메뉴 건너뛰기




Volumn 20, Issue 3, 2006, Pages 571-591

Pathogenesis of ankylosing spondylitis: Current concepts

Author keywords

arthritogenic peptide; heavy chain dimers; HLA B27 misfolding; macrophages; toll like receptors; unfolded protein response

Indexed keywords

BETA 2 MICROGLOBULIN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; HLA B27 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 33746897749     PISSN: 15216942     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.berh.2006.03.001     Document Type: Review
Times cited : (81)

References (118)
  • 2
    • 0015938046 scopus 로고
    • Ankylosing spondylitis and HL-A 27
    • Brewerton D.A., Hart F.D., Nicholls A., et al. Ankylosing spondylitis and HL-A 27. Lancet 1 (1973) 904-907
    • (1973) Lancet , vol.1 , pp. 904-907
    • Brewerton, D.A.1    Hart, F.D.2    Nicholls, A.3
  • 4
    • 0033694989 scopus 로고    scopus 로고
    • Histopathologic evidence that sacroiliitis in ankylosing spondylitis is not merely enthesitis
    • Francois R.J., Gardner D.L., Degrave E.J., and Bywaters E.G. Histopathologic evidence that sacroiliitis in ankylosing spondylitis is not merely enthesitis. Arthritis and Rheumatism 43 (2000) 2011-2024
    • (2000) Arthritis and Rheumatism , vol.43 , pp. 2011-2024
    • Francois, R.J.1    Gardner, D.L.2    Degrave, E.J.3    Bywaters, E.G.4
  • 5
    • 0028903218 scopus 로고
    • Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis
    • Braun J., Bollow M., Neure L., et al. Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis and Rheumatism 38 (1995) 499-505
    • (1995) Arthritis and Rheumatism , vol.38 , pp. 499-505
    • Braun, J.1    Bollow, M.2    Neure, L.3
  • 6
    • 0034069191 scopus 로고    scopus 로고
    • Quantitative analyses of sacroiliac biopsies in spondyloarthropathies: T-cells and macrophages predominate in early and active sacroiliitis-cellularity correlates with the degree of enhancementdetected by magnetic resonance imaging
    • Bollow M., Fischer T., Reisshauer H., et al. Quantitative analyses of sacroiliac biopsies in spondyloarthropathies: T-cells and macrophages predominate in early and active sacroiliitis-cellularity correlates with the degree of enhancementdetected by magnetic resonance imaging. Annals of the Rheumatic Diseases 59 (2000) 135-140
    • (2000) Annals of the Rheumatic Diseases , vol.59 , pp. 135-140
    • Bollow, M.1    Fischer, T.2    Reisshauer, H.3
  • 8
    • 0027180557 scopus 로고
    • Reduced synovial membrane macrophage numbers, ELAM-1 expression, and lining layer hyperplasia in psoriatic arthritis as compared with rheumatoid arthritis
    • Veale D., Yanni G., Rogers S., et al. Reduced synovial membrane macrophage numbers, ELAM-1 expression, and lining layer hyperplasia in psoriatic arthritis as compared with rheumatoid arthritis. Arthritis and Rheumatism 36 (1993) 893-900
    • (1993) Arthritis and Rheumatism , vol.36 , pp. 893-900
    • Veale, D.1    Yanni, G.2    Rogers, S.3
  • 9
    • 0033510414 scopus 로고    scopus 로고
    • Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis
    • Reece R.J., Canete J.D., Parsons W.J., et al. Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis. Arthritis and Rheumatism 42 (1999) 1481-1484
    • (1999) Arthritis and Rheumatism , vol.42 , pp. 1481-1484
    • Reece, R.J.1    Canete, J.D.2    Parsons, W.J.3
  • 10
    • 0033637389 scopus 로고    scopus 로고
    • Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity
    • Baeten D., Demetter P., Cuvelier C., et al. Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity. Annals of the Rheumatic Diseases 59 (2000) 945-953
    • (2000) Annals of the Rheumatic Diseases , vol.59 , pp. 945-953
    • Baeten, D.1    Demetter, P.2    Cuvelier, C.3
  • 11
    • 0036187210 scopus 로고    scopus 로고
    • Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy
    • Baeten D., Demetter P., Cuvelier C.A., et al. Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy. The Journal of Pathology 196 (2002) 343-350
    • (2002) The Journal of Pathology , vol.196 , pp. 343-350
    • Baeten, D.1    Demetter, P.2    Cuvelier, C.A.3
  • 12
    • 0031655957 scopus 로고    scopus 로고
    • Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis
    • Smeets T.J., Dolhain R.J., Breedveld F.C., and Tak P.P. Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis. The Journal of Pathology 186 (1998) 75-81
    • (1998) The Journal of Pathology , vol.186 , pp. 75-81
    • Smeets, T.J.1    Dolhain, R.J.2    Breedveld, F.C.3    Tak, P.P.4
  • 13
    • 0032726579 scopus 로고    scopus 로고
    • Immunohistological analysis of synovial tissue for differential diagnosis in early arthritis
    • Kraan M.C., Haringman J.J., Post W.J., et al. Immunohistological analysis of synovial tissue for differential diagnosis in early arthritis. Rheumatology (Oxford, England) 38 (1999) 1074-1080
    • (1999) Rheumatology (Oxford, England) , vol.38 , pp. 1074-1080
    • Kraan, M.C.1    Haringman, J.J.2    Post, W.J.3
  • 14
    • 2342555072 scopus 로고    scopus 로고
    • Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis
    • Baeten D., Moller H.J., Delanghe J., et al. Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis. Arthritis and Rheumatism 50 (2004) 1611-1623
