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Volumn 6, Issue 5, 2004, Pages 291-305

Functional imaging of intratumoral hypoxia

Author keywords

Electron Paramagnetic Resonance Imaging; Functional imaging; Hypoxia; Magnetic resonance imaging; Magnetic resonance spectroscopy; Positron emission tomography

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; 2 (2 NITRO 1 IMIDAZOLYL) N (3,3,3 TRIFLUORO 2 HYDROXYPROPYL)ACETAMIDE; 2 (2 NITRO 1H IMIDAZOL 1 YL) N (2,2,3,3,3 PENTAFLUOROPROPYL)ACETAMIDE; 2 NITROIMIDAZOLE; ANTINEOPLASTIC AGENT; BMS 194769; BRU 59 21; CARBOPLATIN; CISPLATIN; DIACETYLBIS(N4 METHYLTHIOSEMICARBAZONE) COPPER; FLUORINE; FLUORINE 18; FLUOROERYTHRONITROIMIDAZOLE F 18; FLUOROURACIL; GLUCOSE; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; HYPOXIA INDUCIBLE FACTOR 1; IODOAZOMYCIN ARABINOSIDE IODINE 123; ISOTOPE; MISONIDAZOLE; NITROIMIDAZOLE; NITROXIDE; OXO[3,3,9,9 TETRAMETHYL 1 (2 NITRO 1H IMIDAZOL 1 YL) 4,8 DIAZAUNDECANE 2,10 DIONEDIOXIMATO]TECHNETIUM TC 99M; OXYGEN; PHOSPHORUS 31; PIMONIDAZOLE; SEMICARBAZONE DERIVATIVE; TIRAPAZAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UPENAZIME TC 99M;

EID: 4644248790     PISSN: 15361632     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mibio.2004.06.007     Document Type: Article
Times cited : (98)

References (149)
  • 1
    • 0030069889 scopus 로고    scopus 로고
    • Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers
    • J. Overgaard M.R. Horsman Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers Semin. Radiat. Oncol. 6 1996 10-21
    • (1996) Semin. Radiat. Oncol. , vol.6 , pp. 10-21
    • Overgaard, J.1    Horsman, M.R.2
  • 2
    • 0001626824 scopus 로고    scopus 로고
    • Overcoming hypoxic cell radioresistance
    • G.G. Steel (Ed.) Edward Arnold London
    • J. Overgaard Overcoming hypoxic cell radioresistance In: G.G. Steel (Ed.) Basic clinical radiobiology for radiation oncologists 1997 Edward Arnold London 141-151
    • (1997) Basic Clinical Radiobiology for Radiation Oncologists , pp. 141-151
    • Overgaard, J.1
  • 3
    • 0034104328 scopus 로고    scopus 로고
    • Cisplatin and tirapazamine in subjects with advanced previously untreated non-small-cell lung tumors
    • Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group
    • J. von Pawel R. von Roemeling U. Gatzemeier Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and tirapazamine in subjects with advanced previously untreated non-small-cell lung tumors J. Clin. Oncol. 18 2000 1351-1359
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1351-1359
    • von Pawel, J.1    von Roemeling, R.2    Gatzemeier, U.3
  • 4
    • 0027094234 scopus 로고
    • Blood flow and tissue oxygenation of human tumors: An update
    • P. Vaupel K. Schlenger M. Hoeckel Blood flow and tissue oxygenation of human tumors: an update Adv. Exp. Med. Biol. 317 1992 139-151
    • (1992) Adv. Exp. Med. Biol. , vol.317 , pp. 139-151
    • Vaupel, P.1    Schlenger, K.2    Hoeckel, M.3
  • 5
    • 0025968029 scopus 로고
    • Measurement of tumor hypoxia by invasive and non-invasive procedures: A review of recent clinical studies
    • J.D. Chapman Measurement of tumor hypoxia by invasive and non-invasive procedures: a review of recent clinical studies Radiother. Oncol 20 suppl 1991 13-19
    • (1991) Radiother. Oncol , vol.20 , Issue.SUPPL. , pp. 13-19
    • Chapman, J.D.1
  • 7
    • 0023932431 scopus 로고
    • Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
    • R.A. Gatenby H.B. Kessler J.S. Rosenblum et al. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy Int. J. Radiat. Oncol. Biol. Phys. 14 1988 831-838
    • (1988) Int. J. Radiat. Oncol. Biol. Phys. , vol.14 , pp. 831-838
    • Gatenby, R.A.1    Kessler, H.B.2    Rosenblum, J.S.3
  • 9
    • 0030742027 scopus 로고    scopus 로고
    • Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
    • D.M. Brizel G.S. Sibley L.R. Prosnitz et al. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck Int. J. Radiat. Oncol. Biol. Phys. 38 1997 285-289
    • (1997) Int. J. Radiat. Oncol. Biol. Phys. , vol.38 , pp. 285-289
    • Brizel, D.M.1    Sibley, G.S.2    Prosnitz, L.R.3
  • 10
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • M. Nordsmark M. Overgaard J. Overgaard Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck Radiother. Oncol. 41 1996 31-30
    • (1996) Radiother. Oncol. , vol.41
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 11
    • 0033022176 scopus 로고    scopus 로고
    • Influence of the hypoxic subvolume on the survival of patients with head and neck cancer
    • P. Stadler A. Becker H.J. Feldmann et al. Influence of the hypoxic subvolume on the survival of patients with head and neck cancer Int. J. Radiat. Oncol. Biol. Phys. 44 1999 749-754
    • (1999) Int. J. Radiat. Oncol. Biol. Phys. , vol.44 , pp. 749-754
    • Stadler, P.1    Becker, A.2    Feldmann, H.J.3
  • 12
    • 0030716348 scopus 로고    scopus 로고
    • Predictive assays of radiation response in patients with head and neck squamous cell carcinoma: A review of the Institute Gustave Roussy experience
    • F. Eschwege J. Bourhis T. Girinski et al. Predictive assays of radiation response in patients with head and neck squamous cell carcinoma: a review of the Institute Gustave Roussy experience Int. J. Radiat. Oncol. Biol. Phys. 39 1997 849-853
    • (1997) Int. J. Radiat. Oncol. Biol. Phys. , vol.39 , pp. 849-853
    • Eschwege, F.1    Bourhis, J.2    Girinski, T.3
  • 13
    • 0034002284 scopus 로고    scopus 로고
    • Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: Relationships to pretreatment tumor oxygenation and vascularization
    • K. Sundfor H. Lyng C.G. Trope et al. Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: relationships to pretreatment tumor oxygenation and vascularization Radiother. Oncol. 54 2000 101-107
    • (2000) Radiother. Oncol. , vol.54 , pp. 101-107
    • Sundfor, K.1    Lyng, H.2    Trope, C.G.3
  • 14
    • 0031716020 scopus 로고    scopus 로고
    • Oxygenation predicts radiation response and survival in patients with cervix cancer
    • A.W. Fyles M. Milosevic R. Wong et al. Oxygenation predicts radiation response and survival in patients with cervix cancer Radiother. Oncol. 48 1998 149-156
    • (1998) Radiother. Oncol. , vol.48 , pp. 149-156
    • Fyles, A.W.1    Milosevic, M.2    Wong, R.3
  • 15
    • 0032585864 scopus 로고    scopus 로고
    • Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix
    • T.H. Knocke H.D. Weitmann H.J. Feldmann et al. Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix Radiother. Oncol. 53 1999 99-104
    • (1999) Radiother. Oncol. , vol.53 , pp. 99-104
    • Knocke, T.H.1    Weitmann, H.D.2    Feldmann, H.J.3
  • 16
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • M. Hockel K. Schlenger B. Aral et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix Cancer Res. 56 1996 4509-4515
    • (1996) Cancer Res. , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3
  • 17
    • 0035917618 scopus 로고    scopus 로고
    • Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations
    • M. Nordsmark J. Alsner J. Keller et al. Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations Br. J. Cancer 84 2001 1070-1075
    • (2001) Br. J. Cancer , vol.84 , pp. 1070-1075
    • Nordsmark, M.1    Alsner, J.2    Keller, J.3
