature
, vol.376
, pp. 66-70
-
-
Fong, G.H.1
Rossant, J.2
Gertsenstein, M.3
Breitman, M.L.4
-
32
-
-
0028963912
-
Gene knock-out technology: A methodological overview for the interested novice
-
Galli-Taliadoros, L. A., J. D. Sedgwick, S. A. Wood, and H. Korner. 1995. Gene knock-out technology: a methodological overview for the interested novice. J. Immunol. Methods 181:1-15.
-
(1995)
J. Immunol. Methods
, vol.181
, pp. 1-15
-
-
Galli-Taliadoros, L.A.1
Sedgwick, J.D.2
Wood, S.A.3
Korner, H.4
-
33
-
-
0037815292
-
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
-
Gerhardt, H., M. Golding, M. Fruttiger, C. Ruhrberg, A. Lundkvist, A. Abramsson, M. Jeltsch, C. Mitchell, K. Alitalo, D. Shima, and C. Betsholtz. 2003. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 161:1163-1177.
-
(2003)
J. Cell Biol.
, vol.161
, pp. 1163-1177
-
-
Gerhardt, H.1
Golding, M.2
Fruttiger, M.3
Ruhrberg, C.4
Lundkvist, A.5
Abramsson, A.6
Jeltsch, M.7
Mitchell, C.8
Alitalo, K.9
Shima, D.10
Betsholtz, C.11
-
34
-
-
0037229065
-
Nfl has an essential role in endothelial cells
-
Gitler, A. D., Y. Zhu, F. A. Ismat, M. M. Lu, Y. Yamauchi, L. F. Parada, and J. A. Epstein. 2003. Nfl has an essential role in endothelial cells. Nat. Genet. 33:75-79.
-
(2003)
Nat. Genet.
, vol.33
, pp. 75-79
-
-
Gitler, A.D.1
Zhu, Y.2
Ismat, F.A.3
Lu, M.M.4
Yamauchi, Y.5
Parada, L.F.6
Epstein, J.A.7
-
35
-
-
0026587657
-
Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
-
Guy, C. T., R. D. Cardiff, and W. J. Muller. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol. Cell. Biol. 12:954-961.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 954-961
-
-
Guy, C.T.1
Cardiff, R.D.2
Muller, W.J.3
-
36
-
-
0028788570
-
Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
-
Henkemeyer, M., D. J. Rossi, D. P. Holmyard, M. C. Puri, G. Mbamalu, K. Harpal, T. S. Shih, T. Jacks, and T. Pawson. 1995. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature 377:695-701.
-
(1995)
Nature
, vol.377
, pp. 695-701
-
-
Henkemeyer, M.1
Rossi, D.J.2
Holmyard, D.P.3
Puri, M.C.4
Mbamalu, G.5
Harpal, K.6
Shih, T.S.7
Jacks, T.8
Pawson, T.9
-
37
-
-
0033991659
-
Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells
-
Hidaka, M., G. Caruana, W. L. Stanford, M. Sam, P. H. Correll, and A. Bernstein. 2000. Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells. Mech. Dev. 90:3-15.
-
(2000)
Mech. Dev.
, vol.90
, pp. 3-15
-
-
Hidaka, M.1
Caruana, G.2
Stanford, W.L.3
Sam, M.4
Correll, P.H.5
Bernstein, A.6
-
38
-
-
0042386426
-
Differential αv integrin-mediated Ras-ERK signaling during two pathways of angiogenesis
-
Hood, J. D., R. Frausto, W. B. Kiosses, M. A. Schwartz, and D. A. Cheresh. 2003. Differential αv integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. J. Cell Biol. 162:933-943.
-
(2003)
J. Cell Biol.
, vol.162
, pp. 933-943
-
-
Hood, J.D.1
Frausto, R.2
Kiosses, W.B.3
Schwartz, M.A.4
Cheresh, D.A.5
-
39
-
-
33751269676
-
Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability
-
Huang, Q., and Y. Yuan. 1997. Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability. Am. J. Physiol. 273:H2442-H2451.
-
(1997)
Am. J. Physiol.