    • (2004) Arthritis and Rheumatism , vol.50 , pp. 1611-1623
    • Baeten, D.1    Moller, H.J.2    Delanghe, J.3
  • 15
    • 0035050859 scopus 로고    scopus 로고
    • Expression of host defense scavenger receptors in spondylarthropathy
    • Seta N., Granfors K., Sahly H., et al. Expression of host defense scavenger receptors in spondylarthropathy. Arthritis and Rheumatism 44 (2001) 931-939
    • (2001) Arthritis and Rheumatism , vol.44 , pp. 931-939
    • Seta, N.1    Granfors, K.2    Sahly, H.3
  • 16
    • 0035069607 scopus 로고    scopus 로고
    • Immunohistological study of entheses in spondyloarthropathies: comparison in rheumatoid arthritis and osteoarthritis
    • Laloux L., Voisin M.C., Allain J., et al. Immunohistological study of entheses in spondyloarthropathies: comparison in rheumatoid arthritis and osteoarthritis. Annals of the Rheumatic Diseases 60 (2001) 316-321
    • (2001) Annals of the Rheumatic Diseases , vol.60 , pp. 316-321
    • Laloux, L.1    Voisin, M.C.2    Allain, J.3
  • 17
    • 0036095471 scopus 로고    scopus 로고
    • Histological assessment of the early enthesitis lesion in spondyloarthropathy
    • McGonagle D., Marzo-Ortega H., O'Connor P., et al. Histological assessment of the early enthesitis lesion in spondyloarthropathy. Annals of the Rheumatic Diseases 61 (2002) 534-537
    • (2002) Annals of the Rheumatic Diseases , vol.61 , pp. 534-537
    • McGonagle, D.1    Marzo-Ortega, H.2    O'Connor, P.3
  • 18
    • 0023245617 scopus 로고
    • HLA-restricted recognition of viral antigens in HLA transgenic mice
    • Kievits F., Ivanyi P., Krimpenfort P., et al. HLA-restricted recognition of viral antigens in HLA transgenic mice. Nature 329 (1987) 447-449
    • (1987) Nature , vol.329 , pp. 447-449
    • Kievits, F.1    Ivanyi, P.2    Krimpenfort, P.3
  • 19
    • 0023355068 scopus 로고
    • Crosses of two independently derived transgenic mice demonstrate functional complementation of the genes encoding heavy (HLA-B27) and light (β2-microglobulin) chains of HLA class I antigens
    • Krimpenfort P., Rudenko G., Hochstenbach F., et al. Crosses of two independently derived transgenic mice demonstrate functional complementation of the genes encoding heavy (HLA-B27) and light (β2-microglobulin) chains of HLA class I antigens. The EMBO Journal 6 (1987) 1673-1676
    • (1987) The EMBO Journal , vol.6 , pp. 1673-1676
    • Krimpenfort, P.1    Rudenko, G.2    Hochstenbach, F.3
  • 20
    • 0030924851 scopus 로고    scopus 로고
    • The role of MHC class I heterodimer expression in mouse ankylosing enthesopathy
    • Weinreich S., Hoebe-Hewryk B., van der Horst A.R., et al. The role of MHC class I heterodimer expression in mouse ankylosing enthesopathy. Immunogenetics 46 (1997) 35-40
    • (1997) Immunogenetics , vol.46 , pp. 35-40
    • Weinreich, S.1    Hoebe-Hewryk, B.2    van der Horst, A.R.3
  • 21
    • 0342264383 scopus 로고    scopus 로고
    • Germ-free mice do not develop ankylosing enthesopathy, a spontaneous joint disease
    • Rehakova Z., Capkova J., Stepankova R., et al. Germ-free mice do not develop ankylosing enthesopathy, a spontaneous joint disease. Human Immunology 61 (2000) 555-558
    • (2000) Human Immunology , vol.61 , pp. 555-558
    • Rehakova, Z.1    Capkova, J.2    Stepankova, R.3
  • 23
    • 0025633436 scopus 로고
    • 2-m: an animal model of HLA-B27-associated human disorders
    • 2-m: an animal model of HLA-B27-associated human disorders. Cell 63 (1990) 1099-1112
    • (1990) Cell , vol.63 , pp. 1099-1112
    • Hammer, R.E.1    Maika, S.D.2    Richardson, J.A.3
  • 24
  • 25
  • 26
    • 0030060392 scopus 로고    scopus 로고
    • T-cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats
    • Breban M., Fernandez-Sueiro J.L., Richardson J.A., et al. T-cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats. Journal of Immunology 156 (1996) 794-803
    • (1996) Journal of Immunology , vol.156 , pp. 794-803
    • Breban, M.1    Fernandez-Sueiro, J.L.2    Richardson, J.A.3
  • 27
    • 0037438486 scopus 로고    scopus 로고
    • CD8αβ T-cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats
    • May E., Dorris M.L., Satumtira N., et al. CD8αβ T-cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. Journal of Immunology 170 (2003) 1099-1105
    • (2003) Journal of Immunology , vol.170 , pp. 1099-1105
    • May, E.1    Dorris, M.L.2    Satumtira, N.3
  • 28
    • 0028003794 scopus 로고
    • The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats
    • Taurog J.D., Richardson J.A., Croft J.T., et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. The Journal of Experimental Medicine 180 (1994) 2359-2364
    • (1994) The Journal of Experimental Medicine , vol.180 , pp. 2359-2364
    • Taurog, J.D.1    Richardson, J.A.2    Croft, J.T.3
  • 30
    • 0032984363 scopus 로고    scopus 로고
    • Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli
    • Rath H.C., Wilson K.H., and Sartor R.B. Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli. Infection and Immunity 67 (1999) 2969-2974
    • (1999) Infection and Immunity , vol.67 , pp. 2969-2974
    • Rath, H.C.1    Wilson, K.H.2    Sartor, R.B.3
  • 31
    • 0034057943 scopus 로고    scopus 로고