  • 18
    • 0019349297 scopus 로고
    • Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells
    • B.A. Teicher J.S. Lazo A.C. Sartorelli Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells Cancer Res. 41 1981 73-81
    • (1981) Cancer Res. , vol.41 , pp. 73-81
    • Teicher, B.A.1    Lazo, J.S.2    Sartorelli, A.C.3
  • 19
    • 0028206173 scopus 로고
    • Effects of hypoxia on detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells
    • P.J. O'Dwyer K.S. Yao P. Ford et al. Effects of hypoxia on detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells Cancer Res. 54 1994 3082-3087
    • (1994) Cancer Res. , vol.54 , pp. 3082-3087
    • O'Dwyer, P.J.1    Yao, K.S.2    Ford, P.3
  • 20
    • 0004580887 scopus 로고
    • Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells
    • G.C. Rice C. Hoy R.T. Schimke Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells Proc. Natl. Acad. Sci. USA 83 1986 5978-5982
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5978-5982
    • Rice, G.C.1    Hoy, C.2    Schimke, R.T.3
  • 21
    • 0028348423 scopus 로고
    • Kinetics of cell labeling and thymidine replacement after continuous infusion of halogenated pyrimidines in vivo
    • R. Rodriguez M.A. Ritter J.F. Fowler et al. Kinetics of cell labeling and thymidine replacement after continuous infusion of halogenated pyrimidines in vivo Int. J. Radiat. Oncol. Biol. Phys. 29 1994 105-113
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.29 , pp. 105-113
    • Rodriguez, R.1    Ritter, M.A.2    Fowler, J.F.3
  • 22
    • 0028603270 scopus 로고
    • The influence of microenvironmental factors during cancer therapy
    • R.E. Durand The influence of microenvironmental factors during cancer therapy In Vivo 8 1994 691-702
    • (1994) In Vivo , vol.8 , pp. 691-702
    • Durand, R.E.1
  • 23
    • 0037480606 scopus 로고    scopus 로고
    • Hypoxic cervical cancers with low apoptotic index are highly aggressive
    • M. Hockel K. Schlenger S. Hockel et al. Hypoxic cervical cancers with low apoptotic index are highly aggressive Cancer Res. 59 1999 4525-4528
    • (1999) Cancer Res. , vol.59 , pp. 4525-4528
    • Hockel, M.1    Schlenger, K.2    Hockel, S.3
  • 24
    • 0030022252 scopus 로고    scopus 로고
    • Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
    • D.M. Brizel S.P. Scully J.M. Harrelson et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma Cancer Res. 56 1996 941-943
    • (1996) Cancer Res. , vol.56 , pp. 941-943
    • Brizel, D.M.1    Scully, S.P.2    Harrelson, J.M.3
  • 25
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • T.G. Graeber C. Osmanian T. Jacks et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours Nature 379 1996 88-91
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 26
    • 0033867776 scopus 로고    scopus 로고
    • Hypoxia modulated gene expression: Angiogenesis, metastasis and therapeutic exploitation
    • G.U. Dachs G.M. Tozer Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation Eur. J. Cancer. 36 2000 1649-1660
    • (2000) Eur. J. Cancer. , vol.36 , pp. 1649-1660
    • Dachs, G.U.1    Tozer, G.M.2
  • 27
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • T.Y. Reynolds S. Rockwell P.M. Glazer Genetic instability induced by the tumor microenvironment Cancer Res. 56 1996 5754-5777
    • (1996) Cancer Res. , vol.56 , pp. 5754-5777
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 28
    • 0031823016 scopus 로고    scopus 로고
    • The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target
    • C. Blancher A.L. Harris The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target Cancer Metastasis Rev. 17 1998 187-194
    • (1998) Cancer Metastasis Rev. , vol.17 , pp. 187-194
    • Blancher, C.1    Harris, A.L.2
  • 29
    • 0035884701 scopus 로고    scopus 로고
    • HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
    • H.M. Sowter P.J. Ratcliffe P. Watson et al. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors Cancer Res. 61 2001 6669-6673
    • (2001) Cancer Res. , vol.61 , pp. 6669-6673
    • Sowter, H.M.1    Ratcliffe, P.J.2    Watson, P.3
  • 30
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • M. Hockel P. Vaupel Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects J. Natl. Cancer Inst. 93 2001 266-276
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 31
    • 0026356726 scopus 로고
    • Oxygenation of carcinomas of the uterine cervix: Evaluation by computerized O2 tension measurements
    • M. Hockel K. Schlenger C. Knoop et al. Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements Cancer Res. 51 1991 6098-6102
    • (1991) Cancer Res. , vol.51 , pp. 6098-6102
    • Hockel, M.1    Schlenger, K.2    Knoop, C.3
  • 32
    • 0034989311 scopus 로고    scopus 로고
    • Biological consequences of tumor hypoxia
    • M. Hockel P. Vaupel Biological consequences of tumor hypoxia Semin. Oncol. 28 2001 36-41
    • (2001) Semin. Oncol. , vol.28 , pp. 36-41
    • Hockel, M.1    Vaupel, P.2
  • 33
    • 0002377529 scopus 로고
    • Oxygenation status of human tumours: A reappraisal using computerised histography
    • P.W. Vaupel (Ed.) Gustav Fischer Verlag Marburg, Germany
    • P.W. Vaupel M. Hockel Oxygenation status of human tumours: a reappraisal using computerised histography In: P.W. Vaupel (Ed.) Tumour reoxygenation 1995 Gustav Fischer Verlag Marburg, Germany 219-232
    • (1995) Tumour Reoxygenation , pp. 219-232
    • Vaupel, P.W.1    Hockel, M.2
  • 34
    • 0028242772 scopus 로고
    • Measurement of human tumour oxygenation status by a polarographic needle electrode. An analysis of inter- and intratumour heterogeneity
    • M. Nordsmark S.M. Bentzen J. Overgaard Measurement of human tumour oxygenation status by a polarographic needle electrode. An analysis of inter- and intratumour heterogeneity Acta Oncol. 33 1994 383-389
    • (1994) Acta Oncol. , vol.33 , pp. 383-389
    • Nordsmark, M.1    Bentzen, S.M.2    Overgaard, J.3
  • 35
    • 0000924790 scopus 로고
    • Microelectrodes for measuring local oxygen tensions in animal tissue
    • P. Davies F., Brink Jr. Microelectrodes for measuring local oxygen tensions in animal tissue Rev. Sci. Instrum. 13 1942 524-528
    • (1942) Rev. Sci. Instrum. , vol.13 , pp. 524-528
    • Davies, P.1    Brink Jr., F.2
  • 36
    • 0027339592 scopus 로고
    • Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix
    • M. Hockel C. Knoop K. Schlenger et al. Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix Radiother. Oncol. 26 1993 45-50
    • (1993) Radiother. Oncol. , vol.26 , pp. 45-50
    • Hockel, M.1    Knoop, C.2    Schlenger, K.3
  • 37
    • 0027141149 scopus 로고
    • Oxygen in human tumors: Correlations between methods of measurement and response to therapy
    • Summary of a workshop held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland
    • H.B. Stone J.M. Brown T.L. Phillips et al. Oxygen in human tumors: correlations between methods of measurement and response to therapy. Summary of a workshop held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland Radiat. Res. 136 1993 422-434
    • (1993) Radiat. Res. , vol.136 , pp. 422-434
    • Stone, H.B.1    Brown, J.M.2    Phillips, T.L.3
  • 38
    • 0035698467 scopus 로고    scopus 로고
    • Measuring hypoxia in solid tumours - Is there a gold standard?