, vol.273
-
-
Huang, Q.1
Yuan, Y.2
-
40
-
-
0345135149
-
K-ras is an essential gene in the mouse with partial functional overlap with N-ras
-
Johnson, L., D. Greenbaum, K. Cichowski, K. Mercer, E. Murphy, E. Schmitt, R. T. Bronson, H. Umanoff, W. Edelmann, R. Kucherlapati, and T. Jacks. 1997. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11:2468-2481.
-
(1997)
Genes Dev.
, vol.11
, pp. 2468-2481
-
-
Johnson, L.1
Greenbaum, D.2
Cichowski, K.3
Mercer, K.4
Murphy, E.5
Schmitt, E.6
Bronson, R.T.7
Umanoff, H.8
Edelmann, W.9
Kucherlapati, R.10
Jacks, T.11
-
41
-
-
13144282666
-
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
-
Kawasaki, H., G. M. Springett, S. Toki, J. J. Canales, P. Harlan, J. P. Blumenstiel, E. J. Chen, I. A. Bany, N. Mochizuki, A. Ashbacher, M. Matsuda, D. E. Housman, and A. M. Graybiel. 1998. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc. Natl. Acad. Sci. USA 95:13278-13283.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13278-13283
-
-
Kawasaki, H.1
Springett, G.M.2
Toki, S.3
Canales, J.J.4
Harlan, P.5
Blumenstiel, J.P.6
Chen, E.J.7
Bany, I.A.8
Mochizuki, N.9
Ashbacher, A.10
Matsuda, M.11
Housman, D.E.12
Graybiel, A.M.13
-
42
-
-
0036530222
-
Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division
-
Kearney, J. B., C. A. Ambler, K. A. Monaco, N. Johnson, R. G. Rapoport, and V. L. Bautch. 2002. Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division. Blood 99:2397-2407.
-
(2002)
Blood
, vol.99
, pp. 2397-2407
-
-
Kearney, J.B.1
Ambler, C.A.2
Monaco, K.A.3
Johnson, N.4
Rapoport, R.G.5
Bautch, V.L.6
-
43
-
-
0346220080
-
In vitro differentiation of mouse ES cells: Hematopoietic and vascular development
-
Kearney, J. B., and V. L. Bautch. 2003. In vitro differentiation of mouse ES cells: hematopoietic and vascular development. Methods Enzymol. 365:83-98.
-
(2003)
Methods Enzymol.
, vol.365
, pp. 83-98
-
-
Kearney, J.B.1
Bautch, V.L.2
-
44
-
-
2942556514
-
The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis
-
Kearney, J. B., N. C. Kappas, C. Ellerstrom, F. W. DiPaola, and V. L. Bautch. 2004. The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis. Blood 103:4527-4535.
-
(2004)
Blood
, vol.103
, pp. 4527-4535
-
-
Kearney, J.B.1
Kappas, N.C.2
Ellerstrom, C.3
DiPaola, F.W.4
Bautch, V.L.5
-
45
-
-
0030829782
-
K-ras is essential for the development of the mouse embryo
-
Koera, K., K. Nakamura, K. Nakao, J. Miyoshi, K. Toyoshima, T. Hatta, H. Otani, A. Alba, and M. Katsuki. 1997. K-ras is essential for the development of the mouse embryo. Oncogene 15:1151-1159.
-
(1997)
Oncogene
, vol.15
, pp. 1151-1159
-
-
Koera, K.1
Nakamura, K.2
Nakao, K.3
Miyoshi, J.4
Toyoshima, K.5
Hatta, T.6
Otani, H.7
Alba, A.8
Katsuki, M.9
-
46
-
-
0034061660
-
The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters
-
Lorenzo, P. S., M. Beheshti, G. R. Pettit, J. C. Stone, and P. M. Blumberg. 2000. The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters. Mol. Pharmacol. 57:840-846.
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 840-846
-
-
Lorenzo, P.S.1
Beheshti, M.2
Pettit, G.R.3
Stone, J.C.4
Blumberg, P.M.5
-
47
-
-
0035117119
-
Phorbol esters modulate the Ras exchange factor RasGRP3
-
Lorenzo, P. S., J. W. Kung, D. A. Botterff, S. H. Garfield, J. C. Stone, and P. M. Blumberg. 2001. Phorbol esters modulate the Ras exchange factor RasGRP3. Cancer Res. 61:943-949.
