Neprilysin Degrades Both Amyloid β Peptides 1-40 and 1-42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases

Journal of Biological Chemistry

Volumn 276, Issue 24, 2001, Pages 21895-21901

  Shirotani, Keiro ^a   Tsubuki, Satoshi ^a   Iwata, Nobuhisa ^a   Takaki, Yoshie ^a   Harigaya, Wakako ^a   Maruyama, Kei ^d   Kiryu Seo, Sumiko ^c   Kiyama, Hiroshi ^c   Iwata, Hiroshi ^b   Tomita, Taisuke ^b   Iwatsubo, Takeshi ^b   Saido, Takaomi C ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CHROMOSOMES; CLONING; DATA REDUCTION; ENZYME KINETICS; POLYPEPTIDES;

ENZYMATIC ACTIVITIES;

BIOCHEMISTRY;

AMYLOID BETA PEPTIDE[1-40]; AMYLOID BETA PEPTIDE[1-42]; AMYLOID BETA PROTEIN; MEMBRANE METALLOENDOPEPTIDASE; NEPRILYSIN LIKE PEPTIDASE ALPHA; NEPRILYSIN LIKE PEPTIDASE BETA; NEPRILYSIN LIKE PEPTIDASE GAMMA; NEURONAL ENDOPEPTIDASE; PEPTIDASE; PEX PROTEIN; PHOSPHORAMIDON; PROTEIN; PROTEINASE; THIORPHAN; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); ENZYME INHIBITOR; GLYCOPEPTIDE; ISOENZYME; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; HUMAN; HUMAN CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PHOSPHATE REGULATING GENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEQUENCE HOMOLOGY; X CHROMOSOME; AMINO ACID SEQUENCE; CHEMISTRY; CHROMOSOME MAP; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; NERVE CELL;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; BASE SEQUENCE; CHROMOSOME MAPPING; CLONING, MOLECULAR; ENDOPEPTIDASES; ENZYME INHIBITORS; GLYCOPEPTIDES; HUMANS; ISOENZYMES; KINETICS; MOLECULAR SEQUENCE DATA; NEPRILYSIN; NEURONS; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THIORPHAN; X CHROMOSOME;

EID: 0035877747     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008511200     Document Type: Article

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