    • Colitis in HLA-B27/beta 2 microglobulin transgenic rats
    • Sartor R.B. Colitis in HLA-B27/beta 2 microglobulin transgenic rats. International Reviews of Immunology 19 (2000) 39-50
    • (2000) International Reviews of Immunology , vol.19 , pp. 39-50
    • Sartor, R.B.1
  • 32
    • 1842611840 scopus 로고    scopus 로고
    • Reduced ratio of protective versus proinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats
    • Dieleman L.A., Hoentjen F., Qian B.F., et al. Reduced ratio of protective versus proinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats. Clinical and Experimental Immunology 136 (2004) 30-39
    • (2004) Clinical and Experimental Immunology , vol.136 , pp. 30-39
    • Dieleman, L.A.1    Hoentjen, F.2    Qian, B.F.3
  • 33
    • 2042434553 scopus 로고    scopus 로고
    • HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations
    • Colmegna I., Cuchacovich R., and Espinoza L.R. HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations. Clinical Microbiology Reviews 17 (2004) 348-369
    • (2004) Clinical Microbiology Reviews , vol.17 , pp. 348-369
    • Colmegna, I.1    Cuchacovich, R.2    Espinoza, L.R.3
  • 35
    • 0034040081 scopus 로고    scopus 로고
    • Evidence of subclinical intestinal inflammation by 99mtechnetium leukocyte scintigraphy in patients with HLA-B27 postiive juvenile onset active spondyloarthropathy
    • Lionetti P., Pupi A., Veltroni M., et al. Evidence of subclinical intestinal inflammation by 99mtechnetium leukocyte scintigraphy in patients with HLA-B27 postiive juvenile onset active spondyloarthropathy. The Journal of Rheumatology 27 (2000)
    • (2000) The Journal of Rheumatology , vol.27
    • Lionetti, P.1    Pupi, A.2    Veltroni, M.3
  • 36
    • 19944433186 scopus 로고    scopus 로고
    • Colon mucosa of both spondyloarthritis and Crohn's disease patients is enriched with macrophages expressing the scavenger receptor CD163
    • Demetter P., De Vos M., Van Huysse J.A., et al. Colon mucosa of both spondyloarthritis and Crohn's disease patients is enriched with macrophages expressing the scavenger receptor CD163. Annals of the Rheumatic Diseases 64 (2005) 321-324
    • (2005) Annals of the Rheumatic Diseases , vol.64 , pp. 321-324
    • Demetter, P.1    De Vos, M.2    Van Huysse, J.A.3
  • 38
    • 0345490916 scopus 로고    scopus 로고
    • Cytokines in the seronegative spondyloarthropathies and their modification by TNF blockade: a brief report and literature review
    • Keller C., Webb A., and Davis J. Cytokines in the seronegative spondyloarthropathies and their modification by TNF blockade: a brief report and literature review. Annals of the Rheumatic Diseases 62 (2003) 1128-1132
    • (2003) Annals of the Rheumatic Diseases , vol.62 , pp. 1128-1132
    • Keller, C.1    Webb, A.2    Davis, J.3
  • 39
    • 0036813084 scopus 로고    scopus 로고
    • Serum levels of IL-1 beta, TNF-alpha, IL-8, and acute phase proteins in seronegative spondyloarthropathies
    • Sonel B., Tutkak H., and Duzgun N. Serum levels of IL-1 beta, TNF-alpha, IL-8, and acute phase proteins in seronegative spondyloarthropathies. Joint, Bone, Spine 69 (2002) 463-467
    • (2002) Joint, Bone, Spine , vol.69 , pp. 463-467
    • Sonel, B.1    Tutkak, H.2    Duzgun, N.3
  • 40
    • 0027943397 scopus 로고
    • Serum cytokines (IL-6, TNF-alpha, IL-1 beta and IFN-gamma) in ankylosing spondylitis: a close correlation between serum IL-6 and disease activity and severity
    • Gratacos J., Collado A., Filella X., et al. Serum cytokines (IL-6, TNF-alpha, IL-1 beta and IFN-gamma) in ankylosing spondylitis: a close correlation between serum IL-6 and disease activity and severity. British Journal of Rheumatology 33 (1994) 927-931
    • (1994) British Journal of Rheumatology , vol.33 , pp. 927-931
    • Gratacos, J.1    Collado, A.2    Filella, X.3
  • 41
    • 0030760238 scopus 로고    scopus 로고
    • IL-10 plasma levels correlate with disease activity in spondyloarthropathy
    • Claudepierre P., Rymer J.C., and Chevalier X. IL-10 plasma levels correlate with disease activity in spondyloarthropathy. The Journal of Rheumatology 24 (1997) 1659-1661
    • (1997) The Journal of Rheumatology , vol.24 , pp. 1659-1661
    • Claudepierre, P.1    Rymer, J.C.2    Chevalier, X.3
  • 42
    • 0345385014 scopus 로고    scopus 로고
    • Lower level of synovial fluid interferon-gamma in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis
    • Bas S., Kvien T.K., Buchs N., et al. Lower level of synovial fluid interferon-gamma in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis. Rheumatology (Oxford, England) 42 (2003) 461-467
    • (2003) Rheumatology (Oxford, England) , vol.42 , pp. 461-467
    • Bas, S.1    Kvien, T.K.2    Buchs, N.3
  • 43
    • 0035170976 scopus 로고    scopus 로고
    • Low T-cell production of TNFα and IFN γ in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism
    • Rudwaleit M., Siegert S., Yin Z., et al. Low T-cell production of TNFα and IFN γ in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism. Annals of the Rheumatic Diseases 60 (2001) 36-42
    • (2001) Annals of the Rheumatic Diseases , vol.60 , pp. 36-42
    • Rudwaleit, M.1    Siegert, S.2    Yin, Z.3
  • 44