-
(2001)
Cancer Res.
, vol.61
, pp. 943-949
-
-
Lorenzo, P.S.1
Kung, J.W.2
Botterff, D.A.3
Garfield, S.H.4
Stone, J.C.5
Blumberg, P.M.6
-
48
-
-
0035966004
-
Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation
-
Meadows, K. N., P. Bryant, and K. Pumiglia. 2001. Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J. Biol. Chem. 276:49289-49298.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 49289-49298
-
-
Meadows, K.N.1
Bryant, P.2
Pumiglia, K.3
-
49
-
-
0942301171
-
Activated Ras induces a proangiogenic phenotype in primary endothelial cells
-
Meadows, K. N., P. Bryant, P. A. Vincent, and K. M. Pumiglia. 2004. Activated Ras induces a proangiogenic phenotype in primary endothelial cells. Oncogene 23:192-200.
-
(2004)
Oncogene
, vol.23
, pp. 192-200
-
-
Meadows, K.N.1
Bryant, P.2
Vincent, P.A.3
Pumiglia, K.M.4
-
50
-
-
0033793921
-
Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression
-
Miquerol, L., B. L. Langille, and A. Nagy. 2000. Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression. Development 127:3941-3946.
-
(2000)
Development
, vol.127
, pp. 3941-3946
-
-
Miquerol, L.1
Langille, B.L.2
Nagy, A.3
-
51
-
-
0032585352
-
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
-
Nagase, T., K. Ishikawa, M. Suyama, R. Kikuno, M. Hirosawa, N. Miyajima, A. Tanaka, H. Kotani, N. Nomura, and O. Ohara. 1998. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5:355-364.
-
(1998)
DNA Res.
, vol.5
, pp. 355-364
-
-
Nagase, T.1
Ishikawa, K.2
Suyama, M.3
Kikuno, R.4
Hirosawa, M.5
Miyajima, N.6
Tanaka, A.7
Kotani, H.8
Nomura, N.9
Ohara, O.10
-
52
-
-
0030053505
-
Protein kinase C β 1 overexpression augments phorbol ester-induced increase in endothelial permeability
-
Nagpala, P. G., A. B. Malik, P. T. Vuong, and H. Lum. 1996. Protein kinase C β 1 overexpression augments phorbol ester-induced increase in endothelial permeability. J. Cell. Physiol. 166:249-255.
-
(1996)
J. Cell. Physiol.
, vol.166
, pp. 249-255
-
-
Nagpala, P.G.1
Malik, A.B.2
Vuong, P.T.3
Lum, H.4
-
53
-
-
0347593996
-
Requirement for Ras guanine nucleolide releasing protein 3 in coupling phospholipase C-γ2 to Ras in B cell receptor signaling
-
Oh-hora, M., S. Johmura, A. Hashimoto, M. Hikida, and T. Kurosaki. 2003. Requirement for Ras guanine nucleolide releasing protein 3 in coupling phospholipase C-γ2 to Ras in B cell receptor signaling. J. Exp. Med. 198:1841-1851.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1841-1851
-
-
Oh-Hora, M.1
Johmura, S.2
Hashimoto, A.3
Hikida, M.4
Kurosaki, T.5
-
54
-
-
0036364408
-
A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases
-
Quilliam, L. A., J. F. Rebhun, and A. F. Castro. 2002. A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. Prog. Nucleic Acid Res. Mol. Biol. 71:391-444.
-
(2002)
Prog. Nucleic Acid Res. Mol. Biol.