    • P.L. Olive J.P. Banath C. Aquino-Parsons Measuring hypoxia in solid tumours - is there a gold standard? Acta Oncol. 40 2001 917-923
    • (2001) Acta Oncol. , vol.40 , pp. 917-923
    • Olive, P.L.1    Banath, J.P.2    Aquino-Parsons, C.3
  • 39
    • 8544273661 scopus 로고    scopus 로고
    • Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker
    • M. Nozue I. Lee F. Yuan et al. Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker J. Surg. Oncol. 66 1997 30-38
    • (1997) J. Surg. Oncol. , vol.66 , pp. 30-38
    • Nozue, M.1    Lee, I.2    Yuan, F.3
  • 40
    • 0030825252 scopus 로고    scopus 로고
    • Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia
    • H. Lyng K. Sundfor E.K. Rofstad Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia Radiother. Oncol. 44 1997 163-169
    • (1997) Radiother. Oncol. , vol.44 , pp. 163-169
    • Lyng, H.1    Sundfor, K.2    Rofstad, E.K.3
  • 41
    • 0026696613 scopus 로고
    • Does the direct measurement of oxygen tension in tumors have any adverse effects?
    • E. Lartigau F. Lespinasse L. Vitu et al. Does the direct measurement of oxygen tension in tumors have any adverse effects? Int. J. Radiat. Oncol. Biol. Phys. 22 1992 949-951
    • (1992) Int. J. Radiat. Oncol. Biol. Phys. , vol.22 , pp. 949-951
    • Lartigau, E.1    Lespinasse, F.2    Vitu, L.3
  • 42
    • 0037377261 scopus 로고    scopus 로고
    • Estimating hypoxic status in human tumors: A simulation using Eppendorf oxygen probe data in cervical cancer patients
    • C.M. Doll M. Milosevic M. Pintilie et al. Estimating hypoxic status in human tumors: a simulation using Eppendorf oxygen probe data in cervical cancer patients Int. J. Radiat. Oncol. Biol. Phys. 55 2003 1239-1246
    • (2003) Int. J. Radiat. Oncol. Biol. Phys. , vol.55 , pp. 1239-1246
    • Doll, C.M.1    Milosevic, M.2    Pintilie, M.3
  • 44
    • 0035254205 scopus 로고    scopus 로고
    • Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma
    • M. Nordsmark J. Loncaster S.C. Chou et al. Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma Int. J. Radiat. Oncol. Biol. Phys. 49 2001 581-586
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.49 , pp. 581-586
    • Nordsmark, M.1    Loncaster, J.2    Chou, S.C.3
  • 45
    • 0031688165 scopus 로고    scopus 로고
    • Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
    • K. Sundfor H. Lyng E.K. Rofstad Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix Br. J. Cancer 78 1998 822-827
    • (1998) Br. J. Cancer , vol.78 , pp. 822-827
    • Sundfor, K.1    Lyng, H.2    Rofstad, E.K.3
  • 46
    • 0027477360 scopus 로고
    • Oxygenation of head and neck tumors
    • E. Lartigau A.M. Le Ridant P. Lambin et al. Oxygenation of head and neck tumors Cancer 71 1993 2319-2325
    • (1993) Cancer , vol.71 , pp. 2319-2325
    • Lartigau, E.1    Le Ridant, A.M.2    Lambin, P.3
  • 47
    • 0344936018 scopus 로고    scopus 로고
    • Oxygenation of squamous cell carcinoma of the head and neck: Comparison of primary tumors, neck node metastases, and normal tissue
    • A. Becker G. Hansgen M. Bloching et al. Oxygenation of squamous cell carcinoma of the head and neck: comparison of primary tumors, neck node metastases, and normal tissue Int. J. Radiat. Oncol. Biol. Phys. 42 1998 35-41
    • (1998) Int. J. Radiat. Oncol. Biol. Phys. , vol.42 , pp. 35-41
    • Becker, A.1    Hansgen, G.2    Bloching, M.3
  • 48
    • 0037963317 scopus 로고    scopus 로고
    • Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients
    • Q.T. Le M.S. Kovacs M.J. Dorie et al. Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients Int. J. Radiat. Oncol. Biol. Phys. 56 2003 375-383
    • (2003) Int. J. Radiat. Oncol. Biol. Phys. , vol.56 , pp. 375-383
    • Le, Q.T.1    Kovacs, M.S.2    Dorie, M.J.3
  • 49
    • 0032708195 scopus 로고    scopus 로고
    • Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
    • D.M. Brizel R.K. Dodge R.W. Clough et al. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome Radiother. Oncol. 53 1999 113-117
    • (1999) Radiother. Oncol. , vol.53 , pp. 113-117
    • Brizel, D.M.1    Dodge, R.K.2    Clough, R.W.3
  • 50
    • 0030199968 scopus 로고    scopus 로고
    • The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas
    • M. Nordsmark M. Hoyer J. Keller et al. The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas Int. J. Radiat. Oncol. Biol. Phys. 35 1996 701-708
    • (1996) Int. J. Radiat. Oncol. Biol. Phys. , vol.35 , pp. 701-708
    • Nordsmark, M.1    Hoyer, M.2    Keller, J.3
  • 51
    • 0038642530 scopus 로고    scopus 로고
    • Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours
    • L. Bentzen S. Keiding M. Nordsmark et al. Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours Radiother. Oncol. 67 2003 339-344
    • (2003) Radiother. Oncol. , vol.67 , pp. 339-344
    • Bentzen, L.1    Keiding, S.2    Nordsmark, M.3
  • 53
    • 0030731275 scopus 로고    scopus 로고
    • Tumour oxygenation assessed by polarographic needle electrodes and bioenergetic status measured by 31P magnetic resonance spectroscopy in human soft tissue tumours
    • M. Nordsmark J. Keller O.S. Nielsen et al. Tumour oxygenation assessed by polarographic needle electrodes and bioenergetic status measured by 31P magnetic resonance spectroscopy in human soft tissue tumours Acta Oncol. 36 1997 565-571
    • (1997) Acta Oncol. , vol.36 , pp. 565-571
    • Nordsmark, M.1    Keller, J.2    Nielsen, O.S.3
  • 54
  • 55
    • 0020309922 scopus 로고
    • Oxygen tension and prediction of the radiation response. Polarographic study in human breast cancer
    • N. Pappova E. Siracka A. Vacek et al. Oxygen tension and prediction of the radiation response. Polarographic study in human breast cancer Neoplasma 29 1982 669-674
    • (1982) Neoplasma , vol.29 , pp. 669-674
    • Pappova, N.1    Siracka, E.2    Vacek, A.3
  • 56
    • 0025807618 scopus 로고
    • Oxygenation of human tumors: Evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements
    • P. Vaupel K. Schlenger C. Knoop et al. Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements Cancer Res. 51 1991 3316-3322
    • (1991) Cancer Res. , vol.51 , pp. 3316-3322
    • Vaupel, P.1    Schlenger, K.2    Knoop, C.3
  • 57
    • 0028215490 scopus 로고
    • Direct measurement of the PO2 distribution in human malignant brain tumours
    • G.S. Cruickshank R.P. Rampling W. Cowans Direct measurement of the PO2 distribution in human malignant brain tumours Adv. Exp. Med. Biol. 345 1994 465-470
    • (1994) Adv. Exp. Med. Biol. , vol.345 , pp. 465-470
    • Cruickshank, G.S.1    Rampling, R.P.2    Cowans, W.3
  • 58
    • 0031058592 scopus 로고    scopus 로고
    • Measurement of tumor oxygenation: A comparison between polarographic needle electrodes and a time-resolved luminescence-based optical sensor
    • D.R. Collingridge W.K. Young B. Vojnovic et al. Measurement of tumor oxygenation: a comparison between polarographic needle electrodes and a time-resolved luminescence-based optical sensor Radiat. Res. 147 1997 329-334
    • (1997) Radiat. Res. , vol.147 , pp. 329-334
    • Collingridge, D.R.1    Young, W.K.2    Vojnovic, B.3
  • 59
    • 0034798395 scopus 로고    scopus 로고
    • Hypoxia in human prostate carcinoma: An Eppendorf PO2 study
    • B. Movsas J.D. Chapman A.L. Hanlon et al. Hypoxia in human prostate carcinoma: an Eppendorf PO2 study Am. J. Clin. Oncol. 24 2001 458-461