    • 0037809605 scopus 로고    scopus 로고
    • Up regulation of the production of tumour necrosis factor alpha and interferon gamma by T-cells in ankylosing spondylitis during treatment with etanercept
    • Zou J., Rudwaleit M., Brandt J., et al. Up regulation of the production of tumour necrosis factor alpha and interferon gamma by T-cells in ankylosing spondylitis during treatment with etanercept. Annals of the Rheumatic Diseases 62 (2003) 561-564
    • (2003) Annals of the Rheumatic Diseases , vol.62 , pp. 561-564
    • Zou, J.1    Rudwaleit, M.2    Brandt, J.3
  • 45
    • 0037333440 scopus 로고    scopus 로고
    • Down-regulation of the nonspecific and antigen-specific T-cell cytokine response in ankylosing spondylitis during treatment with infliximab
    • Zou J., Rudwaleit M., Brandt J., et al. Down-regulation of the nonspecific and antigen-specific T-cell cytokine response in ankylosing spondylitis during treatment with infliximab. Arthritis and Rheumatism 48 (2003) 780-790
    • (2003) Arthritis and Rheumatism , vol.48 , pp. 780-790
    • Zou, J.1    Rudwaleit, M.2    Brandt, J.3
  • 46
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A., and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nature Immunology 5 (2004) 987-995
    • (2004) Nature Immunology , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 48
    • 23644437537 scopus 로고    scopus 로고
    • The tolls of arthritis
    • Corr M. The tolls of arthritis. Arthritis and Rheumatism 52 (2005) 2233-2236
    • (2005) Arthritis and Rheumatism , vol.52 , pp. 2233-2236
    • Corr, M.1
  • 49
    • 18644364701 scopus 로고    scopus 로고
    • A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
    • Gautier G., Humbert M., Deauvieau F., et al. A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. The Journal of Experimental Medicine 201 (2005) 1435-1446
    • (2005) The Journal of Experimental Medicine , vol.201 , pp. 1435-1446
    • Gautier, G.1    Humbert, M.2    Deauvieau, F.3
  • 50
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway
    • Yamamoto M., Sato S., Hemmi H., et al. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301 (2003) 640-643
    • (2003) Science , vol.301 , pp. 640-643
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3
  • 51
    • 0037177825 scopus 로고    scopus 로고
    • Novel signal transduction pathway utilized by extracellular HSP70: role of Toll-like receptor (TLR) 2 and TLR4
    • Asea A., Rehli M., Kabingu E., et al. Novel signal transduction pathway utilized by extracellular HSP70: role of Toll-like receptor (TLR) 2 and TLR4. The Journal of Biological Chemistry 277 (2002) 15028-15034
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 15028-15034
    • Asea, A.1    Rehli, M.2    Kabingu, E.3
  • 52
    • 0035971217 scopus 로고    scopus 로고
    • The extra domain A of fibronectin activates Toll-like receptor 4
    • Okamura Y., Watari M., Jerud E.S., et al. The extra domain A of fibronectin activates Toll-like receptor 4. The Journal of Biological Chemistry 276 (2001) 10229-10233
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 10229-10233
    • Okamura, Y.1    Watari, M.2    Jerud, E.S.3
  • 53
    • 0036839577 scopus 로고    scopus 로고
    • Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses
    • Beg A.A. Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends in Immunology 23 (2002) 509-512
    • (2002) Trends in Immunology , vol.23 , pp. 509-512
    • Beg, A.A.1
  • 54
    • 10444278132 scopus 로고    scopus 로고
    • Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma
    • Radstake T.R., Roelofs M.F., Jenniskens Y.M., et al. Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis and Rheumatism 50 (2004) 3856-3865
    • (2004) Arthritis and Rheumatism , vol.50 , pp. 3856-3865
    • Radstake, T.R.1    Roelofs, M.F.2    Jenniskens, Y.M.3
  • 55
    • 22244489703 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy
    • De Rycke L., Vandooren B., Kruithof E., et al. Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy. Arthritis and Rheumatism 52 (2005) 2146-2158
    • (2005) Arthritis and Rheumatism , vol.52 , pp. 2146-2158
    • De Rycke, L.1    Vandooren, B.2    Kruithof, E.3
  • 56
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • Cario E., and Podolsky D.K. Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infection and Immunity 68 (2000) 7010-7017
    • (2000) Infection and Immunity , vol.68 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 57
    • 0025234494 scopus 로고
    • Guilt by association: HLA-B27 and ankylosing spondylitis
    • Benjamin R.J., and Parham P. Guilt by association: HLA-B27 and ankylosing spondylitis. Immunology Today 11 (1990) 137-142
    • (1990) Immunology Today , vol.11 , pp. 137-142
    • Benjamin, R.J.1    Parham, P.2
  • 58
  • 59
    • 0034214169 scopus 로고    scopus 로고
    • HLA-B27 misfolding: a solution to the spondyloarthropathy conundrum?
    • Colbert R.A. HLA-B27 misfolding: a solution to the spondyloarthropathy conundrum?. Molecular Medicine Today 6 (2000) 224-230
    • (2000) Molecular Medicine Today , vol.6 , pp. 224-230
    • Colbert, R.A.1
  • 61
    • 0032833157 scopus 로고    scopus 로고
    • HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27?