, vol.71
, pp. 391-444
-
-
Quilliam, L.A.1
Rebhun, J.F.2
Castro, A.F.3
-
55
-
-
0034634534
-
Identification of guanine nucleotide exchange factors (GEFs) for the Rapl GTPase. Regulation of MR-GEF by M-Ras-GTP interaction
-
Rebhun, J. F., A. F. Castro, and L. A. Quilliam. 2000. Identification of guanine nucleotide exchange factors (GEFs) for the Rapl GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. J. Biol. Chem. 275:34901-34908.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34901-34908
-
-
Rebhun, J.F.1
Castro, A.F.2
Quilliam, L.A.3
-
56
-
-
0037163027
-
RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia
-
Reuther, G. W., Q. T. Lambert, J. F. Rebhun, M. A. Caligiuri, L. A. Quilliam, and C. J. Der. 2002. RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia. J. Biol. Chem. 277:30508-30514.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30508-30514
-
-
Reuther, G.W.1
Lambert, Q.T.2
Rebhun, J.F.3
Caligiuri, M.A.4
Quilliam, L.A.5
Der, C.J.6
-
57
-
-
0030952289
-
Mechanisms of angiogenesis
-
Risau, W. 1997. Mechanisms of angiogenesis. Nature 386:671-674.
-
(1997)
Nature
, vol.386
, pp. 671-674
-
-
Risau, W.1
-
58
-
-
0033840069
-
Coexpression of neuropilin-1, FIk1, and VEGF164 in developing and mature mouse kidney glomeruli
-
Robert, B., X. Zhao, and D. R. Abrahamson. 2000. Coexpression of neuropilin-1, FIk1, and VEGF164 in developing and mature mouse kidney glomeruli. Am. J. Physiol. Renal Physiol. 279:F275-F282.
-
(2000)
Am. J. Physiol. Renal Physiol.
, vol.279
-
-
Robert, B.1
Zhao, X.2
Abrahamson, D.R.3
-
59
-
-
1942437424
-
The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation
-
Roberts, D. M., J. B. Kearney, J. H. Johnson, M. P. Rosenberg, R. Kumar, and V. L. Bautch. 2004. The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation. Am. J. Pathol. 164:1531-1535.
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 1531-1535
-
-
Roberts, D.M.1
Kearney, J.B.2
Johnson, J.H.3
Rosenberg, M.P.4
Kumar, R.5
Bautch, V.L.6
-
60
-
-
0029010434
-
Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
-
Roberts, W. G., and G. E. Palade. 1995. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J. Cell Sci. 108:2369-2379.
-
(1995)
J. Cell Sci.
, vol.108
, pp. 2369-2379
-
-
Roberts, W.G.1
Palade, G.E.2
-
61
-
-
0027310879
-
Whole-mount in situ hybridization in the mouse embryo: Gene expression in three dimensions
-
Rosen, B., and R. S. Beddington. 1993. Whole-mount in situ hybridization in the mouse embryo: gene expression in three dimensions. Trends Genet. 9:162-167.
-
(1993)
Trends Genet.
, vol.9
, pp. 162-167
-
-
Rosen, B.1
Beddington, R.S.2
-
62
-
-
0037108152
-
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
-
Ruhrberg, C., H. Gerhardt, M. Golding, R. Watson, S. Ioannidou, H. Fujisawa, C. Betsholtz, and D. T. Shima. 2002. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev. 16:2684-2698.
-
(2002)
Genes Dev.
, vol.16
, pp. 2684-2698
-
-
Ruhrberg, C.1
Gerhardt, H.2
Golding, M.3
Watson, R.4
Ioannidou, S.5
Fujisawa, H.6
Betsholtz, C.7
Shima, D.T.8
-
63
-
-
0029006696
-
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
-
Shalaby, F., J. Rossant, T. P. Yamaguchi, M. Gertsenstein, X. F. Wu, M. L. Breitman, and A. C. Schuh. 1995. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376:62-66.
-
(1995)
Nature
, vol.376
, pp. 62-66
-
-
Shalaby, F.1
Rossant, J.2
Yamaguchi, T.P.3
Gertsenstein, M.4
Wu, X.F.5
Breitman, M.L.6
Schuh, A.C.7
-
64
-
-
0141996422
-
Vascular endothelial growth factor receptor-2: Its unique signaling and specific ligand, VEGF-E
-
Shibuya, M. 2003. Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E. Cancer Sci. 94:751-756.
-
(2003)
Cancer Sci.