    • (2001) Am. J. Clin. Oncol. , vol.24 , pp. 458-461
    • Movsas, B.1    Chapman, J.D.2    Hanlon, A.L.3
  • 60
    • 0033954168 scopus 로고    scopus 로고
    • Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1
    • S.M. Evans A.V. Kachur C.Y. Shiue et al. Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1 J. Nucl. Med. 41 2000 327-336
    • (2000) J. Nucl. Med. , vol.41 , pp. 327-336
    • Evans, S.M.1    Kachur, A.V.2    Shiue, C.Y.3
  • 61
    • 0036048395 scopus 로고    scopus 로고
    • Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5
    • C.J. Koch Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5 Methods Enzymol. 352 2002 3-31
    • (2002) Methods Enzymol. , vol.352 , pp. 3-31
    • Koch, C.J.1
  • 62
    • 0037430244 scopus 로고    scopus 로고
    • GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding
    • R.E. Airley J. Loncaster J.A. et al. Raleigh GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding Int. J. Cancer. 104 2003 85-91
    • (2003) Int. J. Cancer. , vol.104 , pp. 85-91
    • Airley, R.E.1    Loncaster, J.2    Raleigh, J.A.3
  • 63
    • 0035145590 scopus 로고    scopus 로고
    • Estimation of oxygen distribution in RIF-1 tumors by diffusion model-based interpretation of pimonidazole hypoxia and eppendorf measurements
    • B.W. Pogue K.D. Paulsen J.A. O'Hara et al. Estimation of oxygen distribution in RIF-1 tumors by diffusion model-based interpretation of pimonidazole hypoxia and eppendorf measurements Radiat. Res. 155 2001 15-25
    • (2001) Radiat. Res. , vol.155 , pp. 15-25
    • Pogue, B.W.1    Paulsen, K.D.2    O'Hara, J.A.3
  • 64
    • 0032959983 scopus 로고    scopus 로고
    • DNA damage and repair in individual cells: Applications of the comet assay in radiobiology
    • P.L. Olive DNA damage and repair in individual cells: applications of the comet assay in radiobiology Int. J. Radiat. Biol. 75 1999 395-405
    • (1999) Int. J. Radiat. Biol. , vol.75 , pp. 395-405
    • Olive, P.L.1
  • 66
    • 0029870458 scopus 로고    scopus 로고
    • Comparing techniques of measuring tumor hypoxia in different murine tumors: Eppendorf pO2 Histograph, [3H]misonidazole binding and paired survival assay
    • M.C. Kavanagh A. Sun Q. Hu et al. Comparing techniques of measuring tumor hypoxia in different murine tumors: Eppendorf pO2 Histograph, [3H]misonidazole binding and paired survival assay Radiat. Res. 145 1996 491-500
    • (1996) Radiat. Res. , vol.145 , pp. 491-500
    • Kavanagh, M.C.1    Sun, A.2    Hu, Q.3
  • 67
    • 0032988222 scopus 로고    scopus 로고
    • Comparison between the comet assay and the oxygen microelectrode for measurement of tumor hypoxia
    • C. Aquino-Parsons C. Luo C.M. Vikse Comparison between the comet assay and the oxygen microelectrode for measurement of tumor hypoxia Radiother. Oncol. 51 1999 179-185
    • (1999) Radiother. Oncol. , vol.51 , pp. 179-185
    • Aquino-Parsons, C.1    Luo, C.2    Vikse, C.M.3
  • 68
    • 0035524455 scopus 로고    scopus 로고
    • The functional and clinical roles of osteopontin in cancer and metastasis
    • K.A. Furger R.K. Menon A.B. Tuckl et al. The functional and clinical roles of osteopontin in cancer and metastasis Curr. Mol. Med. 1 2001 621-632
    • (2001) Curr. Mol. Med. , vol.1 , pp. 621-632
    • Furger, K.A.1    Menon, R.K.2    Tuckl, A.B.3
  • 69
    • 12244267969 scopus 로고    scopus 로고
    • Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas
    • Q.T. Le P.D. Sutphin S. Raychaudhuri et al. Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas Clin. Cancer Res. 9 2003 59-67
    • (2003) Clin. Cancer Res. , vol.9 , pp. 59-67
    • Le, Q.T.1    Sutphin, P.D.2    Raychaudhuri, S.3
  • 70
    • 0038172576 scopus 로고    scopus 로고
    • Cancer: Out of air is not out of action
    • D.P. Bottaro L.A. Liotta Cancer: out of air is not out of action Nature 423 2003 593-595
    • (2003) Nature , vol.423 , pp. 593-595
    • Bottaro, D.P.1    Liotta, L.A.2
  • 72
    • 0029885464 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy and imaging methods for measuring tumour and tissue oxygenation
    • C.L. McCoy D.J. McIntyre S.P. Robinson et al. Magnetic resonance spectroscopy and imaging methods for measuring tumour and tissue oxygenation Br. J. Cancer 27 suppl 1996 S226-S231
    • (1996) Br. J. Cancer , vol.27 , Issue.SUPPL.
    • McCoy, C.L.1    McIntyre, D.J.2    Robinson, S.P.3
  • 73
    • 0025630001 scopus 로고
    • Brain magnetic resonance imaging with contrast dependent on blood oxygenation
    • S. Ogawa T.M. Lee A.R. Kay et al. Brain magnetic resonance imaging with contrast dependent on blood oxygenation Proc. Natl. Acad. Sci. U S A 87 1990 9868-9872
    • (1990) Proc. Natl. Acad. Sci. U S A , vol.87 , pp. 9868-9872
    • Ogawa, S.1    Lee, T.M.2    Kay, A.R.3
  • 74
    • 0028398378 scopus 로고
    • Inflow versus deoxyhemoglobin effects in BOLD functional MRI using gradient echoes at 1.5 T
    • J.H. Duyn C.T. Moonen G.H. van Yperen et al. Inflow versus deoxyhemoglobin effects in BOLD functional MRI using gradient echoes at 1.5 T. NMR Biomed 7 1994 83-88
    • (1994) NMR Biomed. , vol.7 , pp. 83-88
    • Duyn, J.H.1    Moonen, C.T.2    van Yperen, G.H.3
  • 75
    • 18544407722 scopus 로고    scopus 로고
    • The response of human tumors to carbogen breathing, monitored by gradient-recalled echo magnetic resonance imaging
    • J.R. Griffiths N.J. Taylor F.A. Howe et al. The response of human tumors to carbogen breathing, monitored by gradient-recalled echo magnetic resonance imaging Int. J. Radiat. Oncol. Biol. Phys. 39 1997 697-701
    • (1997) Int. J. Radiat. Oncol. Biol. Phys. , vol.39 , pp. 697-701
    • Griffiths, J.R.1    Taylor, N.J.2    Howe, F.A.3
  • 76
    • 0032930139 scopus 로고    scopus 로고
    • Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging
    • S.P. Robinson D.R. Collingridge F.A. Howe et al. Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging NMR Biomed. 12 1999 98-106
    • (1999) NMR Biomed. , vol.12 , pp. 98-106
    • Robinson, S.P.1    Collingridge, D.R.2    Howe, F.A.3
  • 77
    • 0034999693 scopus 로고    scopus 로고
    • Effects of different levels of hypercapnic hyperoxia on tumour R(2)* and arterial blood gases
    • S.P. Robinson L.M. Rodrigues F.A. Howe et al. Effects of different levels of hypercapnic hyperoxia on tumour R(2)* and arterial blood gases Magn. Reson. Imaging 19 2001 161-166
    • (2001) Magn. Reson. Imaging , vol.19 , pp. 161-166
    • Robinson, S.P.1    Rodrigues, L.M.2    Howe, F.A.3
  • 78
    • 0036680134 scopus 로고    scopus 로고
    • Effects of breathing a hyperoxic hypercapnic gas mixture on blood oxygenation and vascularity of head-and-neck tumors as measured by magnetic resonance imaging
    • M. Rijpkema J.H. Kaanders F.B. Joosten et al. Effects of breathing a hyperoxic hypercapnic gas mixture on blood oxygenation and vascularity of head-and-neck tumors as measured by magnetic resonance imaging Int. J. Radiat. Oncol. Biol. Phys. 53 2002 1185-1191
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.53 , pp. 1185-1191
    • Rijpkema, M.1    Kaanders, J.H.2    Joosten, F.B.3
  • 79
    • 0036893483 scopus 로고    scopus 로고
    • How does blood oxygen level-dependent (BOLD) contrast correlate with oxygen partial pressure (pO2) inside tumors?