    • Ringrose J.H. HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27?. Annals of the Rheumatic Diseases 58 (1999) 598-610
    • (1999) Annals of the Rheumatic Diseases , vol.58 , pp. 598-610
    • Ringrose, J.H.1
  • 62
    • 0027328672 scopus 로고
    • HLA-B27-restricted CD8 T-cells from synovial fluids of patients with reactive arthritis and ankylosing spondylitis
    • Hermann E., Yu D.T.Y., Meyer zum Buschenfelde K.-H., and Fleischer B. HLA-B27-restricted CD8 T-cells from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet 342 (1993) 646-650
    • (1993) Lancet , vol.342 , pp. 646-650
    • Hermann, E.1    Yu, D.T.Y.2    Meyer zum Buschenfelde, K.-H.3    Fleischer, B.4
  • 63
    • 0031303865 scopus 로고    scopus 로고
    • A single nonamer from the yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in yersinia-induced reactive arthritis
    • Ugrinovic S., Mertz A., Wu P., et al. A single nonamer from the yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in yersinia-induced reactive arthritis. Journal of Immunology 159 (1997) 5715-5723
    • (1997) Journal of Immunology , vol.159 , pp. 5715-5723
    • Ugrinovic, S.1    Mertz, A.2    Wu, P.3
  • 64
    • 0035887754 scopus 로고    scopus 로고
    • Identification of HLA-B27-restricted peptides from Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated disease
    • Kuon W., Holzhutter H.-G., Appel H., et al. Identification of HLA-B27-restricted peptides from Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated disease. Journal of Immunology 167 (2001) 4738-4746
    • (2001) Journal of Immunology , vol.167 , pp. 4738-4746
    • Kuon, W.1    Holzhutter, H.-G.2    Appel, H.3
  • 65
    • 0035114738 scopus 로고    scopus 로고
    • CD4+ and CD8+ clonal T-cell expansions indicate a role of antigens in ankylosing spondylitis; a study in HLA-B27+ monozygotic twins
    • Duchmann R., Lambert C., May E., et al. CD4+ and CD8+ clonal T-cell expansions indicate a role of antigens in ankylosing spondylitis; a study in HLA-B27+ monozygotic twins. Clinical and Experimental Immunology 123 (2001) 315-322
    • (2001) Clinical and Experimental Immunology , vol.123 , pp. 315-322
    • Duchmann, R.1    Lambert, C.2    May, E.3
  • 66
    • 0029046095 scopus 로고
    • HLA-B27 binding of peptide from its own sequence and similar peptides from bacteria: implications for spondyloarthropathies
    • Scofield R.H., Kurien B., Gross T., et al. HLA-B27 binding of peptide from its own sequence and similar peptides from bacteria: implications for spondyloarthropathies. Lancet 345 (1995) 1542-1544
    • (1995) Lancet , vol.345 , pp. 1542-1544
    • Scofield, R.H.1    Kurien, B.2    Gross, T.3
  • 67
    • 0242708850 scopus 로고    scopus 로고
    • HLA-B27-restricted T-cells from patients with ankylosing spondylitis recognize peptides from B*2705 that are similar to bacteria-derived peptides
    • Frauendorf E., von Goessel H., May E., and Marker-Hermann E. HLA-B27-restricted T-cells from patients with ankylosing spondylitis recognize peptides from B*2705 that are similar to bacteria-derived peptides. Clinical and Experimental Immunology 134 (2003) 351-359
    • (2003) Clinical and Experimental Immunology , vol.134 , pp. 351-359
    • Frauendorf, E.1    von Goessel, H.2    May, E.3    Marker-Hermann, E.4
  • 68
    • 0033935853 scopus 로고    scopus 로고
    • +T-cell autoreactivity to an HLA-B27-restricted self-epitope correlates with ankylosing spondylitis
    • +T-cell autoreactivity to an HLA-B27-restricted self-epitope correlates with ankylosing spondylitis. The Journal of Clinical Investigation 106 (2000) 47-53
    • (2000) The Journal of Clinical Investigation , vol.106 , pp. 47-53
    • Fiorillo, M.T.1    Maragno, M.2    Butler, R.3
  • 70
    • 0035976604 scopus 로고    scopus 로고
    • T-cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL
    • Leishman A.J., Naidenko O.V., Attinger A., et al. T-cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. Science 294 (2001) 1936-1939
    • (2001) Science , vol.294 , pp. 1936-1939
    • Leishman, A.J.1    Naidenko, O.V.2    Attinger, A.3
  • 72
    • 0037352755 scopus 로고    scopus 로고
    • Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling
    • Bird L.A., Peh C.A., Kollnberger S., et al. Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling. European Journal of Immunology 33 (2003) 748-759
    • (2003) European Journal of Immunology , vol.33 , pp. 748-759
    • Bird, L.A.1    Peh, C.A.2    Kollnberger, S.3
  • 73
    • 0037108486 scopus 로고    scopus 로고
    • Uniquely conformed peptide-containing beta 2-microglobulin-free heavy chains of HLA-B2705 on the cell surface
    • Malik P., Klimovitsky P., Deng L.W., et al. Uniquely conformed peptide-containing beta 2-microglobulin-free heavy chains of HLA-B2705 on the cell surface. Journal of Immunology 169 (2002) 4379-4387
    • (2002) Journal of Immunology , vol.169 , pp. 4379-4387
    • Malik, P.1    Klimovitsky, P.2    Deng, L.W.3
  • 74
    • 0037189545 scopus 로고    scopus 로고
    • HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum
    • Dangoria N.S., DeLay M.L., Kingsbury D.J., et al. HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum. The Journal of Biological Chemistry 277 (2002) 23459-23468
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 23459-23468