, vol.94
, pp. 751-756
-
-
Shibuya, M.1
-
65
-
-
0034175984
-
Understanding Ras: 'It ain't over 'til it's over
-
Shields, J. M., K. Pruitt, A. McFall, A. Shaub, and C. J. Der. 2000. Understanding Ras: 'it ain't over 'til it's over. Trends Cell Biol. 10:147-154.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 147-154
-
-
Shields, J.M.1
Pruitt, K.2
McFall, A.3
Shaub, A.4
Der, C.J.5
-
66
-
-
0036841720
-
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of Ras and mitogen-activated protein kinases
-
Shu, X., W. Wu, R. D. Mosteller, and D. Broela. 2002. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of Ras and mitogen-activated protein kinases. Mol. Cell. Biol. 22:7758-7768.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7758-7768
-
-
Shu, X.1
Wu, W.2
Mosteller, R.D.3
Broela, D.4
-
67
-
-
0032535384
-
Expression trapping: Identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells
-
Stanford, W. L., G. Caruana, K. A. Vallis, M. Inamdar, M. Hidaka, V. L. Bautch, and A. Bernstein. 1998. Expression trapping: identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells. Blood 92:4622-4631.
-
(1998)
Blood
, vol.92
, pp. 4622-4631
-
-
Stanford, W.L.1
Caruana, G.2
Vallis, K.A.3
Inamdar, M.4
Hidaka, M.5
Bautch, V.L.6
Bernstein, A.7
-
68
-
-
2442683012
-
Rap2B-dependent stimulation of phospholipase C-ε by epidermal growth factor receptor mediated by c-Src phosphorylation of Ras-GRP3
-
Stope, M. B., F. vom Dorp, D. Szatkowski, A. Böhm, M. Keiper, J. Nolte, P. A. Oude Weernink, D. Rosskopf, S. Evellin, K. H. Jakobs, and M. Schmidt. 2004. Rap2B-dependent stimulation of phospholipase C-ε by epidermal growth factor receptor mediated by c-Src phosphorylation of Ras-GRP3. Mol. Cell. Biol. 24:4664-4676.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 4664-4676
-
-
Stope, M.B.1
Vom Dorp, F.2
Szatkowski, D.3
Böhm, A.4
Keiper, M.5
Nolte, J.6
Oude Weernink, P.A.7
Rosskopf, D.8
Evellin, S.9
Jakobs, K.H.10
Schmidt, M.11
-
69
-
-
0031008750
-
The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts
-
Takahashi, T., and M. Shibuya. 1997. The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 14:2079-2089.
-
(1997)
Oncogene
, vol.14
, pp. 2079-2089
-
-
Takahashi, T.1
Shibuya, M.2
-
70
-
-
0033118228
-
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
-
Takahashi, T., H. Ueno, and M. Shibuya. 1999. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18:2221-2230.
-
(1999)
Oncogene
, vol.18
, pp. 2221-2230
-
-
Takahashi, T.1
Ueno, H.2
Shibuya, M.3
-
71
-
-
0042237772
-
Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3
-
Teixeira, C., S. L. Stang, Y. Zheng, N. S. Beswick, and J. C. Stone. 2003. Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. Blood 102:1414-1420.
-
(2003)
Blood
, vol.102
, pp. 1414-1420
-
-
Teixeira, C.1
Stang, S.L.2
Zheng, Y.3
Beswick, N.S.4
Stone, J.C.5
-
73
-
-
0031784267
-
Regulation of RasGRP via a phorbol ester-responsive Cl domain
-
Tognon, C. E., H. E. Kirk, L. A. Passmore, I. P. Whitehead, C. J. Der, and R. J. Kay. 1998. Regulation of RasGRP via a phorbol ester-responsive Cl domain. Mol. Cell. Biol. 18:6995-7008.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 6995-7008
-
-
Tognon, C.E.1
Kirk, H.E.2
Passmore, L.A.3
Whitehead, I.P.4
Der, C.J.5
Kay, R.J.6
-
74
-
-
0028907331
-
The murine N-ras gene is not essential for growth and development
-
Umanoff, H., W. Edelmann, A. Pellicer, and R. Kucherlapati. 1995. The murine N-ras gene is not essential for growth and development. Proc. Natl. Acad. Sci. USA 92:1709-1713.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 1709-1713
-
-
Umanoff, H.1
Edelmann, W.2
Pellicer, A.3
Kucherlapati, R.4
-
75
-
-
0033848682
-
Role of ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction
-
Verin, A. D., F. Liu, N. Bogatcheva, T. Borbiev, M. B. Hershenson, P. Wang, and J. G. Garcia. 2000. Role of ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction. Am. J. Physiol. Lung Cell Mol. Physiol. 279:L360-L370.