    • C. Baudelet B. Gallez How does blood oxygen level-dependent (BOLD) contrast correlate with oxygen partial pressure (pO2) inside tumors? Magn. Reson. Med. 48 2002 980-986
    • (2002) Magn. Reson. Med. , vol.48 , pp. 980-986
    • Baudelet, C.1    Gallez, B.2
  • 80
    • 0032695525 scopus 로고    scopus 로고
    • MR imaging of tumor microcirculation: Promise for the new millennium
    • J.S. Taylor P.S. Tofts R. Port et al. MR imaging of tumor microcirculation: promise for the new millennium Magn. Reson. Imaging. 10 1999 903-907
    • (1999) Magn. Reson. Imaging. , vol.10 , pp. 903-907
    • Taylor, J.S.1    Tofts, P.S.2    Port, R.3
  • 81
    • 0029979794 scopus 로고    scopus 로고
    • The relationship between partial pressure of oxygen and perfusion in two murine tumors after X-ray irradiation: A combined gadopentetate dimeglumine dynamic magnetic resonance imaging and in vivo electron paramagnetic resonance oximetry study
    • F. Goda G. Bacic J.A. O'Hara et al. The relationship between partial pressure of oxygen and perfusion in two murine tumors after X-ray irradiation: a combined gadopentetate dimeglumine dynamic magnetic resonance imaging and in vivo electron paramagnetic resonance oximetry study Cancer Res. 56 1996 3344-3349
    • (1996) Cancer Res. , vol.56 , pp. 3344-3349
    • Goda, F.1    Bacic, G.2    O'Hara, J.A.3
  • 82
    • 0034307049 scopus 로고    scopus 로고
    • Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix
    • R.A. Cooper B.M. Carrington J.A. Loncaster et al. Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix Radiother. Oncol. 57 2000 53-59
    • (2000) Radiother. Oncol. , vol.57 , pp. 53-59
    • Cooper, R.A.1    Carrington, B.M.2    Loncaster, J.A.3
  • 83
    • 0031912025 scopus 로고    scopus 로고
    • Prediction of tumor control in patients with cervical cancer: Analysis of combined volume and dynamic enhancement pattern by MR imaging
    • N.A. Mayr W.T. Yuh J. Zheng et al. Prediction of tumor control in patients with cervical cancer: analysis of combined volume and dynamic enhancement pattern by MR imaging AJR 170 1998 177-182
    • (1998) AJR , vol.170 , pp. 177-182
    • Mayr, N.A.1    Yuh, W.T.2    Zheng, J.3
  • 84
    • 18844479070 scopus 로고    scopus 로고
    • Uterine cervical carcinoma: Comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival
    • H. Hawighorst P.G. Knapstein M.V. Knopp et al. Uterine cervical carcinoma: Comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival Cancer Res. 58 1998 3598-3602
    • (1998) Cancer Res. , vol.58 , pp. 3598-3602
    • Hawighorst, H.1    Knapstein, P.G.2    Knopp, M.V.3
  • 85
    • 0028671039 scopus 로고
    • 1H NMR approach to observe tissue oxygenation with the signals of myoglobin
    • T. Jue U. Kreutzer Y Chung 1H NMR approach to observe tissue oxygenation with the signals of myoglobin Adv. Exp. Med. Biol. 361 1994 111-118
    • (1994) Adv. Exp. Med. Biol. , vol.361 , pp. 111-118
    • Jue, T.1    Kreutzer, U.2    Chung, Y.3
  • 86
    • 0026918864 scopus 로고
    • 1H NMR spectroscopy of subcutaneous tumors in mice: Preliminary studies of effects of growth, chemotherapy and blood flow reduction
    • D.C. Shungu Z.M. Bhujwalla J.P. Wehrle et al. 1H NMR spectroscopy of subcutaneous tumors in mice: preliminary studies of effects of growth, chemotherapy and blood flow reduction NMR Biomed. 5 1992 296-302
    • (1992) NMR Biomed. , vol.5 , pp. 296-302
    • Shungu, D.C.1    Bhujwalla, Z.M.2    Wehrle, J.P.3
  • 87
    • 0024273006 scopus 로고
    • Cerebral lactate detected by regional proton magnetic resonance spectroscopy in a patient with cerebral infarction
    • J.W. Berkelbach van der Sprenkel P.R. Luyten P.C. van Rijen et al. Cerebral lactate detected by regional proton magnetic resonance spectroscopy in a patient with cerebral infarction Stroke 19 1988 1556-1560
    • (1988) Stroke , vol.19 , pp. 1556-1560
    • Berkelbach van der Sprenkel, J.W.1    Luyten, P.R.2    van Rijen, P.C.3
  • 88
    • 0024528020 scopus 로고
    • Cerebral metabolism in man after acute stroke: New observations using localized proton NMR spectroscopy
    • H. Bruhn J. Frahm M.L. Gyngell et al. Cerebral metabolism in man after acute stroke: new observations using localized proton NMR spectroscopy Magn. Reson. Med. 9 1989 126-131
    • (1989) Magn. Reson. Med. , vol.9 , pp. 126-131
    • Bruhn, H.1    Frahm, J.2    Gyngell, M.L.3
  • 89
    • 0033631043 scopus 로고    scopus 로고
    • In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements
    • J.M. Star-Lack E. Adalsteinsson M.F. Adam et al. In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements AJNR 21 2000 183-193
    • (2000) AJNR , vol.21 , pp. 183-193
    • Star-Lack, J.M.1    Adalsteinsson, E.2    Adam, M.F.3
  • 90
    • 0028425451 scopus 로고
    • Intracellular acidosis in murine fibrosarcomas coincides with ATP depletion, hypoxia, and high levels of lactate and total Pi
    • P. Vaupel C. Schaefer P. Okunieff Intracellular acidosis in murine fibrosarcomas coincides with ATP depletion, hypoxia, and high levels of lactate and total Pi NMR Biomed. 7 1994 128-136
    • (1994) NMR Biomed. , vol.7 , pp. 128-136
    • Vaupel, P.1    Schaefer, C.2    Okunieff, P.3
  • 91
    • 0026919666 scopus 로고
    • The contribution made by cell death and oxygenation to 31P MRS observations of tumour energy metabolism
    • G.M. Tozer J.R. Griffiths The contribution made by cell death and oxygenation to 31P MRS observations of tumour energy metabolism NMR Biomed. 5 1992 279-289
    • (1992) NMR Biomed. , vol.5 , pp. 279-289
    • Tozer, G.M.1    Griffiths, J.R.2
  • 92
    • 0032863711 scopus 로고    scopus 로고
    • Monitoring of tumor reoxygenation following irradiation by 31P magnetic resonance spectroscopy: An experimental study of human melanoma xenografts
    • D.R. Olsen E.K. Rofstad Monitoring of tumor reoxygenation following irradiation by 31P magnetic resonance spectroscopy: an experimental study of human melanoma xenografts Radiother. Oncol. 52 1999 261-267
    • (1999) Radiother. Oncol. , vol.52 , pp. 261-267
    • Olsen, D.R.1    Rofstad, E.K.2
  • 93
    • 18744366110 scopus 로고    scopus 로고
    • Correlations between in vivo tumor weight, oxygen pressure, 31P NMR spectroscopy, hypoxic microenvironment marking by beta-D-iodinated azomycin galactopyranoside (beta-D-IAZGP), and radiation sensitivity
    • J. Saitoh H. Sakurai Y. Suzuki et al. Correlations between in vivo tumor weight, oxygen pressure, 31P NMR spectroscopy, hypoxic microenvironment marking by beta-D-iodinated azomycin galactopyranoside (beta-D-IAZGP), and radiation sensitivity Int. J. Radiat. Oncol. Biol. Phys. 54 2002 903-909
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 903-909
    • Saitoh, J.1    Sakurai, H.2    Suzuki, Y.3
  • 94
    • 0022607827 scopus 로고
    • The biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms
    • G.F. Whitmore A.J. Varghese The biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms Biochem. Pharmacol. 35 1986 97-103
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 97-103
    • Whitmore, G.F.1    Varghese, A.J.2
  • 95
    • 0019507711 scopus 로고
    • A marker for hypoxic cells in tumours with potential clinical applicability
    • J.D. Chapman A.J. Franko J. Sharplin A marker for hypoxic cells in tumours with potential clinical applicability Br. J. Cancer. 43 1981 546-550