    • Dangoria, N.S.1    DeLay, M.L.2    Kingsbury, D.J.3
  • 75
    • 0036846149 scopus 로고    scopus 로고
    • Cell surface expression and immune receptor recogntion of HLA-B27 homodimers
    • Kollnberger S., Bird L.A., S M.-Y., et al. Cell surface expression and immune receptor recogntion of HLA-B27 homodimers. Arthritis and Rheumatism 46 (2002) 2972-2982
    • (2002) Arthritis and Rheumatism , vol.46 , pp. 2972-2982
    • Kollnberger, S.1    Bird, L.A.2    Retiere, S.M.Y.3
  • 76
    • 3242798755 scopus 로고    scopus 로고
    • HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors
    • Kollnberger S., Bird L.A., Roddis M., et al. HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors. Journal of Immunology 173 (2004) 1699-1710
    • (2004) Journal of Immunology , vol.173 , pp. 1699-1710
    • Kollnberger, S.1    Bird, L.A.2    Roddis, M.3
  • 77
    • 27744513659 scopus 로고    scopus 로고
    • Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis
    • Chan A.T., Kollnberger S.D., Wedderburn L.R., and Bowness P. Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis. Arthritis and Rheumatism 52 (2005) 3586-3595
    • (2005) Arthritis and Rheumatism , vol.52 , pp. 3586-3595
    • Chan, A.T.1    Kollnberger, S.D.2    Wedderburn, L.R.3    Bowness, P.4
  • 79
    • 0030798758 scopus 로고    scopus 로고
    • HLA-B27 modulates the survival of Salmonella enteritidis in transfected L cells, possibly by impaired nitric oxide production
    • Virtala M., Kirveskari J., and Granfors K. HLA-B27 modulates the survival of Salmonella enteritidis in transfected L cells, possibly by impaired nitric oxide production. Infection and Immunity 65 (1997) 2436-4242
    • (1997) Infection and Immunity , vol.65 , pp. 2436-4242
    • Virtala, M.1    Kirveskari, J.2    Granfors, K.3
  • 80
    • 0030942755 scopus 로고    scopus 로고
    • HLA-B27 modulates intracellular survival of Salmonella enteritidis in human monocytic cells
    • Laitio P., Virtala M., Salmi M., et al. HLA-B27 modulates intracellular survival of Salmonella enteritidis in human monocytic cells. European Journal of Immunology 27 (1997) 1331-1338
    • (1997) European Journal of Immunology , vol.27 , pp. 1331-1338
    • Laitio, P.1    Virtala, M.2    Salmi, M.3
  • 81
    • 3142680151 scopus 로고    scopus 로고
    • Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells: dependency on glutamic acid at position 45 in the B pocket of HLA-B27
    • Penttinen M.A., Heiskanen K.M., Mohapatra R., et al. Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells: dependency on glutamic acid at position 45 in the B pocket of HLA-B27. Arthritis and Rheumatism 50 (2004) 2255-2263
    • (2004) Arthritis and Rheumatism , vol.50 , pp. 2255-2263
    • Penttinen, M.A.1    Heiskanen, K.M.2    Mohapatra, R.3
  • 82
    • 0036270326 scopus 로고    scopus 로고
    • Invasion of salmonella into human intestinal epithelial cells is modulated by HLA-B27
    • Saarinen M., Ekman P., Ikeda M., et al. Invasion of salmonella into human intestinal epithelial cells is modulated by HLA-B27. Rheumatology (Oxford, England) 41 (2002) 651-657
    • (2002) Rheumatology (Oxford, England) , vol.41 , pp. 651-657
    • Saarinen, M.1    Ekman, P.2    Ikeda, M.3
  • 83
    • 0031441577 scopus 로고    scopus 로고
    • Invasion and persistence of salmonella in human fibroblasts positive or negative for endogenous HLA B27
    • Huppertz H.I., and Heesemann J. Invasion and persistence of salmonella in human fibroblasts positive or negative for endogenous HLA B27. Annals of the Rheumatic Diseases 56 (1997) 671-676
    • (1997) Annals of the Rheumatic Diseases , vol.56 , pp. 671-676
    • Huppertz, H.I.1    Heesemann, J.2
  • 84
    • 0034773533 scopus 로고    scopus 로고
    • HLA-B27 expression does not modulate intracellular Chlamydia trachomatis infection of cell lines
    • Young J.L., Smith L., Matyszak M.K., and Gaston J.S.H. HLA-B27 expression does not modulate intracellular Chlamydia trachomatis infection of cell lines. Infection and Immunity 69 (2001) 6670-6675
    • (2001) Infection and Immunity , vol.69 , pp. 6670-6675
    • Young, J.L.1    Smith, L.2    Matyszak, M.K.3    Gaston, J.S.H.4
  • 85
    • 0035090852 scopus 로고    scopus 로고
    • The modulation of chlamydial replication by HLA-B27 depends on the cytoplasmic domain of HLA-B27
    • Kuipers J.G., Bialowons A., Dollman P., et al. The modulation of chlamydial replication by HLA-B27 depends on the cytoplasmic domain of HLA-B27. Clinical and Experimental Rheumatology 19 (2001) 47-52
    • (2001) Clinical and Experimental Rheumatology , vol.19 , pp. 47-52
    • Kuipers, J.G.1    Bialowons, A.2    Dollman, P.3
  • 86
    • 0032742012 scopus 로고    scopus 로고
    • Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies
    • Mear J.P., Schreiber K.L., Munz C., et al. Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. Journal of Immunology 163 (1999) 6665-6670
    • (1999) Journal of Immunology , vol.163 , pp. 6665-6670
    • Mear, J.P.1    Schreiber, K.L.2    Munz, C.3
  • 87
    • 1542305542 scopus 로고    scopus 로고
    • Formation of HLA-B27 homodimers and their relationship to assembly kinetics
    • Antoniou A.N., Ford S., Taurog J.D., et al. Formation of HLA-B27 homodimers and their relationship to assembly kinetics. The Journal of Biological Chemistry 279 (2004) 8895-8902
