Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2000, Pages 921-944

  Nacro, Kassoum ^a   Bienfait, Bruno ^a   Lee, Jeewoo ^b   Han, Kee Chung ^b   Kang, Ji Hye ^b   Benzaria, Samira ^a   Lewin, Nancy E ^c   Bhattacharyya, Dipak K ^c   Blumberg, Peter M ^c   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Seoul National University   (South Korea)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL DERIVATIVE; EPIDERMAL GROWTH FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL DIBUTYRATE; PROTEIN KINASE C;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; ENANTIOMER; ENZYME BINDING; HYDROPHOBICITY; LIPOPHILICITY; MOLECULAR MODEL; PARTITION COEFFICIENT; STRUCTURE ACTIVITY RELATION;

4-BUTYROLACTONE; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; ISOENZYMES; LIGANDS; MODELS, MOLECULAR; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VALERATES;

EID: 0034624775     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9904607     Document Type: Article

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