    • (1981) Br. J. Cancer. , vol.43 , pp. 546-550
    • Chapman, J.D.1    Franko, A.J.2    Sharplin, J.3
  • 96
    • 0024342813 scopus 로고
    • Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo
    • R.J. Maxwell P. Workman J.R. Griffiths Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo Int. J. Radiat. Oncol. Biol. Phys. 16 1989 925-929
    • (1989) Int. J. Radiat. Oncol. Biol. Phys. , vol.16 , pp. 925-929
    • Maxwell, R.J.1    Workman, P.2    Griffiths, J.R.3
  • 97
    • 0025221111 scopus 로고
    • Dynamic measurements of hexafluoromisonidazole (CCI-103F) retention in mouse tumours by 1H/19F magnetic resonance spectroscopy
    • G.Y. Jin S.J. Li J.E. Moulder et al. Dynamic measurements of hexafluoromisonidazole (CCI-103F) retention in mouse tumours by 1H/19F magnetic resonance spectroscopy Int. J. Radiat. Biol. 58 1990 1025-1034
    • (1990) Int. J. Radiat. Biol. , vol.58 , pp. 1025-1034
    • Jin, G.Y.1    Li, S.J.2    Moulder, J.E.3
  • 98
    • 0026357960 scopus 로고
    • Development of an in vivo 19F magnetic resonance method for measuring oxygen deficiency in tumors
    • J.A. Raleigh A.J. Franko D.A. Kelly et al. Development of an in vivo 19F magnetic resonance method for measuring oxygen deficiency in tumors Magn. Reson. Med. 22 1991 451-466
    • (1991) Magn. Reson. Med. , vol.22 , pp. 451-466
    • Raleigh, J.A.1    Franko, A.J.2    Kelly, D.A.3
  • 99
    • 0026542912 scopus 로고
    • Evaluation of a fluorinated 2-nitroimidazole binding to hypoxic cells in tumor-bearing rats by 19F magnetic resonance spectroscopy and immunohistochemistry
    • L. Kwock M. Gill H.L. McMurry et al. Evaluation of a fluorinated 2-nitroimidazole binding to hypoxic cells in tumor-bearing rats by 19F magnetic resonance spectroscopy and immunohistochemistry Radiat. Res. 129 1992 71-78
    • (1992) Radiat. Res. , vol.129 , pp. 71-78
    • Kwock, L.1    Gill, M.2    McMurry, H.L.3
  • 100
    • 0035992408 scopus 로고    scopus 로고
    • Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy
    • B.M. Seddon R.J. Maxwell D.J. Honess et al. Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy Clin. Cancer Res. 8 2002 2323-2335
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2323-2335
    • Seddon, B.M.1    Maxwell, R.J.2    Honess, D.J.3
  • 101
    • 0031964711 scopus 로고    scopus 로고
    • The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554
    • E.O. Aboagye R.J. Maxwell M.R. Horsman et al. The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554 Br. J. Cancer 77 1998 65-70
    • (1998) Br. J. Cancer , vol.77 , pp. 65-70
    • Aboagye, E.O.1    Maxwell, R.J.2    Horsman, M.R.3
  • 102
    • 0031709082 scopus 로고    scopus 로고
    • Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR 4554, CRC 94/17): A non-invasive diagnostic probe for the measurement of tumor hypoxia by magnetic resonance spectroscopy and imaging, and by positron emission tomography
    • E.O. Aboagye A.B. Kelson M. Tracy Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR 4554, CRC 94/17): a non-invasive diagnostic probe for the measurement of tumor hypoxia by magnetic resonance spectroscopy and imaging, and by positron emission tomography Anticancer Drug Des. 13 1998 703-730
    • (1998) Anticancer Drug Des. , vol.13 , pp. 703-730
    • Aboagye, E.O.1    Kelson, A.B.2    Tracy, M.3
  • 103
    • 0027534422 scopus 로고
    • In vivo oxygen tension and temperature: Simultaneous determination using 19F NMR spectroscopy of perfluorocarbon
    • R.P. Mason H. Shukla P.P. Antich In vivo oxygen tension and temperature: simultaneous determination using 19F NMR spectroscopy of perfluorocarbon Magn. Reson. Med. 29 1993 296-302
    • (1993) Magn. Reson. Med. , vol.29 , pp. 296-302
    • Mason, R.P.1    Shukla, H.2    Antich, P.P.3
  • 104
    • 0027413021 scopus 로고
    • Imaging oxygen tension in liver and spleen by 19F NMR
    • S.K. Holland R.P. Kennan M.M. Schaub et al. Imaging oxygen tension in liver and spleen by 19F NMR Magn. Reson. Med. 29 1993 446-458
    • (1993) Magn. Reson. Med. , vol.29 , pp. 446-458
    • Holland, S.K.1    Kennan, R.P.2    Schaub, M.M.3
  • 105
    • 0029658470 scopus 로고    scopus 로고
    • Hexafluorobenzene: A sensitive 19F NMR indicator of tumor oxygenation
    • R.P. Mason W. Rodbumrung P.P. Antich Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation NMR Biomed. 9 1996 125-134
    • (1996) NMR Biomed. , vol.9 , pp. 125-134
    • Mason, R.P.1    Rodbumrung, W.2    Antich, P.P.3
  • 106
    • 0034793879 scopus 로고    scopus 로고
    • Prognostic radiology: Quantitative assessment of tumor oxygen dynamics by MRI
    • D. Zhao A. Constantinescu L. Jiang et al. Prognostic radiology: quantitative assessment of tumor oxygen dynamics by MRI Am. J. Clin. Oncol. 24 2001 462-466
    • (2001) Am. J. Clin. Oncol. , vol.24 , pp. 462-466
    • Zhao, D.1    Constantinescu, A.2    Jiang, L.3
  • 107
    • 0013110881 scopus 로고    scopus 로고
    • Dynamic breast tumor oximetry: The development of prognostic radiology
    • Y. Song A. Constantinescu R.P. Mason Dynamic breast tumor oximetry: the development of prognostic radiology Technol. Cancer Res. Treat. 1 2002 471-478
    • (2002) Technol. Cancer Res. Treat. , vol.1 , pp. 471-478
    • Song, Y.1    Constantinescu, A.2    Mason, R.P.3
  • 108
    • 0031865692 scopus 로고    scopus 로고
    • In vivo measurement of arterial and venous oxygenation in the rat using 3D spectral-spatial electron paramagnetic resonance imaging
    • P. Kuppusamy R.A. Shankar J.L. Zweier In vivo measurement of arterial and venous oxygenation in the rat using 3D spectral-spatial electron paramagnetic resonance imaging Phys. Med. Biol. 43 1998 1837-1844
    • (1998) Phys. Med. Biol. , vol.43 , pp. 1837-1844
    • Kuppusamy, P.1    Shankar, R.A.2    Zweier, J.L.3
  • 109
    • 0025163204 scopus 로고
    • Principles of the metabolism of nitroxides and their implications for spin trapping
    • H.M. Swartz Principles of the metabolism of nitroxides and their implications for spin trapping Free Radic. Res. Commun. 9 1990 399-405
    • (1990) Free Radic. Res. Commun. , vol.9 , pp. 399-405
    • Swartz, H.M.1
  • 110
    • 0024583546 scopus 로고
    • Effects of oxygen on the metabolism of nitroxide spin labels in cells
    • K. Chen J.F. Glockner P.D. Morse et al. 2nd Effects of oxygen on the metabolism of nitroxide spin labels in cells Biochemistry 28 1989 2496-2501
    • (1989) Biochemistry , vol.28 , pp. 2496-2501
    • Chen, K.1    Glockner, J.F.2    Morse II, P.D.3
  • 111
    • 0030066131 scopus 로고    scopus 로고
    • Use of nitroxides for assessing perfusion, oxygenation, and viability of tissues: In vivo EPR and MRI studies
    • B. Gallez G. Bacic F. Goda et al. Use of nitroxides for assessing perfusion, oxygenation, and viability of tissues: in vivo EPR and MRI studies Magn. Reson. Med. 35 1996 97-106
    • (1996) Magn. Reson. Med. , vol.35 , pp. 97-106
    • Gallez, B.1    Bacic, G.2    Goda, F.3
  • 112
    • 0031739119 scopus 로고    scopus 로고
    • Effect on regrowth delay in a murine tumor of scheduling split-dose irradiation based on direct pO2 measurements by electron paramagnetic resonance oximetry
    • J.A. O'Hara F. Goda E. Demidenko et al. Effect on regrowth delay in a murine tumor of scheduling split-dose irradiation based on direct pO2 measurements by electron paramagnetic resonance oximetry Radiat. Res. 150 1998 549-556