    • (2004) The Journal of Biological Chemistry , vol.279 , pp. 8895-8902
    • Antoniou, A.N.1    Ford, S.2    Taurog, J.D.3
  • 88
    • 1842476244 scopus 로고    scopus 로고
    • HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP
    • Tran T.M., Satumtira N., Dorris M.L., et al. HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP. Journal of Immunology 172 (2004) 5110-5119
    • (2004) Journal of Immunology , vol.172 , pp. 5110-5119
    • Tran, T.M.1    Satumtira, N.2    Dorris, M.L.3
  • 90
    • 1442351145 scopus 로고    scopus 로고
    • The immunobiology of HLA-B27: variations on a theme
    • Colbert R.A. The immunobiology of HLA-B27: variations on a theme. Current Molecular Medicine 4 (2004) 21-30
    • (2004) Current Molecular Medicine , vol.4 , pp. 21-30
    • Colbert, R.A.1
  • 93
    • 0036437307 scopus 로고    scopus 로고
    • Transcriptional and translational control in the mammalian unfolded protein response
    • Harding H.P., Calfon M., Urano F., et al. Transcriptional and translational control in the mammalian unfolded protein response. Annual Review of cell and Developmental Biology 18 (2002) 575-599
    • (2002) Annual Review of cell and Developmental Biology , vol.18 , pp. 575-599
    • Harding, H.P.1    Calfon, M.2    Urano, F.3
  • 94
    • 23444431837 scopus 로고    scopus 로고
    • HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response
    • Turner M.J., Sowders D.P., DeLay M.L., et al. HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response. Journal of Immunology 175 (2005) 2438-2448
    • (2005) Journal of Immunology , vol.175 , pp. 2438-2448
    • Turner, M.J.1    Sowders, D.P.2    DeLay, M.L.3
  • 95
    • 8644282751 scopus 로고    scopus 로고
    • Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
    • Deng J., Lu P.D., Zhang Y., et al. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Molecular and Cellular Biology 24 (2004) 10161-10168
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 10161-10168
    • Deng, J.1    Lu, P.D.2    Zhang, Y.3
  • 96
    • 33746873990 scopus 로고    scopus 로고
    • HLA-B27 misfolding and induction by IFN-g activates the unfolded protein response which augments type I IFN production in macrophages from transgenic rats
    • Turner M.J., Sowders D.P., DeLay M.L., et al. HLA-B27 misfolding and induction by IFN-g activates the unfolded protein response which augments type I IFN production in macrophages from transgenic rats. Arthritis and Rheumatism 52 (2005) S691
    • (2005) Arthritis and Rheumatism , vol.52
    • Turner, M.J.1    Sowders, D.P.2    DeLay, M.L.3
  • 97
    • 33746888157 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress-induced unfolded protein response sensitizes macrophages to TLR-dependent IFN-b production
    • Smith J.A., Turner M.J., Sowders D.P., et al. The endoplasmic reticulum stress-induced unfolded protein response sensitizes macrophages to TLR-dependent IFN-b production. Arthritis and Rheumatism 52 (2005) S393
    • (2005) Arthritis and Rheumatism , vol.52
    • Smith, J.A.1    Turner, M.J.2    Sowders, D.P.3
  • 98
    • 0034954034 scopus 로고    scopus 로고
    • Interferons alpha and beta as immune regulators-a new look
    • Biron C.A. Interferons alpha and beta as immune regulators-a new look. Immunity 14 (2001) 661-664
    • (2001) Immunity , vol.14 , pp. 661-664
    • Biron, C.A.1
  • 101
    • 0036668242 scopus 로고    scopus 로고
    • Links between innate and adaptive immunity via type I interferon
    • Le Bon A., and Tough D.F. Links between innate and adaptive immunity via type I interferon. Current Opinion in Immunology 14 (2002) 432-436
    • (2002) Current Opinion in Immunology , vol.14 , pp. 432-436
    • Le Bon, A.1    Tough, D.F.2
  • 102
    • 0037129205 scopus 로고    scopus 로고
    • RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta
    • Takayanagi H., Kim S., Matsuo K., et al. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature 416 (2002) 744-749
    • (2002) Nature , vol.416 , pp. 744-749
    • Takayanagi, H.1    Kim, S.2    Matsuo, K.3
  • 104
    • 33746890080 scopus 로고    scopus 로고
    • Additional human beta-2m curbs HLA-B27 heavy chain misfolding and promotes arthritis and spondylitis but not colitis in male B27 transgenic rats
    • Tran T.M., Dorris M.L., Satumitra N., et al. Additional human beta-2m curbs HLA-B27 heavy chain misfolding and promotes arthritis and spondylitis but not colitis in male B27 transgenic rats. Arthritis and Rheumatism 52 (2005) S447
    • (2005) Arthritis and Rheumatism , vol.52
    • Tran, T.M.1    Dorris, M.L.2    Satumitra, N.3
  • 105
    • 0029738444 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis
    • Miyata T., Hori O., Zhang J., et al. The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis. The Journal of Clinical Investigation 98 (1996) 1088-1094
    • (1996) The Journal of Clinical Investigation , vol.98 , pp. 1088-1094
    • Miyata, T.1    Hori, O.2    Zhang, J.3
  • 106
    • 0034795140 scopus 로고    scopus 로고
    • The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
    • Schmidt A.M., Yan S.D., Yan S.F., and Stern D.M. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. The Journal of Clinical Investigation 108 (2001) 949-955
    • (2001) The Journal of Clinical Investigation , vol.108 , pp. 949-955
    • Schmidt, A.M.1    Yan, S.D.2    Yan, S.F.3    Stern, D.M.4
