An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene

Immunity

Volumn 5, Issue 4, 1996, Pages 377-386

  Rinkenberger, Julie L ^a,b   Wallin, Jeffrey J ^a   Johnson, Kirk W ^a,c   Koshland, Marian Elliott ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN J CHAIN; INTERLEUKIN 2; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; DEVELOPMENT; DOWN REGULATION; GENETIC TRANSCRIPTION; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030273557     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80263-0     Document Type: Article

References (46)

1. Adams, B., Dorfler, P., Aguzzi, A., Kozmik, Z., Urbanek, P., Maurer-Fogy, I., and Busslinger, M. (1992). Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 6, 1589-1607.
2. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K. (1987). Current Protocols in Molecular Biology (New York: Wiley-Interscience).
3. Benezra, R., Davis, R.L., Lockshon, D., Turner, D.L., and Weintraub, H. (1990). The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61, 49-59.
4. Blackman, M.A., Tigges, M.A., Minie, M.E., and Koshland, M.E. (1986). A model system for peptide hormone action in differentiation: interleukin 2 induces a B lymphoma to transcribe the J chain gene. Cell 47, 609-617.
5. Brooks, K., Yuan, D., Uhr, J.W., Krammer, P.M., and Vitetta, E.S. (1983). Lymphokine-induced IgM secretion by clones of neoplastic B cells. Nature 302, 825-826.
6. Busslinger, M., and Urbanek, P. (1995). The role of BSAP (Pax-5) in B-cell development. Curr. Opin. Genet. Dev. 5, 595-601.
7. Cogne, M., Lansford, R., Bottaro, A., Zhang, J., Gorman, J., Young, F., Cheng, H.-L., and Alt, F.W. (1994). A class switch control region in the 3′ end of the immunoglobulin heavy chain locus. Cell 77, 737-747.
8. Czerny, T., Schaffner, G., and Busslinger, M. (1993). DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev. 7, 2048-2061.
9. Durand, D.B., Bush, M.R., Morgan, J.G., Weiss, A., and Crabtree, G.R. (1987). A 275 basepair fragment at the 5′ end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. J. Exp. Med. 165, 395-407.
10. Giese, K., Cox, J., and Grosschedl, R. (1992). The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell 69, 185-195.
11. Gomez-Cuadrado, A., Rousseau, S., Renaud, J., and Ruiz-Carrillo, A. (1992). Repression of the H5 histone gene by a factor from erythrocytes that binds to the region of transcription initiation. EMBO J. 11, 1857-1866.
12. Grosschedl, R., and Baltimore, D. (1985). Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell 41, 885-897.
13. Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T., and Taniguchi, T. (1989). Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58, 729-739.
14. Inostroza, J.A., Mermelstein, F.H., Ha, I., Lane, W.S., and Reinberg, D. (1992). Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. Cell 70, 477-489.
15. Jaynes, J.B., and O'Farrell, P.H. (1988). Activation and repression of transcription by homeodomain-containing proteins that bind a common site. Nature 336, 744-749.
16. Kehrl, J.M., Riva, A., Wilson, G.L., and Thevenin, C. (1994). Molecular mechanisms regulating CD19, CD20 and CD22 gene expression. Immunol. Today 15, 432-436.
17. Klemsz, M.J., McKercher, S.R., Celada, A., van Beveren, C., and Maki, R. (1990). The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61, 113-124.
18. Koshland, M.E. (1985). The coming of age of the immunoglobulin J chain. Annu. Rev. Immunol. 3, 425-453.
19. Kozmik, Z., Wang, S., Dorfler, P., Adams, B., and Busslinger, M. (1992). The promoter of the CD19 gene is a target for the B cellspecific transcription factor BSAP. Mol. Cell. Biol. 12, 2662-2672.
20. Lamson, G., and Koshland, M.E. (1984). Changes in J chain and μ chain RNA expression as a function of B cell differentiation. J. Exp. Med. 160, 877-892.
21. Lansford, R.D., McFadden, H.J., Siu, S.T., Cox, J.S., Cann, G.M., and Koshland, M.E. (1992). A promoter element that exerts positive and negative control of the interleukin 2-responsive J-chain gene. Proc. Natl. Acad. Sci. USA 89, 5966-5970.
22. Liao, F., Birshtein, B.K., Busslinger, M., and Rothman, P. (1994). The transcription factor BSAP (NF-HB) is essential for immunoglobulin germ-line ∈ transcription. J. Immunol. 152, 2904-2911.