    • (1998) Radiat. Res. , vol.150 , pp. 549-556
    • O'Hara, J.A.1    Goda, F.2    Demidenko, E.3
  • 113
    • 0034267721 scopus 로고    scopus 로고
    • Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: Monitoring by EPR and MRI
    • B.F. Jordan P. Misson R. Demeure et al. Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: monitoring by EPR and MRI Int. J. Radiat. Oncol. Biol. Phys. 48 2000 565-570
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.48 , pp. 565-570
    • Jordan, B.F.1    Misson, P.2    Demeure, R.3
  • 114
    • 0036209705 scopus 로고    scopus 로고
    • Imaging spin probe distribution in the tumor of a living mouse with 250 MHz EPR: Correlation with BOLD MRI
    • B.B. Williams H. al Hallaq G.V. Chandramouli et al. Imaging spin probe distribution in the tumor of a living mouse with 250 MHz EPR: correlation with BOLD MRI Magn. Reson. Med. 47 2002 634-638
    • (2002) Magn. Reson. Med. , vol.47 , pp. 634-638
    • Williams, B.B.1    al Hallaq, H.2    Chandramouli, G.V.3
  • 115
    • 0032054824 scopus 로고    scopus 로고
    • In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine model
    • P. Kuppusamy M. Afeworki R.A. Shankar et al. In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine model Cancer Res. 58 1998 1562-1568
    • (1998) Cancer Res. , vol.58 , pp. 1562-1568
    • Kuppusamy, P.1    Afeworki, M.2    Shankar, R.A.3
  • 116
    • 0028557355 scopus 로고
    • Oxymetry deep in tissues with low-frequency electron paramagnetic resonance
    • H.J. Halpern C. Yu M. Peric et al. Oxymetry deep in tissues with low-frequency electron paramagnetic resonance Proc. Natl. Acad. Sci. U S A 91 1994 13047-13051
    • (1994) Proc. Natl. Acad. Sci. U S A , vol.91 , pp. 13047-13051
    • Halpern, H.J.1    Yu, C.2    Peric, M.3
  • 117
    • 0036828969 scopus 로고    scopus 로고
    • Changes in oxygenation of intracranial tumors with carbogen: A BOLD MRI and EPR oximetry study
    • J.F. Dunn J.A. O'Hara Y. Zaim-Wadghiri et al. Changes in oxygenation of intracranial tumors with carbogen: a BOLD MRI and EPR oximetry study J. Magn. Reson. Imaging 16 2002 511-521
    • (2002) J. Magn. Reson. Imaging , vol.16 , pp. 511-521
    • Dunn, J.F.1    O'Hara, J.A.2    Zaim-Wadghiri, Y.3
  • 118
    • 0036159540 scopus 로고    scopus 로고
    • Imaging and quantitation of the hypoxic cell fraction of viable tumor in an animal model of intracerebral high grade glioma using [18F]fluoromisonidazole (FMISO)
    • H.J. Tochon-Danguy J.I. Sachinidis F. Chan et al. Imaging and quantitation of the hypoxic cell fraction of viable tumor in an animal model of intracerebral high grade glioma using [18F]fluoromisonidazole (FMISO) Nucl. Med. Biol. 29 2002 191-197
    • (2002) Nucl. Med. Biol. , vol.29 , pp. 191-197
    • Tochon-Danguy, H.J.1    Sachinidis, J.I.2    Chan, F.3
  • 119
    • 0025285228 scopus 로고
    • Characteristics of the binding of labeled fluoromisonidazole in cells in vitro
    • J.S. Rasey N.J. Nelson L. Chin et al. Characteristics of the binding of labeled fluoromisonidazole in cells in vitro Radiat. Res. 122 1990 301-308
    • (1990) Radiat. Res. , vol.122 , pp. 301-308
    • Rasey, J.S.1    Nelson, N.J.2    Chin, L.3
  • 120
  • 121
    • 0030249455 scopus 로고    scopus 로고
    • Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: A pretherapy study of 37 patients
    • J.S. Rasey W.J. Koh M.L. Evans et al. Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients Int. J. Radiat. Oncol. Biol. Phys. 36 1996 417-428
    • (1996) Int. J. Radiat. Oncol. Biol. Phys. , vol.36 , pp. 417-428
    • Rasey, J.S.1    Koh, W.J.2    Evans, M.L.3
  • 122
    • 12444290525 scopus 로고    scopus 로고
    • 18F)FDG PET imaging in soft tissue sarcomas: Correlation of hypoxia, metabolism and VEGF expression
    • 18F)FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression Eur. J. Nucl. Med. Mol. Imaging 30 2003 695-704
    • (2003) Eur. J. Nucl. Med. Mol. Imaging , vol.30 , pp. 695-704
    • Rajendran, J.G.1    Wilson, D.C.2    Conrad, E.U.3
  • 123
    • 0029145952 scopus 로고
    • Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography
    • W.J. Koh K.S. Bergman J.S. Rasey et al. Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography Int. J. Radiat. Oncol. Biol. Phys. 33 1995 391-398
    • (1995) Int. J. Radiat. Oncol. Biol. Phys. , vol.33 , pp. 391-398
    • Koh, W.J.1    Bergman, K.S.2    Rasey, J.S.3
  • 124
    • 0035863303 scopus 로고    scopus 로고
    • Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer
    • D. Rischin L. Peters R. Hicks et al. Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer J. Clin. Oncol. 19 2001 535-542
    • (2001) J. Clin. Oncol. , vol.19 , pp. 535-542
    • Rischin, D.1    Peters, L.2    Hicks, R.3
  • 125
    • 0013145495 scopus 로고    scopus 로고
    • Correlation of hypoxic cell fraction with glucose metabolic rate in gliomas with 18F-fluoromisonidazole(FMISO) and 18F-fluorodeoxyglucose (FDG) positron emission tomography
    • A.M. Scott S. Ramdave A. Hannah et al. Correlation of hypoxic cell fraction with glucose metabolic rate in gliomas with 18 F-fluoromisonidazole(FMISO) and 18 F-fluorodeoxyglucose (FDG) positron emission tomography J. Nucl. Med. 42 2001 678P
    • (2001) J. Nucl. Med. , vol.42
    • Scott, A.M.1    Ramdave, S.2    Hannah, A.3
  • 127
    • 0031869326 scopus 로고    scopus 로고
    • Design of hypoxia-targeting radiopharmaceuticals: Selective uptake of copper-64 complexes in hypoxic cells in vitro
    • J.L. Dearling J.S. Lewis G.E. Mullen et al. Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro Eur. J. Nucl. Med. 25 1998 788-792
    • (1998) Eur. J. Nucl. Med. , vol.25 , pp. 788-792
    • Dearling, J.L.1    Lewis, J.S.2    Mullen, G.E.3
  • 129
    • 0033625862 scopus 로고    scopus 로고
    • Evaluation of 62Cu labeled diacetyl-bis(N4-methylthiosemicarbazone) as a hypoxic tissue tracer in patients with lung cancer
    • N. Takahashi Y. Fujibayashi Y. Yonekura et al. Evaluation of 62Cu labeled diacetyl-bis(N4-methylthiosemicarbazone) as a hypoxic tissue tracer in patients with lung cancer Ann. Nucl. Med. 14 2000 323-328
    • (2000) Ann. Nucl. Med. , vol.14 , pp. 323-328
    • Takahashi, N.1    Fujibayashi, Y.2    Yonekura, Y.3
  • 131
    • 0002112458 scopus 로고    scopus 로고
    • Evaluation of tumour hypoxia with Cu-60-ATSM and PET
    • F. Dehdashti M.A. Mintun J.S. Lewis et al. Evaluation of tumour hypoxia with Cu-60-ATSM and PET J. Nucl. Med. 41 2000 34P
    • (2000) J. Nucl. Med. , vol.41
    • Dehdashti, F.1    Mintun, M.A.2    Lewis, J.S.3
  • 133
    • 0034843378 scopus 로고    scopus 로고
    • Pharmacokinetics of [18F]FETNIM: A potential marker for PET
    • T. Gronroos O. Eskola K. Lehtio et al. Pharmacokinetics of [18F]FETNIM: a potential marker for PET J. Nucl. Med. 42 2001 1397-1404
    • (2001) J. Nucl. Med. , vol.42 , pp. 1397-1404
    • Gronroos, T.1    Eskola, O.2    Lehtio, K.3
  • 134
    • 0029933781 scopus 로고    scopus 로고
    • Measurement of hypoxia in human tumours by non-invasive spect imaging of iodoazomycin arabinoside
    • R.C. Urtasun M.B. Parliament A.J. McEwan et al. Measurement of hypoxia in human tumours by non-invasive spect imaging of iodoazomycin arabinoside Br. J. Cancer 27 suppl 1996 S209-S212
    • (1996) Br. J. Cancer , vol.27 , Issue.SUPPL.