  • 107
    • 0345306578 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces hyaluronan deposition and leukocyte adhesion
    • Majors A.K., Austin R.C., de la Motte C.A., et al. Endoplasmic reticulum stress induces hyaluronan deposition and leukocyte adhesion. The Journal of Biological Chemistry 278 (2003) 47223-47231
    • (2003) The Journal of Biological Chemistry , vol.278 , pp. 47223-47231
    • Majors, A.K.1    Austin, R.C.2    de la Motte, C.A.3
  • 109
    • 0028839838 scopus 로고
    • Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis
    • D'Amato M., Fiorillo M.T., Carcassi C., et al. Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis. European Journal of Immunology 25 (1995) 3199-3201
    • (1995) European Journal of Immunology , vol.25 , pp. 3199-3201
    • D'Amato, M.1    Fiorillo, M.T.2    Carcassi, C.3
  • 111
    • 0036007897 scopus 로고    scopus 로고
    • The HLA-B*2709 subtype confers susceptibility to spondyloarthropathy
    • Olivieri I., Ciancio G., Padula A., et al. The HLA-B*2709 subtype confers susceptibility to spondyloarthropathy. Arthritis and Rheumatism 46 (2003) 553-554
    • (2003) Arthritis and Rheumatism , vol.46 , pp. 553-554
    • Olivieri, I.1    Ciancio, G.2    Padula, A.3
  • 112
    • 0031051908 scopus 로고    scopus 로고
    • Susceptibility to ankylosing spondylitis correlates with the C-terminal residue of peptides presented by various HLA-B27 subtypes
    • Fiorillo M.T., Meadows L., D'Amato M., et al. Susceptibility to ankylosing spondylitis correlates with the C-terminal residue of peptides presented by various HLA-B27 subtypes. European Journal of Immunology 27 (1997) 368-373
    • (1997) European Journal of Immunology , vol.27 , pp. 368-373
    • Fiorillo, M.T.1    Meadows, L.2    D'Amato, M.3
  • 113
    • 0037053328 scopus 로고    scopus 로고
    • The peptide repertoires of HLA-B27 subtypes differentially associated to spondyloarthropathy (B*2704 and B*2706) differ by specific changes at three anchor positions
    • Sesma L., Montserrat V., Lamas J., et al. The peptide repertoires of HLA-B27 subtypes differentially associated to spondyloarthropathy (B*2704 and B*2706) differ by specific changes at three anchor positions. The Journal of Biological Chemistry 277 (2002) 16744-16749
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 16744-16749
    • Sesma, L.1    Montserrat, V.2    Lamas, J.3
  • 114
    • 0037047424 scopus 로고    scopus 로고
    • Differential association of HLA-B*2705 and B*2709 to ankylosing spondylitis correlates with limited peptide subsets but not with altered cell surface stability
    • Ramos M., Paradela A., Vazquez M., et al. Differential association of HLA-B*2705 and B*2709 to ankylosing spondylitis correlates with limited peptide subsets but not with altered cell surface stability. The Journal of Biological Chemistry 277 (2002) 28749-28756
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 28749-28756
    • Ramos, M.1    Paradela, A.2    Vazquez, M.3
  • 115
    • 31044444245 scopus 로고    scopus 로고
    • Spondylarthritis-associated and non-spondylarthritis-associated B27 subtypes differ in their dependence upon tapasin for surface expression and their incorporation into the peptide loading complex
    • Goodall J.C., Ellis L., and Hill Gaston J.S. Spondylarthritis-associated and non-spondylarthritis-associated B27 subtypes differ in their dependence upon tapasin for surface expression and their incorporation into the peptide loading complex. Arthritis and Rheumatism 54 (2006) 138-147
    • (2006) Arthritis and Rheumatism , vol.54 , pp. 138-147
    • Goodall, J.C.1    Ellis, L.2    Hill Gaston, J.S.3
  • 116
    • 0036903889 scopus 로고    scopus 로고
    • Increased level of HLA-B27 expression in ankylosing spondylitis patients compared with healthy HLA-B27-positive subjects: a possible further susceptibility factor for the development of disease
    • Cauli A., Dessole G., Fiorillo M.T., et al. Increased level of HLA-B27 expression in ankylosing spondylitis patients compared with healthy HLA-B27-positive subjects: a possible further susceptibility factor for the development of disease. Rheumatology (Oxford, England) 41 (2002) 1375-1379
    • (2002) Rheumatology (Oxford, England) , vol.41 , pp. 1375-1379
    • Cauli, A.1    Dessole, G.2    Fiorillo, M.T.3
  • 117
    • 33746895051 scopus 로고    scopus 로고
    • The lack of association between HLA-B*2709 and ankylosing spondylitis is not due to a defective cellular expression of the B*2709 molecules
    • Cauli A., Dessole G., Cappai L., et al. The lack of association between HLA-B*2709 and ankylosing spondylitis is not due to a defective cellular expression of the B*2709 molecules. Arthritis and Rheumatism 52 (2005) S394
    • (2005) Arthritis and Rheumatism , vol.52
    • Cauli, A.1    Dessole, G.2    Cappai, L.3
  • 118
    • 0037990109 scopus 로고    scopus 로고
    • Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: implications for pathogenesis
    • Fiorillo M.T., Cauli A., Carcassi C., et al. Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: implications for pathogenesis. Arthritis and Rheumatism 48 (2003) 1385-1389
    • (2003) Arthritis and Rheumatism , vol.48 , pp. 1385-1389
    • Fiorillo, M.T.1    Cauli, A.2    Carcassi, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.