-
(2000)
Am. J. Physiol. Lung Cell Mol. Physiol.
, vol.279
-
-
Verin, A.D.1
Liu, F.2
Bogatcheva, N.3
Borbiev, T.4
Hershenson, M.B.5
Wang, P.6
Garcia, J.G.7
-
76
-
-
0031043507
-
Mutation in Sosl dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sosl in EGFR signaling and development
-
Wang, D. Z., V. E. Hammond, H. E. Abud, I. Bertoncello, J. W. McAvoy, and D. D. Bowtell. 1997. Mutation in Sosl dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sosl in EGFR signaling and development. Genes Dev. 11:309-320.
-
(1997)
Genes Dev.
, vol.11
, pp. 309-320
-
-
Wang, D.Z.1
Hammond, V.E.2
Abud, H.E.3
Bertoncello, I.4
McAvoy, J.W.5
Bowtell, D.D.6
-
77
-
-
0035669720
-
Protein kinase C and the development of diabetic vascular complications
-
Way, K. J., N. Katai, and G. L. King. 2001. Protein kinase C and the development of diabetic vascular complications. Diabet. Med. 18:945-959.
-
(2001)
Diabet. Med.
, vol.18
, pp. 945-959
-
-
Way, K.J.1
Katai, N.2
King, G.L.3
-
78
-
-
0034682779
-
CalDAG-GEFlII activation of Ras, R-ras, and Rap1
-
Yamashita, S., N. Mochizuki, Y. Ohba, M. Tobiume, Y. Okada, H. Sawa, K. Nagashima, and M. Matsuda. 2000. CalDAG-GEFlII activation of Ras, R-ras, and Rap1. J. Biol. Chem. 275:25488-25493.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25488-25493
-
-
Yamashita, S.1
Mochizuki, N.2
Ohba, Y.3
Tobiume, M.4
Okada, Y.5
Sawa, H.6
Nagashima, K.7
Matsuda, M.8
-
79
-
-
0034648793
-
Vascular-specific growth factors and blood vessel formation
-
Yancopoulos, G. D., S. Davis, N. W. Gale, J. S. Rudge, S. J. Wiegand, and J. Holash. 2000. Vascular-specific growth factors and blood vessel formation. Nature 407:242-248.
-
(2000)
Nature
, vol.407
, pp. 242-248
-
-
Yancopoulos, G.D.1
Davis, S.2
Gale, N.W.3
Rudge, J.S.4
Wiegand, S.J.5
Holash, J.6
-
80
-
-
0036845084
-
Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: Relative roles of KDR and Flt-1 receptors
-
Yang, S., K. Toy, G. Ingle, C. Zlot, P. M. Williams, G. Fuh, B. Li, A. de Vos, and M. E. Gerritsen. 2002. Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: relative roles of KDR and Flt-1 receptors. Arterioscler. Thromb. Vasc. Biol. 22:1797-1803.
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 1797-1803
-
-
Yang, S.1
Toy, K.2
Ingle, G.3
Zlot, C.4
Williams, P.M.5
Fuh, G.6
Li, B.7
De Vos, A.8
Gerritsen, M.E.9
-
81
-
-
0037067713
-
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function
-
Yang, Y., L. Li, G. W. Wong, S. A. Krilis, M. S. Madhusudhan, A. Sali, and R. L. Stevens. 2002. RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. J. Biol. Chem. 277:25756-25774.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25756-25774
-
-
Yang, Y.1
Li, L.2
Wong, G.W.3
Krilis, S.A.4
Madhusudhan, M.S.5
Sali, A.6
Stevens, R.L.7
-
82
-
-
0035920244
-
Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 downmodulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathwavs
-
Zeng, H., H. F. Dvorak, and D. Mukhopadhyay. 2001. Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 downmodulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathwavs. J. Biol. Chem. 276:26969-26979.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 26969-26979
-
-
Zeng, H.1
Dvorak, H.F.2
Mukhopadhyay, D.3
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