Conformationally Constrained Analogues of Diacylglycerol. 20. The Search for an Elusive Binding Site on Protein Kinase C through Relocation of the Carbonyl Pharmacophore Along the sn-1 Side Chain of 1,2-Diacylglycerol Lactones

Journal of Medicinal Chemistry

Volumn 47, Issue 3, 2004, Pages 644-655

  Tamamura, Hirokazu ^a,c   Sigano, Dina M ^a   Lewin, Nancy E ^b   Blumberg, Peter M ^b   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

C1B RECEPTOR; CARBONYL DERIVATIVE; DIACYLGLYCEROL DERIVATIVE; LACTONE DERIVATIVE; PHORBOL 13 O ACETATE; PHORBOL DERIVATIVE; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL MEMBRANE; COMPLEX FORMATION; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME BINDING; MODEL; MOLECULAR MIMICRY; PHARMACOPHORE; STRUCTURE ANALYSIS;

BINDING SITES; DIGLYCERIDES; HYDROGEN BONDING; LACTONES; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; PROTEIN KINASE C;

EID: 1642458686     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030454h     Document Type: Article

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