    • Urtasun, R.C.1    Parliament, M.B.2    McEwan, A.J.3
  • 135
    • 0026585518 scopus 로고
    • Non-invasive assessment of human tumour hypoxia with 123I-iodoazomycin arabinoside: Preliminary report of a clinical study
    • M.B. Parliament J.D. Chapman R.C. Urtasun et al. Non-invasive assessment of human tumour hypoxia with 123I-iodoazomycin arabinoside: preliminary report of a clinical study Br. J. Cancer 65 1992 90-95
    • (1992) Br. J. Cancer , vol.65 , pp. 90-95
    • Parliament, M.B.1    Chapman, J.D.2    Urtasun, R.C.3
  • 137
    • 0031865002 scopus 로고    scopus 로고
    • A dual hypoxic marker technique for measuring oxygenation change within individual tumors
    • R.V. Iyer E. Kim R.F. Schneider et al. A dual hypoxic marker technique for measuring oxygenation change within individual tumors Br. J. Cancer 78 1998 163-169
    • (1998) Br. J. Cancer , vol.78 , pp. 163-169
    • Iyer, R.V.1    Kim, E.2    Schneider, R.F.3
  • 138
    • 0031665079 scopus 로고    scopus 로고
    • Lack of perfusion enhancement after administration of nicotinamide and carbogen in patients with glioblastoma: A 99mTc-HMPAO SPECT study
    • M.C. Hulshof C.J. Rehmann J. Booij et al. Lack of perfusion enhancement after administration of nicotinamide and carbogen in patients with glioblastoma: a 99mTc-HMPAO SPECT study Radiother. Oncol. 48 1998 135-142
    • (1998) Radiother. Oncol. , vol.48 , pp. 135-142
    • Hulshof, M.C.1    Rehmann, C.J.2    Booij, J.3
  • 139
    • 0007367571 scopus 로고    scopus 로고
    • Comparison of MMS 181321 and BMS 194796, nitoimidazoles labeled with Technetium-99m, as markers for tumour hypoxia
    • 45th Annual Meeting of the Radiation Research Society. Provence, RI
    • Melo T. Ballinger J. Rauth A.M. Comparison of MMS 181321 and BMS 194796, nitoimidazoles labeled with Technetium-99m, as markers for tumour hypoxia 45th Annual Meeting of the Radiation Research Society. Provence, RI 1997.
    • (1997)
    • Melo, T.1    Ballinger, J.2    Rauth, A.M.3
  • 141
    • 0030162585 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of a technetium-99m-labeled 2-nitroimidazole (BMS181321) as a marker of tumor hypoxia
    • J.R. Ballinger J.W. Kee A.M. Rauth In vitro and in vivo evaluation of a technetium-99m-labeled 2-nitroimidazole (BMS181321) as a marker of tumor hypoxia J. Nucl. Med. 37 1996 1023-1031
    • (1996) J. Nucl. Med. , vol.37 , pp. 1023-1031
    • Ballinger, J.R.1    Kee, J.W.2    Rauth, A.M.3
  • 142
    • 0033959159 scopus 로고    scopus 로고
    • BRU59-U21, a second-generation 99mTc-labeled 2-nitroimidazole for imaging hypoxia in tumors
    • T. Melo J. Duncan J.R. Ballinger et al. BRU59-U21, a second-generation 99mTc-labeled 2-nitroimidazole for imaging hypoxia in tumors J. Nucl. Med. 41 2000 169-176
    • (2000) J. Nucl. Med. , vol.41 , pp. 169-176
    • Melo, T.1    Duncan, J.2    Ballinger, J.R.3
  • 143
    • 0036373462 scopus 로고    scopus 로고
    • Phase 1 study to identify tumour hypoxia in patients with head and neck cancer using technetium-99m BRU59-21
    • F.J. Hoebers H.L. Janssen A.V. Olmos et al. Phase 1 study to identify tumour hypoxia in patients with head and neck cancer using technetium-99m BRU59-21 Eur. J. Nucl. Med. Mol. Imaging 29 2002 1206-1211
    • (2002) Eur. J. Nucl. Med. Mol. Imaging , vol.29 , pp. 1206-1211
    • Hoebers, F.J.1    Janssen, H.L.2    Olmos, A.V.3
  • 144
    • 0031793733 scopus 로고    scopus 로고
    • Preclinical evaluation of the novel hypoxic marker 99mTc-HL91 (Prognox) in murine and xenograft systems in vivo
    • D.J. Honess S.A. Hill D.R. Collingridge et al. Preclinical evaluation of the novel hypoxic marker 99mTc-HL91 (Prognox) in murine and xenograft systems in vivo Int. J. Radiat. Oncol. Biol. Phys. 42 1998 731-735
    • (1998) Int. J. Radiat. Oncol. Biol. Phys. , vol.42 , pp. 731-735
    • Honess, D.J.1    Hill, S.A.2    Collingridge, D.R.3
  • 145
    • 0025972731 scopus 로고
    • Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation
    • J.M. Brown M.J. Lemmon Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation Int. J. Radiat. Oncol. Biol. Phys. 20 1991 457-461
    • (1991) Int. J. Radiat. Oncol. Biol. Phys. , vol.20 , pp. 457-461
    • Brown, J.M.1    Lemmon, M.J.2
  • 146
    • 0031023702 scopus 로고    scopus 로고
    • Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine
    • M.J. Dorie J.M. Brown Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine Cancer Chemother. Pharmacol. 39 1997 361-366
    • (1997) Cancer Chemother. Pharmacol. , vol.39 , pp. 361-366
    • Dorie, M.J.1    Brown, J.M.2
  • 147
    • 0031926560 scopus 로고    scopus 로고
    • Microenvironmental control of gene expression: Implications for tumor angiogenesis, progression, and metastasis
    • G.U. Dachs D.J. Chaplin Microenvironmental control of gene expression: implications for tumor angiogenesis, progression, and metastasis Semin. Radiat. Oncol. 8 1998 208-216
    • (1998) Semin. Radiat. Oncol. , vol.8 , pp. 208-216
    • Dachs, G.U.1    Chaplin, D.J.2
  • 148
    • 0030968939 scopus 로고    scopus 로고
    • Targeting gene expression to hypoxic tumor cells
    • G.U. Dachs A.V. Patterson J.D. Firth et al. Targeting gene expression to hypoxic tumor cells Nat. Med. 3 1997 515-520
    • (1997) Nat. Med. , vol.3 , pp. 515-520
    • Dachs, G.U.1    Patterson, A.V.2    Firth, J.D.3


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