23. Matsui, K., Nakanishi, K., Cohen, D.I., Hada, T., Furuyama, J.-I., Hamaoka, T., and Higashino, K. (1989). B cell response pathways regulated by IL-5 and IL-2: secretory μH chain-mRNA and J chain mRNA expression are separately controlled events. J. Immunol. 142, 2918-2923.
24. McFadden, H.J., and Koshland, M.E. (1991). Interleukin 2- and interleukin 5-induced changes in the binding of regulatory factors to the J-chain gene promoter. Proc. Natl. Acad. Sci. USA 88, 11027-11031.
25. Michaelson, J.S., Singh, M., and Birshtein, B.K. (1996). B cell lineage-specific activator protein (BSAP), a player at multiple stages of B cell development. J. Immunol. 156, 2349-2351.
26. Minie, M.E., and Koshland, M.E. (1986). Accessibility of the promoter sequence in the J-chain gene is regulated by chromatin changes during B-cell differentiation. Mol. Cell. Biol. 6, 4031-4038.
27. Nakanishi, K., Cohen, E.I., Blackman, M., Nielsen, E., Ohara, J., Hamaoka, T., Koshland, M.E., and Paul, W.E. (1984). Ig RNA expression in normal B cells stimulated with anti-IgM antibody and T cell-derived growth and differentiation factors. J. Exp. Med. 160, 1736-1751.
28. Neurath, M., Strober, W., and Wakatsuki, Y. (1994). The murine Ig 3′ α enhancer is a target site with repressor function for the B cell lineage-specific transcription factor BSAP (NF-HB, Sa-BP). J. Immunol. 153, 730-742.
29. Neurath, M., Max, E.E., and Strober, W. (1995a). Pax 5 (BSAP) regulates the murine immunoglobulin 3′ α enhancer by suppressing binding of NF-αP, a protein that controls heavy chain transcription. Proc. Natl. Acad. Sci. USA 92, 5336-5340.
30. Neurath, M., Stuber, E.R., and Strober, W. (1995b). BSAP: a key regulator of B-cell development and differentiation. Immunol. Today 16, 564-569.
31. Niles, M.J., Matsuuchi, L., and Koshland, M.E. (1995). Polymer IgM assembly and secretion in lymphoid and nonlymphoid cell lines: evidence that J chain is required for pentamer IgM synthesis. Proc. Natl. Acad. Sci. USA 92, 2884-2888.
32. preB1 gene. Eur. J. Immunol. 22, 37-43.
33. Peterson, C.L., Orth, K., and Calame, K.L. (1986). Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA. Mol. Cell. Biol. 6, 4168-4178.
34. Randall, T.D., Brewer, J.W., and Corley, R.B. (1992). Direct evidence that J chain regulates the polymeric structure of IgM in antibody-secreting B cells. J. Biol. Chem. 267, 18002-18007.
35. Ron, D., and Habener, J.F. (1992). CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 6, 439-453.
36. Roth, S.Y., Shimizu, M., Johnson, L., Grunstein, M., and Simpson, R.T. (1992). Stable nucleosome positioning and complete repression by the yeast α2 repressor are disrupted by amino-terminal mutations in histone H4. Genes Dev. 6, 411-425.
37. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory).
38. 2-co-stimulated B lymphocytes. Eur. J. Immunol. 26, 268-271.
39. Shin, M.K., and Koshland, M.E. (1993). Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element. Genes Dev. 7, 2006-2015.
40. Singh, M., and Birshtein, B.K. (1993). NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3′ α enhancer at early stages of B-cell differentiation. Mol. Cell. Biol. 13, 3611-3622.
41. Strachan, T., and Read, A.P. (1994). Pax genes. Curr. Opin. Genet. Dev. 4, 427-438.
42. Turner, C.A., Jr., Mack, D.H., and Davis, M.M. (1994). Blimp-1 a novel zinc finger-containing protein that can drive maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 77, 297-306.
43. Urbanek, P., Wang, A.-Q., Fetka, I., Wagner, E.F., and Busslinger, M. (1994). Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79, 901-912.
44. Wakatsuki, Y., Neurath, M.F., Max, E.D., and Strober, W. (1994). The B cell-specific transcription factor BSAP regulates B cell proliferation. J. Exp. Med. 179, 1099-1108.
45. Yang, J., Glozak, M.A., and Blomberg, B.B. (1995). Identification and localization of a developmental stage-specific promoter activity from the murine λ5 gene. J. Immunol. 155, 2498-2514.
46. Zwollo, P., and Desiderio, S. (1994). Specific recognition of the blk promoter by the B-lymphoid transcription factor B-cell-specific activator protein. J. Biol. Chem. 269, 15310-15317.